Thalamic involvement in patients with neurologic impairment due to Shiga toxin 2

Annals of Neurology

Volumn 73, Issue 3, 2013, Pages 419-429

  Meuth, Sven G ^a   Göbel, Kerstin ^a   Kanyshkova, Tatyana ^a   Ehling, Petra ^a   Ritter, Martin A ^a   Schwindt, Wolfram ^a   Bielaszewska, Martina ^a   Lebiedz, Pia ^a   Coulon, Philippe ^a   Herrmann, Alexander M ^a   Storck, Wiebke ^a   Kohmann, Denise ^a   Müthing, Johannes ^a   Pavenstädt, Hermann ^a   Kuhlmann, Tanja ^a   Karch, Helge ^a   Peters, Georg ^b   Budde, Thomas ^a   Wiendl, Heinz ^a   Pape, Hans Christian ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; GLOBOTRIAOSYLCERAMIDE; VEROTOXIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN ELECTROPHYSIOLOGY; BRAIN REGION; BRAIN SLICE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ELECTROENCEPHALOGRAPHY; FEMALE; HEMOLYTIC UREMIC SYNDROME; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE DEPOLARIZATION; NEUROLOGIC DISEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THALAMUS;

ADULT; AGED; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; ASTROCYTES; CALCIUM; ELECTROENCEPHALOGRAPHY; ESCHERICHIA COLI INFECTIONS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MAGNETIC RESONANCE IMAGING; MEMBRANE POTENTIALS; NERVOUS SYSTEM DISEASES; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, LONG-EVANS; RNA, MESSENGER; SEX CHARACTERISTICS; SHIGA TOXIN 2; THALAMUS; TRIHEXOSYLCERAMIDES; YOUNG ADULT;

EID: 84876467861     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.23814     Document Type: Article

References (30)

1. Gasser C, Gautier E, Steck A, et al. Hemolytic-uremic syndrome: bilateral necrosis of the renal cortex in acute acquired hemolytic anemia [in German]. Schweiz Med Wochenschr 1955; 85: 905-909.
2. Tarr PI, Gordon CA, Chandler WL,. Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome. Lancet 2005; 365: 1073-1086.
3. Karch H,. The role of virulence factors in enterohemorrhagic Escherichia coli (EHEC)-associated hemolytic-uremic syndrome. Semin Thromb Hemost 2001; 27: 207-213.
4. Sandvig K, van Deurs B,. Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives. EMBO J 2000; 19: 5943-5950.
5. Nathanson S, Kwon T, Elmaleh M, et al. Acute neurological involvement in diarrhea-associated hemolytic uremic syndrome. Clin J Am Soc Nephrol 2010; 5: 1218-1228.
6. Cimolai N, Morrison BJ, Carter JE,. Risk factors for the central nervous system manifestations of gastroenteritis-associated hemolytic-uremic syndrome. Pediatrics 1992; 90: 616-621.
7. Eisenhauer PB, Jacewicz MS, Conn KJ, et al. Escherichia coli Shiga toxin 1 and TNF-alpha induce cytokine release by human cerebral microvascular endothelial cells. Microb Pathog 2004; 36: 189-196.
8. Takahashi K, Funata N, Ikuta F, Sato S,. Neuronal apoptosis and inflammatory responses in the central nervous system of a rabbit treated with Shiga toxin-2. J Neuroinflammation 2008; 5: 11.
9. Obata F, Tohyama K, Bonev AD, et al. Shiga toxin 2 affects the central nervous system through receptor globotriaosylceramide localized to neurons. J Infect Dis 2008; 198: 1398-1406.
10. Frank C, Werber D, Cramer JP, et al. Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany. N Engl J Med 2011; 365: 1771-1780.
11. Bielaszewska M, Mellmann A, Zhang W, et al. Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study. Lancet Infect Dis 2011; 11: 671-676.
12. Magnus T, Röther J, Simova O, et al. The neurological syndrome in adults during the 2011 northern German E. coli serotype O104:H4 outbreak. Brain 2012; 135: 1850-1859.
13. Bauwens A, Bielaszewska M, Kemper B, et al. Differential cytotoxic actions of Shiga toxin 1 and Shiga toxin 2 on microvascular and macrovascular endothelial cells. Thromb Haemost 2011; 105: 515-528.
14. + channel 1 (TASK1) and TASK3 channels to the control of activity modes in thalamocortical neurons. J Neurosci 2003; 23: 6460-6469.
15. 2+ imaging via fluorescence lifetime analysis, Cell Calcium 2006; 40: 73-79.
16. Coulon P, Herr D, Kanyshkova T, et al. Burst discharges in neurons of the thalamic reticular nucleus are shaped by calcium-induced calcium release. Cell Calcium 2009; 46: 333-346.
17. Yasuda R, Sabatini BL, Svoboda K,. Plasticity of calcium channels in dendritic spines. Nat Neurosci 2003; 6: 948-955.
18. Maravall M, Mainen ZF, Sabatini BL, Svoboda K,. Estimating intracellular calcium concentrations and buffering without wavelength ratioing. Biophys J 2000; 78: 2655-2667.
19. Garcia J, Beam KG,. Calcium transients associated with the T type calcium current in myotubes. J Gen Physiol 1994; 104: 1113-1128.
20. Zoremba N, Homola A, Slais K, et al. Extracellular diffusion parameters in the rat somatosensory cortex during recovery from transient global ischemia/hypoxia. J Cereb Blood Flow Metab 2008; 28: 1665-1673.
21. Steinborn M, Leiz S, Rudisser K, et al. CT and MRI in haemolytic uraemic syndrome with central nervous system involvement: distribution of lesions and prognostic value of imaging findings. Pediatr Radiol 2004; 34: 805-810.
22. Weiss T, Veh RW,. Morphological and electrophysiological characteristics of neurons within identified subnuclei of the lateral habenula in rat brain slices. Neuroscience 2011; 172: 74-93.
23. Becherer U, Rodeau JL, Feltz A,. Resting potential of rat cerebellar granule cells during early maturation in vitro. J Neurobiol 1997; 32: 11-21.
24. Doengi M, Hirnet D, Coulon P, et al. GABA uptake-dependent Ca(2+) signaling in developing olfactory bulb astrocytes. Proc Natl Acad Sci U S A 2009; 106: 17570-17575.
25. Göbel K, Melzer N, Herrmann AM, et al. Collateral neuronal apoptosis in CNS gray matter during an oligodendrocyte-directed CD8(+) T cell attack. Glia 2010; 58: 469-480.
26. Johannes L, Romer W,. Shiga toxins-from cell biology to biomedical applications. Nat Rev Microbiol 2010; 8: 105-116.
27. Yamamoto T, Satomura K, Okada S, Ozono K,. Risk factors for neurological complications in complete hemolytic uremic syndrome caused by Escherichia coli O157. Pediatr Int 2009; 51: 216-219.
28. Lopez EL, Contrini MM, Devoto S, et al. Tumor necrosis factor concentrations in hemolytic uremic syndrome patients and children with bloody diarrhea in Argentina. Pediatr Infect Dis J 1995; 14: 594-598.
29. Yamamoto T, Nagayama K, Satomura K, et al. Increased serum IL-10 and endothelin levels in hemolytic uremic syndrome caused by Escherichia coli O157. Nephron 2000; 84: 326-332.
30. van de Kar NC, Sauerwein RW, Demacker PN, et al. Plasma cytokine levels in hemolytic uremic syndrome. Nephron 1995; 71: 309-313.