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Volumn 62, Issue 5, 2013, Pages 1409-1416

Independent effects of testosterone on lipid oxidation and VLDL-TG production: A randomized, double-blind, placebo-controlled, crossover study

Author keywords

[No Author keywords available]

Indexed keywords

LEUPRORELIN; NEUTRAL INSULIN; PLACEBO; TESTOSTERONE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

EID: 84876588163     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-0440     Document Type: Article
Times cited : (29)

References (52)
  • 1
    • 77955272470 scopus 로고    scopus 로고
    • Testosterone deficiency: A risk factor for cardiovascular disease?
    • Jones TH. Testosterone deficiency: a risk factor for cardiovascular disease? Trends Endocrinol Metab 2010;21:496-503
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 496-503
    • Jones, T.H.1
  • 2
    • 59849096860 scopus 로고    scopus 로고
    • Testosterone in obesity, metabolic syndrome and type 2 diabetes
    • Stanworth RD, Jones TH. Testosterone in obesity, metabolic syndrome and type 2 diabetes. Front Horm Res 2009;37:74-90
    • (2009) Front Horm Res , vol.37 , pp. 74-90
    • Stanworth, R.D.1    Jones, T.H.2
  • 7
    • 0034819462 scopus 로고    scopus 로고
    • Intramuscular testosterone esters and plasma lipids in hypogonadal men: A meta-analysis
    • DOI 10.1016/S0002-9343(01)00833-6, PII S0002934301008336
    • Whitsel EA, Boyko EJ, Matsumoto AM, Anawalt BD, Siscovick DS. Intramuscular testosterone esters and plasma lipids in hypogonadal men: a meta-analysis. Am J Med 2001;111:261-269 (Pubitemid 32885620)
    • (2001) American Journal of Medicine , vol.111 , Issue.4 , pp. 261-269
    • Whitsel, E.A.1    Boyko, E.J.2    Matsumoto, A.M.3    Anawalt, B.D.4    Siscovick, D.S.5
  • 9
    • 33751259426 scopus 로고    scopus 로고
    • Effects of growth hormone and/or testosterone on very low density lipoprotein apolipoprotein B100 kinetics and plasma lipids in healthy elderly men: A randomised controlled trial
    • DOI 10.1016/j.ghir.2006.08.001, PII S1096637406001110
    • Giannoulis MG, Jackson N, Shojaee-Moradie F, Sonksen PH, Martin FC, Umpleby AM. Effects of growth hormone and/or testosterone on very low density lipoprotein apolipoprotein B100 kinetics and plasma lipids in healthy elderly men: a randomised controlled trial. Growth Horm IGF Res 2006;16:308-317 (Pubitemid 44793714)
    • (2006) Growth Hormone and IGF Research , vol.16 , Issue.5-6 , pp. 308-317
    • Giannoulis, M.G.1    Jackson, N.2    Shojaee-Moradie, F.3    Sonksen, P.H.4    Martin, F.C.5    Umpleby, A.M.6
  • 10
    • 1842684155 scopus 로고    scopus 로고
    • Serum adiponectin levels in hypogonadal males: Influence of testosterone replacement therapy
    • DOI 10.1111/j.1365-2265.2004.02007.x
    • Lanfranco F, Zitzmann M, Simoni M, Nieschlag E. Serum adiponectin levels in hypogonadal males: influence of testosterone replacement therapy. Clin Endocrinol (Oxf) 2004;60:500-507 (Pubitemid 38482514)
    • (2004) Clinical Endocrinology , vol.60 , Issue.4 , pp. 500-507
    • Lanfranco, F.1    Zitzmann, M.2    Simoni, M.3    Nieschlag, E.4
  • 13
    • 78751528564 scopus 로고    scopus 로고
    • Basal and insulin mediated VLDL-triglyceride kinetics in type 2 diabetic men
    • Sørensen LP, Andersen IR, Søndergaard E, et al. Basal and insulin mediated VLDL-triglyceride kinetics in type 2 diabetic men. Diabetes 2011;60:88-96
    • (2011) Diabetes , vol.60 , pp. 88-96
    • Sørensen, L.P.1    Andersen, I.R.2    Søndergaard, E.3
  • 14
    • 84857426282 scopus 로고    scopus 로고
    • Effects of male hypogonadism on regional adipose tissue fatty acid storage and lipogenic proteins
    • Santosa S, Jensen MD. Effects of male hypogonadism on regional adipose tissue fatty acid storage and lipogenic proteins. PLoS ONE 2012;7:e31473
    • (2012) PLoS ONE , vol.7
    • Santosa, S.1    Jensen, M.D.2
  • 16
    • 67349284327 scopus 로고    scopus 로고
    • Plasma lipid transfer enzymes in non-diabetic lean and obese men and women
    • Magkos F, Mohammed BS, Mittendorfer B. Plasma lipid transfer enzymes in non-diabetic lean and obese men and women. Lipids 2009;44:459-464
    • (2009) Lipids , vol.44 , pp. 459-464
    • Magkos, F.1    Mohammed, B.S.2    Mittendorfer, B.3
  • 20
    • 46249091950 scopus 로고    scopus 로고
    • Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor
    • Lin HY, Yu IC, Wang RS, et al. Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor. Hepatology 2008;47:1924-1935
    • (2008) Hepatology , vol.47 , pp. 1924-1935
    • Lin, H.Y.1    Yu, I.C.2    Wang, R.S.3
  • 21
    • 0029263607 scopus 로고
    • Effects of testosterone on triglyceride uptake and mobilization in different adipose tissues in male rats in vivo
    • Li M, Björntorp P. Effects of testosterone on triglyceride uptake and mobilization in different adipose tissues in male rats in vivo. Obes Res 1995;3:113-119
    • (1995) Obes Res , vol.3 , pp. 113-119
    • Li, M.1    Björntorp, P.2
  • 22
    • 0026399706 scopus 로고
    • Effect of testosterone on abdominal adipose tissue in men
    • Rebuffé-Scrive M, Mårin P, Björntorp P. Effect of testosterone on abdominal adipose tissue in men. Int J Obes 1991;15:791-795
    • (1991) Int J Obes , vol.15 , pp. 791-795
    • Rebuffé-Scrive, M.1    Mårin, P.2    Björntorp, P.3
  • 23
    • 0028797188 scopus 로고
    • Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: Effects of androgens
    • Mårin P, Odén B, Björntorp P. Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens. J Clin Endocrinol Metab 1995;80:239-243
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 239-243
    • Mårin, P.1    Odén, B.2    Björntorp, P.3
  • 24
    • 80052564156 scopus 로고    scopus 로고
    • Testosterone or 17beta-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes
    • Salehzadeh F, Rune A, Osler M, Al-Khalili L. Testosterone or 17beta-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes. J Endocrinol 2011;210:219-229
    • (2011) J Endocrinol , vol.210 , pp. 219-229
    • Salehzadeh, F.1    Rune, A.2    Osler, M.3    Al-Khalili, L.4
  • 25
    • 72249095821 scopus 로고    scopus 로고
    • VLDL-TG kinetics: A dual isotope study for quantifying VLDL-TG pool size, production rates, and fractional oxidation in humans
    • Sørensen LP, Gormsen LC, Nielsen S. VLDL-TG kinetics: a dual isotope study for quantifying VLDL-TG pool size, production rates, and fractional oxidation in humans. Am J Physiol Endocrinol Metab 2009;297:E1324-E1330
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Sørensen, L.P.1    Gormsen, L.C.2    Nielsen, S.3
  • 26
    • 67449144471 scopus 로고
    • Aerobic work capacity in men and women with special reference to age
    • ASTRAND I. Aerobic work capacity in men and women with special reference to age. Acta Physiol Scand Suppl 1960;49:1-92
    • (1960) Acta Physiol Scand Suppl , vol.49 , pp. 1-92
    • Astrand, I.1
  • 27
    • 34547643044 scopus 로고    scopus 로고
    • Testosterone treatment to mimic hormone physiology in androgen replacement therapy: A view on testosterone gel and other preparations available
    • DOI 10.1517/14712598.7.7.1093
    • Fabbri A, Giannetta E, Lenzi A, Isidori AM. Testosterone treatment to mimic hormone physiology in androgen replacement therapy. A view on testosterone gel and other preparations available. Expert Opin Biol Ther 2007;7:1093-1106 (Pubitemid 47204361)
    • (2007) Expert Opinion on Biological Therapy , vol.7 , Issue.7 , pp. 1093-1106
    • Fabbri, A.1    Isidori, A.M.2    Giannetta, E.3    Lenzi, A.4
  • 28
    • 4243132763 scopus 로고    scopus 로고
    • Stable isotope tracer dilution for quantifying very low-density lipoprotein-triacylglycerol kinetics in man
    • DOI 10.1016/j.clnu.2003.11.006, PII S0261561403002498
    • Sidossis LS, Magkos F, Mittendorfer B, Wolfe RR. Stable isotope tracer dilution for quantifying very low-density lipoprotein-triacylglycerol kinetics in man. Clin Nutr 2004;23:457-466 (Pubitemid 39107023)
    • (2004) Clinical Nutrition , vol.23 , Issue.4 , pp. 457-466
    • Sidossis, L.S.1    Magkos, F.2    Mittendorfer, B.3    Wolfe, R.R.4
  • 29
    • 30844453813 scopus 로고    scopus 로고
    • Measuring VLDL-triglyceride turnover in humans using ex vivo-prepared VLDL tracer
    • DOI 10.1194/jlr.M500205-JLR200
    • Gormsen LC, Jensen MD, Nielsen S. Measuring VLDL-triglyceride turnover in humans using ex vivo-prepared VLDL tracer. J Lipid Res 2006;47:99-106 (Pubitemid 43107453)
    • (2006) Journal of Lipid Research , vol.47 , Issue.1 , pp. 99-106
    • Gormsen, L.C.1    Jensen, M.D.2    Nielsen, S.3
  • 30
    • 0029874313 scopus 로고    scopus 로고
    • Abdominal fat and insulin resistance in normal and overweight women: Direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM
    • Carey DG, Jenkins AB, Campbell LV, Freund J, Chisholm DJ. Abdominal fat and insulin resistance in normal and overweight women: direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM. Diabetes 1996;45:633-638 (Pubitemid 26140548)
    • (1996) Diabetes , vol.45 , Issue.5 , pp. 633-638
    • Carey, D.G.1    Jenkins, A.B.2    Campbell, L.V.3    Freund, J.4    Chisholm, D.J.5
  • 32
    • 77952650308 scopus 로고    scopus 로고
    • CaMKII regulates contraction- but not insulin-induced glucose uptake in mouse skeletal muscle
    • Witczak CA, Jessen N, Warro DM, et al. CaMKII regulates contraction- but not insulin-induced glucose uptake in mouse skeletal muscle. Am J Physiol Endocrinol Metab 2010;298:E1150-E1160
    • (2010) Am J Physiol Endocrinol Metab , vol.298
    • Witczak, C.A.1    Jessen, N.2    Warro, D.M.3
  • 33
    • 24144493455 scopus 로고    scopus 로고
    • Androgens, insulin resistance and vascular disease in men
    • DOI 10.1111/j.1365-2265.2005.02299.x
    • Kapoor D, Malkin CJ, Channer KS, Jones TH. Androgens, insulin resistance and vascular disease in men. Clin Endocrinol (Oxf) 2005;63:239-250 (Pubitemid 41233438)
    • (2005) Clinical Endocrinology , vol.63 , Issue.3 , pp. 239-250
    • Kapoor, D.1    Malkin, C.J.2    Channer, K.S.3    Jones, T.H.4
  • 34
    • 77954421915 scopus 로고    scopus 로고
    • Adverse events associated with testosterone administration
    • Basaria S, Coviello AD, Travison TG, et al. Adverse events associated with testosterone administration. N Engl J Med 2010;363:109-122
    • (2010) N Engl J Med , vol.363 , pp. 109-122
    • Basaria, S.1    Coviello, A.D.2    Travison, T.G.3
  • 35
    • 79953171546 scopus 로고    scopus 로고
    • Elevated LH predicts ischaemic heart disease events in older men: The Health in Men Study
    • Hyde Z, Norman PE, Flicker L, et al. Elevated LH predicts ischaemic heart disease events in older men: the Health in Men Study. Eur J Endocrinol 2011;164:569-577
    • (2011) Eur J Endocrinol , vol.164 , pp. 569-577
    • Hyde, Z.1    Norman, P.E.2    Flicker, L.3
  • 36
    • 79961243360 scopus 로고    scopus 로고
    • Low testosterone in men with type 2 diabetes: Significance and treatment
    • Grossmann M. Low testosterone in men with type 2 diabetes: significance and treatment. J Clin Endocrinol Metab 2011;96:2341-2353
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 2341-2353
    • Grossmann, M.1
  • 37
    • 80052530001 scopus 로고    scopus 로고
    • Update: Hypogonadotropic hypogonadism in type 2 diabetes and obesity
    • Dandona P, Dhindsa S. Update: hypogonadotropic hypogonadism in type 2 diabetes and obesity. J Clin Endocrinol Metab 2011;96:2643-2651
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 2643-2651
    • Dandona, P.1    Dhindsa, S.2
  • 38
    • 0023658503 scopus 로고
    • Deprivation and repletion of androgen in vivo modifies triacylglycerol synthesis by rat hepatocytes
    • Elam MB, Umstot ES, Andersen RN, Solomon SS, Heimberg M. Deprivation and repletion of androgen in vivo modifies triacylglycerol synthesis by rat hepatocytes. Biochim Biophys Acta 1987;921:531-540
    • (1987) Biochim Biophys Acta , vol.921 , pp. 531-540
    • Elam, M.B.1    Umstot, E.S.2    Andersen, R.N.3    Solomon, S.S.4    Heimberg, M.5
  • 41
    • 0016252769 scopus 로고
    • The interrelation of glucagon and gonadectomy upon hepatic triglyceride metabolism in rats
    • Weinstein I, Seltzer M, Belitsky R. The interrelation of glucagon and gonadectomy upon hepatic triglyceride metabolism in rats. Biochim Biophys Acta 1974;348:14-22
    • (1974) Biochim Biophys Acta , vol.348 , pp. 14-22
    • Weinstein, I.1    Seltzer, M.2    Belitsky, R.3
  • 42
    • 84863252348 scopus 로고    scopus 로고
    • Testosterone increases the muscle protein synthesis rate but does not affect very-low-density lipoprotein metabolism in obese premenopausal women
    • Wang X, Smith GI, Patterson BW, et al. Testosterone increases the muscle protein synthesis rate but does not affect very-low-density lipoprotein metabolism in obese premenopausal women. Am J Physiol Endocrinol Metab 2012;302:E740-E746
    • (2012) Am J Physiol Endocrinol Metab , vol.302
    • Wang, X.1    Smith, G.I.2    Patterson, B.W.3
  • 44
    • 44749094644 scopus 로고    scopus 로고
    • Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line
    • Puljak L, Parameswara V, Dolovcak S, et al. Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line. Exp Cell Res 2008;314:2100-2109
    • (2008) Exp Cell Res , vol.314 , pp. 2100-2109
    • Puljak, L.1    Parameswara, V.2    Dolovcak, S.3
  • 45
    • 25644437695 scopus 로고    scopus 로고
    • The possible role of Ca2+ on the activation of microsomal triglyceride transfer protein in rat hepatocytes
    • Cho HJ, Kang HC, Choi SA, Ju YC, Lee HS, Park HJ. The possible role of Ca2+ on the activation of microsomal triglyceride transfer protein in rat hepatocytes. Biol Pharm Bull 2005;28:1418-1423
    • (2005) Biol Pharm Bull , vol.28 , pp. 1418-1423
    • Cho, H.J.1    Kang, H.C.2    Choi, S.A.3    Ju, Y.C.4    Lee, H.S.5    Park, H.J.6
  • 46
    • 0035955616 scopus 로고    scopus 로고
    • Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation
    • Trickett JI, Patel DD, Knight BL, Saggerson ED, Gibbons GF, Pease RJ. Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation. J Biol Chem 2001;276:39522-39532
    • (2001) J Biol Chem , vol.276 , pp. 39522-39532
    • Trickett, J.I.1    Patel, D.D.2    Knight, B.L.3    Saggerson, E.D.4    Gibbons, G.F.5    Pease, R.J.6
  • 47
    • 0025979966 scopus 로고
    • Testosterone increases lipolysis and the number of beta-adrenoceptors in male rat adipocytes
    • Xu XF, De Pergola G, Björntorp P. Testosterone increases lipolysis and the number of beta-adrenoceptors in male rat adipocytes. Endocrinology 1991;128:379-382
    • (1991) Endocrinology , vol.128 , pp. 379-382
    • Xu, X.F.1    De Pergola, G.2    Björntorp, P.3
  • 49
    • 0030798890 scopus 로고    scopus 로고
    • Fatty acid regulation of very low density lipoprotein production
    • DOI 10.1097/00041433-199706000-00004
    • Lewis GF. Fatty acid regulation of very low density lipoprotein production. Curr Opin Lipidol 1997;8:146-153 (Pubitemid 27290460)
    • (1997) Current Opinion in Lipidology , vol.8 , Issue.3 , pp. 146-153
    • Lewis, G.F.1
  • 51
    • 70349665186 scopus 로고    scopus 로고
    • Testosterone stimulates extra-hepatic but not hepatic fat oxidation (Fox): Comparison of oral and transdermal testosterone administration in hypopituitary men
    • Oxf
    • Birzniece V, Meinhardt UJ, Handelsman DJ, Ho KK. Testosterone stimulates extra-hepatic but not hepatic fat oxidation (Fox): comparison of oral and transdermal testosterone administration in hypopituitary men. Clin Endocrinol (Oxf) 2009;71:715-721
    • (2009) Clin Endocrinol , vol.71 , pp. 715-721
    • Birzniece, V.1    Meinhardt, U.J.2    Handelsman, D.J.3    Ho, K.K.4
  • 52
    • 70849117428 scopus 로고    scopus 로고
    • Testosterone deficiency, insulin resistance and the metabolic syndrome
    • Zitzmann M. Testosterone deficiency, insulin resistance and the metabolic syndrome. Nat Rev Endocrinol 2009;5:673-681
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 673-681
    • Zitzmann, M.1


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