Venous thromboembolism in adults with sickle cell disease: A serious and under-recognized complication

American Journal of Medicine

Volumn 126, Issue 5, 2013, Pages 443-449

  Naik, Rakhi P ^a   Streiff, Michael B ^a   Haywood, Carlton ^a,b   Nelson, Julie A ^a   Lanzkron, Sophie ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Deep venous thrombosis; Mortality; Pulmonary embolism; Sickle cell disease; Venous thromboembolism

Indexed keywords

ADULT; AGED; ARTICLE; COMORBIDITY; DEEP VEIN THROMBOSIS; FEMALE; GENOTYPE; HUMAN; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MORTALITY; PREVALENCE; PRIORITY JOURNAL; RECURRENT DISEASE; RISK FACTOR; SICKLE CELL ANEMIA; TRICUSPID VALVE REGURGITATION; VENOUS THROMBOEMBOLISM;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANEMIA, SICKLE CELL; COMORBIDITY; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; PREVALENCE; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE; VENOUS THROMBOEMBOLISM; YOUNG ADULT;

EID: 84876268737     PISSN: 00029343     EISSN: 15557162     Source Type: Journal    
DOI: 10.1016/j.amjmed.2012.12.016     Document Type: Article

References (41)

1. K.I. Ataga, C.G. Moore, C.A. Hillery Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension Haematologica 93 1 2008 20 26
2. S. Shabat, A. Nyska, P.H. Long Osteonecrosis in a chemically induced rat model of human hemolytic disorders associated with thrombosis - a new model for avascular necrosis of bone Calcif Tissue Int 74 3 2004 220 228
3. D.A. Tam Protein C and protein S activity in sickle cell disease and stroke J Child Neurol 12 1 1997 19 21
4. B.N. Setty, A.K. Rao, M.J. Stuart Thrombophilia in sickle cell disease: the red cell connection Blood 98 12 2001 3228 3233
5. D.K. Kaul, R.L. Nagel, D. Chen, H.M. Tsai Sickle erythrocyte-endothelial interactions in microcirculation: The role of von Willebrand factor and implications for vasoocclusion Blood 81 9 1993 2429 2438
6. A. Hidalgo, J. Chang, J.E. Jang, A.J. Peired, E.Y. Chiang, P.S. Frenette Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury Nat Med 15 4 2009 384 391
7. A.A. Famodu, D. Oduwa Platelet count and platelet factor 3 (PF-3) availability in sickle cell disease Br J Biomed Sci 52 4 1995 323 324
8. I. Foulon, D. Bachir, F. Galacteros, J. Maclouf Increased in vivo production of thromboxane in patients with sickle cell disease is accompanied by an impairment of platelet functions to the thromboxane A2 agonist U46619 Arterioscler Thromb 13 3 1993 421 426
9. M.W. Kenny, A.J. George, J. Stuart Platelet hyperactivity in sickle-cell disease: a consequence of hyposplenism J Clin Pathol 33 7 1980 622 625
10. J. Villagra, S. Shiva, L.A. Hunter, R.F. Machado, M.T. Gladwin, G.J. Kato Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin Blood 110 6 2007 2166 2172
11. M.P. Westerman, D. Green, A. Gilman-Sachs Antiphospholipid antibodies, proteins C and S, and coagulation changes in sickle cell disease J Lab Clin Med 134 4 1999 352 362
12. Z. Zhou, M. Behymer, P. Guchhait Role of extracellular hemoglobin in thrombosis and vascular occlusion in patients with sickle cell anemia Anemia 2011 2011 918916
13. P.D. Stein, A. Beemath, F.A. Meyers, E. Skaf, R.E. Olson Deep venous thrombosis and pulmonary embolism in hospitalized patients with sickle cell disease Am J Med 119 10 2006 897.e7 897.e11
14. E.M. Novelli, C. Huynh, M.T. Gladwin, C.G. Moore, M.V. Ragni Pulmonary embolism in sickle cell disease: a case-control study J Thromb Haemost 10 5 2012 760 766
15. M.O. Adedeji, J. Cespedes, K. Allen, C. Subramony, M.D. Hughson Pulmonary thrombotic arteriopathy in patients with sickle cell disease Arch Pathol Lab Med 125 11 2001 1436 1441
16. J.K. Graham, M. Mosunjac, R.L. Hanzlick, M. Mosunjac Sickle cell lung disease and sudden death: a retrospective/prospective study of 21 autopsy cases and literature review Am J Forensic Med Pathol 28 2 2007 168 172
17. H.M. Haupt, G.W. Moore, T.W. Bauer, G.M. Hutchins The lung in sickle cell disease Chest 81 3 1982 332 337
18. E.A. Manci, D.E. Culberson, Y.M. Yang Causes of death in sickle cell disease: an autopsy study Br J Haematol 123 2 2003 359 365
19. M.S. Villers, M.G. Jamison, L.M. De Castro, A.H. James Morbidity associated with sickle cell disease in pregnancy Am J Obstet Gynecol 199 2 2008 125.e1 125.e5
20. A.H. James, M.G. Jamison, L.R. Brancazio, E.R. Myers Venous thromboembolism during pregnancy and the postpartum period: Incidence, risk factors, and mortality Am J Obstet Gynecol 194 5 2006 1311 1315
21. O.S. Platt, D.J. Brambilla, W.F. Rosse Mortality in sickle cell disease Life expectancy and risk factors for early death N Engl J Med 330 23 1994 1639 1644
22. M. Frezzato, A. Tosetto, F. Rodeghiero Validated questionnaire for the identification of previous personal or familial venous thromboembolism Am J Epidemiol 143 12 1996 1257 1265
23. M.R. Jeng, J. Feusner, C. Skibola, E. Vichinsky Central venous catheter complications in sickle cell disease Am J Hematol 69 2 2002 103 108
24. D.R. Powars, L.S. Chan, A. Hiti, E. Ramicone, C. Johnson Outcome of sickle cell anemia: a 4-decade observational study of 1056 patients Medicine (Baltimore) 84 6 2005 363 376
25. M.T. Gladwin, V. Sachdev, M.L. Jison Pulmonary hypertension as a risk factor for death in patients with sickle cell disease N Engl J Med 350 9 2004 886 895
26. S.K. Ballas, S. Lieff, L.J. Benjamin Definitions of the phenotypic manifestations of sickle cell disease Am J Hematol 85 1 2010 6 13
27. W.M. Lijfering, J.L. Brouwer, N.J. Veeger Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives Blood 113 21 2009 5314 5322
28. F.A. Spencer, C. Emery, S.W. Joffe Incidence rates, clinical profile, and outcomes of patients with venous thromboembolism The Worcester VTE study J Thromb Thrombolysis 28 4 2009 401 409
29. H. Austin, N.S. Key, J.M. Benson Sickle cell trait and the risk of venous thromboembolism among blacks Blood 110 3 2007 908 912
30. S. Alkindi, S. Matwani, A. Al-Maawali, B. Al-Maskari, A. Pathare Complications of PORT-A-CATH((R)) in patients with sickle cell disease J Infect Public Health 5 1 2012 57 62
31. S.M. Downes, I.R. Hambleton, E.L. Chuang, N. Lois, G.R. Serjeant, A.C. Bird Incidence and natural history of proliferative sickle cell retinopathy: Observations from a cohort study Ophthalmology 112 11 2005 1869 1875
32. A. Poignard, C.H. Flouzat-Lachaniette, J. Amzallag, F. Galacteros, P. Hernigou The natural progression of symptomatic humeral head osteonecrosis in adults with sickle cell disease J Bone Joint Surg Am 94 2 2012 156 162
33. G.J. Kato, M.T. Gladwin, M.H. Steinberg Deconstructing sickle cell disease: Reappraisal of the role of hemolysis in the development of clinical subphenotypes Blood Rev 21 1 2007 37 47
34. A. Taher, H. Isma'eel, G. Mehio Prevalence of thromboembolic events among 8,860 patients with thalassaemia major and intermedia in the Mediterranean area and Iran Thromb Haemost 96 4 2006 488 491
35. B.K. Walker, S.K. Ballas, E.R. Burka The diagnosis of pulmonary thromboembolism in sickle cell disease Am J Hematol 7 3 1979 219 232
36. P. Girard, O. Sanchez, C. Leroyer Deep venous thrombosis in patients with acute pulmonary embolism: Prevalence, risk factors, and clinical significance Chest 128 3 2005 1593 1600
37. F.S. Collins, E.P. Orringer Pulmonary hypertension and cor pulmonale in the sickle hemoglobinopathies Am J Med 73 6 1982 814 821
38. A.K. Haque, S. Gokhale, B.A. Rampy, P. Adegboyega, A. Duarte, M.J. Saldana Pulmonary hypertension in sickle cell hemoglobinopathy: a clinicopathologic study of 20 cases Hum Pathol 33 10 2002 1037 1043
39. E.J. van Beers, B.L. van Eck-Smit, M.R. Mac Gillavry Large and medium-sized pulmonary artery obstruction does not play a role of primary importance in the etiology of sickle-cell disease-associated pulmonary hypertension Chest 133 3 2008 646 652
40. J.J. Field, A.R. Madadi, M.J. Siegel, V. Narra Pulmonary thrombi are not detected by 3D magnetic resonance angiography in adults with sickle cell anemia and an elevated tricuspid regurgitant jet velocity Am J Hematol 84 10 2009 686 688
41. D.C. Brousseau, P.L. Owens, A.L. Mosso, J.A. Panepinto, C.A. Steiner Acute care utilization and rehospitalizations for sickle cell disease JAMA 303 13 2010 1288 1294