Altered TGF-β2 and bFGF expression in scleral desmocytes from an experimentally-induced myopia guinea pig model

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 251, Issue 4, 2013, Pages 1133-1144

  Chen, Bo Yu ^a   Wang, Chao Ying ^a   Chen, Wei Yi ^b   Ma, Jing Xue ^c  

^a BETHUNE INTERNATIONAL PEACE HOSPITAL   (China)

^b TAIYUAN UNIVERSITY OF TECHNOLOGY   (China)

^c HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

bFGF; Cultured cells; Myopia; Scleral desmocytes; TGF 2

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA2;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR EYE CHAMBER; ARTICLE; CELL GROWTH; CELL STRUCTURE; CONTROLLED STUDY; DISEASE COURSE; FIBROBLAST; GUINEA PIG; MYOPIA; NONHUMAN; PATHOPHYSIOLOGY; POSTERIOR EYE CHAMBER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCLERAL DESMOCYTE;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DESMIN; DISEASE MODELS, ANIMAL; FIBROBLAST GROWTH FACTOR 2; FIBROBLASTS; GUINEA PIGS; KERATINS; MYOPIA; REAL-TIME POLYMERASE CHAIN REACTION; S100 PROTEINS; SCLERA; TRANSFORMING GROWTH FACTOR BETA2; VIMENTIN;

EID: 84876676113     PISSN: 0721832X     EISSN: 1435702X     Source Type: Journal    
DOI: 10.1007/s00417-013-2269-8     Document Type: Article

References (23)

1. Rada JA, Nickla DL, Troilo D (2000) Decreased proteoglycan synthesis associated with form deprivation myopia in mature primate eyes [J]. Invest Ophthalmol Vis Sci 41(I):2050-2058 (Pubitemid 30450972)
2. Hu D (2004) Progress in the study of myopic etiology and pathogenesis. Chin J Optometry Ophthalmol 6(1):1-5
3. Hu D, McComick SA (2000) Role of RPE Choroid axis on the occurrence of myopia [J]. Chin J Optometry Ophthalmol 2(4):197-200
4. Zhu X, Park TW, Winawer J, Walman J (2005) In a matter of minutes, the eye can know which way to grow [J]. Invest Ophthalmol Vis Sci 46(7):2238-2241 (Pubitemid 43119464)
5. Honda S, Fujii S, Sekiya Y, Yamamoto M (1996) Retinal control on the axial length mediated by transforming growth factor-βin chick eye [J]. Invest Ophthalmol Vis Sci 37(2):2519-2526 (Pubitemid 26391289)
6. Mathis U, Schaeffel F (2010) Transforming growth factor-beta in the chicken fundal layers: an immunohistochemical study. Exp Eye Res 90(6):780-790
7. Seko Y, Shimokawa H, Tokoro T (1995) Expression of bFGF and TGF-β2 in experimental myopia in chickens [J]. Invest ophthalmol Vis Sci 36(6):1183-1187
8. Seko Y, Tanaka Y, Tokoro T (1995) Influence of bFGF as a potent growth stimulator and TGF-β as a growth regulator on scleral chondrocytes and scleral fibroblasts in vitro [J]. Ophthalmic Res 27(3):144-152
9. Ouyang CH, Hu WZ, Chu RY (2002) Effects of concave lens on eyes of guinea pig. Chin Ophthal Res 20(5):391-393
10. Chen BY, Ma JX, Wang CY, Chen WY (2012) Mechanical behavior of scleral fibroblasts in experimental myopia. Graefes Archive Clin Exp Ophthalmol 250(3):341-348
11. Laihu MO, Saksela O, Andresen PA, Keski-Qja J (1986) Enhanced production and extracellular deposition of die endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transfoming growth factor-beta [J]. J Cell B ion 103:2403-2410 (Pubitemid 17216664)
12. Bikfalvi A, Klein S, Pintucci G, Rifkin DB (1997) Biological roles of fibroblast growth factor-2 [J]. Endocr Rev 18(1):26-45 (Pubitemid 27076454)
13. Qu J, Li H, Zhou XT, Hu DN, Zhang LH, Fu XY, Lü F (2005) Expression of bFGF receptor and TGF-beta receptors in cultured human scleral fibroblasts. Zhonghua. Yan Ke Za Zhi 41(5):464-467
14. Gentle A, McBrien NA (2002) Retinoscleral control of scleral remodelling in refractive development: a role for endogenous FGF-2? Cytokine 18(6):344-348 (Pubitemid 35007483)
15. Rohrer B, Iuvone PM, Stell WK (1995) Stimulation of dopaminergic amacrine cells by stroboscopic illumination or fibroblast growth factor (bFGF, FGF-2) injections: possible roles in prevention of form-deprivation myopia in the chick. Brain Res 686:169
16. Jobling AI, Nguyen M, Gentle A, McBrien NA (2004) Isoform-specific changes in scleral transforming growth factor-beta expression and the regulation of collagen synthesis during myopia progression. J Biol Chem 279(18):18121-18126 (Pubitemid 38623224)
17. Rohrer B, Stell WK (1994) Basic fibroblast growth factor and transforming growth factor act as stop and go signals to modulate postnatal ocular growth in the chick. Exp Eye Res 58:553-561 (Pubitemid 24249764)
18. Rohrer B, Tao J, Stell WK (1997) Basic fibroblast growth factor, its high and low affinity receptors and their relationship to form deprivation myopia in the chick [J]. NeuroSci 79(3):775 (Pubitemid 27292674)
19. Hu DN, McCormick SA (2000) Effect of TGF-β and cAMP-elevating agents on the growth of human scleral fibroblasts in vitro (A). In: Lin LK (Ed) Myopia updates II. Proceedings, VII International Conference on Myopia [M]. Springer, Tokyo, pp 131-132
20. Kee CS, Marazani D, Wallman J (2001) Differences in time course and visual requirements of ocular responses to lenses and diffusers [J]. Invest Ophthalmol Vis Sci 42:575-583 (Pubitemid 32206894)
21. Ejedor J, de la Villa P (2003) Refractive changes induced by form deprivation in the mouse eye [J]. Invest Ophthalmol Vis Sci 44:32-36 (Pubitemid 36134253)
22. Barathi VA, Weon SR, Beuerman RW (2009) Expression of muscarinic receptors in human and mouse sclera and their role in the regulation of scleral fibroblasts proliferation. Mol Vis 15:1277-1293
23. Shelton L, Rada JA (2009) Inhibition of human scleral fibroblast cell attachment to collagen Type I by TGFBIp. Invest Ophthalmol Vis Sci 50(8):3542-3552