Excitotoxicity upregulates SARM1 protein expression and promotes Wallerian-like degeneration of retinal ganglion cells and their axons

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 4, 2013, Pages 2771-2780

  Massoll, Charlotte ^a   Mando, Wasym ^a   Chintala, Shravan K ^a  

^a OAKLAND UNIVERSITY   (United States)

Author keywords

Axonal degeneration; Excitotoxicity; Retinal degeneration

Indexed keywords

KAINIC ACID; PHOSPHATE BUFFERED SALINE; REGULATOR PROTEIN; SMALL INTERFERING RNA; STERILE ALPHA ARMADILLO TOLL INTERLEUKIN RECEPTOR HOMOLOGY DOMAIN 1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXCITOTOXICITY; FLUORESCENCE MICROSCOPY; GENE SILENCING; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; MOUSE; NERVE CELL DEGENERATION; NERVE DEGENERATION; NERVE FIBER DEGENERATION; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RETINA GANGLION CELL; UPREGULATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; ARMADILLO DOMAIN PROTEINS; AXONS; BLOTTING, WESTERN; CYTOSKELETAL PROTEINS; EXCITATORY AMINO ACID AGONISTS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE SILENCING; INTRAVITREAL INJECTIONS; KAINIC ACID; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; OPTIC NERVE; RETINAL GANGLION CELLS; RNA, SMALL INTERFERING; UP-REGULATION; WALLERIAN DEGENERATION;

EID: 84876491616     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-10973     Document Type: Article

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