Mitral annular calcification and incident ischemic stroke in treated hypertensive patients: The LIFE study

American Journal of Hypertension

Volumn 26, Issue 4, 2013, Pages 567-573

  De Marco, Marina ^a   Gerdts, Eva ^a,b,c   Casalnuovo, Giuseppina ^a   Migliore, Teresa ^a   Wachtell, Kristian ^d,e   Boman, Kurt ^f   Dahlöf, Björn ^g   Olsen, Michael H ^h,i   Kizer, Jorge R ^j   Devereux, Richard B ^j   De Simone, Giovanni ^a,j  

^a FEDERICO II UNIVERSITY HOSPITAL   (Italy)

^b UNIVERSITY OF BERGEN   (Norway)

^c HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^d GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f UMEÅ UNIVERSITY   (Sweden)

^g SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^h ODENSE UNIVERSITY HOSPITAL   (Denmark)

ⁱ NORTH WEST UNIVERSITY   (South Africa)

^j WEILL CORNELL MEDICAL COLLEGE   (United States)

more..

Author keywords

blood pressure; hypertension; mitral annulus calcification; risk factors; stroke

Indexed keywords

LOSARTAN;

ADULT; AGED; ARTICLE; BRAIN ISCHEMIA; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; DISEASE ASSOCIATION; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAM; FEMALE; FOLLOW UP; HEART ATRIUM FIBRILLATION; HEART LEFT ATRIUM; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HUMAN; HYPERTENSION; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MITRAL ANNULAR CALCIFICATION; PREVALENCE; PRIORITY JOURNAL; PROTEINURIA; SYSTOLIC BLOOD PRESSURE;

AGED; AGED, 80 AND OVER; CALCINOSIS; CARDIOMYOPATHIES; ECHOCARDIOGRAPHY; FEMALE; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; LOSARTAN; MALE; MIDDLE AGED; MITRAL VALVE; STROKE;

EID: 84876536281     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1093/ajh/hps082     Document Type: Article

References (34)

1. Sell S, Scully RE. Aging changes in the aortic and mitral valves. Histologic and histochemical studies, with observations on the pathogenesis of calcific aortic stenosis and calcification of the mitral annulus. Am J Pathol 1965;46:345-365.
2. Fulkerson PK, Beaver BM, Auseon JC, Graber HL. Calcification of the mitral annulus: etiology, clinical associations, complications and therapy. Am J Med 1979;66:967-977. (Pubitemid 9198581)
3. Boon A, Cheriex E, Lodder J, Kessels F. Cardiac valve calcification: characteristics of patients with calcification of the mitral annulus or aortic valve. Heart 1997;78:472-474. (Pubitemid 27515107)
4. Allison MA, Cheung P, Criqui MH, Langer RD, Wright CM. Mitral and aortic annular calcification are highly associated with systemic calcified atherosclerosis. Circulation 2006;113:861-866.
5. Adler Y, Koren A, Fink N, Tanne D, Fusman R, Assali A, Yahav J, Zelikovski A, Sagie A. Association between mitral annulus calcification and carotid atherosclerotic disease. Stroke 1998;29:1833-1837. (Pubitemid 28399973)
6. Benjamin EJ, Plehn JF, D'Agostino RB, Belanger AJ, Comai K, Fuller DL, Wolf PA, Levy D. Mitral annular calcification and the risk of stroke in an elderly cohort. N Engl J Med 1992;327:374-379.
7. Kizer JR, Wiebers DO, Whisnant JP, Galloway JM, Welty TK, Lee ET, Best LG, Resnick HE, Roman MJ, Devereux RB. Mitral annular calcification, aortic valve sclerosis, and incident stroke in adults free of clinical cardiovascular disease: the Strong Heart Study. Stroke 2005;36:2533-2537.
8. Kohsaka S, Jin Z, Rundek T, Boden-Albala B, Homma S, Sacco RL, Di Tullio MR. Impact of mitral annular calcification on cardiovascular events in a multiethnic community: the Northern Manhattan Study. JACC Cardiovasc Imaging 2008;1:617-623.
9. Boon A, Lodder J, Cheriex E, Kessels F. Mitral annulus calcification is not an independent risk factor for stroke: a cohort study of 657 patients. J Neurol 1997;244:535-541. (Pubitemid 27464097)
10. Dahl B, Devereux RB, Kjeldsen SE, Julius S, Beevers G, de Faire U, Fyhrquist F, Ibsen H, Kristiansson K, Lederballe-Pedersen O, Lindholm LH, Nieminen MS, Omvik P, Oparil S, Wedel H; LIFE Study Group. Cardiovascular morbidity and mortality in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002;359:995-1003. (Pubitemid 34286536)
11. Dahl B, Devereux RB, Julius S, Kjeldsen SE, Beevers G, de Faire U, Fyhrquist F, Hedner T, Ibsen H, Kristianson K, Lederballe-Pedersen O, Lindholm LH, Nieminen MS, Omvik P, Oparil S, Wedel H. Characteristics of 9194 patients with left ventricular hypertrophy: the LIFE study. Losartan Intervention for Endpoint Reduction in Hypertension. Hypertension 1998;32:989-997. (Pubitemid 29001425)
12. Dahl B, Devereux R, de Faire U, Fyhrquist F, Hedner T, Ibsen H, Julius S, Kjeldsen S, Kristianson K, Lederballe-Pedersen O, Lindholm LH, Nieminen MS, Omvik P, Oparil S, Wedel H.; the LIFE Study Group. The Losartan Intervention for Endpoint Reduction (LIFE) in Hypertension study: rationale, design, and methods. Am J Hypertens 1997;10:705-713. (Pubitemid 27313815)
13. Devereux RB, Dahl B, Gerdts E, Boman K, Nieminen MS, Papademetriou V, Rokkedal J, Harris KE, Edelman JM, Wachtell K. Regression of hypertensive left ventricular hypertrophy by losartan compared with atenolol: the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) trial. Circulation 2004;110:1456-1462. (Pubitemid 39238023)
14. Wachtell K, Lehto M, Gerdts E, Olsen MH, Hornestam B, Dahl B, Ibsen H, Julius S, Kjeldsen SE, Lindholm LH, Nieminen MS, Devereux RB. Angiotensin II receptor blockade reduces new-onset atrial fibrillation and subsequent stroke compared to atenolol: the Losartan Intervention for End Point Reduction in Hypertension (LIFE) study. J Am Coll Cardiol 2005;45:712-719. (Pubitemid 40282586)
15. Olsen MH, Wachtell K, Beevers G, Dahl B, de Simone G, Devereux RB, de Faire U, Fyhrquist F, Ibsen H, Kjeldsen SE, Lederballe-Pedersen O, Lindholm LH, Lyle PA, Nieminen MS, Omvik P, Oparil S, Wedel H. Effects of losartan compared with atenolol on lipids in patients with hypertension and left ventricular hypertrophy: the Losartan Intervention for Endpoint reduction in hypertension study. J Hypertens 2009;27:567-574.
16. Wachtell K, Palmieri V, Olsen MH, Bella JN, Aalto T, Dahlof B, Gerdts E, Wright JT Jr, Papademetriou V, Mogensen CE, Borch-Johnsen K,Ibsen H, Devereux RB. Urine albumin/creatinine ratio and echocardiographic left ventricular structure and function in hypertensive patients with electrocardiographic left ventricular hypertrophy: the LIFE study. Losartan Intervention for Endpoint Reduction. Am Heart J 2002;143:319-326.
17. Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, Hogg RJ, Perrone RD, Lau J, Eknoyan G; National Kidney Foundation. National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification and stratification. Ann Intern Med 2003;139:137-147.
18. WHO Study Group. Diabetes mellitus (technical report series 727).WHO: Geneva, Switzerland, 1985.
19. Lindholm LH, Ibsen H, Borch-Johnsen K, Olsen MH, Wachtell K, Dahl B, Devereux RB, Beevers G, de Faire U, Fyhrquist F, Julius S, Kjeldsen SE, Kristianson K, Lederballe-Pedersen O, Nieminen MS, Omvik P, Oparil S, Wedel H, Aurup P, Edelman JM, Snapinn S; LIFE study group. Risk of new-onset diabetes in the Losartan Intervention for Endpoint reduction in hypertension study. J Hypertens 2002;20:1879-1886.
20. Wolf PA, D'Agostino RB, O'Neal A, Sytkowski P, Kase CS, Belanger AJ, Kannel WB. Secular trends in stroke incidence and mortality. The Framingham Study. Stroke 1992;23:1551-1555.
21. Kizer JR, Dahl B, Kjeldsen SE, Julius S, Beevers G, de Faire U, Fyhrquist F, Ibsen H, Kristianson K, Lederballe-Pedersen O, Lindholm LH, Nieminen MS, Omvik P, Oparil S, Wedel H, Wachtell K, Edelman JM, Snapinn SM, Harris KE, Devereux RB. Stroke reduction in hypertensive adults with cardiac hypertrophy randomized to losartan versus atenolol: the Losartan Intervention for Endpoint reduction in hypertension study. Hypertension 2005;45:46-52. (Pubitemid 40066412)
22. Sahn DJ, DeMaria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation 1978;58:1072-1083. (Pubitemid 9091990)
23. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R,Feigenbaum H, Gutgesell H, Reichek N, Sahn D, Schnittger I. Recommendations for quantitation of the left ventricle by two dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989;2:358-367.
24. Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, Reichek N. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 1986;57:450-458. (Pubitemid 16119719)
25. de Simone G, Devereux RB, Daniels SR, Koren MJ, Meyer RA, Laragh JH. Effect of growth on variability of left ventricular mass: assessment of allometric signals in adults and children and their capacity to predict cardiovascular risk. J Am Coll Cardiol 1995;25:1056-1062.
26. Ganau A, Devereux RB, Roman MJ, de Simone G, Pickering TG, Saba PS, Vargiu P, Simongini I, Laragh JH. Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension. J Am Coll Cardiol 1992;19:1550-1558.
27. de Simone G, Devereux RB, Ganau A, Hahn RT, Saba PS, Mureddu GF, Roman MJ, Howard BV. Estimation of left ventricular chamber and stroke volume by limited M-mode echocardiography and validation by two-dimensional and Doppler echocardiography. Am J Cardiol 1996;78:801-807. (Pubitemid 126657152)
28. de Simone G, Devereux RB, Roman MJ, Ganau A, Saba PS, Alderman MH, Laragh JH. Assessment of left ventricular function by midwall fractional shortening/end-systolic stress relation in human hypertension. J Am Coll Cardiol 1994;23:1444-1451. (Pubitemid 24158016)
29. Snapinn SM, Jiang Q, Iglewicz B. Illustrating the impact of a time-varying covariate with an extended Kaplan-Meier estimator. Am Statistician 2005;59:301-307. (Pubitemid 41616828)
30. Adler Y, Herz I, Vaturi M, Fusman R, Shohat-Zabarski R, Fink N, Porter A, Shapira Y, Assali A, Sagie A. Mitral annular calcium detected by transthoracic echcoardiography is a marker for high prevalence and severity of coronary artery disease in patients undergoing coronary angiography. Am J Cardiol 1998;82:1183-1186. (Pubitemid 28544537)
31. Casalnuovo G, Gerdts E, de Simone G, Izzo R, De Marco M, Giudice R, Trimarco B, De Luca N. Arterial stiffness is associated with carotid atherosclerosis in hypertensive patients (the Campania Salute Network). Am J Hypertens 2012;25:739-745.
32. Lin C, Schwartz IS, Chapman I. Calcification of the mitral annulus fibrosus with systemic embolization: a clinicopathologic study of 16 cases. Arch Pathol Lab Med 1987;111:411-414. (Pubitemid 17073558)
33. Shohat-Zabarski R, Paz R, Adler Y, Vaturi M, Jortner R, Sagie A. Mitral annulus calcification with a mobile component as a possible source of embolism. Am J Geriatr Cardiol 2001;10:196-198. (Pubitemid 32655787)
34. Eicher JC, Soto FX, DeNadai L, Ressencourt O, Falcon-Eicher S, Giroud M, Louis P, Wolf JE. Possible association of thrombotic, nonbacterial vegetations of the mitral ring-mitral annular calcium and stroke. Am J Cardiol 1997;79:1712-1715. (Pubitemid 27339494)