The concept of the onychodermis (specialized nail mesenchyme): An embryological assessment and a comparative analysis with the hair follicle

Journal of Cutaneous Pathology

Volumn 40, Issue 5, 2013, Pages 463-471

  Sellheyer, Klaus ^a,b   Nelson, Paula ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b Nelson Dermatopathology Associates   (United States)

Author keywords

CD10; CD34; nail unit; onychodermis; onychofibroblasts

Indexed keywords

BIOLOGICAL MARKER; CD34 ANTIGEN; INTERMEDIATE FILAMENT PROTEIN; MEMBRANE METALLOENDOPEPTIDASE; NERVE PROTEIN; NESTIN;

ADULT; AGE; ARTICLE; COMPARATIVE STUDY; CYTOLOGY; FEMALE; HAIR FOLLICLE; HUMAN; MESENCHYMAL STROMA CELL; MESODERM; METABOLISM; NAIL; PREGNANCY; PRENATAL DEVELOPMENT; SECOND TRIMESTER PREGNANCY;

ADULT; AGE FACTORS; ANTIGENS, CD34; BIOLOGICAL MARKERS; FEMALE; HAIR FOLLICLE; HUMANS; INTERMEDIATE FILAMENT PROTEINS; MESENCHYMAL STROMAL CELLS; MESODERM; NAILS; NEPRILYSIN; NERVE TISSUE PROTEINS; PREGNANCY; PREGNANCY TRIMESTER, SECOND;

EID: 84876230556     PISSN: 03036987     EISSN: 16000560     Source Type: Journal    
DOI: 10.1111/cup.12101     Document Type: Article

References (28)

1. Tobin DJ, Gunin A, Magerl M, Handijski B, Paus R,. Plasticity and cytokinetic dynamics of the hair follicle mesenchyme: implications for hair growth control. J Invest Dermatol 2003; 120: 895.
2. Jahoda CA,. Cell movement in the hair follicle dermis-more than a two-way street? J Invest Dermatol 2003; 121: ix.
3. Tiede S, Kloepper JE, Ernst N, et al. Nestin in human skin: exclusive expression in intramesenchymal skin compartments and regulation by leptin. J Invest Dermatol 2009; 129: 2711.
4. Sellheyer K, Krahl D,. Spatiotemporal expression pattern of neuroepithelial stem cell marker nestin suggests a role in dermal homeostasis, neovasculogenesis and tumor stroma development. A study on embryonic and adult human skin. J Am Acad Dermatol 2010; 63: 93.
5. Sellheyer K,. Stem cell markers can help identify adnexal tumor differentiation when evaluated in the context of morphology: methodology matters. J Cutan Pathol 2011; 38: 460.
6. Lee KJ, Kim WS, Lee JH, et al. CD10, a marker for specialized mesenchymal cells (onychofibroblasts) in the nail unit. J Dermatol Sci 2006; 42: 65.
7. Lee DY, Lee KJ, Kim WS, Yang JM,. Presence of specialized mesenchymal cells (onychofibroblasts) in the nail unit: implications for ingrown nail surgery. J Eur Acad Dermatol Venereol 2007; 21: 575.
8. Lee DY, Yang JM, Mun GH, Jang KT, Cho KH,. Immunohistochemical study of specialized nail mesenchyme containing onychofibroblasts in transverse sections of the nail unit. Am J Dermatopathol 2011; 33: 266.
9. Lee DY, Park JH, Shin HT, Jang KT, Kwon GY, Shim JS,. Onychodermis (specialized nail mesenchyme) containing onychofibroblasts in horizontal sections of the nail unit. Br J Dermatol 2012; 166: 1127.
10. Park JH, Lee DY,. CD10 is expressed in nail mesenchyme (onychodermis) containing onychofibroblasts of the adult nail unit. Clin Exp Dermatol 2012; 37: 685.
11. Lee DY, Park JH, Shin HT, et al. The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study. Histopathology 2012; 61: 123.
12. Lee DY, Yang JM, Mun GH,. Onychofibroblasts induce hard keratin in skin keratinocytes in vitro. Br J Dermatol 2009; 161: 960.
13. Toma JG, Akhavan M, Fernandes KJ, et al. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 2001; 3: 778.
14. Toma JG, McKenzie IA, Bagli D, Miller FD,. Isolation and characterization of multipotent skin-derived precursors from human skin. Stem Cells 2005; 23: 727.
15. Mercer BM, Sklar S, Shariatmadar A, Gillieson MS, D'Alton ME,. Fetal foot length as a predictor of gestational age. Am J Obstet Gynecol 1987; 156: 350.
16. Drey EA, Kang MS, McFarland W, Darney PD,. Improving the accuracy of fetal foot length to confirm gestational duration. Obstet Gynecol 2005; 105: 773.
17. Egawa K, Kuroki M, Inoue Y, Ono T,. Nail bed keratinocytes express an antigen of the carcinoembryonic antigen family. Br J Dermatol 2000; 143: 79.
18. Greaves MF, Brown G, Rapson NT, Lister TA,. Antisera to acute lymphoblastic leukemia cells. Clin Immunol Immunopathol 1975; 4: 67.
19. Letarte M, Vera S, Tran R, et al. Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase. J Exp Med 1988; 168: 1247.
20. de Feraudy S, Mar N, McCalmont TH,. Evaluation of CD10 and procollagen 1 expression in atypical fibroxanthoma and dermatofibroma. Am J Surg Pathol 2008; 32: 1111.
21. Yada K, Kashima K, Daa T, Kitano S, Fujiwara S, Yokoyama S,. Expression of CD10 in basal cell carcinoma. Am J Dermatopathol 2004; 26: 463.
22. Poblet E, Jiménez F,. D10 and CD34 in fetal and adult human hair follicles: dynamic changes in their immunohistochemical expression during embryogenesis and hair cycling. Br J Dermatol 2008; 159: 646.
23. Misago N, Toda S, Narisawa Y,. CD34 expression in human hair follicles and tricholemmoma: a comprehensive study. J Cutan Pathol 2011; 38: 609.
24. Lee KJ, Choi YL, Kim WS, et al. CD10 is expressed in dermal sheath cells of the hair follicles in human scalp. Br J Dermatol 2006; 155: 858.
25. Sellheyer K, Nelson P,. The ventral proximal nail fold: stem cell niche of the nail and equivalent to the follicular bulge - a study on developing human skin. J Cutan Pathol 2012; 39: 835.
26. Clarke LE,. Fibrous and fibrohistiocytic neoplasms: an update. Dermatol Clin 2012; 30: 643.
27. Buonaccorsi JN, Plaza JA,. Role of CD10, wide-spectrum keratin, p63, and podoplanin in the distinction of epithelioid and spindle cell tumors of the skin: an immunohistochemical study of 81 cases. Am J Dermatopathol 2012; 34: 404.
28. Wieland CN, Dyck R, Weenig RH, Comfere NI,. The role of CD10 in distinguishing atypical fibroxanthoma from sarcomatoid (spindle cell) squamous cell carcinoma. J Cutan Pathol 2011; 38: 884.