Immunocytochemistry for MUC4 and MUC16 is a useful adjunct in the diagnosis of pancreatic adenocarcinoma on fine-needle aspiration cytology

Archives of Pathology and Laboratory Medicine

Volumn 137, Issue 4, 2013, Pages 546-551

  Horn, Adam ^a   Chakraborty, Subhankar ^a   Dey, Parama ^b   Haridas, Dhanya ^b   Souchek, Joshua ^b   Batra, Surinder K ^b   Lele, Subodh M ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CA 125 ANTIGEN; MEMBRANE PROTEIN; MUC16 PROTEIN, HUMAN; MUC4 PROTEIN, HUMAN; MUCIN 4; TUMOR MARKER;

ADENOCARCINOMA; ARTICLE; CYTODIAGNOSIS; FINE NEEDLE ASPIRATION BIOPSY; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; PANCREAS TUMOR; PATHOLOGY; PREDICTIVE VALUE; REPRODUCIBILITY; UPREGULATION;

ADENOCARCINOMA; BIOPSY, FINE-NEEDLE; CA-125 ANTIGEN; CYTODIAGNOSIS; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MUCIN-4; PANCREATIC NEOPLASMS; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 84876566043     PISSN: 00039985     EISSN: 15432165     Source Type: Journal    
DOI: 10.5858/arpa.2011-0229-OA     Document Type: Article

References (18)

1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60(5):277-300.
2. Chakraborty S, Baine MJ, Sasson AR, Batra SK. Current status of molecular markers for early detection of sporadic pancreatic cancer. Biochim Biophys Acta. 2011;1815(1):44-64.
3. Eloubeidi MA, Jhala D, Chhieng DC, et al. Yield of endoscopic ultrasoundguided fine-needle aspiration biopsy in patients with suspected pancreatic carcinoma. Cancer. 2003;99(5):285-292.
4. Gress F, Gottlieb K, Sherman S, Lehman G. Endoscopic ultrasonographyguided fine-needle aspiration biopsy of suspected pancreatic cancer. Ann Intern Med. 2001;134(6):459-464. (Pubitemid 32225947)
5. Eltoum IA, Chhieng DC, Jhala D, et al. Cumulative sum procedure in evaluation of EUS-guided FNA cytology: the learning curve and diagnostic performance beyond sensitivity and specificity. Cytopathology. 2007;18(3):143- 150. (Pubitemid 46934504)
6. Fisher L, Segarajasingam DS, Stewart C, Deboer WB, Yusoff IF. Endoscopic ultrasound guided fine needle aspiration of solid pancreatic lesions: performance and outcomes. J Gastroenterol Hepatol. 2009;24(1):90-96.
7. Touchefeu Y, Le Rhun M, Coron E, et al. Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of solid pancreatic masses: the impact on patient-management strategy. Aliment Pharmacol Ther. 2009;30(10):1070-1077.
8. Jhala N, Jhala D, Vickers SM, et al. Biomarkers in diagnosis of pancreatic carcinoma in fine-needle aspirates. Am J Clin Pathol. 2006;126(4):572-579.
9. Bafna S, Kaur S, Batra SK. Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells. Oncogene. 2010;29(20): 2893-2904.
10. Moniaux N, Andrianifahanana M, Brand RE, Batra SK. Multiple roles of mucins in pancreatic cancer, a lethal and challenging malignancy. Br J Cancer. 2004;91(9):1633-1638. (Pubitemid 39546133)
11. Bolignano D, Donato V, Lacquaniti A, et al. Neutrophil gelatinaseassociated lipocalin (NGAL) in human neoplasias: a new protein enters the scene. Cancer Lett. 2010;288(1):10-16.
12. Tong Z, Kunnumakkara AB, Wang H, et al. Neutrophil gelatinaseassociated lipocalin: A novel suppressor of invasion and angiogenesis in pancreatic cancer. Cancer Res. 2008;68(15):6100-6108.
13. Han L, Pansare V, Al-Abbadi M, Husain M, Feng J. Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytology. Diagn Cytopathol. 2010;38(5):333-336.
14. Swartz MJ, Batra SK, Varshney GC, et al. MUC4 expression increases progressively in pancreatic intraepithelial neoplasia. Am J Clin Pathol. 2002; 117(5):791-796. (Pubitemid 34457016)
15. Westgaard A, Schjolberg AR, Cvancarova M, Eide TJ, Clausen OP, Gladhaug IP. Differentiation markers in pancreatic head adenocarcinomas: MUC1 and MUC4 expression indicates poor prognosis in pancreatobiliary differentiated tumours. Histopathology. 2009;54(3):337-347.
16. Moniaux N, Chakraborty S, Yalniz M, et al. Early diagnosis of pancreatic cancer: neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia. Br J Cancer. 2008;98(9):1540-1547. (Pubitemid 351652327)
17. Stoesz SP, Friedl A, Haag JD, Lindstrom MJ, Clark GM, Gould MN. Heterogeneous expression of the lipocalin NGAL in primary breast cancers. Int J Cancer. 1998;79(6):565-572. (Pubitemid 28549466)
18. Wilder JL, Shajahan S, Khattar NH, et al. Tamoxifen-associated malignant endometrial tumors: pathologic features and expression of hormone receptors estrogen-α, estrogen-β and progesterone; a case controlled study. Gynecol Oncol. 2004;92(2):553-558. (Pubitemid 38183144)