High-normal TSH values in obesity: Is it insulin resistance or adipose tissue's guilt?

Obesity

Volumn 21, Issue 1, 2013, Pages 101-106

  Muscogiuri, Giovanna ^a   Sorice, Gian P ^a   Mezza, Teresa ^a   Prioletta, Annamaria ^a   Lassandro, Anna P ^a   Pirronti, Tommaso ^a   Casa, Silvia Della ^a   Pontecorvi, Alfredo ^a   Giaccari, Andrea ^a,b  

^a CATHOLIC UNIVERSITY   (Italy)

^b IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIOTHYRONINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; THYROTROPIN; THYROXINE; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ADULT; ARTICLE; BODY COMPOSITION; BODY MASS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; EUTHYROIDISM; FEMALE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HYPOTHALAMUS HYPOPHYSIS THYROID SYSTEM; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; MAJOR CLINICAL STUDY; MALE; OBESITY; SUBCUTANEOUS FAT; THYROID FUNCTION;

ADULT; AGED; BODY COMPOSITION; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; FEMALE; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; LIPIDS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OBESITY; THYROTROPIN;

EID: 84876289503     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2012.157     Document Type: Article

References (27)

1. Bray GA The syndromes of obesity: an endocrine approach. In: De Groot L (ed). Endocrinology, vol. 3. Elsevier Science: Philadelphia, 1995, pp 2642-2662.
2. Knudsen N, Laurberg P, Rasmussen LB et al. Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J Clin Endocrinol Metab 2005;90:4019-4024. (Pubitemid 41058166)
3. Michalaki MA, Vagenakis AG, Leonardou AS et al. Thyroid function in humans with morbid obesity. Thyroid 2006;16:73-78. (Pubitemid 43348719)
4. Manji N, Boelaert K, Sheppard MC et al. Lack of association between serum TSH or free T4 and body mass index in euthyroid subjects. Clin Endocrinol (Oxf) 2006; 64:125-128.
5. Nannipieri M, Cecchetti F, Anselmino M et al. Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight loss. Int J Obes (Lond) 2009;33:1001-1006.
6. Foley JE, Laursen AL, Sonne O, Gliemann J. Insulin binding and hexose transport in rat adipocytes. Relation to cell size. Diabetologia 1980;19:234-241. (Pubitemid 10003185)
7. Gavin LA, Moller M, McMahon F, Gulli R, Cavalieri RR. Carbohydrate reactivation of thyroxine 50-deiodinase (type II) in cultured mouse neuroblastoma cells is dependent upon new protein synthesis. Endocrinology 1989;124:635-641. (Pubitemid 19057048)
8. Iacobellis G, Ribaudo MC, Zappaterreno A, Iannucci CV, Leonetti F. Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. Clin Endocrinol (Oxf) 2005;62:487-491.
9. De Pergola G, Ciampolillo A, Paolotti S, Trerotoli P, Giorgino R. Free triiodothyronine and thyroid stimulating hormone are directly associated with waist circumference, independently of insulin resistance, metabolic parameters and blood pressure in overweight and obese women. Clin Endocrinol (Oxf) 2007;67:265-269. (Pubitemid 47076304)
10. Dimitriadis G, Mitrou P, Lambadiari V et al. Insulin action in adipose tissue and muscle in hypothyroidism. J Clin Endocrinol Metab 2006;91: 4930-4937. (Pubitemid 44917329)
11. Dimitriadis G, Mitrou P, Lambadiari V et al. Glucose and lipid fluxes in the adipose tissue after meal ingestion in hyperthyroidism. J Clin Endocrinol Metab 2006; 91:1112-1118. (Pubitemid 43357789)
12. Karelis AD. Metabolically healthy but obese individuals. Lancet 2008;372: 1281-1283.
13. Björntorp P. Metabolic implications of body fat distribution. Diabetes Care 1991; 14:1132-1143.
14. Lohman TG, Roche AF, Martorelli R. Anthropometric Standardization Reference Manual. Human Kinetics Books: Champaign, IL, 1988, pp 177.
15. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237: E214-E223. (Pubitemid 9249478)
16. Muscogiuri G, Sorice GP, Prioletta A et al. 25-Hydroxyvitamin D concentration correlates with insulin-sensitivity and BMI in obesity. Obesity (Silver Spring) 2010; 18:1906-1910.
17. Sari R, Balci MK, Altunbas H, Karayalcin U. The effect of body weight and weight loss on thyroid volume and function in obese women. Clin Endocrinol (Oxf) 2003; 59:258-262. (Pubitemid 36918663)
18. Wesche MF, Wiersinga WM, Smits NJ. Lean body mass as a determinant of thyroid size. Clin Endocrinol (Oxf) 1998;48:701-706. (Pubitemid 28289237)
19. Reinehr T, Andler W. Thyroid hormones before and after weight loss in obesity. Arch Dis Child 2002;87:320-323.
20. Westerink J, van der Graaf Y, Faber DR, Visseren FL; SMART study group. The relation between thyroid-stimulating hormone and measures of adiposity in patients with manifest vascular disease. Eur J Clin Invest 2011;41:159-166.
21. Haraguchi K, Shimura H, Lin L et al. Functional expression of thyrotropin receptor in differentiated 3T3-L1 cells: a possible model cell line of extrathyroidal expression of thyrotropin receptor. Biochem Biophys Res Commun 1996;223:193-198. (Pubitemid 26202499)
22. Lu M, Lin RY. TSH stimulates adipogenesis in mouse embryonic stem cells. J Endocrinol 2008;196:159-169.
23. Brüning JC, Gautam D, Burks DJ et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000;289:2122-2125.
24. Chidakel A, Mentuccia D, Celi FS. Peripheral metabolism of thyroid hormone and glucose homeostasis. Thyroid 2005;15:899-903. (Pubitemid 41339268)
25. Antunes TT, Gagnon A, Langille ML, Sorisky A. Thyroid-stimulating hormone induces interleukin-6 release from human adipocytes through activation of the nuclear factor-kappaB pathway. Endocrinology 2008;149:3062-3066. (Pubitemid 351724542)
26. Antunes TT, Gagnon A, Chen B et al. Interleukin-6 release from human abdominal adipose cells is regulated by thyroid-stimulating hormone: effect of adipocyte differentiation and anatomic depot. Am J Physiol Endocrinol Metab 2006;290: E1140-E1144. (Pubitemid 43847897)
27. Legradi G, Emerson CH, Ahima RS, Flier JS, Lechan RM. Leptin prevents fastinginduced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology 1997; 138:2569-2576. (Pubitemid 27215264)