Derivation of the Crick-Wyman equation for allosteric proteins defining the difference between the number of binding sites and the hill coefficient

Journal of Molecular Biology

Volumn 425, Issue 9, 2013, Pages 1497-1499

  Poitevin, Frédéric ^a,b   Edelstein, Stuart J ^c  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

^c BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

Allostery; Cooperativity; Hill coefficient

Indexed keywords

LIGAND; OLIGOMER; PROTEIN;

ALLOSTERISM; ARTICLE; BINDING SITE; CRICK WYMAN EQUATION; HILL COEFFICIENT; LIGAND BINDING; MATHEMATICAL PARAMETERS; PRIORITY JOURNAL; PUBLICATION; SCIENTIST;

EID: 84876408440     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.03.014     Document Type: Article

References (5)

1. F.H.C. Crick, and J. Wyman A footnote on allostery J. Mol. Biol. 1965
2. A.V. Hill The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves J. Physiol. 40 1910 4 7
3. J. Monod, J. Wyman, and J.-P. Changeux On the nature of allosteric transitions: a plausible model J. Mol. Biol. 12 1965 88 118
4. J. Wyman Linked functions and reciprocal effects in hemoglobin: a second look Adv. Protein Chem. 19 1964 223 286
5. S.J. Edelstein, and W.G. Bardsley Contributions of individual molecular species to the Hill coefficient for ligand binding by an oligomeric protein J. Mol. Biol. 267 1997 10 16