Olfactory Training in Patients with Parkinson's Disease

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Haehner, Antje ^a   Tosch, Clara ^a   Wolz, Martin ^b,c   Klingelhoefer, Lisa ^b   Fauser, Mareike ^b   Storch, Alexander ^b   Reichmann, Heinz ^a   Hummel, Thomas ^a  

^a UNIVERSITY OF DRESDEN MEDICAL SCHOOL   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c Elblandkliniken Meissen ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CINEOLE; CITRONELLAL; EUGENOL; PHENYLETHYLALCOHOL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLOVE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EUCALYPTUS; FEMALE; HUMAN; LEMON; MAJOR CLINICAL STUDY; MALE; NEUROLOGIC EXAMINATION; ODOR; OLFACTORY DISCRIMINATION; OLFACTORY TRAINING; PARKINSON DISEASE; PERCEPTIVE DISCRIMINATION; PERCEPTIVE THRESHOLD; PROSPECTIVE STUDY; ROSE; SENSORY STIMULATION; SMELLING DISORDER; THERAPY; THERAPY EFFECT; TREATMENT DURATION;

ADULT; AGED; ALDEHYDES; CYCLOHEXANOLS; DISCRIMINATION (PSYCHOLOGY); EUGENOL; FEMALE; HUMANS; MALE; MIDDLE AGED; MONOTERPENES; OLFACTORY PERCEPTION; PARKINSON DISEASE; SENSORY THRESHOLDS;

CITRUS LIMON; EUCALYPTUS;

EID: 84876235702     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0061680     Document Type: Article

References (30)

1. Haehner A, Boesveldt S, Berendse HW, MackaySim A, Fleischmann J, et al. (2009) Prevalence of smell loss in Parkinson's disease - a multicenter study. Parkinsonism Relat Disord 15: 490-494.
2. Hummel T, Nordin S, (2005) Olfactory disorders and their consequences for quality of life-a review. Acta Oto-Laryngol 125: 116-121.
3. Politis M, Wu K, Molloy S, Bain PG, Chaudhuri R, et al. (2010) Parkinson's Disease Symptoms: The Patient's Perspective. Mov Disord 25 (11): 1646-1651.
4. Gopinath B, Anstey KJ, Sue CM, Kifley A, Mitchell P, (2011) Olfactory impairment in older adults is associated with depressive symptoms and poorer quality of life scores. Am J Geriatr Psychiatry 19 (9): 830-834.
5. Smeets MA, Veldhuizen MG, Galle S, Gouweloos J, de Haan AM, et al. (2009) Sense of smell disorder and health-related quality of life. Rehabil Psychol 54 (4): 404-412.
6. Doty RL, Deems D, Steller S, (1988) Olfactory dysfunction in Parkinson's disease: A general deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology 38: 1237-44.
7. Rösser N, Berger K, Vomhof P, Knecht S, Breitenstein C, et al. (2008) Lack of improvement in odor identification by levodopa in humans. Physiol Behav 93 (4-5): 1024-1029.
8. Roth J, Radil T, Ruzicka E, Jech R, Tichy J, (1998) Apomorphine does not influence olfactory thresholds in Parkinson's disease. Funct Neurol 13: 99-103.
9. Hummel T, Jahnke U, Sommer U, Reichmann H, Müller A, (2005) Olfactory function in patients with idiopathic Parkinson's disease: Effects of deep brain stimulation in the subthalamic nucleus. J Neural Transm 2005 112: 669-676.
10. Guo X, Gao G, Wang X, Li L, Li W, et al. (2008) Effects of bilateral deep brain stimulation of the subthalamic nucleus on olfactory function in Parkinson's disease patients. Stereotact Funct Neurosurg 86 (4): 237-244.
11. Fonoff ET, de Oliveira YS, Driollet S, Garrido GJ, de Andrade DC, et al. (2010) Pet findings in reversible improvement of olfactory dysfunction after STN stimulation in a Parkinson's disease patient. Mov Disord 25 (14): 2466-8.
12. Cain WS, Stevens JC, Nickou CM, Giles A, Johnston I, et al. (1995) Life-span development of odor identification, learning, and olfactory sensitivity. Perception 24: 1457-1472.
13. Livermore A, Laing DG, (1996) Influence of Training and experience on the perception of multicomponent odor mixtures. J Exp Psychol Hum Percept Perform 22: 267-277.
14. Hummel T, Rissom K, Reden J, Haehner A, Weidenbecher M, et al. (2009) Effects of "olfactory training" in patients with olfactory loss. Laryngoscope 119 (3): 496-499.
15. Litvan I, Bhatia KP, Burn DJ, Goetz CG, Lang AE, et al. (2003) Society Scientific Issues Committee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders. Mov Disord 18: 467-86.
16. Henning H (1916) Der Geruch. Leipzig, Germany: Johann Ambrosius Barth.
17. Amoore JE, (1977) Specific anosmia and the concept of primary odors. Chem Sens Flav 2: 267-281.
18. Hummel T, Kobal G, Gudziol H, Mackay-Sim A, (2007) Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch Otorhinolaryngol 264: 237-243.
19. Cain WS, Gent JF, Goodspeed RB, Leonard G, (1988) Evaluation of olfactory dysfunction in the Connecticut Chemosensory Clinical Research Center (CCCRC). Laryngoscope 98: 83-88.
20. Doty RL, McKeown DA, Lee WW, Shaman P, (1995) A study of the test-retest reliability of ten olfactory tests. Chem Senses 1995 20: 645-656.
21. Gudziol V, Lötsch J, Haehner A, Zahnert T, Hummel T, (2006) Clinical significance of results from olfactory testing. Laryngoscope 116 (10): 1858-1863.
22. Wang H-W, Wysocki CJ, Gold GH, (1993) Induction of olfactory receptor sensitivity in mice. Science 260: 998-1000.
23. Youngentob SL, Kent PF, (1995) Enhancement of odorant-induced mucosal activity patterns in rats trained on an odorant identification task. Brain Res 23 670 (1): 82-8.
24. Czarnecki LA, Moberly AH, Turkel DJ, Rubinstein T, Pottackal J, et al. (2012) Functional rehabilitation of cadmium-induced neurotoxicity despite persistent peripheral pathophysiology in the olfactory system. Toxicol Sci 126 (2): 534-544.
25. Wang L, Chen L, Jacob T, (2004) Evidence for peripheral plasticity in human odour response. J Physiol 554: 236-244.
26. Zatorre RJ, Jones-Gotman M, (1991) Human olfactory discrimination after unilateral frontal or temporal lobectomy. Brain 14: 71-84.
27. Hedner M, Larsson M, Arnold N, Zucco G, Hummel T, (2010) Cognitive factors in odor detection, odor discrimination, and odor identification tasks. J Clin Exp Neuropsychol 32 (10): 1062-1067.
28. Chapuis J, Wilson DA, (2006) Bidirectional plasticity of cortical pattern recognition and behavioral sensory acuity. Nat Neurosci 15 (1): 155-161.
29. Katzen HL, Levin BE, Weiner W, (2006) Side and type of motor symptom influence cognition in Parkinson's disease. Mov Disord 21: 1947-1953.
30. Oh JY, Kim YS, Choi BH, Sohn EH, Lee AY, (2009) Relationship between clinical phenotypes and cognitive impairment in Parkinson's disease (PD). Arch Gerontol Geriatr 49 (3): 351-354.