Colon cancer cells produce immunoregulatory glucocorticoids

OncoImmunology

Volumn 1, Issue 4, 2012, Pages 529-530

  Sidler, Daniel ^a   Renzulli, Pietro ^a,b   Schnoz, Christina ^a   Berger, Barbara ^a   Schneider Jakob, Sabine ^a   Flück, Christa ^a   Inderbitzin, Daniel ^a   Corazza, Nadia ^a   Candinas, Daniel ^a   Brunner, Thomas ^c  

^a UNIVERSITY OF BERN   (Switzerland)

^b Kantonsspital Muensterlingen   (Switzerland)

^c UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

Apoptosis; Colon cancer; Glucocorticoids; Immune evasion; Liver receptor homolog 1; Steroidogenesis

Indexed keywords

GLUCOCORTICOID; LIVER RECEPTOR HOMOLOG 1;

CANCER CELL; CANCER GROWTH; CANCER SURVIVAL; CARCINOGENESIS; CELL INFILTRATION; COLON CANCER; CORTICOSTEROID RELEASE; HORMONE SYNTHESIS; HUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR IMMUNITY;

EID: 84876484858     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.19459     Document Type: Note

References (10)

1. Pagès F, Galon J, Dieu-Nosjean MC, Tartour E, Sautès-Fridman C, Fridman WH. Immune infiltration in human tumors: a prognostic factor that should not be ignored. Oncogene 2010; 29:1093-102; http://dx.doi.org/10.1038/onc.2009.416
2. Sidler D, Renzulli P, Schnoz C, Berger B, Schneider-Jakob S, Flück C, et al. Colon cancer cells produce immunoregulatory glucocorticoids. Oncogene 2011; 30:2411-9; http://dx.doi.org/10.1038/onc.2010.629
3. Noti M, Sidler D, Brunner T. Extra-adrenal glucocorticoid synthesis in the intestinal epithelium: more than a drop in the ocean? Semin Immunopathol 2009; 31:237-48; http://dx.doi.org/10.1007/s00281-009-0159-2
4. Hostettler N, Bianchi P, Gennari-Moser C, Kassahn D, Schoonjans K, Corazza N, et al. Local glucocorticoid production in the mouse lung is induced by immune cell stimulation. Allergy 2012; 67:227-34; http://dx.doi.org/10.1111/j.1398-9995.2011.02749.x
5. Cima I, Corazza N, Dick B, Fuhrer A, Herren S, Jakob S, et al. Intestinal epithelial cells synthesize glucocorticoids and regulate T cell activation. J Exp Med 2004; 200:1635-46; http://dx.doi.org/10.1084/jem.20031958
6. Noti M, Corazza N, Mueller C, Berger B, Brunner T. TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis. J Exp Med 2010; 207:1057-66; http://dx.doi.org/10.1084/jem.20090849
7. Coste A, Dubuquoy L, Barnouin R, Annicotte JS, Magnier B, Notti M, et al. LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease. Proc Natl Acad Sci U S A 2007; 104:13098-103; http://dx.doi.org/10.1073/pnas.0702440104
8. Fernandez-Marcos PJ, Auwerx J, Schoonjans K. Emerging actions of the nuclear receptor LRH-1 in the gut. Biochim Biophys Acta 2011; 1812:947-55
9. Mueller M, Cima I, Noti M, Fuhrer A, Jakob S, Dubuquoy L, et al. The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine. J Exp Med 2006; 203:2057-62; http://dx.doi.org/10.1084/jem.20060357
10. Lee YK, Choi YH, Chua S, Park YJ, Moore DD. Phosphorylation of the hinge domain of the nuclear hormone receptor LRH-1 stimulates transactivation. J Biol Chem 2006; 281:7850-5; http://dx.doi.org/10.1074/jbc.M509115200