In vitro antimicrobial activity of vancomycin-eluting bioresorbable β-TCP-polylactic acid nanocomposite material for load-bearing bone repair

Journal of Materials Science: Materials in Medicine

Volumn 24, Issue 3, 2013, Pages 679-687

  Makarov, C ^a   Berdicevsky, I ^a   Raz Pasteur, A ^a   Gotman, I ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-MICROBIAL ACTIVITY; ANTIBIOTIC DRUGS; BETA TRICALCIUM PHOSPHATE; BIORESORBABLE MATERIALS; IMPLANT-ASSOCIATED INFECTION; LOAD-BEARING BONE REPAIR; MECHANICAL SUPPORT; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS;

ANTIBIOTICS; BACTERIA; BEARINGS (MACHINE PARTS); BIOMATERIALS; BONE; COMPRESSIVE STRENGTH; ENZYME INHIBITION; MECHANICAL PROPERTIES;

NANOCOMPOSITES;

CALCIUM PHOSPHATE; POLYLACTIC ACID; VANCOMYCIN;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIUM COLONY; BONE REMODELING; COMPRESSIVE STRENGTH; DRUG EFFICACY; DRUG RELEASE; IN VIVO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PRIORITY JOURNAL; ROOM TEMPERATURE; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION;

ANTI-BACTERIAL AGENTS; BONE SUBSTITUTES; CALCIUM PHOSPHATES; MICROBIAL SENSITIVITY TESTS; MICROSCOPY, ELECTRON, SCANNING; NANOCOMPOSITES; POLYESTERS; STAPHYLOCOCCUS AUREUS; THERMOGRAVIMETRY; VANCOMYCIN;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

EID: 84876417476     PISSN: 09574530     EISSN: 15734838     Source Type: Journal    
DOI: 10.1007/s10856-012-4832-y     Document Type: Article

References (29)

1. Middleton JC, Tipton AJ. Synthetic biodegradable polymers as orthopedic devices. Biomaterials. 2000;21:2335-46.
2. Takayama T, Todo M. Improvement of mechanical properties of poly(L-lactic acid) by blending of lysine triisocyanate. J Mater Sci. 2009;44:5017-20.
3. Kasuga T, Ota Y, Nogami M, Abe Y. Preparation and mechanical properties of polylactic acid composites containing hydroxyapatite fibers. Biomaterials. 2001;22:19-23.
4. Gay S, Arostegui S, Lemaitre J. Preparation and characterization of dense nanohydroxyapatite/PLLA composites. Mater Sci Eng C. 2009;29:172-7.
5. Hong Z, Zhang P, He C, Qiu X, Liu A, Chen L, Chen X, Jing X. Nanocomposite of poly(l-lactide) and surface grafted hydroxyapatite: mechanical properties. Biomaterials. 2005;26:6296-304.
6. Wang X, Song G, Lou T. Fabrication and characterization of nano composite scaffold of poly(L-lactic acid)/hydroxyapatite. J Mater Sci Mater Med. 2010;21:183-8.
7. Huttunen M, Ashammakhi N, Törmälä P, Kellomäki M. Fibre reinforced bioresorbable composites for spinal surgery. Acta Biomater. 2006;2:575-87.
8. Ignjatovic N, Delijic K, Vukcevic M, Uskokovic D. The designing of properties of hydroxyapatite/poly-l-lactide composite biomaterials by hot pressing. Z Metallkunde. 2001;92:145-9.
9. Rakovsky A, Gutmanas EY, Gotman I. Ca-deficient hydroxyapatite/ polylactide nanocomposites with chemically modified interfaces by high pressure consolidation at room temperature. J Mater Sci. 2010;45:6339-44.
10. Makarov C, Gotman I, Radin S, Ducheyne P, Gutmanas EY. Vancomycin release from bioresorbable calcium phosphate-polymer composites with high ceramic volume fractions. J Mater Sci. 2010;45:6320-4.
11. Moriarty TF, Schlegel U, Perren S, Richards RG. Infection in fracture fixation: can we influence infection rates through implant design? J Mater Sci Mater Med. 2010;21:1031-5.
12. Cyteval C, Bourdon A. Imaging orthopedic implant infections. Diagn Interv Imaging. 2012;93:547-57.
13. Eglin D, Alini M. Degradable polymeric materials for osteosynthesis: tutorial. Eur Cell Mater. 2008;16:80-91.
14. Garvin K, Feschuk C. Polylactide-polyglycolide antibiotic implants. Clin Orhtop Rel Res. 2006;437:105-10.
15. Hetrick EM, Schoenfisch MH. Reducing implant-related infections: active release strategies. Chem Soc Rev. 2006;35:780-9.
16. Wu P, Grainger DW. Drug/device combinations for local drug therapies and infection prophylaxis. Biomaterials. 2006;27:2450-67.
17. Ashammakhi N, Veiranto M, Suokas E, Tiainen J, Niemelä SM, Törmälä P. Innovation in multifunctional bioabsorbable osteoconductive drug-releasing hard tissue fixation devices. J Mater Sci Mater Med. 2006;17:1275-82.
18. Mäkinen TJ, Veiranto M, Knuuti J, Jalava J, Törmälä P, Aro HT. Efficacy of bioabsorbable antibiotic containing bone screw in the prevention of biomaterial-related infection due to Staphylococcus aureus. Bone. 2006;36:292-9.
19. Russias J, Saiz E, Nalla RK, Gryn K, Ritchie RO, Tomsia AP. Fabrication and mechanical properties of PLA/HA composites: a study of in vitro degradation. Mat Sci Eng C. 2006;26:1289-95.
20. Bernstein M, Makarov C, Gotman I, Phadke A, Radin S, Ducheyne P, Gutmanas EY. Low temperature fabrication of β-TCP-PCL nanocomposites for bone implants. Adv Eng Mater. 2010;12:B341-7.
21. Winkler H, Janata O, Berger C, Wein W, Georgopoulus A. In vitro release of vancomycin and tobramycin from impregnated human and bovine bone grafts. J Antimicrob Chemoth. 2000;46:426-8.
22. Gutmanas EY. Cold sintering-high pressure consolidation vol. 7 Powder metal technologies and applications. ASM Handbook. Materials Park: ASM International; 1998. p. 574-82.
23. Thomas M. In: Ando DJ, editor. Ultraviolet and visible spectroscopy, vol. 2. England: Wiley; 1996. p. 16.
24. Smith TL, Pearson LM, Wilcox KR, Cruz C, Lancaster MV, Robinson-Dunn B, Tenover FC, Zervos MJ, Band JD, White E, Jarvis WR. Emergence of vancomycin resistance in Staphylococcus aureus. N Engl J Med. 1999;340:493-501.
25. Turner CH, Wang T, Burr DB. Shear strength and fatigue properties of human cortical bone determined from pure shear tests. Calcif Tissue Int. 2001;69:373-8.
26. Currey JD. Mechanical properties of vertebrate hard tissues. Proc Inst Mech Eng H. 1998;212:341-99.
27. Makarov C. Bioresorbable calcium phosphate ceramic-polymer nanocomposites for load bearing bone healing devices-low temperature synthesis and drug incorporation. PhD thesis, Technion, Haifa, Israel; 2012.
28. Russias J, Saiz E, Kikuchi M, Koyama Y, Takakuda K, Miyairi H, Shirahama N, Tanaka J. In vitro change in mechanical strength of β-tricalcium phosphate/copolymerized poly-l-lactide composites and their application for guided bone regeneration. J Biomed Mater Res. 2002;62:265-72.
29. Weber C, Stephan R, Druggan P, Joosten H, Iversen C. Improving the enrichment procedure for enterobacteriaceae detection. Food Microbiol. 2009;26:565-72.