The R230C variant of the ATP binding cassette protein A1 (ABCA1) gene is associated with a decreased response to glyburide therapy in patients with type 2 diabetes mellitus

Metabolism: Clinical and Experimental

Volumn 62, Issue 5, 2013, Pages 638-641

  Aguilar Salinas, Carlos A ^a,b   Muñoz Hernandez, Linda Liliana ^a   Cobos Bonilla, Monica ^a   Ramírez Márquez, Marcos Rafael ^a   Ordoñez Sanchez, Maria Luisa ^c   Mehta, Roopa ^a   Medina Santillan, Roberto ^b   Tusie Luna, Maria Teresa ^c  

^a INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

ABC A1; Glyburide; Pharmacogenomics

Indexed keywords

ABC TRANSPORTER A1; GLIBENCLAMIDE; GLUCOSE; HEMOGLOBIN A1C; METFORMIN; SULFONYLUREA;

ADULT; AGE; ARTICLE; BODY MASS; BODY WEIGHT; CONTROLLED STUDY; DIABETIC PATIENT; DIET RESTRICTION; DRUG RESPONSE; FEMALE; GENDER; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; LIFESTYLE MODIFICATION; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; PRESCRIPTION; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE BLIND PROCEDURE; TREATMENT DURATION;

ADULT; AGED; AMINO ACID SUBSTITUTION; ARGININE; ATP-BINDING CASSETTE TRANSPORTERS; CYSTEINE; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GLYBURIDE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MIDDLE AGED; MUTATION, MISSENSE; POLYMORPHISM, SINGLE NUCLEOTIDE; SINGLE-BLIND METHOD; YOUNG ADULT;

EID: 84876694184     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2012.11.006     Document Type: Article

References (17)

1. J.F. Oram, and J.W. Heinecke ATP-binding cassette transporter A1: A cell cholesterol exporter that protects against cardiovascular disease Physiol Rev 85 2005 1343 1372 (Pubitemid 41362273)
2. L.R. Brunham, R. Singaraja, and M.R. Hayden Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis Annu Rev Nutr 26 2006 17.1 17.26
3. C.A. Aguilar-Salinas, S. Canizales-Quinteros, and R. Rojas- Martínez Hypoalphalipoproteinemia in populations of Native American ancestry: An opportunity to assess the interaction of genes and the environment Curr Opin Lipidol 20 2009 92 97
4. C.A. Aguilar-Salinas, S. Canizales-Quinteros, and R. Rojas- Martínez The non-synonymous Arg230Cys variant (R230C) of the ATP-binding cassette transporter A1 is associated with low HDL cholesterol concentrations in Mexican adults: A population based nation wide study Atherosclerosis 216 2011 146 150
5. M.T. Villarreal-Molina, C.A. Aguilar-Salinas, and M. Rodríguez- Cruz The ABCA1 R230C variant affects HDL cholesterol levels and body mass index in the Mexican population: Association with obesity and obesity-related comorbidities Diabetes 56 2007 1881 1887 (Pubitemid 47025444)
6. M.T. Villarreal-Molina, M.T. Flores-Dorantes, and O. Arellano-Campos Association of the ABCA1 R230C variant with early-onset type 2 diabetes in the Mexican population Diabetes 57 2008 509 513
7. L.R. Brunham, J.K. Kruit, and T.D. Pape Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment Nat Med 13 2007 340 347 (Pubitemid 46376682)
8. N. Wijesekara, L.H. Zhang, and M.H. Kang miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets Diabetes 61 2012 653 658
9. J.K. Kruit, N. Wijesekara, and C. Westwell-Roper Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function Diabetes 61 2012 659 664
10. M. Daimon, T. Kido, and M. Baba Association of the ABCA1 gene polymorphisms with type 2 DM in a Japanese population Biochem Biophys Res Commun 329 2005 205 210 (Pubitemid 40255441)
11. C. Aquilante Sulfonylurea pharmacogenomics in type 2 diabetes: The influence of drug target and diabetes risk polymorphisms Expert Rev Cardiovasc Ther 8 2010 359 372
12. J.K. Kruit, N. Wijesekara, and J.E. Fox Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules Diabetes 60 2011 3186 3196
13. C.A. Aguilar Salinas, I. Cruz-Bautista, and R. Mehta The ATP-binding cassette transporter subfamily A member 1 (ABC-A1) and type 2 diabetes: An association beyond HDL cholesterol Curr Diabetes Rev 3 2007 264 267 (Pubitemid 350111110)
14. V. Acuña-Alonzo, T. Flores-Dorantes, and J.K. Kruit A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans Hum Mol Genet 19 2010 2877 2885
15. D. Ng, and N. Saw The role of HDL and its modulator in the development of diabetes Curr Opin Lipidol 23 2012 167 168
16. G. Getz, and C. Reardon High-density lipoprotein function in regulating insulin secretion: possible relevance to metabolic syndrome Arterioscler Thromb Vasc Biol 30 2010 1497 1499
17. D.S. Bell Practical considerations and guidelines for dosing sulfonylureas as monotherapy or combination therapy Clin Ther 26 11 2004 Nov 1714 1727 (Pubitemid 40089487)