메뉴 건너뛰기




Volumn 62, Issue 5, 2013, Pages 505-508

Antiretroviral therapy initiated during acute HIV infection fails to prevent persistent T-cell activation

Author keywords

Acute HIV infection; Antiretroviral therapy; Immune activation; NNRTIs; Viral dynamics

Indexed keywords

ANTIRETROVIRUS AGENT; CD38 ANTIGEN; DIDANOSINE; EFAVIRENZ PLUS EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; EMTRICITABINE; HLA DR ANTIGEN; NELFINAVIR; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; STAVUDINE; TENOFOVIR;

EID: 84876409568     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0b013e318285cd33     Document Type: Article
Times cited : (50)

References (24)
  • 2
    • 64049116643 scopus 로고    scopus 로고
    • Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections
    • Stacey AR, Norris PJ, Qin L, et al. Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections. J Virol. 2009;83:3719-3733.
    • (2009) J Virol , vol.83 , pp. 3719-3733
    • Stacey, A.R.1    Norris, P.J.2    Qin, L.3
  • 3
    • 79955918570 scopus 로고    scopus 로고
    • Cross-sectional detection of acute HIV infection: Timing of transmission, inflammation and antiretroviral therapy
    • Gay C, Dibben O, Anderson JA, et al. Cross-sectional detection of acute HIV infection: timing of transmission, inflammation and antiretroviral therapy. PLoS One. 2011;6:e19617.
    • (2011) PLoS One , vol.6
    • Gay, C.1    Dibben, O.2    Anderson, J.A.3
  • 4
    • 3843056825 scopus 로고    scopus 로고
    • Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load
    • Deeks SG, Kitchen CMR, Liu L, et al. Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load. Blood. 2004;104:942-947.
    • (2004) Blood , vol.104 , pp. 942-947
    • Deeks, S.G.1    Kitchen, C.M.R.2    Liu, L.3
  • 5
    • 0032504919 scopus 로고    scopus 로고
    • Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements
    • Fahey JL, Taylor JMG, Manna B, et al. Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements. AIDS. 1998;12:1581-1590.
    • (1998) AIDS , vol.12 , pp. 1581-1590
    • Fahey, J.L.1    Taylor, J.M.G.2    Manna, B.3
  • 6
    • 0038701685 scopus 로고    scopus 로고
    • T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy
    • Hunt PW, Martin JN, Sinclair E, et al. T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis. 2003;187:1534-1543.
    • (2003) J Infect Dis , vol.187 , pp. 1534-1543
    • Hunt, P.W.1    Martin, J.N.2    Sinclair, E.3
  • 7
    • 58749093399 scopus 로고    scopus 로고
    • Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS clinical trials group protocol 384
    • Robbins GK, Spritzler JG, Chan ES, et al. Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS Clinical Trials Group protocol 384. Clin Infect Dis. 2009;48:350-361.
    • (2009) Clin Infect Dis , vol.48 , pp. 350-361
    • Robbins, G.K.1    Spritzler, J.G.2    Chan, E.S.3
  • 8
    • 79954576655 scopus 로고    scopus 로고
    • Efficacy of NNRTI-based antiretroviral therapy initiated during acute HIV infection
    • Gay CL, Mayo AJ, Mfalila CK, et al. Efficacy of NNRTI-based antiretroviral therapy initiated during acute HIV infection. AIDS. 2011;25:941-949.
    • (2011) AIDS , vol.25 , pp. 941-949
    • Gay, C.L.1    Mayo, A.J.2    Mfalila, C.K.3
  • 9
    • 77957596628 scopus 로고    scopus 로고
    • Clinical management of acute HIV infection: Best practice remains unknown
    • Bell SK, Little SJ, Rosenberg ES. Clinical management of acute HIV infection: best practice remains unknown. J Infect Dis. 2010;202:S278-S288.
    • (2010) J Infect Dis , vol.202
    • Bell, S.K.1    Little, S.J.2    Rosenberg, E.S.3
  • 10
    • 84864021119 scopus 로고    scopus 로고
    • Should we treat acute HIV infection?
    • O'Brien M, Markowitz M. Should we treat acute HIV infection? Curr HIV/AIDS Rep. 2012;9:101-110.
    • (2012) Curr HIV/AIDS Rep , vol.9 , pp. 101-110
    • O'brien, M.1    Markowitz, M.2
  • 11
    • 34250015490 scopus 로고    scopus 로고
    • Slower CD4 cell decline following cessation of a 3 month course of HAART in primary HIV infection: Findings from an observational cohort
    • Fidler S, Fox J, Touloumi G, et al. Slower CD4 cell decline following cessation of a 3 month course of HAART in primary HIV infection: findings from an observational cohort. AIDS. 2007;21:1283-1291.
    • (2007) AIDS , vol.21 , pp. 1283-1291
    • Fidler, S.1    Fox, J.2    Touloumi, G.3
  • 12
    • 33748428894 scopus 로고    scopus 로고
    • A multicenter observational study of the potential benefits of initiating combination antiretroviral therapy during acute HIV infection
    • Hecht FM, Wang L, Collier A, et al. A multicenter observational study of the potential benefits of initiating combination antiretroviral therapy during acute HIV infection. J Infect Dis. 2006;194:725-733.
    • (2006) J Infect Dis , vol.194 , pp. 725-733
    • Hecht, F.M.1    Wang, L.2    Collier, A.3
  • 13
    • 81055144859 scopus 로고    scopus 로고
    • Early antiretroviral therapy during primary HIV-1 infection results in a transient reduction of the viral setpoint upon treatment interruption
    • Von Wyl V, Gianella S, Fischer M, et al. Early antiretroviral therapy during primary HIV-1 infection results in a transient reduction of the viral setpoint upon treatment interruption. PLoS One. 2011;6:e27463.
    • (2011) PLoS One , vol.6
    • Von Wyl, V.1    Gianella, S.2    Fischer, M.3
  • 14
    • 84871864237 scopus 로고    scopus 로고
    • Acute HIV infection in the southeastern United States: A cohort study
    • McKellar MS, Cope AB, Gay CL, et al. Acute HIV infection in the southeastern United States: a cohort study. AIDS Res Hum Retroviruses. 2013;29:121-128.
    • (2013) AIDS Res Hum Retroviruses , vol.29 , pp. 121-128
    • McKellar, M.S.1    Cope, A.B.2    Gay, C.L.3
  • 15
    • 0033767914 scopus 로고    scopus 로고
    • Diagnosis of primary HIV-1 infection and duration of follow-up after HIV exposure
    • Linback S, Thorstensson R, Karlsson AC, et al. Diagnosis of primary HIV-1 infection and duration of follow-up after HIV exposure. AIDS. 2000;14:2333-2339.
    • (2000) AIDS , vol.14 , pp. 2333-2339
    • Linback, S.1    Thorstensson, R.2    Karlsson, A.C.3
  • 16
    • 84862189831 scopus 로고    scopus 로고
    • Immediate antiviral therapy appears to restrict resting CD4+ cell HIV-1 infection without accelerating the decay of latent infection
    • Archin NM, Vaidya NK, Kuruc JD, et al. Immediate antiviral therapy appears to restrict resting CD4+ cell HIV-1 infection without accelerating the decay of latent infection. Proc Natl Acad Sci. 2012;109:9523-9528.
    • (2012) Proc Natl Acad Sci , vol.109 , pp. 9523-9528
    • Archin, N.M.1    Vaidya, N.K.2    Kuruc, J.D.3
  • 17
    • 34147190899 scopus 로고    scopus 로고
    • Role of immune activation in HIV pathogenesis
    • Hunt PW. Role of immune activation in HIV pathogenesis. Curr HIV/AIDS Rep. 2007;4:42-47.
    • (2007) Curr HIV/AIDS Rep , vol.4 , pp. 42-47
    • Hunt, P.W.1
  • 18
    • 70349768299 scopus 로고    scopus 로고
    • Antiretroviral therapy in acute and recent HIV infection: A prospective multicenter stratified trial of intentionally interrupted treatment
    • Volberding P, Demeter L, Bosch RJ, et al. Antiretroviral therapy in acute and recent HIV infection: a prospective multicenter stratified trial of intentionally interrupted treatment. AIDS. 2009;23:1987-1995.
    • (2009) AIDS , vol.23 , pp. 1987-1995
    • Volberding, P.1    Demeter, L.2    Bosch, R.J.3
  • 19
    • 84879169421 scopus 로고    scopus 로고
    • ART initiation during acute/early HIV infection compared to later ART initiation is associated with improved immunologic and virologic parameters during suppressive ART
    • abstract #517, Paper presented at:, Boston, MA
    • Jain V, Hartogensis W, Bacchetti P, et al. ART initiation during acute/early HIV infection compared to later ART initiation is associated with improved immunologic and virologic parameters during suppressive ART [abstract #517]. Paper presented at: 18th Conference on Retroviruses and Opportunistic Infections; 2011; Boston, MA.
    • (2011) 18th Conference on Retroviruses and Opportunistic Infections
    • Jain, V.1    Hartogensis, W.2    Bacchetti, P.3
  • 20
    • 48749093073 scopus 로고    scopus 로고
    • Collagen deposition limits immune reconstitution in the gut
    • Estes J, Baker JV, Brenchley JM, et al. Collagen deposition limits immune reconstitution in the gut. J Infect Dis. 2008;198:456-464.
    • (2008) J Infect Dis , vol.198 , pp. 456-464
    • Estes, J.1    Baker, J.V.2    Brenchley, J.M.3
  • 21
    • 65649102237 scopus 로고    scopus 로고
    • Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection
    • Jiang W, Lederman MM, Hunt P, et al. Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection. J Infect Dis. 2009;199:1177-1185.
    • (2009) J Infect Dis , vol.199 , pp. 1177-1185
    • Jiang, W.1    Lederman, M.M.2    Hunt, P.3
  • 22
    • 33845904393 scopus 로고    scopus 로고
    • Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection
    • Mehandru S, Poles MA, Tenner-Racz K, et al. Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection. PLoS Med. 2006;3:e484.
    • (2006) PLoS Med , vol.3
    • Mehandru, S.1    Poles, M.A.2    Tenner-Racz, K.3
  • 23
    • 70449411747 scopus 로고    scopus 로고
    • HIV-1 residual viremia correlates with persistent T-cell activation in poor immunological responders to combination antiretroviral therapy
    • Mavigner M, Delobel P, Cazabat M, et al. HIV-1 residual viremia correlates with persistent T-cell activation in poor immunological responders to combination antiretroviral therapy. PLoS One. 2009;4:e7658.
    • (2009) PLoS One , vol.4
    • Mavigner, M.1    Delobel, P.2    Cazabat, M.3
  • 24
    • 84876409512 scopus 로고    scopus 로고
    • Gut epithelial barrier dysfunction, inflammation, and coagulation predict higher mortality during treated HIV/AIDS
    • abstract #278, Paper presented at, Seattle, WA
    • Hunt PW, Rodriguez B, Shive C, et al. Gut epithelial barrier dysfunction, inflammation, and coagulation predict higher mortality during treated HIV/AIDS [abstract #278]. Paper presented at: 19th Conference on Retroviruses and Opportunistic Infections; 2012; Seattle, WA.
    • (2012) 19th Conference on Retroviruses and Opportunistic Infections
    • Hunt, P.W.1    Rodriguez, B.2    Shive, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.