Functional differences between Streptococcus pyogenes cluster 1 and cluster 2b streptokinases are determined by their β-domains

FEBS Letters

Volumn 587, Issue 9, 2013, Pages 1304-1309

  Zhang, Yueling ^a   Liang, Zhong ^a   Glinton, Kristofor ^a   Ploplis, Victoria A ^a   Castellino, Francis J ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

Fibrinolysis; Protein domains; Streptococcus pyogenes; Streptokinase; Virulence

Indexed keywords

BACTERIAL ENZYME; CLUSTER 1 STREPTOKINASE; CLUSTER 2B STREPTOKINASE; PLASMINOGEN; STREPTOKINASE; STREPTOKINASE ALPHA1BETA1GAMMA1; STREPTOKINASE ALPHA1BETA1GAMMA2B; STREPTOKINASE ALPHA1BETA2BGAMMA1; STREPTOKINASE ALPHA1BETA2BGAMMA2B; STREPTOKINASE ALPHA2BBETA1GAMMA1; STREPTOKINASE ALPHA2BBETA1GAMMA2B; STREPTOKINASE ALPHA2BBETA2BGAMMA1; STREPTOKINASE ALPHA2BBETA2BGAMMA2B; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL VIRULENCE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; GENE MUTATION; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; STREPTOCOCCUS PYOGENES; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; CONSERVED SEQUENCE; ENZYME ACTIVATION; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PLASMINOGEN; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STREPTOCOCCUS PYOGENES; STREPTOKINASE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

STREPTOCOCCUS PYOGENES;

EID: 84876475534     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.02.033     Document Type: Article

References (33)

1. F.J. Castellino Plasminogen K.A. High, H.R. Roberts, Molecular Basis of Thrombosis and Hemostasis 1995 Marcel Dekker Inc. New York, NY 495 515
2. F.J. Castellino, and V.A. Ploplis Human plasminogen: Structure, Activation, and Function. Plasminogen Structure, Activation, and Regulation Kluwer 2003 Academic/Plenum Publishers pp. 3-17
3. S.M. Cook, A. Skora, C.M. Gillen, M.J. Walker, and J.D. McArthur Streptokinase variants from Streptococcus pyogenes isolates display altered plasminogen activation characteristics-implications for pathogenesis Mol. Microbiol. 86 2012 1052 1062
4. F.J. Castellino, and V.A. Ploplis Plasminogen and streptokinase F. Bachmann, Handbook of Pharmacology vol. 146 2001 Springer-Verlag 25 56
5. J.L. Anderson A randomized trial of intracoronary streptokinase in the treatment of acute myocardial infarction N. Engl. J. Med. 308 1983 1312 1318
6. H.M. Hoffmeister Thrombolytic therapy in acute myocardial infarction-comparison of procoagulant effects of streptokinase and alteplase regimens with focus on the kallikrein system and plasmin Circulation 98 1998 2527 2533
7. M.B. Boffa, W. Wang, L. Bajzar, and M.E. Nesheim Plasma and recombinant thrombin-activable fibrinolysis inhibitor (TAFI) and activated TAFI compared with respect to glycosylation, thrombin/thrombomodulin-dependent activation, thermal stability, and enzymatic properties J. Biol. Chem. 273 1998 2127 2135
8. P. Rodriguez The streptokinase domain responsible for plasminogen binding Fibrinolysis 8 1994 276 285
9. L.F. Lin, S. Oeun, A. Houng, and G.L. Reed Mutation of lysines in a plasminogen binding region of streptokinase identifies residues important for generating a functional activator complex Biochemistry 35 1996 16879 16885
10. F. Conejero-Lara, J. Parrado, A.I. Azuaga, C.M. Dobson, and C.P. Ponting Analysis of the interactions between streptokinase domains and human plasminogen Protein Sci. 7 1998 2190 2199
11. A. Chaudhary, S. Vasudha, K. Rajagopal, S.S. Komath, N. Garg, M. Yadav, S.C. Mande, and G. Sahni Function of the central domain of streptokinase in substrate plasminogen docking and processing revealed by site-directed mutagenesis Protein Sci. 8 1999 2791 2805
12. J.A. Loy, X. Lin, M. Schenone, F.J. Castellino, X.C. Zhang, and J. Tang Domain interactions between streptokinase and human plasminogen Biochemistry 40 2001 14686 14695
13. D.H. Wu, G.Y. Shi, W.J. Chuang, J.M. Hsu, K.C. Young, C.W. Chang, and H.L. Wu Coiled coil region of streptokinase gamma-domain is essential for plasminogen activation J. Biol. Chem. 276 2001 15025 15033
14. D.M. Kim, S.J. Lee, S.K. Yoon, and S.M. Byun Specificity role of the streptokinase C-terminal domain in plasminogen activation Biochem. Biophys. Res. Commun. 290 2002 585 588
15. N. Wakeham, S. Terzyan, P. Zhai, J.A. Loy, J. Tang, and X.C. Zhang Effects of deletion of streptokinase residues 48-59 on plasminogen activation Protein Eng. 15 2002 753 761
16. V. Sundram, J.S. Nanda, K. Rajagopal, J. Dhar, A. Chaudhary, and G. Sahni Domain truncation studies reveal that the streptokinase-plasmin activator complex utilizes long range protein-protein interactions with macromolecular substrate to maximize catalytic turnover J. Biol. Chem. 278 2003 30569 30577
17. R.R. Bean, I.M. Verhamme, and P.E. Bock Role of the streptokinase alpha-domain in the interactions of streptokinase with plasminogen and plasmin J. Biol. Chem. 280 2005 7504 7510
18. S. Yadav, M. Datt, B. Singh, and G. Sahni Role of the 88-97 loop in plasminogen activation by streptokinase probed through site-specific mutagenesis Biochim. Biophys. Acta 1784 2008 1310 1318
19. S. Yadav, R. Aneja, P. Kumar, M. Datt, S. Sinha, and G. Sahni Identification through combinatorial random and rational mutagenesis of a substrate-interacting exosite in the gamma domain of streptokinase J. Biol. Chem. 286 2011 6458 6469
20. A. Kalia, and D.E. Bessen Natural selection and evolution of streptococcal virulence genes involved in tissue-specific adaptations J. Bacteriol. 186 2004 110 121
21. Y. Zhang, Z. Liang, H.T. Hsueh, V.A. Ploplis, and F.J. Castellino Characterization of streptokinases from Group A Streptococci reveals a strong functional relationship that supports the coinheritance of plasminogen-binding M-Protein and cluster 2b streptokinase J. Biol. Chem. 287 2012 42093 42103
22. S. Lizano, and K.H. Johnston Structural diversity of streptokinase and activation of human plasminogen Infect. Immun. 73 2005 4451 4453
23. T. Iwaki, and F.J. Castellino A single plasmid transfection that offers a significant advantage associated with puromycin selection in Drosophila Schneider S2 cells expressing heterologous proteins Cytotechnology 57 2008 45 49
24. J. Lee, H.-J. Lee, M.-K. Shin, and W.-S. Ryu Versatile PCR-mediated insertion or deletion mutagenesis Biotechniques 36 2004 398 400
25. S.G. Wang, G.L. Reed, and L. Hedstrom Zymogen activation in the streptokinase-plasminogen complex-ile1 is required for the formation of a functional active site Eur. J. Biochem. 267 2000 3994 4001
26. B.N. Violand, R. Byrne, and F.J. Castellino The effect of a-w-amino acids on human plasminogen structure and activation J. Biol. Chem. 253 1978 5395 5401
27. 1]plasminogen by human urokinase Proc. Natl. Acad. Sci. USA 84 1987 4031 4034
28. 1]plasminogen Proc. Natl. Acad. Sci. USA 83 1986 1237 1241
29. J.D. McArthur Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation FASEB J. 22 2008 3146 3153
30. X.Q. Wang, X.L. Lin, J.A. Loy, J. Tang, and X.J.C. Zhang Crystal structure of the catalytic domain of human plasmin complexed with streptokinase Science 281 1998 1662 1665
31. F. Conejero-Lara, J. Parrado, A.I. Azuaga, R.A.G. Smith, C.P. Ponting, and C.M. Dobson Thermal stability of the three domains of streptokinase studied by circular dichroism and nuclear magnetic resonance Protein Sci. 5 1996 2583 2591
32. W.M. McShan Genome sequence of a nephritogenic and highly transformable M49 strain of Streptococcus pyogenes J. Bacteriol. 190 2008 7773 7785
33. M.A. Larkin Clustal W and Clustal X version 2.0 Bioinformatics 23 2007 2947 2948