Comparison of intravaginal progesterone gel and intramuscular 17-α-hydroxyprogesterone caproate in luteal phase support

Experimental and Therapeutic Medicine

Volumn 5, Issue 6, 2013, Pages 1740-1744

  Satir, Funda ^a   Toptas, Tayfun ^a   Inel, Murat ^a   Erman Akar, Munire ^a   Taskin, Omur ^a  

^a AKDENIZ UNIVERSITY   (Turkey)

Author keywords

17 a hydroxyprogesterone; Intravaginal progesterone gel; Luteal phase support

Indexed keywords

CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN BETA SUBUNIT; ESTRADIOL; FOLLITROPIN; GESTONORONE CAPROATE; HYDROXYPROGESTERONE CAPROATE; PROGESTERONE;

ADULT; ARTICLE; COMPARATIVE STUDY; EMBRYO TRANSFER; ENDOMETRIAL THICKNESS; FEMALE; FERTILIZATION IN VITRO; HUMAN; LUTEAL PHASE; LUTEAL PHASE SUPPORT; MAJOR CLINICAL STUDY; OOCYTE; OVARY INSUFFICIENCY; PREDICTIVE VALUE; PREGNANCY OUTCOME; PREGNANCY RATE; RETROSPECTIVE STUDY;

EID: 84876555514     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2013.1049     Document Type: Article

References (28)

1. Practice Committee of American Society for Reproductive Medicine in collaboration with Society for Reproductive Endocrinology and Infertility: Progesterone supplementation during the luteal phase and in early pregnancy in the treatment of infertility: an educational bulletin. Fertil Steril 90 (Suppl): S150-S153, 2008.
2. Fatemi HM, Popovic-Todorovic B, Papanikolaou E, Donoso P and Devroey P: An update of luteal phase support in stimulated IVF cycles. Hum Reprod Update 13: 581-590, 2007.
3. Penzias AS: Luteal phase support. Fertil Steril 77: 318-323, 2002.
4. Smitz J, Erard P, Camus M, et al: Pituitary gonadotrophin secretory capacity during the luteal phase in superovulation using GnRH-agonists and HMG in a desensitization or flare-up protocol. Hum Reprod 7: 1225-1229, 1992.
5. Albano C, Grimbizis G, Smitz J, et al: The luteal phase of nonsupplemented cycles after ovarian superovulation with human menopausal gonadotropin and the gonadotropin-releasing hormone antagonist Cetrorelix. Fertil Steril 70: 357-359, 1998.
6. Daya S and Gunby JL: Luteal phase support in assisted reproduction cycles. Cochrane Database Syst Rev 3: CD004830, 2004.
7. Levine H: Luteal support in IVF using the novel vaginal progesterone gel Crinone 8%: results of an open-label trial in 1184 women from 16 US centers. Fertil Steril 74: 836-837, 2000.
8. Penzias AS and Alper MM: Luteal support with vaginal micronized progesterone gel in assisted reproduction. Reprod Biomed Online 6: 287-295, 2003.
9. Miles RA, Paulson RJ, Lobo RA, Press MF, Dahmoush L and Sauer MV: Pharmacokinetics and endometrial tissue levels of progesterone after administration by intramuscular and vaginal routes: a comparative study. Fertil Steril 62: 485-490, 1994.
10. Zarutskie PW and Phillips JA: A meta-analysis of the route of administration of luteal phase support in assisted reproductive technology: vaginal versus intramuscular progesterone. Fertil Steril 92: 163-169, 2009.
11. ICH Topic E 6 (R1) Guideline for Good Clinical Practice. In: ICH Harmonised Tripartite Guideline. Version of July 1996 including post step errata of July 2002. European Medicines Agency, London, UK, 2002. Available from: http://www.emea.europa.eu/pdfs/human/ich/013595en.pdf. Accessed April 3, 2013.
12. Arslan M, Bocca S, Mirkin S, Barroso G, Stadtmauer L and Oehninger S: Controlled ovarian hyperstimulation protocols for in vitro fertilization: two decades of experience after the birth of Elizabeth Carr. Fertil Steril 84: 555-569, 2005.
13. Friedler S, Raziel A, Schachter M, Strassburger D, Bukovsky I and Ron-El R: Luteal support with micronized progesterone following in-vitro fertilization using a down-regulation protocol with gonadotropin-releasing hormone agonist: a comparative study between vaginal and oral administration. Hum Reprod 14: 1944-1948, 1999.
14. Pouly JL, Bassil S, Frydman R, et al: Luteal support after in-vitro fertilization. Crinone 8%, a sustained release vaginal progesterone gel versus Utrogestan, an oral micronized progesterone. Hum Reprod 11: 2085-2089, 1996.
15. Arafat ES, Hargrove JT, Maxson WS, Desiderio DM, Wentz AC and Andersen RN: Sedative and hypnotic effects of oral administration of micronized progesterone may be mediated through its metabolites. Am J Obstet Gynecol 159: 1203-1209, 1998.
16. Maxon W and Hargrove JT: Bioavailability of oral micronized progesterone. Fertil Steril 44: 622-626, 1985.
17. Artini PG, Volpe A, Angioni S, Galassi MC, Battaglia C and Genazzani AR: A comparative randomized study of three different progesterone support of the luteal phase following IVF/ET programme. J Endocrinol Invest 18: 51-56, 1995.
18. Abate A, Perino M, Abate FG, Brigandì A, Costabile L and Manti F: Intramuscular versus vaginal administration of progesterone for luteal phase support after in vitro fertilization and embryo transfer: a comparative study. Clin Exp Obstet Gynecol 26: 203-206, 1999.
19. Abate A, Brigandi A, Abate FG, Manti F, Unfer V and Perino M: Luteal phase support with 17 alpha-hydroxyprogesterone versus unsupported cycles in in vitro fertilization: a comparative randomized study. Gynecol Obstet Invest 48: 78-80, 1999.
20. Costabile L, Gerli S, Manna C, Rossetti D, Di Renzo GC and Unfer V: A prospective randomized study comparing intramuscular progesterone and 17α-hydroxyprogesterone caproate in patients undergoing in vitro fertilization-embryo transfer cycles. Fertil Steril 76: 394-396, 2001.
21. Ludwig M, Schwartz P, Babahan B, et al: Luteal phase support using either Crinone 8% or Utrogest: results of a prospective randomized study. Eur J Obstet Gynecol Reprod Biol 103: 48-52, 2002.
22. Ng EH, Miao B, Cheung W and Ho PC: A randomized comparison of side effects and patient inconvenience of two vaginal progesterone formulations used for luteal support in in vitro fertilization cycles. Eur J Obstet Gynecol Reprod Biol 111: 50-54, 2003.
23. Kimzey LM, Gumowski J, Merriam GR, Grimes GJ Jr and Nelson LM: Absorption of micronized progesterone from a nonqualifying vaginal cream. Fertil Steril 56: 995-996, 1991.
24. Propst AM, Hill JA, Ginsburg ES, Hurwitz S, Politch J and Yanushpolsky EH: A randomized study comparing Crinone 8% and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles. Fertil Steril 76: 1144-1149, 2001.
25. Perino M, Brigandi FG, Abate FG, Costabile L, Balzano E and Abate A: Intramuscular versus vaginal progesterone in assisted reproduction: a comparative study. Clin Exp Obstet Gynecol 24: 228-231, 1997.
26. Smitz J, Devroey P, Faguer B, Bourgain C, Camus M and Van Steirteghem AC: A prospective randomized comparison of intramuscular or intravaginal natural progesterone as a luteal phase and early pregnancy supplement. Hum Reprod 7: 168-175, 1992.
27. Damario MA, Goudas VT, Session DR, Hamit DG and Dumesic DA: Crinone 8% vaginal progesterone results in lower implantation efficiency after IVF-ET. Fertil Steril 72: 830-836, 1999.
28. Unfer V, Casini ML, Costabile L, Gerli S, Baldini D and Di Renzo GC: 17α-hydroxyprogesterone caproate versus intravaginal progesterone in IVF-embryo transfer cycles: a prospective randomized study. Reprod Biomed Online 9: 17-21, 2004.