Detection of Epstein-Barr virus-infected lymphoid cells in nasal mucosa or nasopharynx: Appearances can be deceptive

Virchows Archiv

Volumn 462, Issue 4, 2013, Pages 391-397

  Ha, Seung Yeon ^a   An, Jungsuk ^a   Park, Sanghui ^b  

^a Gachon University   (South Korea)

^b Ewha Womans University School of Medicine   (South Korea)

Author keywords

Epstein Barr virus; Immunohistochemistry; In situ hybridization; Nasal mucosa; Nasopharynx

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; B LYMPHOCYTE; CHILD; CONTROLLED STUDY; EPSTEIN BARR VIRUS; EPSTEIN BARR VIRUS INFECTION; FEMALE; HUMAN; HUMAN CELL; IMMUNODETECTION; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION; INFLAMMATORY CELL; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX; NK T CELL LYMPHOMA; NOSE MUCOSA; NOSE OBSTRUCTION; NOSE POLYP; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; T LYMPHOCYTE;

ADOLESCENT; ADULT; CHILD; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LYMPHOCYTES; LYMPHOMA, EXTRANODAL NK-T-CELL; MALE; NASAL MUCOSA; NASOPHARYNX; RETROSPECTIVE STUDIES;

EID: 84876478010     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-013-1396-2     Document Type: Article

References (13)

1. Steven H, Swerdlow EC, Harris NL, Jaffe ES, Pireli SA, Stein H, Thiele J, Vardiman JW (2008) WHO classification of Tumours of haematopoietic and lymphoid tissues. World Health Organization classification of tumours. International Agency for Research on Cancer (IARC), Lyon
2. Watanabe K, Hanamura A, Mori N (2010) A unique case of nasal NK/T cell lymphoma with frequent remission and relapse showing different histological features during 12 years of follow up. J Clin Exp Hematopathol 50(1):65-69
3. Hasserjian RP, Harris NL (2007) NK-cell lymphomas and leukemias: a spectrum of tumors with variable manifestations and immunophenotype. Am J Clin Pathol 127(6):860-868. doi: 10.1309/2f39nx1al3l54wu8
4. Ho FC, Choy D, Loke SL, Kung IT, Fu KH, Liang R, Todd D, Khoo RK (1990) Polymorphic reticulosis and conventional lymphomas of the nose and upper aerodigestive tract: a clinicopathologic study of 70 cases, and immunophenotypic studies of 16 cases. Hum Pathol 21(10):1041-1050 (Pubitemid 20349228)
5. Tao Q, Srivastava G, Dickens P, Ho FC (1996) Detection of Epstein-Barr virus-infected mucosal lymphocytes in nasal polyps. Am J Pathol 149(4):1111-1118 (Pubitemid 26337230)
6. Kozak FK, Mahony JB, Chernesky MA, Newhouse MT, Dolovich J, Hitch DA, Rossman CM (1991) Nasal polyposis: in search of a viral etiology using DNA hybridization. J Otolaryngol 20(6):404-407
7. Anagnostopoulos I, Hummel M, Kreschel C, Stein H (1995) Morphology, immunophenotype, and distribution of latently and/or productively Epstein-Barr virus-infected cells in acute infectious mononucleosis: implications for the interindividual infection route of Epstein-Barr virus. Blood 85(3):744-750
8. Tao Q, Srivastava G, Chan AC, Chung LP, Loke SL, Ho FC (1995) Evidence for lytic infection by Epstein-Barr virus in mucosal lymphocytes instead of nasopharyngeal epithelial cells in normal individuals. J Med Virol 45(1):71-77
9. Tao Q, Srivastava G, Chan AC, Ho FC (1995) Epstein-Barr-virus-infected nasopharyngeal intraepithelial lymphocytes. Lancet 345(8960):1309-1310
10. Niedobitek G, Herbst H, Young LS, Brooks L, Masucci MG, Crocker J, Rickinson AB, Stein H (1992) Patterns of Epstein-Barr virus infection in non-neoplastic lymphoid tissue. Blood 79(10):2520-2526
11. Tonoyama Y, Teramoto N, Sarker AB, Yoshino T, Hayashi K, Takahashi K, Akagi T (1996) Detection of Epstein-Barr virus RNA and related antigens in non-neoplastic lymphoid lesions. Acta Medica Okayama 50(2):89-96 (Pubitemid 126445502)
12. Kimura H (2006) Pathogenesis of chronic active Epstein-Barr virus infection: is this an infectious disease, lymphoproliferative disorder, or immunodeficiency? Rev Med Virol 16(4):251-261. doi: 10.1002/rmv.505 (Pubitemid 44140721)
13. Ohshima K, Kimura H, Yoshino T, Kim CW, Ko YH, Lee SS, Peh SC, Chan JK (2008) Proposed categorization of pathological states of EBV-associated T/natural killer-cell lymphoproliferative disorder (LPD) in children and young adults: overlap with chronic active EBV infection and infantile fulminant EBV T-LPD. Pathol Int 58(4):209-217. doi: 10.1111/j.1440-1827.2008.02213.x (Pubitemid 351347666)