Does rituximab induce hypogammaglobulinemia in patients with pediatric idiopathic nephrotic syndrome?

Pediatric Nephrology

Volumn 28, Issue 3, 2013, Pages 447-451

  Delbe Bertin, Laëtitia ^a   Aoun, Bilal ^a   Tudorache, Elena ^a,b   Lapillone, Hélène ^a,b   Ulinski, Tim ^a,b  

^a ARMAND TROUSSEAU HOSPITAL   (France)

^b SORBONNE UNIVERSITÉ   (France)

Author keywords

Hypogammaglobulinemia; Immunoglobulin G; Immunosuppression; Nephrotic syndrome; Rituximab

Indexed keywords

CYCLOSPORIN A; IMMUNOGLOBULIN G; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RITUXIMAB;

ARTICLE; ASEPTIC MENINGITIS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG INDUCED DISEASE; FEMALE; FOLLOW UP; HOSPITALIZATION; HUMAN; HUMORAL IMMUNE DEFICIENCY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN DEFICIENCY; INFECTION RISK; INFECTIOUS COMPLICATION; MALE; NEPHROTIC SYNDROME; PRIORITY JOURNAL; RELAPSE; SCHOOL CHILD; SUPPLEMENTATION;

ADOLESCENT; AGAMMAGLOBULINEMIA; ANALYSIS OF VARIANCE; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; B-LYMPHOCYTES; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; DOWN-REGULATION; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENTS; MALE; NEPHROTIC SYNDROME; PROSPECTIVE STUDIES; RECURRENCE; REMISSION INDUCTION; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84876291214     PISSN: 0931041X     EISSN: 1432198X     Source Type: Journal    
DOI: 10.1007/s00467-012-2361-z     Document Type: Article

References (15)

1. Benz K, Dotsch J, Rascher W, Stachel D (2004) Change of the course of steroid-dependent nephrotic syndrome after rituximab therapy. Pediatr Nephrol 19:794-797
2. Guigonis V, Dallocchio A, Baudouin V, Dehennault M, Hachon-Le Camus C, Afanetti M, Groothoff J, Llanas B, Niaudet P, Nivet H, Raynaud N, Taque S, Ronco P, Bouissou F (2008) Rituximab treatment for severe steroid- or cyclosporine-dependent nephrotic syndrome: a multicentric series of 22 cases. Pediatr Nephrol 23:1269-1279
3. Francois H, Daugas E, Bensman A, Ronco P (2007) Unexpected efficacy of rituximab in multirelapsing minimal change nephrotic syndrome in the adult: first case report and pathophysiological considerations. Am J Kidney Dis 49:158-161
4. Dotsch J, Muller-Wiefel DE, Kemper MJ (2008) Rituximab: is replacement of cyclophosphamide and calcineurin inhibitors in steroid-dependent nephrotic syndrome possible? Pediatr Nephrol 23:3-7
5. Gilbert RD, Hulse E, Rigden S (2006) Rituximab therapy for steroid-dependent minimal change nephrotic syndrome. Pediatr Nephrol 21:1698-1700
6. Hofstra JM, Deegens JK, Wetzels JF (2007) Rituximab: effective treatment for severe steroid-dependent minimal change nephrotic syndrome? Nephrol Dial Transplant 22:2100-2102
7. Peters HP, van de Kar NC, Wetzels JF (2008) Rituximab in minimal change nephropathy and focal segmental glomerulosclerosis: report of four cases and review of the literature. Neth J Med 66:408-415
8. Kamei K, Ito S, Nozu K, Fujinaga S, Nakayama M, Sako M, Saito M, Yoneko M, Iijima K (2009) Single dose of rituximab for refractory steroid-dependent nephrotic syndrome in children. Pediatr Nephrol 24:1321-1328
9. Sellier-Leclerc AL, Macher MA, Loirat C, Guerin V, Watier H, Peuchmaur M, Baudouin V, Deschenes G (2010) Rituximab efficiency in children with steroid-dependent nephrotic syndrome. Pediatr Nephrol 25:1109-1115
10. Sellier-Leclerc AL, Baudouin V, Kwon T, Macher MA, Guerin V, Lapillonne H, Deschenes G, Ulinski T (2012) Rituximab in steroid-dependent idiopathic nephrotic syndrome in childhood-follow-up after CD19 recovery. Nephrol Dial Transplant 27:1083-1089
11. Cambridge G, Leandro MJ, Edwards JC, Ehrenstein MR, Salden M, Bodman-Smith M, Webster AD (2003) Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis. Arthritis Rheum 48:2146-2154
12. Leandro MJ, Cambridge G, Edwards JC, Ehrenstein MR, Isenberg DA (2005) B-cell depletion in the treatment of patients with systemic lupus erythematosus: a longitudinal analysis of 24 patients. Rheumatology (Oxford) 44:1542-1545
13. Diwakar L, Gorrie S, Richter A, Chapman O, Dhillon P, Al-Ghanmi F, Noorani S, Krishna MT, Huissoon A (2010) Does rituximab aggravate pre-existing hypogammaglobulinaemia? J Clin Pathol 63:275-277
14. Corales R, Chua J, Mawhorter S, Young JB, Starling R, Tomford JW, McCarthy P, Braun WE, Smedira N, Hobbs R, Haas G, Pelegrin D, Majercik M, Hoercher K, Cook D, Avery RK (2000) Significant post-transplant hypogammaglobulinemia in six heart transplant recipients: an emerging clinical phenomenon? Transpl Infect Dis 2:133-139
15. Ganschow R, Englert C, Grabhorn E, Richter A, Hinrichs B, Broering DC, Rogiers X, Burdelski M (2005) Hypogammaglobulinemia in pediatric liver transplant recipients. Pediatr Transplant 9:215-219