Intraperitoneal nebulization of ropivacaine for pain control after laparoscopic cholecystectomy: A double-blind, randomized, placebo-controlled trial

British Journal of Anaesthesia

Volumn 110, Issue 5, 2013, Pages 800-806

  Ingelmo, P M ^a   Bucciero, M ^a   Somaini, M ^a   Sahillioglu E ^b   Garbagnati, A ^a   Charton, A ^c   Rossini, V ^a   Sacchi, V ^a   Scardilli, M ^a   Lometti, A ^a   Joshi, G P ^d   Fumagalli, R ^a   Diemunsch, P ^c  

^a SAN GERARDO HOSPITAL   (Italy)

^b Anadolu Medical Center   (Turkey)

^c HÔPITAL DE HAUTEPIERRE   (France)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

acute pain; anaesthetic techniques; analgesics; insufflation; local anaesthetics; postoperative; regional; regional techniques; ropivacaine

Indexed keywords

ATROPINE; CISATRACURIUM; DEXAMETHASONE; DIAZEPAM; MORPHINE; NEOSTIGMINE; ONDANSETRON; PARACETAMOL; PLACEBO; PROPOFOL; ROPIVACAINE;

ADULT; AGED; ANALGESIA; ARTICLE; BREATHING DEPTH; CHOLECYSTECTOMY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG USE; FEMALE; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; POSTOPERATIVE NAUSEA AND VOMITING; POSTOPERATIVE PAIN; PREOPERATIVE CARE; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECOVERY ROOM; SHOULDER PAIN; TREATMENT DURATION; TREATMENT OUTCOME;

EID: 84876545558     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aes495     Document Type: Article

References (18)

1. Mouton WG, Bessell JR, Otten KT, Maddern GJ. Pain after laparoscopy. Surg Endosc 1999; 13: 445-8
2. Kehlet H, Gray AW, Bonnet F, et al. A procedure-specific systematic review and consensus recommendations for postoperative analgesia following laparoscopic cholecystectomy. Surg Endosc 2005; 19: 1396-415
3. Gupta A. Local anaesthesia for pain relief after laparoscopic cholecystectomy-a systematic review. Best Pract Res Anaesthesiol 2005; 19: 275-92
4. Bucciero M, Ingelmo PM, Fumagalli R, et al. Intraperitoneal ropivacaine nebulization for pain management after laparoscopic cholecystectomy: a comparison with intraperitoneal instillation. Anesth Analg 2011; 113: 1266-71
5. Kahokehr A, Sammour T, Soop M, Hill AG. Intraperitoneal use of local anaesthetic in laparoscopic cholecystectomy: systematic review and metaanalysis of randomized controlled trials. J Hepatobiliary Pancreas Sci 2010; 17: 637-56
6. Alkhamesi NA, Peck DH, Lomax D, Darzi AW. Intraperitoneal aerosolization of bupivacaine reduces postoperative pain in laparoscopic surgery: a randomized prospective controlled double-blind clinical trial. Surg Endosc 2007; 21: 602-6
7. Schlotterbeck H, Schaeffer R, Dow WA, Diemunsch P. Cold nebulization used to prevent heat loss during laparoscopic surgery: an experimental study in pigs. Surg Endosc 2008; 22: 2616-20
8. Greib N, Schlotterbeck H, Dow WA, Joshi GP, Geny B, Diemunsch PA. An evaluation of gas humidifying devices as a means of intraperitoneal local anesthetic administration for laparoscopic surgery. Anesth Analg 2008; 107: 549-51
9. Alkhamesi NA, Ridgway PF, Ramwell A, McCullough PW, Peck DH, Darzi AW. Peritoneal nebulizer: a novel technique for delivering intraperitoneal therapeutics in laparoscopic surgery to prevent locoregional recurrence. Surg Endosc 2005; 19: 1142-6
10. Zimmer PW, McCann MJ, O'Brien MM. Bupivacaine use in the Insuflow device during laparoscopic cholecystectomy: results of a prospective randomized double-blind controlled trial. Surg Endosc 2010; 24: 1524-7
11. Kazis L, Anderson J, Meenan R. Effect sizes for interpreting changes in health status. Med Care 1989; 27: 178-89
12. Katz J, Clarke H, Seltzer Z. Preventive analgesia: quo vadimus? Anesth Analg 2011; 113: 1242-53.
13. Bauer A, McGlynn P, Bovet LL, Mims PL, Curry LA, Hanrahan JP. Output and aerosol properties of 5 nebulizer/compressor systems with arformoterol inhalation solution. Respir Care 2009; 54: 1342-7
14. Martin AR, Thompson RB, Finlay WH. MRI measurement of regional lung deposition in mice exposed nose-only to nebulized superparamagnetic iron oxide nanoparticles. J Aerosol Med Pulm Drug Deliv 2008; 21: 335-42
15. Woolf CJ. Pain: moving from symptom control towards mechanism-specific pharmacologic management. Ann Intern Med 2004; 140: 441-51
16. Leduc C, Gentili ME, Estèbe JP, Le Corre P, Moulinoux JP, Ecoffey C. The effect of local anesthetics and amitriptyline on peroxidation in vivo in an inflammatory rat model: preliminary reports. Anesth Analg 2002; 95: 992-6
17. Betton D, Greib N, Schlotterbeck H, Joshi G, Ubeaud-Sequier G, Diemunsch P. The pharmacokinetics of ropivacaine after intraperitoneal administration: instillation versus nebulization. Anesth Analg 2010; 111: 1140-5
18. Berde C, Strichartz G. Local anesthetics. In: Miller RD, Eriksson LI, Fleisher LA, Wiener-Kronish JP, Young WL, eds. Miller's Anesthesia, 7th Edn. Philadelphia: Churchill Livingstone Elsevier, 2010; 962.