Human mesenchymal stem cell transfusion is safe and improves liver function in acute-on-chronic liver failure patients

Stem Cells Translational Medicine

Volumn 1, Issue 10, 2012, Pages 725-731

  Shi, Ming ^a,b   Zhang, Zheng ^a   Xu, Ruonan ^a   Lin, Hu ^a   Fu, Junliang ^a   Zou, Zhengsheng ^a   Zhang, Aimin ^a   Shi, Jianfei ^a   Chen, Liming ^a   Lv, Sa ^a   He, Weiping ^a   Geng, Hua ^a   Jin, Lei ^a   Liu, Zhenwen ^b   Wang, Fu Sheng ^a  

^a Institute of Translational Hepatology   (China)

^b BEIJING 302 HOSPITAL   (China)

Author keywords

Clinical trials; Liver; Stem cell transplantation; Umbilical cord

Indexed keywords

5' NUCLEOTIDASE; ALANINE AMINOTRANSFERASE; ALBUMIN; ALPHA FETOPROTEIN; BILIRUBIN; CD31 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; CHOLESTEROL; CHOLINESTERASE; ENDOGLIN; FUROSEMIDE; HEMOGLOBIN; HERMES ANTIGEN; LAMIVUDINE; PROTHROMBIN; SPIRONOLACTONE; THY 1 ANTIGEN;

ACUTE ON CHRONIC LIVER FAILURE; ADULT; ARTICLE; ASCITES; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; END STAGE LIVER DISEASE; FEMALE; FEVER; FOLLOW UP; HEPATITIS B; HUMAN; LIVER FUNCTION; LIVER INJURY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; OPEN STUDY; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; SAFETY; SCORING SYSTEM; SURVIVAL RATE; THROMBOCYTE COUNT; UMBILICAL CORD;

EID: 84876510973     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2012-0034     Document Type: Article

References (31)

1. Bernuau J, Rueff B, Benhamou JP. Fulminant and subfulminant liver failure: Definitions and causes. Semin Liver Dis 1986;6:97-106.
2. Farci P, Alter HJ, Shimoda A et al. Hepatitis C virus-associated fulminant hepatic failure. N Engl J Med 1996;335:631-634.
3. Navarro VJ, Senior JR. Drug-related hepatotoxicity. N Engl J Med 2006;35:731-739.
4. Sarin SK, Kumar A, Almeida JA et al. Acuteonchronic liver failure: Consensusrecommendations of the Asian Pacific Association for the study of the liver (APASL). Hepatol Int 2009;3:269-282.
5. Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147.
6. Lee KD, Kuo TK, Whang-Peng J et al. In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology 2004;40:1275-1284.
7. Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008;8:726-736.
8. Shi M, Liu ZW, Wang FS. Immunomodulatory properties and therapeutic application of mesenchymal stem cells. Clin Exp Immunol 2011;164:1-8.
9. Singer NG, Caplan AI. Mesenchymal stem cells: Mechanisms of inflammation. Annu Rev Pathol 2011;6:457-478.
10. Le Blanc K, Frassoni F, Ball L et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase II study. Lancet 2008;371:1579-1586.
11. Rabani V, Shahsavani M, Gharavi M et al. Mesenchymal stem cell infusion therapy in a carbon tetrachloride-induced liver fibrosis model affects matrix metalloproteinase expression. Cell Biol Int 2010;34:601-605.
12. Chang YJ, Liu JW, Lin PC et al. Mesenchymal stem cells facilitate recovery from chemically induced liver damage and decrease liver fibrosis. Life Sci 2009;85:517-525.
13. Kuo TK, Hung SP, Chuang CH et al. Stem cell therapy for liver disease: Parameters governing the success of using bone marrow mesenchymal stem cells. Gastroenterology 2008; 134:2111-2121.
14. van Poll D, Parekkadan B, Cho CH et al. Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo. Hepatology 2008;47:1634-1643.
15. Terai S, Ishikawa T, Omori K et al. Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy. STEM CELLS 2006;24:2292-2298.
16. Mohamadnejad M, Alimoghaddam K, Mohyeddin-Bonab M et al. Phase 1 trial of autologous bonemarrowmesenchymal stem cell transplantation in patients with decompensated liver cirrhosis. Arch Iran Med 2007;10:459-466.
17. Kharaziha P, Hellström PM, Noorinayer B et al. Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: A phase I-II clinical trial. Eur J Gastroenterol Hepatol 2009;21:1199-1205.
18. Zhang Z, Lin H, Shi M et al. Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients. J Gastroenterol Hepatol 2012;27(suppl 2):112-120.
19. Peng L, Xie DY, Lin BL et al. Autologous bone mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: Short-term and long-term outcomes. Hepatology 2011;54:820-828.
20. Lu LL, Liu YJ, Yang SG et al. Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica 2006;91:1017-1026.
21. Garg V, Garg H, Khan A et al. Granulocytecolony stimulating factor mobilizes CD34+ cells and improves survival of patients with acute-on-chronic liver failure. Gastroenterology 2012;142:505-512.
22. Zhong YS, Lin N, Deng MH et al. Deficient proliferation of bone marrow-derived mesenchymal stem cells in patients with chronic hepatitis B viral infections and cirrhosis of the liver. Dig Dis Sci 2010;55:438-445.
23. Jung KH, Shin HP, Lee S et al. Effect of human umbilical cord blood-derived mesenchymal stem cells in a cirrhotic rat model. Liver Int 2009;29:898-909.
24. Tsai PC, Fu TW, Chen YM et al. The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis. Liver Transpl 2009;15:484-495.
25. Hong SH, Gang EJ, Jeong JA et al. In vitro differentiation of human umbilical cord bloodderived mesenchymal stem cells into hepatocyte- like cells. Biochem Biophys Res Commun 2005;330:1153-1161.
26. Aurich I, Mueller LP, Aurich H et al. Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers. Gut 2007;56:405-415.
27. Yu Y, Lu L, Qian X et al. Antifibrotic effect of hepatocyte growth factor-expressing mesenchymal stem cells in small-for-size liver transplant rats. Stem Cells Dev 2010;19:903-914.
28. Sato Y, Araki H, Kato J et al. Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood 2005;106:756-763.
29. Friedman R, Betancur M, Boissel L et al. Umbilical cord mesenchymal stem cells: Adjuvants for human cell transplantation. Biol Blood Marrow Transplant 2007;13:1477-1486.
30. Schinköthe T, Bloch W, Schmidt A. In vitro secreting profile of human mesenchymal stem cells. Stem Cells Dev 2008;17:199-206.
31. Fong CY, Gauthaman K, Cheyyatraivendran S et al. Human umbilical cord Wharton's jelly stem cells and its conditioned medium support hematopoietic stem cell expansion ex vivo. J Cell Biochem 2012;113:658-668.