Species-specific vesicular monoamine transporter 2 (VMAT2) expression in mammalian pancreatic beta cells: Implications for optimising radioligand-based human beta cell mass (BCM) imaging in animal models

Diabetologia

Volumn 56, Issue 5, 2013, Pages 1047-1056

  Schafer M K H ^a   Hartwig, N R ^a   Kalmbach, N ^a   Klietz, M ^a   Anlauf, M ^b   Eiden, L E ^c   Weihe, E ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Beta cell mass; Imaging; Pancreas; Tetrabenazine; Vesicular monoamine transporter

Indexed keywords

INSULIN; MESSENGER RNA; PROTEIN ANTIBODY; TETRABENAZINE; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER 2; VESICULAR MONOAMINE TRANSPORTER 2 ANTIBODY;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SPECIFICITY; CELLULAR PARAMETERS; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMAGING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LASER CAPTURE MICRODISSECTION; MALE; MAST CELL; MOLECULAR CLONING; MOLECULAR PROBE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PANCREAS ISLET BETA CELL MASS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPECIES COMPARISON; SPECIES DIFFERENCE; SWINE; SYMPATHETIC INNERVATION; VALIDATION PROCESS; VMAT2 GENE;

AGED; ANIMALS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INSULIN-SECRETING CELLS; LIGANDS; MALE; MAST CELLS; MICE; MIDDLE AGED; NERVE ENDINGS; PANCREAS; RADIOLIGAND ASSAY; RATS; SPECIES SPECIFICITY; SUS SCROFA; SYMPATHETIC NERVOUS SYSTEM; TETRABENAZINE; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 84876497698     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-2847-7     Document Type: Article

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