9-cis–rich β-carotene powder of the alga dunaliella reduces the severity of chronic plaque psoriasis: A randomized, double-blind, placebo-controlled clinical trial

Journal of the American College of Nutrition

Volumn 31, Issue 5, 2012, Pages 320-326

  Greenberger, Shoshana ^a   Harats, Dror ^a   Salameh, Fares ^a   Lubish, Tamar ^a   Harari, Ayelet ^a   Trau, Henri ^a   Shaish, Aviv ^a  

^a SHEBA MEDICAL CENTER   (Israel)

Author keywords

9 cis carotene; Double blind; Dunaliella; Placebo controlled clinical trial; Psoriasis

Indexed keywords

ANTIPSORIASIS AGENT; BETA CAROTENE; PLACEBO; STARCH;

ABSENCE OF SIDE EFFECTS; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DERMATOLOGY LIFE QUALITY INDEX; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DUNALIELLA BARDAWIL; FEMALE; HUMAN; MALE; PROSPECTIVE STUDY; PSORIASIS AREA AND SEVERITY INDEX; PSORIASIS VULGARIS; QUALITY OF LIFE INDEX; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE;

ADULT; AGED; BETA CAROTENE; CHLOROPHYTA; CHRONIC DISEASE; DOUBLE-BLIND METHOD; DRUG EVALUATION; FEMALE; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; POWDERS; PROSPECTIVE STUDIES; PSORIASIS; QUALITY OF LIFE; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

ALGAE; DUNALIELLA; DUNALIELLA BARDAWIL;

EID: 84876308993     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2012.10720430     Document Type: Article

References (30)

1. LiuY, KruegerJG, BowcockAM: Psoriasis: genetic associations and immune system changes. Genes Immun8:1-12, 2007.
2. ValdimarssonH: The genetic basis of psoriasis. Clin Dermatol25:563-567, 2007.
3. SampognaF, TabolliS, AbeniD: Living with psoriasis: prevalence of shame, anger, worry, and problems in daily activities and social life. Acta Derm Venereol92:299-303, 2012.
4. BhosleMJ, KulkarniA, FeldmanSR, BalkrishnanR: Quality of life in patients with psoriasis. Health Qual Life Outcomes4:35, 2006.
5. KruegerG, KooJ, LebwohlM, MenterA, SternRS, RolstadT: The impact of psoriasis on quality of life: results of a 1998 National Psoriasis Foundation patient-membership survey. Arch Dermatol137:280-284, 2001.
6. MenterA, GottliebA, FeldmanSR, Van VoorheesAS, LeonardiCL, GordonKB, LebwohlM, KooJY, ElmetsCA, KormanNJ, BeutnerKR, BhushanR: Guidelines of care for the management of psoriasis and psoriatic arthritis: section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics. J Am Acad Dermatol58:826-850, 2008.
7. WhittleCH, WoodsB, GrangeRV, CarpenterRG, CasboldJA: The treatment of psoriasis with vitamin A and triamcinolone. Interim report. Br J Dermatol73:433-438, 1961.
8. MacdonaldA, McMinnRM, FryL: Effect of retinoic acid in psoriasis. II. Long term study. Br J Dermatol87:256-260, 1972.
9. FryL, MacdonaldA, McMinnRM: Effect of retinoic acid in psoriasis. Br J Dermatol83:391-396, 1970.
10. van de KerkhofPC: Update on retinoid therapy of psoriasis in: an update on the use of retinoids in dermatology. Dermatol Ther 19:252-263, 2006.
11. OrmerodAD, CampalaniE, GoodfieldMJ: British Association of Dermatologists guidelines on the efficacy and use of acitretin in dermatology. Br J Dermatol162:952-963, 2010.
12. Ben-AmotzA, AvronM: On the factors which determine massive beta-carotene accumulation in the halotolerant alga Dunaliella bardawil. Plant Physiol72:593-597, 1983.
13. Ben-AmotzA, MokadyS, AvronM: The beta-carotene-rich alga Dunaliella bardawil as a source of retinol in a rat diet. Br J Nutr59:443-449, 1988.
14. Ben-AmotzA, LersA, AvronM: Stereoisomers of beta-carotene and phytoene in the alga Dunaliella bardawil. Plant Physiol86:1286-1291, 1988.
15. WangXD, KrinskyNI, BenottiPN, RussellRM: Biosynthesis of 9-cis-retinoic acid from 9-cis-beta-carotene in human intestinal mucosa in vitro. Arch Biochem Biophys313:150-155, 1994.
16. NapoliJL: Biochemical pathways of retinoid transport, metabolism, and signal transduction. Clin Immunol Immunopathol80:S52-S62, 1996.
17. BissonnetteR, DiepgenTL, ElsnerP, EnglishJ, Graham-BrownR, HomeyB, LugerT, LyndeC, MaaresJ, MaibachHI: Redefining treatment options in chronic hand eczema (CHE). J Eur Acad Dermatol Venereol24(Suppl 3):1-20, 2010.
18. BollagW, OttF: Successful treatment of chronic hand eczema with oral 9-cis-retinoic acid. Dermatology199:308-312, 1999.
19. RuzickaT, LyndeCW, JemecGB, DiepgenT, Berth-JonesJ, CoenraadsPJ, KaszubaA, BissonnetteR, VarjonenE, HolloP, CambazardF, LahfaM, ElsnerP, NybergF, SvenssonA, BrownTC, HarschM, MaaresJ: Efficacy and safety of oral alitretinoin (9- cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial. Br J Dermatol158:808-817, 2008.
20. SmitJV, de JongEM, van HooijdonkCA, OteroME, BoezemanJB, van de KerkhofPC: Systemic treatment of psoriatic patients with bexarotene decreases epidermal proliferation and parameters for inflammation, and improves differentiation in lesional skin. J Am Acad Dermatol51:257-264, 2004.
21. SmitJV, FranssenME, de JongEM, LambertJ, RoseeuwDI, De WeertJ, YocumRC, StevensVJ, van De KerkhofPC: A phase II multicenter clinical trial of systemic bexarotene in psoriasis. J Am Acad Dermatol51:249-256, 2004.
22. ShaishA, HarariA, HananshviliL, CohenH, BitzurR, LuvishT, UlmanE, GolanM, Ben-AmotzA, GavishD, RotsteinZ, Harats D: 9-cis beta-carotene-rich powder of the alga Dunaliella bardawil increases plasma HDL-cholesterol in fibrate-treated patients. Atherosclerosis189:215-221, 2006.
23. RollmanO, VahlquistA: Psoriasis and vitamin A. Plasma transport and skin content of retinol, dehydroretinol and carotenoids in adult patients versus healthy controls. Arch Dermatol Res278:17-24, 1985.
24. FisherGJ, TalwarHS, XiaoJH, DattaSC, ReddyAP, GaubMP, Rochette-EglyC, ChambonP, VoorheesJJ: Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin. J Biol Chem269:20629-20635, 1994.
25. XiaoJH, DurandB, ChambonP, VoorheesJJ: Endogenous retinoic acid receptor (RAR)-retinoid X receptor (RXR) heterodimers are the major functional forms regulating retinoid-responsive elements in adult human keratinocytes: binding of ligands to RAR only is sufficient for RAR-RXR heterodimers to confer liganddependent activation of hRAR beta 2/RARE (DR5). J Biol Chem270:3001-3011, 1995.
26. AnderssonE, VahlquistA, RosdahlI: Beta-carotene uptake and bioconversion to retinol differ between human melanocytes and keratinocytes. Nutr Cancer39:300-306, 2001.
27. YamauchiPS, RiskD, KormeiliT: Systemic retinoids. In Weinstein GD, Gottlieb AB (eds): “Therapy of Moderate-to- Severe Psoriasis.” New York: Marcel Dekker, Inc, pp 137-150, 2003.
28. PiskinS, GurkokF, EkukluG, SenolM: Serum lipid levels in psoriasis. Yonsei Med J44:24-26, 2003.
29. RoenigkHH Jr, CallenJP, GuzzoCA, KatzHI, LoweN, MadisonK, NigraT, FiedlerVC, ArmstrongRB: Effects of acitretin on the liver. J Am Acad Dermatol41:584-588, 1999.
30. HarariA, HaratsD, MarkoD, CohenH, BarshackI, KamariY, GonenA, GerberY, Ben-AmotzA, ShaishA: A 9-cis betacarotene- enriched diet inhibits atherogenesis and fatty liver formation in LDL receptor knockout mice. J Nutr 138:1923-1930, 2008.