Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease

Neurology

Volumn 80, Issue 13, 2013, Pages 1194-1201

  Ewers, Michael ^a,b,c   Insel, Philip S ^b   Stern, Yaakov ^d   Weiner, Michael W ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; FLUORODEOXYGLUCOSE F 18;

ADULT; AGED; ALZHEIMER DISEASE; ANGULAR GYRUS; ARTICLE; BRAIN METABOLISM; CEREBROSPINAL FLUID ANALYSIS; COGNITIVE RESERVE; CONTROLLED STUDY; EDUCATION; FEMALE; HUMAN; INFERIOR TEMPORAL GYRUS; MAJOR CLINICAL STUDY; MALE; MIDDLE TEMPORAL GYRUS; PARIETAL CORTEX; POSITRON EMISSION TOMOGRAPHY; POSTERIOR CINGULATE; PREFRONTAL CORTEX; PRIORITY JOURNAL; TEMPORAL CORTEX; VOXEL BASED MORPHOMETRY;

BRAIN STEM; COGNITION; COGNITION DISORDERS; HUMANS; LOCUS COERULEUS; NEURONS;

EID: 84876279596     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e31828970c2     Document Type: Article

References (39)

1. Stern Y. Cognitive reserve. Neuropsychologia 2009;47: 2015-2028.
2. Stern Y. What is cognitive reserve? Theory and research application of the reserve concept. J Int Neuropsychol Soc 2002;8:448-460.
3. Stern Y, Alexander GE, Prohovnik I, Mayeux R. Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer's disease. Ann Neurol 1992;32: 371-375.
4. Scarmeas N, Zarahn E, Anderson KE, et al. Association of life activities with cerebral blood flow in Alzheimer disease: implications for the cognitive reserve hypothesis. Arch Neurol 2003;60:359-365.
5. Perneczky R, Drzezga A, Diehl-Schmid J, et al. Schooling mediates brain reserve in Alzheimer's disease: findings of fluoro-deoxy-glucose-positron emission tomography. J Neurol Neurosurg Psychiatry 2006;77:1060-1063.
6. Stern Y, Alexander GE, Prohovnik I, et al. Relationship between lifetime occupation and parietal flow: implications for a reserve against Alzheimer's disease pathology. Neurology 1995;45:55-60.
7. Sperling RA, Aisen PS, Beckett LA, et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011;7:280-292.
8. Bennett DA, Schneider JA, Wilson RS, Bienias JL, Arnold SE. Education modifies the association of amyloid but not tangles with cognitive function. Neurology 2005;65:953-955.
9. Ewers M, Walsh C, Trojanowski JQ, et al. Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance. Neurobiol Aging 2012;33:1203-1214.
10. Shaw LM, Vanderstichele H, Knapik-Czajka M, et al. Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects. Ann Neurol 2009;65:403-413.
11. Ewers M, Insel P, Jagust WJ, et al. CSF biomarker and PiB-PET-derived beta-amyloid signature predicts metabolic, gray matter, and cognitive changes in nondemented subjects. Cereb Cortex 2012;22:1993-2004.
12. De Meyer G, Shapiro F, Vanderstichele H, et al. Diagnosisindependent Alzheimer disease biomarker signature in cognitively normal elderly people. Arch Neurol 2010;67:949-956.
13. Crane PK, Carle A, Gibbons LE, et al. Development and assessment of a composite score for memory in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Available at: http://www.ncbi.nlm.nih.gov/pubmed/22782295. Accessed July 11, 2012.
14. Gibbons LE, Carle AC, Mackin RS, et al. A composite score for executive functioning, validated in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with baseline mild cognitive impairment. Brain Imaging Behav 2012;6:517-527.
15. Jagust WJ, Landau SM, Shaw LM, et al. Relationships between biomarkers in aging and dementia. Neurology 2009;73:1193-1199.
16. Landau SM, Harvey D, Madison CM, et al. Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI. Neurobiol Aging 2011;32: 1207-1218.
17. Venables WN, Ripley BD. Modern Applied Statistics with S, 4th ed. New York: Springer; 2002.
18. Cohen J. A power primer. Psychol Bull 1992;112:155-159.
19. Drzezga A, Lautenschlager N, Siebner H, et al. Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study. Eur J Nucl Med Mol Imaging 2003;30:1104-1113.
20. Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol 1997;42:85-94.
21. Kemppainen NM, Aalto S, Karrasch M, et al. Cognitive reserve hypothesis: Pittsburgh compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease. Ann Neurol 2008;63:112-118.
22. Roe CM, Mintun MA, D'Angelo G, Xiong C, Grant EA, Morris JC. Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh compound B uptake. Arch Neurol 2008;65: 1467-1471.
23. Roe CM, Mintun MA, Ghoshal N, et al. Alzheimer disease identification using amyloid imaging and reserve variables: proof of concept. Neurology 2010;75:42-48.
24. Rentz DM, Locascio JJ, Becker JA, et al. Cognition, reserve, and amyloid deposition in normal aging. Ann Neurol 2010;67:353-364.
25. Roe CM, Fagan AM, Williams MM, et al. Improving CSF biomarker accuracy in predicting prevalent and incident Alzheimer disease. Neurology 2011;76:501-510.
26. Vemuri P, Weigand SD, Przybelski SA, et al. Cognitive reserve and Alzheimer's disease biomarkers are independent determinants of cognition. Brain 2011;134:1479-1492.
27. Alexander GE, Furey ML, Grady CL, et al. Association of premorbid intellectual function with cerebral metabolism in Alzheimer's disease: implications for the cognitive reserve hypothesis. Am J Psychiatry 1997;154:165-172.
28. Liao YC, Liu RS, Teng EL, et al. Cognitive reserve: a SPECT study of 132 Alzheimer's disease patients with an education range of 0-19 years. Dement Geriatr Cogn Disord 2005;20:8-14.
29. Morris JC, Roe CM, Xiong C, et al. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Ann Neurol 2010;67:122-131.
30. Klunk WE. Amyloid imaging as a biomarker for cerebral beta-amyloidosis and risk prediction for Alzheimer dementia. Neurobiol Aging 2011;32(suppl 1):S20-S36.
31. Stern Y, Habeck C, Moeller J, et al. Brain networks associated with cognitive reserve in healthy young and old adults. Cereb Cortex 2005;15:394-402.
32. Scarmeas N, Zarahn E, Anderson KE, et al. Cognitive reserve modulates functional brain responses during memory tasks: a PET study in healthy young and elderly subjects. Neuroimage 2003;19:1215-1227.
33. Stern Y, Zarahn E, Habeck C, et al. A common neural network for cognitive reserve in verbal and object working memory in young but not old. Cereb Cortex 2008;18:959-967.
34. Bosch B, Bartres-Faz D, Rami L, et al. Cognitive reserve modulates task-induced activations and deactivations in healthy elders, amnestic mild cognitive impairment and mild Alzheimer's disease. Cortex 2010;46:451-461.
35. Scarmeas N, Zarahn E, Anderson KE, et al. Cognitive reserve-mediated modulation of positron emission tomographic activations during memory tasks in Alzheimer disease. Arch Neurol 2004;61:73-78.
36. Grady CL, Furey ML, Pietrini P, Horwitz B, Rapoport SI. Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease. Brain 2001;124:739-756.
37. Perneczky R, Wagenpfeil S, Lunetta KL, et al. Head circumference, atrophy, and cognition: implications for brain reserve in Alzheimer disease. Neurology 2010;75:137-142.
38. Teipel SJ, Meindl T, Wagner M, et al. White matter microstructure in relation to education in aging and Alzheimer's disease. J Alzheimers Dis 2009;17:571-583.
39. Bartres-Faz D, Sole-Padulles C, Junque C, et al. Interactions of cognitive reserve with regional brain anatomy and brain function during a working memory task in healthy elders. Biol Psychol 2009;80:256-259.