Quantitative determination of rupestonic acid in rat plasma by high-performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study

Biomedical Chromatography

Volumn 27, Issue 5, 2013, Pages 563-567

  Gu, Zhengyi ^a   He, Jinhua ^a   Yang, Xi ^a,b   Sha, Xianyi ^c  

^a Xinjiang Institute of Materia Medica   (China)

^b XINJIANG MEDICAL UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

HPLC MS MS; Pharmacokinetics; Rat plasma; Rupestonic acid

Indexed keywords

BODY FLUIDS; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; POSITIVE IONS; PRECIPITATION (CHEMICAL); RATS; SODIUM;

HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; HPLC-MS-MS; INTERNAL STANDARDS; ITS APPLICATIONS; PHARMACOKINETIC STUDIES; QUANTITATIVE DETERMINATIONS; RAT PLASMA; RUPESTONIC ACID; WARFARIN SODIUM;

PHARMACOKINETICS;

PLANT MEDICINAL PRODUCT; RUPESTONIC ACID; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CHINESE MEDICINE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CONCENTRATION; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG RETENTION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; NONHUMAN; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 84876311379     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2828     Document Type: Article

References (6)

1. Jakupovic J, Tan RX, Bohlmann F, Jia ZJ and Huneck S. Sesquiterpene lactones from Artemisia rutifolia. Phytochemistry 1991; 30: 1714-1716.
2. Ma Y, Aisha HA, Liao L, Aibai S, Zhang T and Ito Y. Preparative isolation and purification of rupestonic acid from the Chinese medicinal plant Artemisia rupestris L. by high-speed counter-current chromatography. Journal of Chromatography. A 2005; 107: 198-201.
3. Sheu JH, Hung KC, Wang GH and Duh CY. New cytotoxic sesquiterpenes from the gorgonian isis hippuris. Journal of Natural Products 2000; 63: 1603-1607.
4. Su Z, Wu HK, He F, Slukhan U and Aisa HA. New guaipyridine sesquiterpene alkaloids from Artemisia rupestris L. Helvetica Chimica Acta 2010; 93: 33-38.
5. Yang Y, Gu D, Yili A, Zhao Y, He D and Aisa HA. One-step separation and purification of rupestonic acid and chrysosptertin B from Artemisia rupestris L. by high-speed counter-current chromatography. Phytochemical Analysis 2010; 21: 205-209.
6. Yong JP and Aisa HA. Synthesis of rupestonic acid amide derivatives and their in vitro activity against type A3 and B flu virus and herpes simplex I and II. Chemistry of Natural Compounds 2008; 44: 311-314.