Skin pH: From basic science to basic skin care

Acta Dermato-Venereologica

Volumn 93, Issue 3, 2013, Pages 261-267

  Ali, Saba M ^a   Yosipovitch, Gil ^a  

^a WAKE FOREST BAPTIST HEALTH   (United States)

Author keywords

Acid mantle; Acne; Atopic dermatitis; Barrier homeosta sis; Diaper dermatitis; Intertrigo; Serine protease; Skin pH; Stratum corneum; Syndets

Indexed keywords

ACETONE; ADHESIVE AGENT; BENZOYL PEROXIDE; DESMOGLEIN 1; GLUCOSYLCERAMIDASE; KALLIKREIN 5; RESORCINOL; SERINE PROTEINASE; SOAP; SPHINGOMYELIN PHOSPHODIESTERASE; STRATUM CORNEUM CHYMOTRYPTIC ENZYME; SULFUR;

ACNE; ANTIMICROBIAL ACTIVITY; ATOPIC DERMATITIS; CANDIDA ALBICANS; DERMATOLOGIST; DIAPER DERMATITIS; EPIDERMIS HYPERPLASIA; ETHNIC DIFFERENCE; GENETIC PREDISPOSITION; HOST SUSCEPTIBILITY; HUMAN; ICHTHYOSIS VULGARIS; IN VIVO STUDY; INTERTRIGO; IRRITANT DERMATITIS; NONHUMAN; PERMEABILITY BARRIER; PH; PREMATURITY; PRIORITY JOURNAL; REVIEW; SEBUM; SKIN CARE; SKIN IRRITATION; SKIN MANIFESTATION; SKIN SURFACE; STRATUM CORNEUM; TINEA PEDIS; TRANSGENIC MOUSE; X LINKED ICHTHYOSIS;

ANIMALS; HOMEOSTASIS; HUMANS; HYDROGEN-ION CONCENTRATION; SKIN; SKIN CARE; SKIN DISEASES; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84876572438     PISSN: 00015555     EISSN: 16512057     Source Type: Journal    
DOI: 10.2340/00015555-1531     Document Type: Review

References (90)

1. Schade H, Marchionini A. Der Säuremantel der Haut nach Gaskettenmessngen. klin Wochenschr 1928; 7: 12-14.
2. Behne MJ, Meyer JW, Hanson kM, Barry NP, Murata S, Crumrine D, et al. NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment aci-difcation assessed with fuorescence lifetime imaging. J Biol Chem 2002; 277: 47399-47406.
3. Fluhr JW, kao J, Jain M, Ahn SK, Feingold KR, Elias PM. Generation of free fatty acids from phospholipids regulates stratum corneum acidifcation and integrity. J Invest Der-matol 2001; 117: 52-58.
4. Gunathilake R, Schurer NY, Shoo BA, Celli A, Hachem JP, Crumrine D, et al. pH-regulated mechanisms account for pigment-type differences in epidermal barrier function. J Invest Dermatol 2009; 129: 1719-1729.
5. Hachem JP, Crumrine D, Fluhr J, Brown BE, Feingold KR, Elias PM. pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion. J Invest Dermatol 2003; 121: 345-353.
6. Hachem JP, Man MQ, Crumrine D, Uchida Y, Brown BE, rogiers V, et al. Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity. J Invest Dermatol 2005; 125: 510-520.
7. rippke F, Schreiner V, Schwanitz HJ. The acidic milieu of the horny layer: New fndings on the physiology and pathophysiology of skin pH. Am J Clin Dermatol 2002; 3: 261-272.
8. Dikstein S, Zlotogorski A. Measurement of skin pH. Acta Derm Venereol Suppl 1994; 185: 18-20.
9. Zlotogorski A. Distribution of skin surface pH on the forehead and cheek of adults. Arch Dermatol res 1987; 279: 398-401.
10. Yosipovitch G, Maibach HI. Skin surface pH: a protective acid mantle. Cosmet Toiletries 1996; 111: 101-102.
11. Yosipovitch G, Maayan-Metzger A, Merlob P, Sirota L. Skin barrier properties in different body areas in neonates. Pediatrics 2000; 106: 105-108.
12. Fox C, Nelson D, Wareham J. The timing of skin acidif-cation in very low birth weight infants. J Perinatol 1998; 18: 272-275.
13. Green M, Carol B, Behrendt H. Physiologic skin pH patterns in infants of low birth weight. The onset of surface acidifcation. Am J Dis child 1968; 115: 9-16.
14. Hoeger P H, Enzmann C. Skin physiology of the neonate and young infant: a prospective study of functional skin parameters during early infancy. Pediatr Dermatol 2002; 19: 256-262.
15. Fluhr JW, Pfstere S, Gloor M. Direct comparison of skin physiology in children and adults with bioengineering methods. Pediatr Dermatol 2000; 17: 436-439.
16. Fluhr JW, Darlenski R, Taieb A, Hachem JP, Baudouin C, Msika P, et al. Functional skin adaptation in infancy - almost complete but not fully competent. Exp Dermatol 2010; 19: 1-10.
17. Fluhr JW, Darlenski R, lachmann N, Baudouin C, Msika P, De Belilovsky C, Hachem JP. Infant epidermal skin-physiology: Adaptation after birth. Br J Dermatol 2012; 166: 483-490.
18. laufer A, Dikstein S. objective measurement and self-assessment of skin-care treatments. Cosmet Toiletries 1996; 111: 91-98.
19. Thune P, Nilsen T, Hanstad IK, Gustavsen T, lövig Dahl H. The water barrier function of the skin in relation to the water content of stratum corneum, pH and skin lipids. The effect of alkaline soap and syndet on dry skin in elderly, non-atopic patients. Acta Derm Venereol 1988; 68: 277-283.
20. Jin K, Higaki Y, Takagi Y, Higuchi K, Yada Y, kawashima M, Imokawa G. Analysis of beta-glucocerebrosidase and ceramidase activities in atopic and aged dry skin. Acta Derm Venereol 1994; 74: 337-340
21. Braun-Falco O, korting HC. Der normale pH-Wert der Haut. Hautarzt 1986; 37: 126-129.
22. korting HC, lucacs A, Braun-Falco O. Mikrobielle Flora und Geruch der menschlichen Haut. Hautarzt 1988; 39: 564-568.
23. Stenzaly-Achtert S, Schölermann A, Schreiber J, Diec Kh, Rippke F, Bielfeldt S. Axillary pH and infuence of deodorants. Skin res Technol 2000; 6: 87-91.
24. Elias PM, Menon GK. Structural and lipid biochemical correlates of the epidermal permeability barrier. Adv lipid res 1991; 24: 1-26.
25. Mauro T, Holleran WM, Grayson S, Gao WN, Man MQ, kriehuber E, et al. Barrier recovery is impeded at neutral pH, independent of ionic effects: implications for extracellular lipid processing. Arch Dermatol res 1998; 290: 215-222.
26. Bouwstra JA, Gooris GS, Dubbelaar FE, Weerheim AM, Ponec M. pH, cholesterol sulfate, and fatty acids affect the stratum corneum lipid organization. J Invest Dermatol 1998; 3: 69-74.
27. Friberg SE. Micelles, microemulsions, liquid crystals, and the structure of stratum corneum lipids. J Soc Cosmet Chem 1990; 41: 155-171.
28. osborne DW, Friberg SE. role of stratum corneum lipids as moisture retaining agent. J Dispers Sci Technol 1987; 8: 173-179.
29. Hatano Y. Man M-Q. Uchida Y. Crumrine D. Scharschmidt TC. kim EG, et al. Maintenance of an acidic stratum cor-neum prevents emergence of murine atopic dermatitis. J Invest Dermatol 2009; 129: 1824-1835.
30. Choi EH, Man MQ, Xu P, Xin S, liu Z, Crurine DA, et al. Stratum corneum acidifcation is impaired in moderately aged human and murine skin. J Invest Dermatol 2007; 127: 2847-2856.
31. Fluhr JW, Mao-Qiang M, Brown BE, Hachem JP, Mos-kowitz DG, Demerjian M, et al. Functional consequences of a neutral pH in neonatal rat stratum corneum. J Invest Dermatol 2004; 123: 140-151.
32. Hachem JP, roelandt T, Schurer N, Pu X, Fluhr J, Guiddelo C, et al. Acute acidifcation of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes. J Invest Dermatol 2010; 130: 500-510.
33. Brattsand M, Egelrud T. Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. J Biol Chem 1999; 274: 30033-30040.
34. Ekholm E, Egelrud T. Expression of stratum corneum chy-motryptic enzyme in relation to other markers of epidermal differentiation in a skin explant model. Exp Dermatol 2000; 9: 65-70.
35. Ekholm E, Brattsand M, Egelrud T. Stratum corneum tryptic enzyme in normal epidermis: A missing link in the desquamation process? J Invest Dermatol 2000; 114: 56-63.
36. Hachem JP, Houben E, Crumrine D, Man MQ, Schurer N, roelandt T, et al. Serine protease signaling of epidermal permeability barrier homeostasis. J Invest 2006; 126: 2074-2086.
37. leyden JJ, Stewart R, kligman AM. Updated in vivo methods for evaluating topical antimicrobial agents on human skin. J Invest Dermatol 72: 165-170, 1979.
38. korting HC, Hubner K, Greiner K, Hamm G, Braun-Falco O. Differences in the skin surface pH and bacterial microfora due to the long-term application of synthetic detergent preparations of pH 5.5 and pH 7.0. results of a crossover trial in healthy volunteers. Acta Derm Venereol 1990; 70: 429-431.
39. Schittek B, Hipfel R, Sauer B, Bauer J, kalbacher H, Steva-novic S, et al. Dermicidin: a novel human antibiotic peptide secreted by sweat glands. Nat Immunol 2001; 2: 1133-1137.
40. Chikakane K, Takahashi H. Measurement of skin pH and its signifcance in cutaneous diseases. Clin Dermatol 1995; 13: 299-306.
41. Weller R, Price RJ, Ormerod AD. Antimicrobial effect of acidifed nitrite on dermatophyte fungi, Candida and bacterial skin pathogens. J Appl Microbiol 2001; 90: 648-652.
42. Seidenari S, Giusti G. Objective assessment of the skin of children affected by atopic dermatitis: a Study of pH, capacitance and TEWl in eczematous and clinically uninvolved skin. Acta Derm Venereol 1995; 75: 429-433.
43. Eberlein-könig B, Schäfer T, Huss-Marp J, Darsow U, Möh-renschlager M, Herbert O, et al. Skin surface pH, stratum corneum hydration, trans-epidermal water loss and skin roughness related to atopic eczema and skin dryness in a population of primary school children. Acta Derm Venereol 2000; 80: 188-191.
44. Sparavigna A, Setaro M, Gualandri V. Cutaneous pH in children affected by atopic dermatitis and in healthy children: a multicenter study. Skin res Technol 1999; 5: 221-227.
45. krien PM, kermici M. Evidence for the existence of a self-regulating enzymatic process within the human stratum corneum: an unexpected role for urocanic acid. J Invest Dermatol 2000; 115: 414-420.
46. Tanaka M, okada M, Zhen YX, Inamura N, kitano T, Shirai S, et al. Decreased hydration state of the stratum corneum and reduced amino acid content of the skin in patients with seasonal allergic rhinitis. Br J Dermatol 1998; 139: 618-621.
47. Parkkinen MU, kiistala R, kiistala U. Sweating response to moderate thermal stress in atopic dermatitis. Br J Dermatol 1992; 126: 346-350.
48. Fartasch M, Diepgen TL. The barrier function in atopic dry skin: disturbance of membrane-coating granule exocytosis and formation of epidermal lipids? Acta Derm Venereol Suppl 1992; 176: 26-31.
49. Chapman SJ, Walsh A. Membrane-coating granules are acidic organelles which possess proton pumps. J Invest Dermatol 1989; 93: 466-470.
50. Pilgram GS, Vissers DC, van der Meulen H, Pavel S, lavrijsen SP, Bouwstra JA, Koerten HK. Aberrant lipid organization in stratum corneum of patients with atopic dermatitis and lamellar ichthyosis. J Invest Dermatol 2001; 117: 710-717.
51. Hansson L, Bäckman A, Ny A, Edlund M, Ekholm E, Ek-strand Hammarström B, et al. Epidermal over expression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis. J Invest Dermatol 2002; 118: 444-449.
52. Steinhoff M, Neisius U, Ikoma A, Fartasch M, Heyer G, Skov PS, et al. Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci 2003; 23: 6176-6180.
53. Whiting RC, Sackitey S, Calderone S, Morely K, Phillips JG. Model for the survival of Staphylococcus aureus in non growth environments. Int J Food Microbiol 1996; 31: 231-243.
54. Gianuzzi L, Contrera E, Zaritzky N. Modeling the aerobic growth and decline of Staphylococcus aureus as affected by pH and potassium sorbate concentration. J Food Prot 1999; 62: 356-362.
55. kumaran D, Eswaramoorthy S, Furey W, Sax M, Swa-minathan S. Structure of staphylococcal enterotoxin C2 at various pH levels. Acta Crystallogr D Biol Crystallogr 2001; 57: 1270-1275.
56. Mempel M, Schmidt T, Weidinger S, Schnopp C, Foster T, ring J, Abeck D. role of Staphylococcus aureus surface associated proteins in the attachment to cultured HaCaT keratinocytes in a new adhesion assay. J Invest Dermatol 1998; 111: 452-456.
57. Öhman H, Vahlquist A. The pH gradient over the stratum corneum differs in x-linked recessive and autosomal dominant ichthyosis: a clue to the molecular origin of the "acid skin mantle"? J Invest Dermatol 1998; 111: 674-677.
58. Odds FC. Morphogenesis in Candida, with special reference to C. albicans. In: Candida and candidosis. A review and bibliography. 2nd edn. london: Bailliere Tindall, 1988: 42-58.
59. Buffo J, Herman MA, Soll DR. A characterization of pH-regulated dimorphism in Candida albicans. Mycopathologia 1984; 85: 21-30.
60. Scherwitz C. Ultrastructure of human cutaneous candidosis. J Invest Dermatol 1982; 78: 200-205.
61. runeman B, Faergemann J, Larkö O. Experimental Candida albicans lesions in healthy humans: dependence on skin pH. Acta Derm Venereol 2000; 80: 421-424.
62. Weller R, ormerod AD, Hobson RP, Benjamin NJ. A randomized trial of acidifed nitrite cream in the treatment of tinea pedis. J Am Acad Dermatol 1998; 38: 559-563.
63. Yosipovitch G, Tur E, Cohen O. Skin surface pH in inter-triginous areas in NIDDM patients. Possible correlation to candidal intertrigo. Diabetes Care 1993; 16: 560-563.
64. Adam, R. Skin Care of the Diaper Area. Pediatr Dermatol 2008; 25: 427-433.
65. Berg RW, Milligan MC, Sarbaugh FC. Association of skin wetness and pH with diaper dermatitis. Ped Dermatol 1994; 11: 18-20.
66. Beguin AM, Malaquin-Pavan E, Guihaire C, Hallet-lezy AM, Souchon S, Homann V, et al. Improving diaper design to address incontinence associated dermatitis. BMC Geriatr 2010; 10: 86.
67. Adam R, Schnetz B, Mathey P, Pericoi M, de Prost Y. Clinical demonstration of skin mildness and suitability for sensative infant skin of a new baby wipe. Pediatr Dermatol 2009; 26: 506-513.http: //www.rephreshbrilliant.com
68. Seidenari S, Francomano M, Mantovani L. Baseline biophysical parameters in subjects with sensative skin. Contact Dermatitis 1998; 38: 311-315.
69. Wilhelm k P, Maibach HI. Susceptibility to irritant dermatitis induced by sodium lauryl sulphate. J Am Acad Dermatol 1990; 23: 123-124.
70. korting HC, Braun-Falco O. The effect of detergents on skin pH and its consequences. Clin Dermatol 1996; 14: 23-27.
71. Korting HC, Ponce-Pöschl E, klövekorn W, Schmötzer G, Arens-Corell M, Braun-Falco O. The infuence of the regular use of a soap or an acidic syndet bar on pre-acne. Infection 1995; 23: 89-93.
72. Yosipovitch G, Tur E, Morduchowicz, Boner G. Skin surface pH, moisture, and pruritus in haemodialysis patients. Nephrol Dial Transplant 1993; 8: 1129-1132.
73. Bencini PL, Montagnino G, Citterio A, Graziani G, Crosti C, Ponticelli C. Cutaneous abnormalities in uremic patients. Nephro 1985; 40: 316-321.
74. rippke F, Schreiner V, Doering T, Maibach H. Stratum corneum pH in atopic dermatitis: impact on skin barrier function and colonization with staphylococcus aureus. Am J Clin Dermatol 2004; 5: 217-223.
75. Ananthapadmanabhan kP, Moore DJ, Subramanyan K, Misra M, Meyer F. Cleansing without compromise: the impact of cleansers on the skin barrier and the technology of mild cleansing. Dermatologic Therapy 2004; 17: 16-25.
76. Ertel KD, keswick BH, Bryant PB. A forearm controlled application technique for estimating the relative mildness of personal cleansing products. J Soc Cosmet Chem 1995: 46: 67-76.
77. Frosch PJ, kligman AM. The soap chamber test. J Am Acad Dermatol 1979: 1: 35-41.
78. Sharko PT, Murahata RI, leyden JL, Grove GL. Arm wash with instrumental evaluation - a sensitive technique for differentiating the irritation potential of personal washing products. J Dermoclin Eval Soc 1991: 2: 19-27.
79. Simion FA. Human in vivo methods for assessing the irritation potential of cleansing systems. In: MM riger, lD rhein, editors. Surfactants in Cosmetics. Surfactant Science Series, Vol. 68. New York, NY: Marcel Dekker, 1997: 519-532.
80. Simion FA, rhein LD, Morrison BM Jr, Scala DD, Salko DM, kligman AM, Grove GL. Self-perceived sensory response to soap and synthetic detergent bars correlate with clinical signs of irritation. J Am Acad Dermatol 1995: 32: 205-211.
81. Strube DA, Koontz SW, Murahata RI, Theiler R. The flex wash test: a method for evaluating the mildness of personal washing products. J Soc Cosmet Chem 1989: 40: 297-306.
82. Ananthapadmanabhan KP, lips A, Vincent C, Meyer F, Caso S, Johnson A, et al. pH-induced alterations in stratum corneum properties. Int J Cosmet Sci 2003; 25: 103-112.
83. Baranda L, González-Amaro R, Torres-Alvarez B, Alvarez C, ramírez V. Correlation between pH and irritant effect of cleansers marketed for dry skin. Int J Dermatol 2002; 41: 494-499.
84. Shi V, Tran K, lio P. A comparison of physicochemical properties of a selection of modern moisturizers: hydrophilic index and pH. J Drugs Dermatol 2012; 11: 633-636.
85. rawlings AV, Davies A, Carlomusto M, Pillai S, Zhang K, kosturko R, et al. Effect of lactic acid isomers on kerati-nocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function. Arch Dermatol res 1996; 288: 383-390.
86. Imokawa G, Abe A, Jin K, Higaki Y, kawashima M, Hidano A. Decreased levels of ceramides in stratum corneum of atopic dermatitis: an etiological factor in atopic dry skin? J Invest Dermatol 1991; 96: 523-526.
87. Yamamoto A, Serizawa S, Ito M, Sato Y. Stratum corneum lipid abnormalities in atopic dermatitis. Arch Dermatol res 1991; 283: 219-223.
88. Sasai-Takedatsu M, kojima T, Yamamoto A, Hattori K, Yoshijima S, Taniuchi S, et al. reduction of Staphylococcus aureus in atopic skin lesions with acid electrolytic water: a new therapeutic strategy for atopic dermatitis. Allergy 1997; 52: 1012-1016.
89. kubota K, Machida I, Tamura K, Take H, kurabayashi H, Akiba T, Tamura J. Treatment of refractory cases of atopic dermatitis with acidic hot-spring bathing. Acta Derm Ve -nereol 1997; 77: 452-454.
90. Fluhr, JW, Bankova L, Dikstein S. Skin surface pH, mechanism, measurement, importance. In: Handbook of Non Invasive Methods and the Skin, second edn. Ed. Serup J, Jemec G, Grove l, editors. Taylor & Francis Boca raton 2006: p. 411-420.