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Volumn 19, Issue 5, 2013, Pages 831-837

A phase 1 study of bendamustine and melphalan conditioning for autologous stem cell transplantation in multiple myeloma

Author keywords

Autologous; Bendamustine; Conditioning; Melphalan; Multiple myeloma; Transplantation

Indexed keywords

ACICLOVIR; BENDAMUSTINE; CYTARABINE; DEXAMETHASONE; ETOPOSIDE; FLUCONAZOLE; GRANULOCYTE COLONY STIMULATING FACTOR; LENALIDOMIDE; LEVOFLOXACIN; MELPHALAN; PLERIXAFOR;

EID: 84876273138     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2013.02.013     Document Type: Article
Times cited : (30)

References (31)
  • 1
    • 8944220233 scopus 로고    scopus 로고
    • A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Francais du Myelome
    • Attal M., Harousseau J.L., Stoppa A.M., et al. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Francais du Myelome. N Engl J Med 1996, 335:91-97.
    • (1996) N Engl J Med , vol.335 , pp. 91-97
    • Attal, M.1    Harousseau, J.L.2    Stoppa, A.M.3
  • 2
    • 0037739753 scopus 로고    scopus 로고
    • High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma
    • Child J.A., Morgan G.J., Davies F.E., et al. High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma. N Engl J Med 2003, 348:1875-1883.
    • (2003) N Engl J Med , vol.348 , pp. 1875-1883
    • Child, J.A.1    Morgan, G.J.2    Davies, F.E.3
  • 3
    • 79955821742 scopus 로고    scopus 로고
    • Current trends in autologous stem-cell transplantation for myeloma in the era of novel therapies
    • Moreau P., Avet-Loiseau H., Harousseau J.L., Attal M. Current trends in autologous stem-cell transplantation for myeloma in the era of novel therapies. J Clin Oncol 2011, 29:1898-1906.
    • (2011) J Clin Oncol , vol.29 , pp. 1898-1906
    • Moreau, P.1    Avet-Loiseau, H.2    Harousseau, J.L.3    Attal, M.4
  • 4
    • 57449109100 scopus 로고    scopus 로고
    • Influence of pre- and post-transplantation responses on outcome of patients with multiple myeloma: sequential improvement of response and achievement of complete response are associated with longer survival
    • Lahuerta J.J., Mateos M.V., Martinez-Lopez J., et al. Influence of pre- and post-transplantation responses on outcome of patients with multiple myeloma: sequential improvement of response and achievement of complete response are associated with longer survival. J Clin Oncol 2008, 26:5775-5782.
    • (2008) J Clin Oncol , vol.26 , pp. 5775-5782
    • Lahuerta, J.J.1    Mateos, M.V.2    Martinez-Lopez, J.3
  • 5
    • 78049488759 scopus 로고    scopus 로고
    • Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed multiple myeloma: results of the IFM 2005-01 phase III trial
    • Harousseau J.L., Attal M., Avet-Loiseau H., et al. Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed multiple myeloma: results of the IFM 2005-01 phase III trial. J Clin Oncol 2010, 28:4621-4629.
    • (2010) J Clin Oncol , vol.28 , pp. 4621-4629
    • Harousseau, J.L.1    Attal, M.2    Avet-Loiseau, H.3
  • 6
    • 70350433797 scopus 로고    scopus 로고
    • The role of complete response in multiple myeloma
    • Harousseau J.L., Attal M., Avet-Loiseau H. The role of complete response in multiple myeloma. Blood 2009, 114:3139-3146.
    • (2009) Blood , vol.114 , pp. 3139-3146
    • Harousseau, J.L.1    Attal, M.2    Avet-Loiseau, H.3
  • 7
    • 77956259865 scopus 로고    scopus 로고
    • Importance of Achieving a Complete Response in Multiple Myeloma, and the Impact of Novel Agents
    • Chanan-Khan A.A., Giralt S. Importance of Achieving a Complete Response in Multiple Myeloma, and the Impact of Novel Agents. J Clin Oncol 2010, 28:2612-2624.
    • (2010) J Clin Oncol , vol.28 , pp. 2612-2624
    • Chanan-Khan, A.A.1    Giralt, S.2
  • 8
    • 48249127515 scopus 로고    scopus 로고
    • Complete remission sustained 3 years from treatment initiation is a powerful surrogate for extended survival in multiple myeloma
    • Barlogie B., Anaissie E., Haessler J., et al. Complete remission sustained 3 years from treatment initiation is a powerful surrogate for extended survival in multiple myeloma. Cancer 2008, 113:355-359.
    • (2008) Cancer , vol.113 , pp. 355-359
    • Barlogie, B.1    Anaissie, E.2    Haessler, J.3
  • 9
    • 30144439125 scopus 로고    scopus 로고
    • Tandem autologous stem cell transplantation in high-risk de novo multiple myeloma: final results of the prospective and randomized IFM 99-04 protocol
    • Moreau P., Hullin C., Garban F., et al. Tandem autologous stem cell transplantation in high-risk de novo multiple myeloma: final results of the prospective and randomized IFM 99-04 protocol. Blood 2006, 107:397-403.
    • (2006) Blood , vol.107 , pp. 397-403
    • Moreau, P.1    Hullin, C.2    Garban, F.3
  • 10
    • 78149239960 scopus 로고    scopus 로고
    • 2 as conditioning regimens for autologous transplantation in newly diagnosed multiple myeloma patients included in the PETHEMA/GEM2000 study
    • 2 as conditioning regimens for autologous transplantation in newly diagnosed multiple myeloma patients included in the PETHEMA/GEM2000 study. Haematologica 2010, 95:1913-1920.
    • (2010) Haematologica , vol.95 , pp. 1913-1920
    • Lahuerta, J.J.1    Mateos, M.V.2    Martinez-Lopez, J.3
  • 11
    • 40749085662 scopus 로고    scopus 로고
    • Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents
    • Leoni L.M., Bailey B., Reifert J., et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res 2008, 14:309-317.
    • (2008) Clin Cancer Res , vol.14 , pp. 309-317
    • Leoni, L.M.1    Bailey, B.2    Reifert, J.3
  • 12
    • 31344443373 scopus 로고    scopus 로고
    • Treatment of bendamustine and prednisone in patients with newly diagnosed multiple myeloma results in superior complete response rate, prolonged time to treatment failure and improved quality of life compared to treatment with melphalan and prednisone-a randomized phase III study of the East German Study Group of Hematology and Oncology (OSHO)
    • Ponisch W., Mitrou P.S., Merkle K., et al. Treatment of bendamustine and prednisone in patients with newly diagnosed multiple myeloma results in superior complete response rate, prolonged time to treatment failure and improved quality of life compared to treatment with melphalan and prednisone-a randomized phase III study of the East German Study Group of Hematology and Oncology (OSHO). J Cancer Res Clin Oncol 2006, 132:205-212.
    • (2006) J Cancer Res Clin Oncol , vol.132 , pp. 205-212
    • Ponisch, W.1    Mitrou, P.S.2    Merkle, K.3
  • 13
    • 84856301250 scopus 로고    scopus 로고
    • Bendamustine, Thalidomide and Dexamethasone is an effective salvage regimen for advanced stage multiple myeloma
    • [letter]
    • Grey-Davies E., Bosworth J.L., Boyd K.D., et al. Bendamustine, Thalidomide and Dexamethasone is an effective salvage regimen for advanced stage multiple myeloma. Br J Haematol 2012, 156:552-555. [letter].
    • (2012) Br J Haematol , vol.156 , pp. 552-555
    • Grey-Davies, E.1    Bosworth, J.L.2    Boyd, K.D.3
  • 14
    • 84859013389 scopus 로고    scopus 로고
    • Efficacy of bendamustine in relapsed/refractory myeloma patients: results from the French compassionate use program
    • Damaj G., Malard F., Hulin C., et al. Efficacy of bendamustine in relapsed/refractory myeloma patients: results from the French compassionate use program. Leuk Lymphoma 2012, 53:632-634.
    • (2012) Leuk Lymphoma , vol.53 , pp. 632-634
    • Damaj, G.1    Malard, F.2    Hulin, C.3
  • 15
    • 84861208513 scopus 로고    scopus 로고
    • Combination of bendamustine, lenalidomide, and dexamethasone (BLD) in patients with relapsed or refractory multiple myeloma is feasible and highly effective: results of phase I/II open-label, dose escalation study
    • Lentzsch S., O'Sullivan A., Kennedy R.C., et al. Combination of bendamustine, lenalidomide, and dexamethasone (BLD) in patients with relapsed or refractory multiple myeloma is feasible and highly effective: results of phase I/II open-label, dose escalation study. Blood 2012, 119:4608-4613.
    • (2012) Blood , vol.119 , pp. 4608-4613
    • Lentzsch, S.1    O'Sullivan, A.2    Kennedy, R.C.3
  • 16
    • 25444512381 scopus 로고    scopus 로고
    • The efficacy and toxicity of bendamustine in recurrent multiple myeloma after high-dose chemotherapy
    • Knop S., Straka C., Haen M., et al. The efficacy and toxicity of bendamustine in recurrent multiple myeloma after high-dose chemotherapy. Haematologica 2005, 90:1287-1288.
    • (2005) Haematologica , vol.90 , pp. 1287-1288
    • Knop, S.1    Straka, C.2    Haen, M.3
  • 17
    • 80053185604 scopus 로고    scopus 로고
    • BeEAM (bendamustine, etoposide, cytarabine, melphalan) before autologous stem cell transplantation is safe and effective for resistant/relapsed lymphoma patients
    • Visani G., Malerba L., Stefani P.M., et al. BeEAM (bendamustine, etoposide, cytarabine, melphalan) before autologous stem cell transplantation is safe and effective for resistant/relapsed lymphoma patients. Blood 2011, 118:3419-3425.
    • (2011) Blood , vol.118 , pp. 3419-3425
    • Visani, G.1    Malerba, L.2    Stefani, P.M.3
  • 18
    • 34247093863 scopus 로고    scopus 로고
    • A phase I study of bendamustine hydrochloride administered once every 3 weeks in patients with solid tumors
    • Rasschaert M., Schrijvers D., Van den Brande J., et al. A phase I study of bendamustine hydrochloride administered once every 3 weeks in patients with solid tumors. Anticancer Drugs 2007, 18:587-595.
    • (2007) Anticancer Drugs , vol.18 , pp. 587-595
    • Rasschaert, M.1    Schrijvers, D.2    Van den Brande, J.3
  • 19
    • 79955977910 scopus 로고    scopus 로고
    • Consensus recommendations for the uniform reporting of clinical trials: report of the International Myeloma Workshop Consensus Panel 1
    • Rajkumar S.V., Harousseau J.L., Durie B., et al. Consensus recommendations for the uniform reporting of clinical trials: report of the International Myeloma Workshop Consensus Panel 1. Blood 2011, 117:4691-4695.
    • (2011) Blood , vol.117 , pp. 4691-4695
    • Rajkumar, S.V.1    Harousseau, J.L.2    Durie, B.3
  • 20
    • 84876335441 scopus 로고    scopus 로고
    • The Association of Ki67 Percent Positivity and Clinical Outcomes in the Upfront Treatment of Multiple Myeloma
    • 13th International Myeloma Workshop
    • Mark T., Ounsafi I., Christos P., et al. The Association of Ki67 Percent Positivity and Clinical Outcomes in the Upfront Treatment of Multiple Myeloma. Haematologica [abstract] 2011, 96. 13th International Myeloma Workshop.
    • (2011) Haematologica [abstract] , pp. 96
    • Mark, T.1    Ounsafi, I.2    Christos, P.3
  • 21
    • 0036464598 scopus 로고    scopus 로고
    • Comparison of 200 mg/m(2) melphalan and 8 Gy total body irradiation plus 140 mg/m(2) melphalan as conditioning regimens for peripheral blood stem cell transplantation in patients with newly diagnosed multiple myeloma: final analysis of the Intergroupe Francophone du Myelome 9502 randomized trial
    • Moreau P., Facon T., Attal M., et al. Comparison of 200 mg/m(2) melphalan and 8 Gy total body irradiation plus 140 mg/m(2) melphalan as conditioning regimens for peripheral blood stem cell transplantation in patients with newly diagnosed multiple myeloma: final analysis of the Intergroupe Francophone du Myelome 9502 randomized trial. Blood 2002, 99:731-735.
    • (2002) Blood , vol.99 , pp. 731-735
    • Moreau, P.1    Facon, T.2    Attal, M.3
  • 22
    • 0031897817 scopus 로고    scopus 로고
    • Comparable engraftment kinetics following peripheral-blood stem-cell infusion mobilized with granulocyte colony-stimulating factor with or without cyclophosphamide in multiple myeloma
    • Desikan K.R., Barlogie B., Jagannath S., et al. Comparable engraftment kinetics following peripheral-blood stem-cell infusion mobilized with granulocyte colony-stimulating factor with or without cyclophosphamide in multiple myeloma. J Clin Oncol 1998, 16:1547-1553.
    • (1998) J Clin Oncol , vol.16 , pp. 1547-1553
    • Desikan, K.R.1    Barlogie, B.2    Jagannath, S.3
  • 23
    • 0347815503 scopus 로고    scopus 로고
    • Single versus double autologous stem-cell transplantation for multiple myeloma
    • Attal M., Harousseau J.L., Facon T., et al. Single versus double autologous stem-cell transplantation for multiple myeloma. N Engl J Med 2003, 349:2495-2502.
    • (2003) N Engl J Med , vol.349 , pp. 2495-2502
    • Attal, M.1    Harousseau, J.L.2    Facon, T.3
  • 24
    • 11144353760 scopus 로고    scopus 로고
    • 2 with amifostine cytoprotection and autologous hematopoietic stem cell support in non-Hodgkin and Hodgkin lymphoma
    • 2 with amifostine cytoprotection and autologous hematopoietic stem cell support in non-Hodgkin and Hodgkin lymphoma. Bone Marrow Transplant 2004, 33:781-787.
    • (2004) Bone Marrow Transplant , vol.33 , pp. 781-787
    • Phillips, G.L.1    Meisenberg, B.R.2    Reece, D.E.3
  • 25
    • 84895932572 scopus 로고    scopus 로고
    • 2 as a preparative regimen for patients with multiple myeloma undergoing autologous stem cell transplantation
    • 2 as a preparative regimen for patients with multiple myeloma undergoing autologous stem cell transplantation. Blood [abstract] 2012, 120:2009.
    • (2012) Blood [abstract] , vol.120 , pp. 2009
    • Bensinger, W.I.1    Becker, P.S.2    Gooley, T.A.3
  • 26
    • 80051804559 scopus 로고    scopus 로고
    • In vitro and ex vivo activity of SDX-105 (bendamustine) in drug-resistant lymphoma cells
    • Leoni L.M., Bailey B., Niemeyer C.C., et al. In vitro and ex vivo activity of SDX-105 (bendamustine) in drug-resistant lymphoma cells. AACR Meeting Abstracts 2004, 278.
    • (2004) AACR Meeting Abstracts , vol.278
    • Leoni, L.M.1    Bailey, B.2    Niemeyer, C.C.3
  • 27
    • 41149155882 scopus 로고    scopus 로고
    • Prospective oral mucositis audit: oral mucositis in patients receiving high-dose melphalan or BEAM conditioning chemotherapy-European Blood and Marrow Transplantation Mucositis Advisory Group
    • Blijlevens N., Schwenkglenks M., Bacon P., et al. Prospective oral mucositis audit: oral mucositis in patients receiving high-dose melphalan or BEAM conditioning chemotherapy-European Blood and Marrow Transplantation Mucositis Advisory Group. J Clin Oncol 2008, 26:1519-1525.
    • (2008) J Clin Oncol , vol.26 , pp. 1519-1525
    • Blijlevens, N.1    Schwenkglenks, M.2    Bacon, P.3
  • 28
    • 33748991175 scopus 로고    scopus 로고
    • Oral mucositis in myeloma patients undergoing melphalan-based autologous stem cell transplantation: incidence, risk factors and a severity predictive model
    • Grazziutti M.L., Dong L., Miceli M.H., et al. Oral mucositis in myeloma patients undergoing melphalan-based autologous stem cell transplantation: incidence, risk factors and a severity predictive model. Bone Marrow Transplant 2006, 38:501-506.
    • (2006) Bone Marrow Transplant , vol.38 , pp. 501-506
    • Grazziutti, M.L.1    Dong, L.2    Miceli, M.H.3
  • 29
    • 84880212893 scopus 로고    scopus 로고
    • In a high-dose melphalan setting, palifermin compared with placebo had no effect on oral mucositis or related patient's burden
    • D 17, [Epub ahead of print]
    • Blijlevens N., de Chateau M., Krivan G., et al. In a high-dose melphalan setting, palifermin compared with placebo had no effect on oral mucositis or related patient's burden. Bone Marrow Transplant 2012 Dec 17, [Epub ahead of print]. 10.1038/bmt.2012.257.
    • (2012) Bone Marrow Transplant
    • Blijlevens, N.1    de Chateau, M.2    Krivan, G.3
  • 30
    • 84871923086 scopus 로고    scopus 로고
    • A phase 1 dose-escalation trial of high-dose melphalan with palifermin for cytoprotection followed by autologous stem cell transplantation for patients with multiple myeloma with normal renal function
    • Abidi M.H., Agarwal R., Tageja N., et al. A phase 1 dose-escalation trial of high-dose melphalan with palifermin for cytoprotection followed by autologous stem cell transplantation for patients with multiple myeloma with normal renal function. Biol Blood Marrow Transplant 2012, 19:56-61.
    • (2012) Biol Blood Marrow Transplant , vol.19 , pp. 56-61
    • Abidi, M.H.1    Agarwal, R.2    Tageja, N.3
  • 31
    • 67349263413 scopus 로고    scopus 로고
    • Oral integrity and salivary profile in myeloma patients undergoing high-dose therapy followed by autologous SCT
    • Avivi I., Avraham S., Koren-Michowitz M., et al. Oral integrity and salivary profile in myeloma patients undergoing high-dose therapy followed by autologous SCT. Bone Marrow Transplant 2009, 43:801-806.
    • (2009) Bone Marrow Transplant , vol.43 , pp. 801-806
    • Avivi, I.1    Avraham, S.2    Koren-Michowitz, M.3


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