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Klein, R.1
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The prevalence of age-related maculopathy in the rotterdam study
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The natural history and prognosis of neovascular age-related macular degeneration -A systematic review of the literature and meta-analysis
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Wong T, Chakravarthy U, Klein R, et al. The natural history and prognosis of neovascular age-related macular degeneration -a systematic review of the literature and meta-analysis. Ophthalmology 2008; 115:116-126.
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Wong, T.1
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Ranibizumab versus verteporfin for neovascular age-related macular degeneration
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Brown DM, Kaiser PK, Michels M, et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 2006; 355:1432-1444.
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Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the anchor study
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Brown DM, Michels M, Kaiser PK, et al. Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: two-year results of the ANCHOR study. Ophthalmology 2009; 116: 57-65.
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Brown, D.M.1
Michels, M.2
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Discovery and development of bevacizumab, an anti-vegf antibody for treating cancer
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Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004; 3:391-400.
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Ranibizumab and bevacizumab for neovascular age-related macular degeneration
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This study is the largest, prospective, randomized clinical trial to provide Level 1 evidence for bevacizumab use in neovascular AMD, and confirmed the noninferiority of bevacizumab monthly to both ranibizumab monthly and ranibizumab asneeded regimens for neovascular AMD. There are more reported systemic serious adverse events with bevacizumab treatment
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Martin DF, Maguire MG, Ying GS, et al. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med 2011; 364:1897-1908. This study is the largest, prospective, randomized clinical trial to provide Level 1 evidence for bevacizumab use in neovascular AMD, and confirmed the noninferiority of bevacizumab monthly to both ranibizumab monthly and ranibizumab asneeded regimens for neovascular AMD. There are more reported systemic serious adverse events with bevacizumab treatment.
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Martin, D.F.1
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Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration. One-year findings from the ivan randomized trial
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At the1-year timepoint of this study, the authors conclude that ranibizumab and bevacizumab confer equivalent visual function benefits, and although ranibizumab and continuous treatment result in better anatomic outcomes, there was no significant difference in visual function. In contrast with the CATT, in which serious systemic adverse events were higher among bevacizumab-treated participants, in IVAN, there was no difference between drugs in the proportion experiencing a serious systemic adverse event
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Chakravarthy U, Harding SP, Rogers CA, et al. Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration. One-year findings from the IVAN randomized trial. Ophthalmology 2012; 119:1399-1411. At the1-year timepoint of this study, the authors conclude that ranibizumab and bevacizumab confer equivalent visual function benefits, and although ranibizumab and continuous treatment result in better anatomic outcomes, there was no significant difference in visual function. In contrast with the CATT, in which serious systemic adverse events were higher among bevacizumab-treated participants, in IVAN, there was no difference between drugs in the proportion experiencing a serious systemic adverse event.
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(2012)
Ophthalmology
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Chakravarthy, U.1
Harding, S.P.2
Rogers, C.A.3
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11
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Intravitreal aflibercept (vegf trap-eye) in wet age-related macular degeneration
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These study results confirmed aflibercept as an effective treatment regimen for neovascular AMD. Aflibercept given every 8 weeks, following three doses administered monthly, was found to be a noninferior treatment compared with monthly ranibizumab, with similar visual and anatomic gains attained with this aflibercept regimen after 1 year
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Heier JS, Brown DM, Chong V, et al. Intravitreal aflibercept (VEGF Trap-Eye) in wet age-related macular degeneration. Ophthalmology 2012; 119:2537-2548. These study results confirmed aflibercept as an effective treatment regimen for neovascular AMD. Aflibercept given every 8 weeks, following three doses administered monthly, was found to be a noninferior treatment compared with monthly ranibizumab, with similar visual and anatomic gains attained with this aflibercept regimen after 1 year.
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(2012)
Ophthalmology
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Heier, J.S.1
Brown, D.M.2
Chong, V.3
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12
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Horizon: An open-label extension trial of ranibizumab for choroidal neovascularization secondary to age-related macular degeneration
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This open-label extension study provides long-term follow-up of ranibizumab treatment and concludes that ranibizumab treatment for at least 4 years is well tolerated. These study results also confirm that vision gains acquired after monthly ranibizumab tend to decline when patients are switched to less frequent ranibizumab regimens with less frequent follow-up
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Singer MA, Awh CC, Sadda S, et al. HORIZON: an open-label extension trial of ranibizumab for choroidal neovascularization secondary to age-related macular degeneration. Ophthalmology 2012; 119:1175-1183. This open-label extension study provides long-term follow-up of ranibizumab treatment and concludes that ranibizumab treatment for at least 4 years is well tolerated. These study results also confirm that vision gains acquired after monthly ranibizumab tend to decline when patients are switched to less frequent ranibizumab regimens with less frequent follow-up.
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(2012)
Ophthalmology
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Singer, M.A.1
Awh, C.C.2
Sadda, S.3
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13
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Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration (focus): Year 2 results
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Antoszyk AN, Tuomi L, Chung CY, Singh A. Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration (FOCUS): year 2 results. Am J Ophthalmol 2008; 145:862-874.
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Review of ranibizumab trials for neovascular age-related macular degeneration
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Patel RD, Rominder RS, Hariprasad SM. Review of ranibizumab trials for neovascular age-related macular degeneration. Semin Ophthalmol 2011; 26:372-379.
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Hariprasad, S.M.3
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Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: Two-year results
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This study confirms that there is a greater mean decrease in vision in the year 2 after switching from monthly ranibizumab or bevacizumab treatment to as-needed treatment. Patients treated with monthly anti-VEGF inhibitor tended to have higher rates of incident geographic atrophy through year 2
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Martin DF, Maguire MG, Fine SL, et al. Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results. Ophthalmology 2012; 119:1388-1398. This study confirms that there is a greater mean decrease in vision in the year 2 after switching from monthly ranibizumab or bevacizumab treatment to as-needed treatment. Patients treated with monthly anti-VEGF inhibitor tended to have higher rates of incident geographic atrophy through year 2.
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Ophthalmology
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Martin, D.F.1
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Fine, S.L.3
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Aflibercept for age-related macular degeneration: A game-changer or quiet addition
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Browning DJ, Kaiser PK, Rosenfeld PJ, et al. Aflibercept for age-related macular degeneration: a game-changer or quiet additionAm J Ophthalmol 2012; 154:222-226.
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Secure study: Long-term safety of ranibizumab 0.5mg in neovascular age-related macular degeneration
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This study concludes that ranibizumab given on a flexible, vision-guided dosing regimen is well tolerated over 2 years, with a low incidence of ocular or nonocular adverse events and serious adverse events
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Silva R, Axer-Siegel R, Eldem B, et al. SECURE study: long-term safety of ranibizumab 0.5mg in neovascular age-related macular degeneration. Ophthalmology 2013; 120:130-139. This study concludes that ranibizumab given on a flexible, vision-guided dosing regimen is well tolerated over 2 years, with a low incidence of ocular or nonocular adverse events and serious adverse events.
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Ophthalmology
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Silva, R.1
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Efficacy and safety of monthly versus quarterly ranibizumab treatment in neovascular age-related macular degeneration: The excite study
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Schmidt-Erfurth U, Eldem B, Guymer R, et al., EXCITE Study Group. Efficacy and safety of monthly versus quarterly ranibizumab treatment in neovascular age-related macular degeneration: the EXCITE Study. Ophthalmology 2011; 118:831-839.
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Safety and efficacy of a flexible dosing regimen of ranibizumab in neovascular age-related macular degeneration: The sustain study
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SUSTAIN Study Group
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Holz FG, Amoaku W, Donate J, et al., SUSTAIN Study Group. Safety and efficacy of a flexible dosing regimen of ranibizumab in neovascular age-related macular degeneration: the SUSTAIN study. Ophthalmology 2011; 118:663-671.
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Balancing risk in ophthalmic prescribing: Assessing safety of anti-vegf therapies and the risks associated with unlicensed medicines
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Kaiser PK, Cruess AF, Bogaert P, et al. Balancing risk in ophthalmic prescribing: assessing safety of anti-VEGF therapies and the risks associated with unlicensed medicines. Graefes Arch Clin Exp Ophthalmol 2012; 250:1563-1571.
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This study highlights the potential for devastating visual consequences following the intraocular use of improperly compounded bevacizumab
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Goldberg RA, Flynn HW Jr., Isom RF, et al. An outbreak of streptococcus endophthalmitis after intravitreal injection of bevacizumab. Am J Ophthalmol 2012; 15:204-208. This study highlights the potential for devastating visual consequences following the intraocular use of improperly compounded bevacizumab.
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Am J Ophthalmol
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