Human Metapneumovirus Glycoprotein G Disrupts Mitochondrial Signaling in Airway Epithelial Cells

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Bao, Xiaoyong ^a   Kolli, Deepthi ^a   Ren, Junping ^a   Liu, Tianshuang ^a   Garofalo, Roberto P ^a   Casola, Antonella ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CARRIER PROTEIN; CASPASE RECRUITMENT DOMAIN PROTEIN; GLUTAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; MITOCHONDRIAL ANTIVIRAL SIGNALING PROTEIN; THROMBOSPONDIN; UNCLASSIFIED DRUG; VALINE; G GLYCOPROTEIN, HUMAN METAPNEUMOVIRUS; GLYCOPROTEIN; PROTEIN BINDING; RARRES3 PROTEIN, HUMAN; RETINOIC ACID RECEPTOR; VIRUS PROTEIN;

AIRWAY EPITHELIAL CELL; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL COMPONENT; CELL DISRUPTION; CELL FUNCTION; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM; EPITHELIUM CELL; HUMAN METAPNEUMOVIRUS; HUMAN METAPNEUMOVIRUS INFECTION; METAPNEUMOVIRUS INFECTION; MITOCHONDRION; MUTAGENESIS; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; VIRUS RECOMBINANT; CELL LINE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; METAPNEUMOVIRUS; RESPIRATORY TRACT MUCOSA; VIROLOGY;

HUMAN METAPNEUMOVIRUS; PARAMYXOVIRIDAE; RNA VIRUSES;

CELL LINE; ENDOPLASMIC RETICULUM; GLYCOPROTEINS; HUMANS; METAPNEUMOVIRUS; MITOCHONDRIA; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTORS, RETINOIC ACID; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; VIRAL PROTEINS;

EID: 84876550067     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062568     Document Type: Article

References (44)

1. Falsey AR, Erdman D, Anderson LJ, Walsh EE, (2003) Human metapneumovirus infections in young and elderly adults. J Infect Dis 187: 785-790.
2. Broor S, Bharaj P, (2007) Avian and human metapneumovirus. Ann N Y Acad Sci 1102: 66-85.
3. Biacchesi S, Skiadopoulos MH, Yang L, Lamirande EW, Tran KC, et al. (2004) Recombinant human Metapneumovirus lacking the small hydrophobic SH and/or attachment G glycoprotein: deletion of G yields a promising vaccine candidate. J Virol 78: 12877-12887.
4. Biacchesi S, Pham QN, Skiadopoulos MH, Murphy BR, Collins PL, et al. (2005) Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2-2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates. J Virol 79: 12608-12613.
5. Cox RG, Livesay SB, Johnson M, Ohi MD, Williams JV (2012) The Human Metapneumovirus Fusion Protein Mediates Entry Via an Interaction with RGD-binding Integrins. J Virol.
6. Kawai T, Akira S (2006) TLR signaling. Cell Death Differ.
7. Kawai T, Akira S, (2008) Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci 1143: 1-20.
8. Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, et al. (2004) The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 5: 730-737.
9. Yoneyama M, Kikuchi M, Matsumoto K, Imaizumi T, Miyagishi M, et al. (2005) Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol 175: 2851-2858.
10. Yoneyama M, Fujita T, (2007) Function of RIG-I-like receptors in antiviral innate immunity. J Biol Chem 282: 15315-15318.
11. Pichlmair A, Schulz O, Tan CP, Naslund TI, Liljestrom P, et al. (2006) RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. Science 314: 997-1001.
12. Andrejeva J, Childs KS, Young DF, Carlos TS, Stock N, et al. (2004) The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc Natl Acad Sci U S A 101: 17264-17269.
13. Hiscott J, Lin R, Nakhaei P, Paz S, (2006) MasterCARD: a priceless link to innate immunity. Trends Mol Med 12: 53-56.
14. Johnson CL, Gale M Jr, (2006) CARD games between virus and host get a new player. Trends Immunol 27: 1-4.
15. Vance JE, (1990) Phospholipid synthesis in a membrane fraction associated with mitochondria. J Biol Chem 265: 7248-7256.
16. Ishikawa H, Barber GN, (2008) STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455: 674-678.
17. Zhong B, Zhang L, Lei C, Li Y, Mao AP, et al. (2009) The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity 30: 397-407.
18. Bao X, Liu T, Shan Y, Li K, Garofalo RP, et al. (2008) Human metapneumovirus glycoprotein G inhibits innate immune responses. PLoS Pathog 4: e1000077.
19. Kolli D, Bao X, Liu T, Hong C, Wang T, et al. (2011) Human metapneumovirus glycoprotein G inhibits TLR4-dependent signaling in monocyte-derived dendritic cells. J Immunol 187: 47-54.
20. Liao S, Bao X, Liu T, Lai S, Li K, et al. (2008) Role of retinoic acid inducible gene-I in human metapneumovirus-induced cellular signalling. J Gen Virol 89: 1978-1986.
21. Ren J, Kolli D, Liu T, Xu R, Garofalo RP, et al. (2011) Human metapneumovirus inhibits IFN-beta signaling by downregulating Jak1 and Tyk2 cellular levels. PLoS ONE 6: e24496.
22. Bao X, Kolli D, Liu T, Shan Y, Garofalo RP, et al. (2008) Human metapneumovirus small hydrophobic protein inhibits NF-kappaB transcriptional activity. J Virol 82: 8224-8229.
23. Casola A, Garofalo RP, Jamaluddin M, Vlahopoulos S, Brasier AR, (2000) Requirement of a novel upstream response element in RSV induction of interleukin-8 gene expression: stimulus-specific differences with cytokine activation. J Immunol 164: 5944-5951.
24. Ren J, Liu T, Pang L, Li K, Garofalo RP, et al. (2011) A novel mechanism for the inhibition of interferon regulatory factor-3-dependent gene expression by human respiratory syncytial virus NS1 protein. J Gen Virol 92: 2153-2159.
25. Schreiber E, Matthias P, Muller MM, Schaffner W, (1989) Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res 17: 6419.
26. Breiman A, Grandvaux N, Lin R, Ottone C, Akira S, et al. (2005) Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon. J Virol 79: 3969-3978.
27. tenOever BR, Sharma S, Zou W, Sun Q, Grandvaux N, et al. (2004) Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J Virol 78: 10636-10649.
28. Imada K, Leonard WJ, (2000) The Jak-STAT pathway. Mol Immunol 37: 1-11.
29. Castanier C, Zemirli N, Portier A, Garcin D, Bidere N, et al. (2012) MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors. BMC Biol 10: 44.
30. West AP, Shadel GS, Ghosh S, (2011) Mitochondria in innate immune responses. Nat Rev Immunol 11: 389-402.
31. van den Hoogen BG, Bestebroer TM, Osterhaus AD, Fouchier RA, (2002) Analysis of the genomic sequence of a human metapneumovirus. Virology 295: 119-132.
32. Bao X, Chen Y, Lee SH, Lee SC, Reuss L, et al. (2005) Membrane transport proteins with complete replacement of transmembrane helices with polyalanine sequences remain functional. J Biol Chem 280: 8647-8650.
33. Taniguchi T, Ogasawara K, Takaoka A, Tanaka N, (2001) IRF family of transcription factors as regulators of host defense. Annu Rev Immunol 19: 623-655.
34. Lin R, Heylbroeck C, Genin P, Pitha PM, Hiscott J, (1999) Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription. Molec Cellular Biol 19: 959-966.
35. Casola A, Garofalo RP, Haeberle H, Elliott TF, Lin A, et al. (2001) Multiple cis regulatory elements control RANTES promoter activity in alveolar epithelial cells infected with respiratory syncytial virus. J Virol 75: 6428-6439.
36. Garofalo RP, Sabry M, Jamaluddin M, Yu RK, Casola A, et al. (1996) Transcriptional activation of the interleukin-8 gene by respiratory syncytial virus infection in alveolar epithelial cells: Nuclear translocation of the RelA transcription factor as a mechanism producing airway mucosal inflammation. J Virol 70: 8773-8781.
37. Tian B, Zhang Y, Luxon B, Garofalo RP, Casola A, et al. (2002) Identification of NF-kB dependent gene networks in respiratory syncytial virus-infected cells. J Virol 76: 6800-6814.
38. Bao X, Liu T, Spetch L, Kolli D, Garofalo RP, et al. (2007) Airway epithelial cell response to human metapneumovirus infection. Virology 368: 91-101.
39. Kim S, Joo DH, Lee JB, Shim BS, Cheon IS, et al. (2012) Dual role of respiratory syncytial virus glycoprotein fragment as a mucosal immunogen and chemotactic adjuvant. PLoS ONE 7: e32226.
40. Mok H, Cheng X, Xu Q, Zengel JR, Parhy B, et al. (2012) Evaluation of Measles Vaccine Virus as a Vector to Deliver Respiratory Syncytial Virus Fusion Protein or Epstein-Barr Virus Glycoprotein gp350. Open Virol J 6: 12-22.
41. Kim S, Chang J, (2012) Baculovirus-based Vaccine Displaying Respiratory Syncytial Virus Glycoprotein Induces Protective Immunity against RSV Infection without Vaccine-Enhanced Disease. Immune Netw 12: 8-17.
42. Guerrero-Plata A, Casola A, Garofalo RP, (2005) Human metapneumovirus induces a profile of lung cytokines distinct from that of respiratory syncytial virus. J Virol 79: 14992-14997.
43. Guerrero-Plata A, Kolli D, Hong C, Casola A, Garofalo RP, (2009) Subversion of pulmonary dendritic cell function by paramyxovirus infections. J Immunol 182: 3072-3083.
44. Kolli D, Bataki EL, Spetch L, Guerrero-Plata A, Jewell AM, et al. (2008) T lymphocytes contribute to antiviral immunity and pathogenesis in experimental human metapneumovirus infection. J Virol 82: 8560-8569.