Variation in genes in the endothelin pathway and endothelium-dependent and endothelium-independent vasodilation in an elderly population

Acta Physiologica

Volumn 208, Issue 1, 2013, Pages 88-94

  Lind, L ^a   Syvanen A C ^a   Axelsson, T ^a   Lundmark, P ^a   Hagg S ^b   Larsson, A ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Endothelin; Endothelium; Vasodilation; Vasoreactivity

Indexed keywords

ACETYLCHOLINE; ANTIHYPERTENSIVE AGENT; C REACTIVE PROTEIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN CONVERTING ENZYME; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NITROPRUSSIDE SODIUM; TRIACYLGLYCEROL;

AGED; ARTERY BLOOD FLOW; ARTERY DILATATION; ARTICLE; BODY MASS; BRACHIAL ARTERY; CARDIOVASCULAR RISK; DIABETES MELLITUS; DRUG USE; ENDOTHELIUM; FEMALE; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; SYSTOLIC BLOOD PRESSURE; ULTRASOUND;

AGE FACTORS; AGED; AGING; ASPARTIC ACID ENDOPEPTIDASES; BRACHIAL ARTERY; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; FEMALE; FOREARM; GENOTYPE; HUMANS; INFUSIONS, INTRA-ARTERIAL; LINEAR MODELS; MALE; METALLOENDOPEPTIDASES; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; REGIONAL BLOOD FLOW; SWEDEN; VASODILATION; VASODILATOR AGENTS;

EID: 84876308076     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/apha.12068     Document Type: Article

References (19)

1. Bohm, F., Ahlborg, G., Johansson, B.L., Hansson, L.O. & Pernow, J. 2002a Combined endothelin receptor blockade evokes enhanced vasodilatation in patients with atherosclerosis. Arterioscler Thromb Vasc Biol 22, 674-679.
2. Bohm, F., Ahlborg, G. & Pernow, J. 2002b Endothelin-1 inhibits endothelium-dependent vasodilatation in the human forearm: reversal by ETA receptor blockade in patients with atherosclerosis. Clin Sci (Lond) 102, 321-327.
3. Cardillo, C., Kilcoyne, C.M., Cannon, R.O. III & Panza, J.A. 2000 Interactions between nitric oxide and endothelin in the regulation of vascular tone of human resistance vessels in vivo. Hypertension 35, 1237-1241.
4. Cardillo, C., Campia, U., Kilcoyne, C.M., Bryant, M.B. & Panza, J.A. 2002 Improved endothelium-dependent vasodilation after blockade of endothelin receptors in patients with essential hypertension. Circulation 105, 452-456.
5. Celermajer, D.S., Sorensen, K.E., Bull, C., Robinson, J. & Deanfield, J.E. 1994 Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol 24, 1468-1474.
6. Creager, M.A., Cooke, J.P., Mendelsohn, M.E., Gallagher, S.J., Coleman, S.M., Loscalzo, J. & Dzau, V.J. 1990 Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest 86, 228-234.
7. Halcox, J.P., Nour, K.R., Zalos, G. & Quyyumi, A.A. 2001 Coronary vasodilation and improvement in endothelial dysfunction with endothelin ET(A) receptor blockade. Circ Res 89, 969-976.
8. Lind, L., Sarabi, M. & Millgard, J. 1998 Methodological aspects of the evaluation of endothelium-dependent vasodilatation in the human forearm. Clin Physiol 18, 81-87.
9. Lind, L., Hall, J., Larsson, A., Annuk, M., Fellstrom, B. & Lithell, H. 2000 Evaluation of endothelium-dependent vasodilation in the human peripheral circulation. Clin Physiol 20, 440-448.
10. Lind, L., Fors, N., Hall, J., Marttala, K. & Stenborg, A. 2005 A comparison of three different methods to evaluate endothelium-dependent vasodilation in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Arterioscler Thromb Vasc Biol 25, 2368-2375.
11. Panza, J.A., Quyyumi, A.A., Brush, J.E. Jr. & Epstein, S.E. 1990 Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 323, 22-27.
12. Pencina, M.J., D'Agostino, R.B.. Sr, D'Agostino, R.B. Jr. & Vasan, R.S. 2008. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med, 27, 157-172; discussion 207-12.
13. Reriani, M., Raichlin, E., Prasad, A., Mathew, V., Pumper, G.M., Nelson, R.E., Lennon, R., Rihal, C., Lerman, L.O. & Lerman, A. 2010 Long-term administration of endothelin receptor antagonist improves coronary endothelial function in patients with early atherosclerosis. Circulation 122, 958-966.
14. Sarabi, M., Millgard, J., Hagg, A., Ridefelt, P., Henriksson, J. & Lind, L. 1999 Endothelin plays an important role in the endothelium-dependent vasodilatation in the human forearm. Scand J Clin Lab Invest 59, 17-22.
15. Shemyakin, A., Bohm, F., Wagner, H., Efendic, S., Bavenholm, P. & Pernow, J. 2006 Enhanced endothelium-dependent vasodilatation by dual endothelin receptor blockade in individuals with insulin resistance. J Cardiovasc Pharmacol 47, 385-390.
16. Verhaar, M.C., Strachan, F.E., Newby, D.E., Cruden, N.L., Koomans, H.A., Rabelink, T.J. & Webb, D.J. 1998 Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade. Circulation 97, 752-756.
17. Wagner, O.F., Christ, G., Wojta, J., Vierhapper, H., Parzer, S., Nowotny, P.J., Schneider, B., Walldhäusl, W. & Binder, B.R. 1992 Polar secretion of endothelin-1 by cultured endothelial cells. J Biol Chem, 267, 16066-16068.
18. Westby, C.M., Weil, B.R., Greiner, J.J., Stauffer, B.L. & DeSouza, C.A. 2011 Endothelin-1 vasoconstriction and the age-related decline in endothelium-dependent vasodilatation in men. Clin Sci (Lond) 120, 485-491.
19. Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K. & Masaki, T. 1988 A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332, 411-415.