Changes in natural killer cell subpopulations over a winter training season in elite swimmers

European Journal of Applied Physiology

Volumn 113, Issue 4, 2013, Pages 859-868

  Rama, Luís ^a   Teixeira, Ana Maria ^a   Matos, Alice ^b   Borges, Grasiely ^a   Henriques, Ana ^b   Gleeson, Michael ^d   Pedreiro, Susana ^b   Filaire, Edith ^e   Alves, Francisco ^c   Paiva, Artur ^b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b Centro de Histocompatibilidade do Centro Coimbra   (Portugal)

^c UNIVERSIDADE DE LISBOA   (Portugal)

^d LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^e UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

CD56; Cortisol; Immunity; Upper respiratory symptoms

Indexed keywords

BIOLOGICAL MARKER; CD56 ANTIGEN; GAMMA INTERFERON RECEPTOR; GRANZYME; GZMB PROTEIN, HUMAN; HYDROCORTISONE; INTERFERON RECEPTOR; NCAM1 PROTEIN, HUMAN;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ARTICLE; BLOOD; CASE CONTROL STUDY; EXERCISE; FEMALE; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; LONGITUDINAL STUDY; MALE; NATURAL KILLER CELL; RESPIRATORY TRACT INFECTION; SEASON; SWIMMING; TIME;

ADOLESCENT; ANALYSIS OF VARIANCE; ANTIGENS, CD56; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; EXERCISE; FEMALE; GRANZYMES; HUMANS; HYDROCORTISONE; IMMUNITY, INNATE; KILLER CELLS, NATURAL; LONGITUDINAL STUDIES; MALE; RECEPTORS, INTERFERON; RESPIRATORY TRACT INFECTIONS; SEASONS; SWIMMING; TIME FACTORS; YOUNG ADULT;

EID: 84876287348     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-012-2490-x     Document Type: Article

References (41)

1. Bernard A, Nickmilder M et al (2009) Impact of chlorinated swimming pool attendance on the respiratory health of adolescents. Pediatrics 124(4):1110-1118
2. Bishop N (2006) Exercise and Infection Risk. In: Gleeson M (ed) Immune function in sport and exercise. Churchill Livingstone Elsevier, Edinburg, pp 1-14
3. Bonifazi M, Sardella F, Lupo C (2000) Preparatory versus main competitions: differences in performances, lactate responses and pre-competition plasma cortisol concentrations in elite male swimmers. Eur J Appl Physiol 82(5-6):368-373
4. Cooper MA, Fehniger TA, Caligiuri MA (2001a) The biology of human natural killer-cell subsets. Trends Immunol 22(11):633-640
5. Cooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T et al (2001b) Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset. Blood 97(10):3146-3151
6. Cox AJ, Gleeson M, Pyne DB, Callister R, Hopkins WG, Fricker PA (2008) Clinical and laboratory evaluation of upper respiratory symptoms in elite athletes. Clin J Sport Med 18(5):438-445
7. Frey M, Packianathan NB, Fehniger TA, Ross ME, Wang WC, Stewart CC et al (1998) Differential expression and function of L-selectin on CD56bright and CD56dim natural killer cell subsets. J Immunol 161(1):400-410
8. Fricker P, Gleeson M, Flanagan ADP, Warren A, Clancy R (2000) Do elite swimmers experience more upper respiratory illness than nonathletes. Clin Exerc Physiol 2(3):155-158
9. Fricker P, Pyne D, Saunders PU, Cox A, Gleeson M, Telford RD (2005) Influence of training loads on patterns of illness in elite distance runners. Clin J Sport Med 15(4):246-252
10. Gatti G, Cavallo R et al (1987) Inhibition by cortisol of human natural killer (NK) cell activity. J Steroid Biochem 26(1):49-58
11. Gillum TL, Kuennen MR et al (2011) A review of sex differences in immune function after aerobic exercise. Exerc Immunol Rev 17:104-121
12. Gleeson M (2000) Mucosal immune responses and risk of respiratory illness in elite athletes. Exerc Immunol Rev 6:5-42
13. Gleeson M, Bishop NC (2005) The T cell and NK cell immune response to exercise. Ann Transplant 10(4):43-48
14. Gleeson M, McDonald W, Cripps A, Pyne D, Clancy R, Fricker P (1995) The effect on immunity of long-term intensive training in elite swimmers. Clin Exp Immunol 102(1):210-216
15. Gleeson M, McDonald W, Pyne D, Clancy R, Cripps A, Francis J et al (2000) Immune status and respiratory illness for elite swimmers during a 12-week training cycle. Int J Sports Med 21(4):302-307
16. Gleeson M, Pyne D, Callister R (2004) The missing links in exercise effects on mucosal immunity. Exerc Immunol Rev 10:107-128
17. Heath GW, Ford ES, Craven TE, Macera CA, Jackson KL, Pate RR (1991) Exercise and the incidence of upper respiratory tract infections. Med Sci Sports Exerc 23(2):152
18. Heath GW, Macera CA, Nieman DC (1992) Exercise and upper respiratory tract infection: is there a relationship? Sports Med 14(6):353-365
19. Hopkins WG (2002) A new view of statistics: a scale of magnitudes for effect statistics. http://www.sportsci.org/resource/stats/effectmag.html. Retrieved 24 April 2012
20. Ida H, Nakashima T, Kedersha NL, Yamasaki S, Huang M, Izumi Y et al (2003) Granzyme B leakage-induced cell death: a new type of activation-induced natural killer cell death. Eur J Immunol 33(12):3284-3292
21. Lin L, Decker CF (2010) Respiratory tract infections in athletes. Disease-a-Month 56(7):407-413. doi: 10.1016/j.disamonth.2010.05.001
22. Mackinnon L (1997) Immunity in athletes. Int J Sports Med 18(Suppl):S62-S68
23. Morgado JM, Rama L et al (2012) Cytokine production by monocytes, neutrophils, and dendritic cells is hampered by long-term intensive training in elite swimmers. Eur J Appl Physiol 112(2):471-482
24. Mujika I, Chatard JC, Busso T, Geyssant A, Barale F, Lacoste L (1995) Effects of training on performance in competitive swimming. Can J Appl Physiol 20(4):395-406
25. Mujika I, Busso T, Lacoste L, Barale F, Geyssant A, Chatard JC (1996) Modelled responses to training and taper in competitive swimmers. Med Sci Sports Exerc 28(2):251-258
26. Nieman D (1994a) Exercise, infection, and immunity. Int J Sports Med 15(Suppl 3):S131-S141
27. Nieman D (1994b) Exercise, upper respiratory tract infection, and the immune system. Med Sci Sports Exerc 26(2):128-139
28. Nieman D, Pedersen B (1999) Exercise and immune function: recent developments./Developpements recents sur l'activite physique et le systeme immunitaire. Sports Med 27(2):73-80
29. Nieman DC, Buckley KS, Henson DA, Warren BJ, Suttles J, Ahle JC et al (1995) Immune function in marathon runners versus sedentary controls. Med Sci Sports Exerc 27(7):986-992
30. Pedersen BK, Toft AD (2000) Effects of exercise on lymphocytes and cytokines. Br J Sports Med 34(4):246-251
31. Pedersen BK, Ullum H (1994) NK cell response to physical activity: possible mechanisms of action. Med Sci Sports Exerc 26(2):140-146
32. Pedersen BK, Tvede N, Christensen LD, Klarlund K, Kragbak S, Halkjr-Kristensen J (1989) Natural killer cell activity in peripheral blood of highly trained and untrained persons. Int J Sports Med 10(2):129-131
33. Peters E (2004) Postrace upper respiratory tract 'infections' in ultramarathoners - infection, allergy or inflammation? Sports Med 16(1):3-9
34. Pyne D, McDonald W, Gleeson M, Flanagan A, Clancy R, Fricker P (2001) Mucosal immunity, respiratory illness, and competitive performance in elite swimmers. Med Sci Sports Exerc 33(3):348-353
35. Pyne DB, Hopkins WG, Batterham AM, Gleeson M, Fricker PA (2005) Characterising the individual performance responses to mild illness in international swimmers. Br J Sports Med 39(10):752-756
36. Reid VL, Gleeson M, Williams N, Clancy RL (2004) Clinical investigation of athletes with persistent fatigue and/or recurrent infections. Br J Sports Med 38(1):42-45
37. Shephard RJ, Shek PN (1999) Effects of exercise and training on natural killer cell counts and cytolytic activity: a meta-analysis. Sports Med 28(3):177-195
38. Shephard RJ, Rhind S, Shek PN (1994) Exercise and the immune system. Natural killer cells, interleukins and related responses. Sports Med 18(5):340-369
39. Spence L, Brown WJ, Pyne DB, Nissen MD, Sloots TP, McCormack JG et al (2007) Incidence, etiology, and symptomatology of upper respiratory illness in elite athletes. Med Sci Sports Exerc 39(4):577-586
40. Suzui M, Kawai T, Kimura H, Takeda K, Yagita H, Okumura K et al (2004) Natural killer cell lytic activity and CD56dim and CD56bright cell distributions during and after intensive training. J Appl Physiol 96(6):2167-2173
41. Timmons BW, Cieslak T (2008) Human natural killer cell subsets and acute exercise: a brief review. Exerc Immunol Rev 14:8-23