EGFR and MYC gene copy number aberrations are more common in squamous cell carcinoma than keratoacanthoma: A FISH study

Journal of Cutaneous Pathology

Volumn 40, Issue 5, 2013, Pages 447-454

  Jacobs, Melissa S ^a   Persons, Diane L ^a   Fraga, Garth R ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

epidermal growth factor receptor; fluorescence in situ hybridization; keratoacanthoma; MYC; squamous cell carcinoma

Indexed keywords

DNA; TUMOR MARKER;

AGED; ARTICLE; COMPARATIVE STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE DOSAGE; GENETIC MARKER; GENETICS; HUMAN; KERATOACANTHOMA; METABOLISM; METHODOLOGY; MIDDLE AGED; OBSERVER VARIATION; ONCOGENE MYC; PATHOLOGY; PROTO ONCOGENE; REPRODUCIBILITY; SKIN TUMOR; SQUAMOUS CELL CARCINOMA; VERRUCA VULGARIS;

AGED; CARCINOMA, SQUAMOUS CELL; DNA, NEOPLASM; GENE AMPLIFICATION; GENE DOSAGE; GENES, ERBB-1; GENES, MYC; GENETIC MARKERS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KERATOACANTHOMA; MIDDLE AGED; OBSERVER VARIATION; REPRODUCIBILITY OF RESULTS; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; WARTS;

EID: 84876286307     PISSN: 03036987     EISSN: 16000560     Source Type: Journal    
DOI: 10.1111/cup.12117     Document Type: Article

References (35)

1. Ko CJ,. Keratoacanthoma: facts and controversies. Clin Dermatol 2010; 28: 254.
2. Ghadially FN,. A comparative morphological study of the keratoacanthomas of man and similar experimentally produced lesions in the rabbit. J Pathol Bacteriol 1958; 75: 441.
3. Weedon D, Malo J, Brooks D, Williamson R,. Keratoacanthoma: is it really a variant of squamous cell carcinoma? ANZ J Surg 2010; 80: 129.
4. Hodak E, Jones RE, Ackerman AB,. Solitary keratoacanthoma is a squamous-cell carcinoma: three examples with metastases. Am J Dermatopathol 1993; 15: 332.
5. Cribier B, Asch P, Grosshans E,. Differentiating squamous cell carcinoma from keratoacanthoma using histopathological criteria. Is it possible? A study of 296 cases. Dermatology 1999; 199: 208.
6. Ito Y, Kurokawa I, Nishimura K, et al. Keratin and filaggrin expression in keratoacanthoma. J Eur Acad Dermatol Venereol 2008; 22: 353.
7. Melendez ND, Smoller BR, Morgan M,. VCAM (CD-106) and ICAM (CD-54) adhesion molecules distinguish keratoacanthomas from cutaneous squamous cell carcinomas. Mod Pathol 2003; 16: 8.
8. Slater M, Barden JA,. Differentiating keratoacanthoma from squamous cell carcinoma by the use of apoptotic and cell adhesion markers. Histopathology 2005; 47: 170.
9. Papadavid E, Pignatelli M, Zakynthinos S, Krausz T, Chu AC,. The potential role of abnormal E-cadherin and alpha-, beta- and gamma-catenin immunoreactivity in the determination of the biological behaviour of keratoacanthoma. Br J Dermatol 2001; 145: 582.
10. Aroni K, Mastoraki A, Kyriazi E, Ioannidis E, Patsouris E,. Silver-stained organizer regions and immunoglobulins in cutaneous keratoacanthomas and squamous cell carcinomas. Pathol Res Pract 2007; 203: 659.
11. Herzberg AJ, Kerns BJ, Pollack SV, Kinney RB,. DNA image cytometry of keratoacanthoma and squamous cell carcinoma. J Invest Dermatol 1991; 97: 495.
12. Krunic AL, Garrod DR, Madani S, Buchanan MD, Clark RE,. Immunohistochemical staining for desmogleins 1 and 2 in keratinocytic neoplasms with squamous phenotype: actinic keratosis, keratoacanthoma and squamous cell carcinoma of the skin. Br J Cancer 1998; 77: 1275.
13. Clausen OP, Aass HC, Beigi M, et al. Are keratoacanthomas variants of squamous cell carcinomas? A comparison of chromosomal aberrations by comparative genomic hybridization. J Invest Dermatol 2006; 126: 2308.
14. Clausen OP, Beigi M, Bolund L, et al. Keratoacanthomas frequently show chromosomal aberrations as assessed by comparative genomic hybridization. J Invest Dermatol 2002; 119: 1367.
15. Li J, Wang K, Gao F, et al. Array comparative genomic hybridization of keratoacanthomas and squamous cell carcinomas: different patterns of genetic aberrations suggest two distinct entities. J Invest Dermatol 2012; 132: 2060.
16. Groves RW, Allen MH, MacDonald DM,. Abnormal expression of epidermal growth factor receptor in cutaneous epithelial tumours. J Cutan Pathol 1992; 19: 66.
17. Shimizu T, Izumi H, Oga A, et al. Epidermal growth factor receptor overexpression and genetic aberrations in metastatic squamous-cell carcinoma of the skin. Dermatology 2001; 202: 203.
18. Fogarty GB, Conus NM, Chu J, McArthur G,. Characterization of the expression and activation of the epidermal growth factor receptor in squamous cell carcinoma of the skin. Br J Dermatol 2007; 156: 92.
19. Toll A, Salgado R, Yébenes M, et al. Epidermal growth factor receptor gene numerical aberrations are frequent events in actinic keratoses and invasive cutaneous squamous cell carcinomas. Exp Dermatol 2010; 19: 151.
20. Ridd K, Bastian BC,. Somatic mutation of epidermal growth factor receptor in a small subset of cutaneous squamous cell carcinoma. J Invest Dermatol 2010; 130: 901.
21. Toll A, Salgado R, Yébenes M, et al. MYC gene numerical aberrations in actinic keratosis and cutaneous squamous cell carcinoma. Br J Dermatol 2009; 161: 1112.
22. Zandi R, Larsen AB, Andersen P, Stockhausen MT, Poulsen HS,. Mechanisms for oncogenic activation of the epidermal growth factor receptor. Cell Signal 2007; 19: 2013.
23. Fernandez PC, Frank SR, Wang L, et al. Genomic targets of the human c-Myc protein. Genes Dev 2003; 17: 1115.
24. Garte SJ,. The c-myc oncogene in tumor progression. Crit Rev Oncog 1993; 4: 435.
25. Hutchison J,. The crateriform ulcer of the face: a form of epithelial cancer. Trans Pathol Soc Lond 1889; 40: 275.
26. Rook A, Whimster I,. Keratoacanthoma-a thirty year retrospect. Br J Dermatol 1979; 100: 41.
27. Rook A, Whimster I,. Le kerato-acanthome. Arch Belg Dermatol Syphiligr 1950; 6: 137.
28. Kwittken J,. A histologic chronology of the clinical course of the keratocarcinoma (so-called keratoacanthoma). Mt Sinai J Med 1975; 42: 127.
29. Kossard S, Tan KB, Choy C,. Keratoacanthoma and infundibulocystic squamous cell carcinoma. Am J Dermatopathol 2008; 30: 127.
30. Sánchez Yus E, Simõn P, Requena L, Ambrojo P, de Eusebio E,. Solitary keratoacanthoma: a self-healing proliferation that frequently becomes malignant. Am J Dermatopathol 2000; 22: 305.
31. Weedon DD, Malo J, Brooks D, Williamson R,. Squamous cell carcinoma arising in keratoacanthoma: a neglected phenomenon in the elderly. Am J Dermatopathol 2010; 32: 423.
32. Bulj TK, Krunic AL, Cetner AS, Villano JL,. Refractory aggressive keratoacanthoma centrifugum marginatum of the scalp controlled with the epidermal growth factor receptor inhibitor erlotinib. Br J Dermatol 2010; 163: 633.
33. Reid DC, Guitart J, Agulnik M, Lacouture ME,. Treatment of multiple keratoacanthomas with erlotinib. Int J Clin Oncol 2010; 15: 413.
34. Kwon EJ, Kish LS, Jaworsky C,. The histologic spectrum of epithelial neoplasms induced by sorafenib. J Am Acad Dermatol 2009; 61: 522.
35. Robert C, Arnault JP, Mateus C,. RAF inhibition and induction of cutaneous squamous cell carcinoma. Curr Opin Oncol 2011; 23: 177.