Influence of IL-6 haplotypes on clinical and inflammatory response in aggressive periodontitis

Clinical Oral Investigations

Volumn 17, Issue 4, 2013, Pages 1235-1242

  Nibali, L ^a   Pelekos, G ^a   D'Aiuto, F ^a   Chaudhary, N ^a   Habeeb, R ^a   Ready, D ^b   Parkar, M ^a   Donos, N ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Genetic; Inflammation; Interleukin; Periodontitis

Indexed keywords

INTERLEUKIN 6;

ADULT; AGGREGATIBACTER ACTINOMYCETEMCOMITANS; AGGRESSIVE PERIODONTITIS; ARTICLE; BACTERIAL COUNT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GENETICS; GINGIVA; GINGIVITIS; HAPLOTYPE; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; MALE; NONPARAMETRIC TEST; PERIODONTICS; PREVENTIVE DENTISTRY; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGGREGATIBACTER ACTINOMYCETEMCOMITANS; AGGRESSIVE PERIODONTITIS; COLONY COUNT, MICROBIAL; FEMALE; GINGIVA; GINGIVAL CREVICULAR FLUID; HAPLOTYPES; HUMANS; INTERLEUKIN-6; MALE; PERIODONTAL DEBRIDEMENT; PERIODONTAL INDEX; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; STATISTICS, NONPARAMETRIC;

EID: 84876454185     PISSN: 14326981     EISSN: 14363771     Source Type: Journal    
DOI: 10.1007/s00784-012-0804-3     Document Type: Article

References (36)

1. Ebersole JL, Machen RL, Steffen MJ, Willmann DE (1997) Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitis. Clin Exp Immunol 107: 347-352.
2. Katz J, Flugelman MY, Goldberg A, Heft M (2002) Association between periodontal pockets and elevated cholesterol and low density lipoprotein cholesterol levels. J Periodontol 73: 494-500.
3. D'Aiuto F, Sabbah W, Netuveli G, Donos N, Hingorani AD, Deanfield J, Tsakos G (2008) Association of the metabolic syndrome with severe periodontitis in a large U. S. population-based survey. J Clin Endocrinol Metab 93: 3989-94.
4. Lofthus JE, Waki MY, Jolkovsky DL, Otomocorgel J, Newman MG, Flemmig T et al (1991) Bacteremia following subgingival irrigation and scaling and root planing. J Periodontol 62: 602-607.
5. Behle JH, Sedaghatfar MH, Demmer RT, Wolf DL, Celenti R, Kebschull M et al (2009) Heterogeneity of systemic inflammatory responses to periodontal therapy. J Clin Periodontol 36: 287-294.
6. Loos BG, John RP, Laine ML (2005) Identification of genetic risk factors for periodontitis and possible mechanisms of action. J Clin Periodontol 32: 159-179.
7. Nibali L, Donos N, Henderson B (2009) Periodontal infectogenomics. J Med Microbiol 58: 1269-74.
8. Bennermo M, Held C, Stemme S, Ericsson CG, Silveira A, Green F et al (2004) Genetic predisposition of the interleukin-6 response to inflammation: implications for a variety of major diseases? Clin Chem 50: 2136-2140.
9. Bamoulid J, Courivaud C, Deschamps M, Gaugler B, Tiberghien P, Chalopin JM et al (2011) The interleukin-6 gene promoter polymorphism-174 and atherosclerotic events in overweight transplanted patients. J Transplant 2011: 803429.
10. Poikonen K, Lajunen T, Silvennoinen-Kassinen S, Leinonen M, Saikku P (2009) Effects of CD14, TLR2, TLR4, LPB, and IL-6 gene polymorphisms on Chlamydia pneumoniae growth in human macrophages in vitro. Scand J Immunol 70: 34-39.
11. Hirano T, Ishihara K, Hibi M (2000) Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 19: 2548-2556.
12. Jones KG, Brull DJ, Brown LC, Sian M, Greenhalgh RM, Humphries SE et al (2001) Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms. Circulation 103: 2260-2265.
13. Trevilatto PC, Scarel-Caminaga RM, de Brito RB, de Souza AP, Line SRP (2003) Polymorphism at position-174 of IL-6 gene is associated with susceptibility to chronic periodontitis in a Caucasian Brazilian population. J Clin Periodontol 30: 438-442.
14. Nibali L, Ready DR, Parkar M, Brett PM, Wilson M, Tonetti MS et al (2007) Gene polymorphisms and the prevalence of key periodontal pathogens. J Dent Res 86: 416-420.
15. D'Aiuto F, Parkar M, Andreou G, Suvan J, Brett PM, Ready D et al (2004) Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers. J Dent Res 83: 156-160.
16. Nibali L, D'Aiuto F, Donos N, Griffiths GS, Parkar M, Tonetti MS, Humphries SE, Brett PM (2009) Association between periodontitis and common variants in the promoter of the interleukin-6 gene. Cytokine 45: 50-54.
17. Shao MY, Huang P, Cheng R, Hu T (2009) Interleukin-6 polymorphisms modify the risk of periodontitis: a systematic review and meta-analysis. J Zhejiang Univ Sci B 10(12): 920-927.
18. Nikolopoulos GK, Dimou NL, Hamodrakas S, Bagos PG (2008) Cytokine gene polymorphisms in periodontal disease: a meta-analysis of 53 studies including 4178 cases and 4590 controls. J Clin Periodontol 35: 754-767.
19. Salzberg TN, Overstreet BT, Rogers JD, Califano JV, Best AM, Schenkein HA (2006) C-reactive protein in patients with aggressive periodontitis. J Periodontol 77: 933-939.
20. Lang NP, Bartold M, Cullinan M, Mombelli A, Murakami S, Page R et al (1999) Consensus reports: aggressive periodontitis. Ann Periodontol 4: 53.
21. O'Leary TJ, Drake RB, Naylor JE (1972) The plaque control record. J Periodontol 43: 38.
22. Ainamo J, Bay I (1975) Problems and proposals for recording gingivitis and plaque. Int Dent J 25: 229-235.
23. Nibali L, Tonetti MS, Ready D, Parkar M, Brett PM, Donos N, D'Aiuto F (2008) Interleukin-6 polymorphisms are associated with pathogenic bacteria in periodontitis patients. J Periodontol 79: 677-683.
24. Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S et al (1998) The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102: 1369-1376.
25. Fife MS, Ogilvie EM, Kelberman D, Samuel J, Gutierrez A, Humphries SE et al (2005) Novel IL-6 haplotypes and disease association. Genes Immun 6: 367-370.
26. Griffiths GS, Curtis MA, Wilton JMA (1988) Selection of A filter-paper with optimum properties for the collection of gingival crevicular fluid. J Periodont Res 23: 33-38.
27. Matsuki Y, Yamamoto T, Hara K (1992) Detection of inflammatory cytokine messenger-Rna (Messenger Rna)-expressing cells in human inflamed gingiva by combined in situ hybridization and immunohistochemistry. Immunology 76: 42-47.
28. Lappin DF, Macleod CP, Kerr A, Mitchell T, Kinane DF (2001) Anti-inflammatory cytokine IL-10 and T cell cytokine profile in periodontitis granulation tissue. Clin Exp Immunol 123: 294-300.
29. Donati M, Liljenberg B, Padyukov L, Berglundh T (2008) Local expression of interleukin-10 and mCD14 in relation to the -1087 IL-10 and -159 CD14 gene polymorphisms in chronic periodontitis. J Periodontol 79: 517-524.
30. Syed SA, Loesche WJ (1972) Survival of human dental plaque flora in various transport media. Appl Microbiol 24: 638-44.
31. Nibali L, Madden I, Chillida FF, Heitz-Mayfield LJA, Brett PM, Donos N (2011) IL6-174 genotype associated with Aggregatibacter actinomycetemcomitans in Indians. Oral Dis 17: 232-237.
32. Johanssen A, Rydmark I, Soder B, Asberg M (2007) Gingival inflammation, increased periodontal pocket depth and elevated interleukin-6 in gingival crevicular fluid of depressed women on long-term sick leave. J Periodont Res 42: 546-552.
33. Cobb CM (2002) Clinical significance of non-surgical periodontal therapy: an evidence-based perspective of scaling and root planing. J Clin Periodontol 29: 6-16.
34. Heitz-Mayfield LJ, Trombelli L, Heitz F, Needleman I, Moles D (2002) A systematic review of the effect of surgical debridement vs non-surgical debridement for the treatment of chronic periodontitis. J Clin Periodontol 29(suppl 3): 92-102.
35. Tonetti MS, D'Aiuto F, Nibali L, Donald A, Storry C, Parkar M et al (2007) Treatment of periodontitis and endothelial function. N Engl J Med 356: 911-920.
36. Graziani F, Cei S, Tonetti M, Paolantonio M, Serio R, Sammartino G et al (2010) Systemic inflammation following non-surgical and surgical periodontal therapy. J Clin Periodontol 37: 848-854.