Embryo apoptosis may be a significant contributing factor in addition to aneuploidy inhibiting live deliveries once a woman reaches age 45

Clinical and Experimental Obstetrics and Gynecology

Volumn 40, Issue 1, 2013, Pages 22-23

  Check, J H ^a,b   Burgos, S ^b   Slovis, B ^b   Wilson, C ^a  

^a Division of Reproductive Endocrinology and Infertility ^*  (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; In vitro fertilization; Meiosis errors; Pregnancy rates; Reproductive aging

Indexed keywords

CHORIONIC GONADOTROPIN BETA SUBUNIT; FOLLITROPIN;

ADULT; ANEUPLOIDY; APOPTOSIS; ARTICLE; EMBRYO CELL; EMBRYO TRANSFER; FEMALE; FOLLITROPIN BLOOD LEVEL; GROUPS BY AGE; HUMAN; LIVE BIRTH; MATERNAL AGE; MEIOSIS; OVARIAN RESERVE; PREGNANCY DISORDER; PREGNANCY RATE;

EID: 84876245107     PISSN: 03906663     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Check J.H., Peymer M., Lurie D.: "Effect of age on pregnancy outcome without assisted reproductive technology in women with elevated early follicular phase serum follicle-stimulating hormone levels". Gynecol. Obstet. Invest., 1998, 45, 217.
2. Check M.L., Check J.H., Wilson C., Choe J.K., Krotec J.: "Outcome of in vitro fertilization-embryo transfer according to age in poor responders with elevated baseline serum follicle stimulation hormone using minimal or no gonadotropin stimulation". Clin. Exp. Obstet. Gynecol., 2004, 31, 183.
3. Check J.H., Cohen R.: "Evidence that oocyte quality in younger women with diminished oocyte reserve is superior to those of women of advanced reproductive age". Med. Hypotheses, 2010, 74, 264.
4. Check J.H., Summers-Chase D., Yuan W., Horwath D., Wilson C.: "Effect of embryo quality on pregnancy outcome following single embryo transfer in women with a diminished egg reserve". Fertil. Steril., 2007, 87, 749.
5. Check J.H.: "Mild ovarian stimulation". J. Assist. Reprod. Genet., 2007, 24, 621.