A novel non-radioactive primase-pyrophosphatase activity assay and its application to the discovery of inhibitors of Mycobacterium tuberculosis primase DnaG

Nucleic Acids Research

Volumn 41, Issue 4, 2013, Pages

  Biswas, Tapan ^a   Resto Roldá N, Esteban ^a   Sawyer, Sean K ^a   Artsimovitch, Irina ^b   Tsodikov, Oleg V ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSFER RNA LIGASE; DNA PRIMASE; DNA PRIMASE DNAG; DOXORUBICIN; ELLAGIC ACID; INORGANIC PYROPHOSPHATASE; SURAMIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA BINDING; DNA SYNTHESIS; DRUG INHIBITION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME ASSAY; HIGH THROUGHPUT SCREENING; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN AGGREGATION; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS;

ANTIBIOTICS, ANTITUBERCULAR; COLORIMETRY; DNA PRIMASE; DOXORUBICIN; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; INORGANIC PYROPHOSPHATASE; MYCOBACTERIUM TUBERCULOSIS; SURAMIN;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS;

EID: 84876380310     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks1292     Document Type: Article

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