Autoantibodies against aromatic amino acid hydroxylases in patients with autoimmune polyendocrine syndrome type 1 target multiple antigenic determinants and reveal regulatory regions crucial for enzymatic activity

Immunobiology

Volumn 218, Issue 6, 2013, Pages 899-909

  Bratland, Eirik ^a,b   Magitta, Ng'weina Francis ^a,b,c   Bøe Wolff, Anette Susanne ^a,b   Ekern, Trude ^b   Knappskog, Per Morten ^a,b   Kämpe, Olle ^d   Haavik, Jan ^b   Husebye, Eystein Sverre ^a,b  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

^c MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

Aire; Aromatic amino acid hydroxylases; Autoimmune polyendocrine syndrome type 1; Tryptophan hydroxylase; Tyrosine hydroxylase

Indexed keywords

AROMATIC AMINO ACID HYDROXYLASE ANTIBODY; AUTOANTIBODY; AUTOANTIGEN; ENZYME ANTIBODY; EPITOPE; ISOENZYME; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 1; TRYPTOPHAN HYDROXYLASE 1 ANTIBODY; TRYPTOPHAN HYDROXYLASE 2; TRYPTOPHAN HYDROXYLASE 2 ANTIBODY; TYROSINE 3 MONOOXYGENASE; TYROSINE HYDROXYLASE ANTIBODY; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIGEN ANTIBODY REACTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; ENAMEL HYPOPLASIA; ENZYME ASSAY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LOCALIZATION; ENZYME MECHANISM; ETHNIC GROUP; HUMAN; MALABSORPTION; MULTIPLE ENDOCRINE ADENOMATOSIS; NORWEGIAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SCANDINAVIAN; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS; TISSUE DISTRIBUTION; TISSUE SPECIFICITY;

AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; AUTOANTIBODIES; BINDING SITES; BIOCATALYSIS; COHORT STUDIES; DENMARK; EPITOPES; FINLAND; HUMANS; IMMUNOBLOTTING; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NORWAY; POLYENDOCRINOPATHIES, AUTOIMMUNE; PROTEIN STRUCTURE, TERTIARY; SWEDEN; TRYPTOPHAN HYDROXYLASE; TYROSINE 3-MONOOXYGENASE;

EID: 84876300670     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2012.10.006     Document Type: Article

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