Long-term results of the effect of intravitreal ranibizumab on the retinal arteriolar diameter in patients with neovascular age-related macular degeneration

Acta Ophthalmologica

Volumn 91, Issue 3, 2013, Pages

  Mendrinos, Efstratios ^a   Mangioris, Georgios ^a   Papadopoulou, Domniki N ^a   Donati, Guy ^a   Pournaras, Constantin J ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

age related macular degeneration; ranibizumab; retinal arteriolar diameter; retinal vessel analyzer

Indexed keywords

RANIBIZUMAB;

ADULT; AGED; ANALYZER; ARTERY DIAMETER; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; FEMALE; FOLLOW UP; HUMAN; INJECTION SITE REACTION; MALE; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETINA BLOOD VESSEL; RETINA MACULA AGE RELATED DEGENERATION; RETINAL ARTERIOLE; RETINAL VESSEL ANALYZER; SUBRETINAL NEOVASCULARIZATION; VASOCONSTRICTION; VISUAL ACUITY;

AGED; AGED, 80 AND OVER; ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL, HUMANIZED; ARTERIAL PRESSURE; ARTERIOLES; BLOOD PRESSURE; CONSTRICTION, PATHOLOGIC; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTRAOCULAR PRESSURE; INTRAVITREAL INJECTIONS; MALE; MIDDLE AGED; RETINAL ARTERY; RETREATMENT; TOMOGRAPHY, OPTICAL COHERENCE; TREATMENT OUTCOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VISUAL ACUITY; WET MACULAR DEGENERATION;

EID: 84876383991     PISSN: 1755375X     EISSN: 17553768     Source Type: Journal    
DOI: 10.1111/aos.12008     Document Type: Article

References (55)

1. Ameri H, Chader GJ, Kim JG, Sadda SR, Rao NA, &, Humayun MS, (2007): The effects of intravitreous bevacizumab on retinal neovascular membrane and normal capillaries in rabbits. Invest Ophthalmol Vis Sci 48: 5708-5715.
2. Babiak A, Schumm AM, Wangler C, et al., (2004): Coordinated activation of VEGFR-1 and VEGFR-2 is a potent arteriogenic stimulus leading to enhancement of regional perfusion. Cardiovasc Res 61: 789-795.
3. Blaauwgeers HG, Holtkamp GM, Rutten H, et al., (1999): Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation. Am J Pathol 155: 421-428.
4. Blum M, Pils C, Muller UA, &, Strobel J, (2006): The myogenic response of retinal arterioles in diabetic retinopathy. Ophthalmologe 103: 209-213.
5. Bonnin P, Pournaras JA, Lazrak Z, Cohen SY, Legargasson JF, Gaudric A, Levy BI, &, Massin P, (2010): Ultrasound assessment of short-term ocular vascular effects of intravitreal injection of bevacizumab (Avastin((R))) in neovascular age-related macular degeneration. Acta Ophthalmol 88: 641-645.
6. Bouloumie A, Schini-Kerth VB, &, Busse R, (1999): Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells. Cardiovasc Res 41: 773-780.
7. Brown DM, Kaiser PK, Michels M, Soubrane G, Heier JS, Kim RY, Sy JP, &, Schneider S, (2006): Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 355: 1432-1444.
8. Campochiaro PA, Hafiz G, Shah SM, et al., (2008): Ranibizumab for macular edema due to retinal vein occlusions: implication of VEGF as a critical stimulator. Mol Ther 16: 791-799.
9. Chen E, Hsu J, &, Park CH, (2009): Acute visual acuity loss following intravitreal bevacizumab for diabetic macular edema. Ophthalmic Surg Lasers Imaging 40: 68-70.
10. Chun DW, Heier JS, Topping TM, Duker JS, &, Bankert JM, (2006): A pilot study of multiple intravitreal injections of ranibizumab in patients with center-involving clinically significant diabetic macular edema. Ophthalmology 113: 1706-1712.
11. Clayton JA, Chalothorn D, &, Faber JE, (2008): Vascular endothelial growth factor-A specifies formation of native collaterals and regulates collateral growth in ischemia. Circ Res 103: 1027-1036.
12. Congdon N, O'Colmain B, Klaver CC, et al., (2004): Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 122: 477-485.
13. Donati G, Pournaras CJ, Munoz JL, Poitry S, Poitry-Yamate CL, &, Tsacopoulos M, (1995): Nitric oxide controls arteriolar tone in the retina of the miniature pig. Invest Ophthalmol Vis Sci 36: 2228-2237.
14. Feke GT, Tagawa H, Deupree DM, Goger DG, Sebag J, &, Weiter JJ, (1989): Blood flow in the normal human retina. Invest Ophthalmol Vis Sci 30: 58-65.
15. Ferrara N, (2001): Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol 280: C1358-C1366.
16. Fukumura D, Gohongi T, Kadambi A, et al., (2001): Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci USA 98: 2604-2609.
17. Hood JD, Meininger CJ, Ziche M, &, Granger HJ, (1998): VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells. Am J Physiol 274: H1054-H1058.
18. Ikram MK, van Leeuwen R, Vingerling JR, Hofman A, &, de Jong PT, (2005): Retinal vessel diameters and the risk of incident age-related macular disease: the Rotterdam Study. Ophthalmology 112: 548-552.
19. Jeganathan VS, Kawasaki R, Wang JJ, Aung T, Mitchell P, Saw SM, &, Wong TY, (2008): Retinal vascular caliber and age-related macular degeneration: the Singapore Malay Eye Study. Am J Ophthalmol 146: 954-959 e951.
20. Jeppesen P, Sanye-Hajari J, &, Bek T, (2007): Increased blood pressure induces a diameter response of retinal arterioles that increases with decreasing arteriolar diameter. Invest Ophthalmol Vis Sci 48: 328-331.
21. Kaiser PK, (2006): Antivascular endothelial growth factor agents and their development: therapeutic implications in ocular diseases. Am J Ophthalmol 142: 660-668.
22. Kim KS, Chang HR, &, Song S, (2008): Ischaemic change after intravitreal bevacizumab (Avastin) injection for macular oedema secondary to non-ischaemic central retinal vein occlusion. Acta Ophthalmol 86: 925-927.
23. Klein R, Clegg L, Cooper LS, Hubbard LD, Klein BE, King WN, &, Folsom AR, (1999): Prevalence of age-related maculopathy in the Atherosclerosis Risk in Communities Study. Arch Ophthalmol 117: 1203-1210.
24. Klein R, Klein BE, Tomany SC, &, Wong TY, (2004): The relation of retinal microvascular characteristics to age-related eye disease: the Beaver Dam eye study. Am J Ophthalmol 137: 435-444.
25. Kook D, Wolf A, Kreutzer T, Neubauer A, Strauss R, Ulbig M, Kampik A, &, Haritoglou C, (2008): Long-term effect of intravitreal bevacizumab (avastin) in patients with chronic diffuse diabetic macular edema. Retina 28: 1053-1060.
26. Ku DD, Zaleski JK, Liu S, &, Brock TA, (1993): Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries. Am J Physiol 265: H586-H592.
27. Lakshminarayanan S, Antonetti DA, Gardner TW, &, Tarbell JM, (2000): Effect of VEGF on retinal microvascular endothelial hydraulic conductivity: the role of NO. Invest Ophthalmol Vis Sci 41: 4256-4261.
28. Lee CS, &, Koh HJ, (2008): Multiple retinal haemorrhages in diabetic retinopathy after adjunctive intravitreal bevacizumab (Avastin) with pars plana vitrectomy. Acta Ophthalmol 86: 812-813.
29. Liew G, Kaushik S, Rochtchina E, Tan AG, Mitchell P, &, Wang JJ, (2006): Retinal vessel signs and 10-year incident age-related maculopathy: the Blue Mountains Eye Study. Ophthalmology 113: 1481-1487.
30. Mayrovitz HN, &, Roy J, (1983): Microvascular blood flow: evidence indicating a cubic dependence on arteriolar diameter. Am J Physiol 245: H1031-H1038.
31. Micieli JA, Tsui E, Lam WC, Brent MH, Devenyi RG, &, Hudson C, (2012): Retinal blood flow in response to an intravitreal injection of ranibizumab for neovascular age-related macular degeneration. Acta Ophthalmol 90: e13-e20.
32. Moncada S, &, Higgs EA, (2006): The discovery of nitric oxide and its role in vascular biology. Br J Pharmacol 147 (Suppl 1): S193-S201.
33. Neubauer AS, Kook D, Haritoglou C, Priglinger SG, Kampik A, Ulbig MW, &, Ceklic L, (2007): Bevacizumab and retinal ischemia. Ophthalmology 114: 2096.
34. Papadopoulou DN, Mendrinos E, Mangioris G, Donati G, &, Pournaras CJ, (2009): Intravitreal ranibizumab may induce retinal arteriolar vasoconstriction in patients with neovascular age-related macular degeneration. Ophthalmology 116: 1755-1761.
35. Papadopoulou DN, Mangioris G, Petropoulos IK, Mendrinos E, Mavropoulos A, &, Pournaras CJ, (2012): Retinal vessel diameter can reliably be determined in minipigs using Retinal Vessel Analyser with a microscope-mounted fundus camera. Acta Ophthalmol 90: e269-e273.
36. Pascolini D, Mariotti SP, Pokharel GP, Pararajasegaram R, Etya'ale D, Negrel AD, &, Resnikoff S, (2004): 2002 global update of available data on visual impairment: a compilation of population-based prevalence studies. Ophthalmic Epidemiol 11: 67-115.
37. Peters S, Heiduschka P, Julien S, Ziemssen F, Fietz H, Bartz-Schmidt KU, &, Schraermeyer U, (2007): Ultrastructural findings in the primate eye after intravitreal injection of bevacizumab. Am J Ophthalmol 143: 995-1002.
38. Pfitzner J, (1976): Poiseuille and his law. Anaesthesia 31: 273-275.
39. Pieramici DJ, Rabena M, Castellarin AA, et al., (2008): Ranibizumab for the treatment of macular edema associated with perfused central retinal vein occlusions. Ophthalmology 115: e47-e54.
40. Polak K, Dorner G, Kiss B, Polska E, Findl O, Rainer G, Eichler HG, &, Schmetterer L, (2000): Evaluation of the Zeiss retinal vessel analyser. Br J Ophthalmol 84: 1285-1290.
41. Pournaras CJ, Rungger-Brandle E, Riva CE, Hardarson SH, &, Stefansson E, (2008): Regulation of retinal blood flow in health and disease. Prog Retin Eye Res 27: 284-330.
42. Riva CE, Grunwald JE, Sinclair SH, &, Petrig BL, (1985): Blood velocity and volumetric flow rate in human retinal vessels. Invest Ophthalmol Vis Sci 26: 1124-1132.
43. Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, &, Kim RY, (2006): Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 355: 1419-1431.
44. Rouvas AA, Papakostas TD, Ladas ID, &, Vergados I, (2008): Enlargement of the hypofluorescent post photodynamic therapy treatment spot after a combination of photodynamic therapy with an intravitreal injection of bevacizumab for retinal angiomatous proliferation. Graefes Arch Clin Exp Ophthalmol 246: 315-318.
45. Sacu S, Pemp B, Weigert G, Matt G, Garhofer G, Pruente C, Schmetterer L, &, Schmidt-Erfurth U, (2011): Response of retinal vessels and retrobulbar hemodynamics to intravitreal anti-VEGF treatment in eyes with branch retinal vein occlusion. Invest Ophthalmol Vis Sci 52: 3046-3050.
46. Saint-Geniez M, Maldonado AE, &, D'Amore PA, (2006): VEGF expression and receptor activation in the choroid during development and in the adult. Invest Ophthalmol Vis Sci 47: 3135-3142.
47. Scheiner AJ, Riva CE, Kazahaya K, &, Petrig BL, (1994): Effect of flicker on macular blood flow assessed by the blue field simulation technique. Invest Ophthalmol Vis Sci 35: 3436-3441.
48. Seifertl BU, &, Vilser W, (2002): Retinal Vessel Analyzer (RVA)-design and function. Biomed Tech (Berl) 47 (Suppl 1 Pt 2): 678-681.
49. Skinner HB, (1979): Velocity-diameter relationships of the microcirculation. Med Inform (Lond) 4: 243-256.
50. Spaide RF, Chang LK, Klancnik JM, Yannuzzi LA, Sorenson J, Slakter JS, Freund KB, &, Klein R, (2009): Prospective study of intravitreal ranibizumab as a treatment for decreased visual acuity secondary to central retinal vein occlusion. Am J Ophthalmol 147: 298-306.
51. TAP Study Group (1999): Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials-TAP report. Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group. Arch Ophthalmol 117: 1329-1345.
52. Tilton RG, Chang KC, LeJeune WS, Stephan CC, Brock TA, &, Williamson JR, (1999): Role for nitric oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF. Invest Ophthalmol Vis Sci 40: 689-696.
53. Uhlmann S, Friedrichs U, Eichler W, Hoffmann S, &, Wiedemann P, (2001): Direct measurement of VEGF-induced nitric oxide production by choroidal endothelial cells. Microvasc Res 62: 179-189.
54. Vilser W, Nagel E, &, Lanzl I, (2002): Retinal Vessel Analysis-new possibilities. Biomed Tech (Berl) 47 (Suppl 1 Pt 2): 682-685.
55. Yokoyama K, Choshi T, Kimoto K, Shinoda K, &, Nakatsuka K, (2008): Retinal circulatory disturbances following intracameral injection of bevacizumab for neovascular glaucoma. Acta Ophthalmol 86: 927-928.