Colchicine toxicity precipitated by interaction with sunitinib

Journal of Clinical Pharmacy and Therapeutics

Volumn 38, Issue 3, 2013, Pages 243-245

  Abodunde, Oladapo A ^a   Levakaveera, Raghava Reddy ^a   Desai, Ravi ^a   Nweke, Nneka ^a   Berrou, Mohammed ^a  

^a ABINGTON MEMORIAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; DILTIAZEM; FUROSEMIDE; HEMOGLOBIN; LEVOTHYROXINE; NORADRENALIN; RABEPRAZOLE; SUNITINIB; TROPONIN;

ACANTHOCYTOSIS; AGED; ANEMIA; ANTIBIOTIC THERAPY; ARTERY OCCLUSION; CASE REPORT; CORONARY ARTERY DISEASE; DIARRHEA; DYSPNEA; ECHOCARDIOGRAPHY; ERYTHROCYTE; FEVER; HEART CATHETERIZATION; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; HYPOKALEMIA; HYPOMAGNESEMIA; HYPOTENSION; LEUKOCYTE COUNT; LEUKOPENIA; MALE; METABOLIC ACIDOSIS; MULTIPLE CYCLE TREATMENT; PNEUMONIA; REVIEW; RIGOR; SHOCK; SYSTOLIC HEART FAILURE; T WAVE INVERSION; TABLET; THORAX PAIN; THROMBOCYTOPENIA;

AGED, 80 AND OVER; ANGIOGENESIS INHIBITORS; ANTI-INFLAMMATORY AGENTS; COLCHICINE; DRUG INTERACTIONS; HUMANS; INDOLES; MALE; PYRROLES;

EID: 84876693277     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/jcpt.12047     Document Type: Review

References (10)

1. Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, et al,. Colchicine poisoning: the dark side of an ancient drug. Clinic Toxicol, 2010; 48: 407-414.
2. http://www.fda.gov/Drugs/DrugSafety/ PostmarketDrugSafetyInformationforPatientsandProviders/ DrugSafetyInformationforHeathcareProfessionals/ucm174315.htm. FDA research data accessed on June 26, 2012
3. Shukla S, Robey RW, Bates SE, Ambudkar SV,. Sunitinib (Sutent, SU11248) a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2. Drug Metab Distrib, 2009; 37: 359-365.
4. Dahan A, Sabit H, Amidon GL,. Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of P-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine. Drug Metab Dispos, 2009; 37: 2028-2036.
5. Speeg KV, Maldonado AL, Liaci J, Muirhead D., Effect of cyclosporine on colchicine secretion by a liver canalicular transporter studied in vivo. Hepatology, 1992; 15: 899-903.
6. Speeg KV, Maldonado AL, Liaci J, Muirhead D., Effect of cyclosporine on colchicine secretion by the kidney multidrug transporter studied in vivo. J Pharmacol Exp Ther, 1992; 261: 50-55.
7. Levsky ME, Miller MA, Masneri DA, Borys D., Colchicine exposures: the Texas experience. South Med J, 2008; 101: 480-483.
8. Mullins ME, Robertson DG, Norton RL., Troponin I as a marker of cardiac toxicity in acute colchicine overdose. Am J Emerg Med, 2000; 18: 743-744.
9. Davies HO, Hyland RH, Morgan CD, Laroye GJ,. Massive overdose of colchicine. CMAJ 1988; 138: 335-336.
10. Kocak Z, Akay H, Gucenmez S, Tufan A, Donderici O., Colchicine intoxication and infection risk: a case report. J Clin Pharm Ther, 2008; 33: 451-452.