Activity of the efflux pump inhibitor SILA 421 against drug-resistant tuberculosis

International Journal of Antimicrobial Agents

Volumn 41, Issue 5, 2013, Pages 488-489

  Simons, Sami O ^a   Kristiansen, Jette E ^b   Hajos, Gyorgy ^c   Van Der Laan, Tridia ^d   Molnár, József ^e   Boeree, Martin J ^a   Van Ingen, Jakko ^a   Christensen, Jørn B ^f   Viveiros, Miguel ^g   Riedl, Zsuzsanna ^c   Amaral, Leonard ^g   Van Soolingen, Dick ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^d NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^e UNIVERSITY OF SZEGED   (Hungary)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

^g INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPROMAZINE; DESIPRAMINE; ISONIAZID; MULTIDRUG RESISTANCE PROTEIN 1; ORGANOSILICON DERIVATIVE; PROMAZINE; RIFAMPICIN; SILA 421; STREPTOMYCIN; THIORIDAZINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; DRUG POTENCY; DRUG RESISTANT TUBERCULOSIS; LETTER; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ANTITUBERCULAR AGENTS; HUMANS; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; PIPERAZINES; SILOXANES; TUBERCULOSIS, MULTIDRUG-RESISTANT;

EID: 84876293991     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2013.01.001     Document Type: Letter

References (5)

1. M. Martins, M. Viveiros, J. Ramos, I. Couto, J. Molnar, and M. Boeree SILA 421, an inhibitor of efflux pumps of cancer cells, enhances the killing of intracellular extensively drug-resistant tuberculosis (XDR-TB) Int J Antimicrob Agents 33 2009 479 482
2. B. van Klingeren, M. Dessens-Kroon, T. van der Laan, K. Kremer, and D. van Soolingen Drug susceptibility testing of Mycobacterium tuberculosis complex by use of a high-throughput, reproducible, absolute concentration method J Clin Microbiol 45 2007 2662 2668
3. J. van Ingen The broad-spectrum antimycobacterial activities of phenothiazines, in vitro: somewhere in all of this there may be patentable potentials Recent Pat Antiinfect Drug Discov 6 2011 104 109
4. H.K. Thanacoody Thioridazine: resurrection as an antimicrobial agent? Br J Clin Pharmacol 64 2007 566 574
5. L. Amaral, and M. Viveiros Why thioridazine in combination with antibiotics cures extensively drug-resistant Mycobacterium tuberculosis infections Int J Antimicrob Agents 39 2012 376 380