Association of multiple vertebral hemangiomas and severe paraparesis in a patient with a PTEN hamartoma tumor syndrome: Case report

Journal of Neurosurgery

Volumn 107, Issue 4 SUPPL., 2007, Pages 307-313

  Jenny, Benoit ^a   Radovanovic, Ivan ^a   Haenggeli, Charles Antoine ^a   Delavelle, Jacqueline ^a   Rüfenacht, Daniel ^a   Kaelin, André ^a   Blouin, Jean Louis ^a   Bottani, Armand ^a   Rilliet, Béńedict ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Cowden syndrome; Multiple vertebral hemangiomas; Paraparesis; Pediatric neurosurgery; PTEN mutation

Indexed keywords

ARGININE; CYSTEINE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ADOLESCENT; ANGIOGRAPHY; ARTICLE; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; CONGENITAL HEART MALFORMATION; CONGENITAL TUMOR; CYANOSIS; DECOMPRESSION SURGERY; FEMALE; GENETICS; HEMANGIOMA; HETEROZYGOTE; HOSPITALIZATION; HUMAN; MISSENSE MUTATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PARAPLEGIA; PATHOPHYSIOLOGY; SPINAL CORD COMPRESSION; SPINAL CORD TUMOR; VERTEBRA;

ADOLESCENT; ANGIOGRAPHY; ARGININE; CYANOSIS; CYSTEINE; DECOMPRESSION, SURGICAL; FEMALE; HAMARTOMA SYNDROME, MULTIPLE; HEART DEFECTS, CONGENITAL; HEMANGIOMA; HETEROZYGOTE; HUMANS; MAGNETIC RESONANCE IMAGING; MUTATION, MISSENSE; PARAPARESIS; PTEN PHOSPHOHYDROLASE; SEVERITY OF ILLNESS INDEX; SPINAL CORD COMPRESSION; SPINAL NEOPLASMS; THORACIC VERTEBRAE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84876225365     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/ped.2007.107.4.307     Document Type: Article

References (32)

1. Bandiera S, Gasbarrini A, De Iure F, Cappuccio M, Picci P, Boriani S: Symptomatic vertebral hemangioma: the treatment of 23 cases and a review of the literature. Chir Organi Mov 87:1-15, 2002
2. Beyzadeoglu M, Dirican B, Oysul K, Surenkok S, Pak Y: Evaluation of radiation carcinogenesis risk in vertebral hemangioma treated by radiotherapy. Neoplasma 49:338-341, 2002 (Pubitemid 35434599)
3. Blankstein A, Spiegelmann R, Shacked I, Schinder E, Chechick A: Hemangioma of the thoracic spine involving multiple adjacent levels: case report. Paraplegia 26:186-191, 1988
4. Bremnes RM, Hauge HN, Sagsveen R: Radiotherapy in the treatment of symptomatic vertebral hemangiomas: technical case report. Neurosurgery 39:1054-1058, 1996 (Pubitemid 26360869)
5. Camins MB, Oppenheim JS, Perrin RG: Tumors of the vertebral axis: benign, primary malignant and metastatic tumors, in Youmans JR (ed): Neurological Surgery. Philadelphia: WB Saunders, 1996, pp 3135-3167
6. Djindjian M, Nguyen JP, Gaston A, Pavlovitch JM, Poirier J, Awad IA: Multiple vertebral hemangiomas with neurological signs. Case report. J Neurosurg 76:1025-1028, 1992
7. Duprez T, Lokietek W, Clapuyt P, DeMerlier Y, Malghem J, Gadisseux JF: Multiple aggressive vertebral haemangiomas in an adolescent: a case report. Pediatr Radiol 28:51-53, 1998 (Pubitemid 28055107)
8. Eng C: Will the real Cowden syndrome please stand up: revised diagnostic criteria. J Med Genet 37:828-830, 2000
9. Fox MW, Onofrio BM: The natural history and management of symptomatic and asymptomatic vertebral hemangiomas. J Neurosurg 78:36-45, 1993 (Pubitemid 23005351)
10. Gicquel JJ, Vabres P, Bonneau D, Mercié M, Handiri L, Dighiero P: Retinal angioma in a patient with Cowden disease. Am J Ophthalmol 135:400-402, 2003 (Pubitemid 36279536)
11. Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, et al: The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev 19:2054-2065, 2005 (Pubitemid 41247962)
12. Hemmy DC: Vertebral hemangiomas, in Wilkins RH, Rengachary SS (eds): Neurosurgery. New York: McGraw-Hill, 1996, pp 1827-1829
13. Hernalsteen D, Cosnard G, Duprez T: Long-term (6-year) follow-up of untreated multiple aggressive vertebral haemangiomas in an adolescent. Pediatr Radiol 34:831-832, 2004 (Pubitemid 39378367)
14. Karaeminogullari O, Tuncay C, Demirors H, Akin K, Sahin O, Ozyurek A, et al: Multilevel vertebral hemangiomas: two episodes of spinal cord compression at separate levels 10 years apart. Eur Spine J 14:706-710, 2005 (Pubitemid 41417718)
15. Kubo Y, Urano Y, Hida Y, Ikeuchi T, Nomoto M, Kunitomo K, et al: A novel PTEN mutation in a Japanese patient with Cowden disease. Br J Dermatol 142:1100-1105, 2000 (Pubitemid 30418294)
16. Kulshrestha M, Byrne P: Multiple primary haemangiomas of bone mimicking vertebral metastases. J R Soc Med 90:632-634, 1997 (Pubitemid 27501106)
17. Lee S, Hadlow AT: Extraosseous extension of vertebral hemangioma, a rare cause of spinal cord compression. Spine 24:2111-2114, 1999 (Pubitemid 29489426)
18. Lok C, Viseux V, Avril MF, Richard MA, Gondry-Jouet C, Deramond H, et al: Brain magnetic resonance imaging in patients with Cowden syndrome. Medicine (Baltimore) 84:129-136, 2005 (Pubitemid 40418641)
19. Longy M, Coulon V, Duboué B, David A, Larrègue M, Eng C, et al: Mutations of PTEN in patients with Bannayan-Riley-Ruvalcaba phenotype. J Med Genet 35:886-889, 1998 (Pubitemid 28486613)
20. Marsh DJ, Dahia PL, Zheng Z, Liaw D, Parsons R, Gorlin RJ, et al: Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat Genet 16:333-334, 1997
21. Murugan L, Samson RS, Chandy MJ: Management of symptomatic vertebral hemangiomas: review of 13 patients. Neurol India 50:300-305, 2002
22. Obana Y, Tanji K, Furuta I, Yamazumi T, Hashimoto S, Kikuchi H, et al: A case of malignant transformation in thoracic vertebral hemangioma following repetitive irradiation and extraction. Pathol Int 46:71-78, 1996 (Pubitemid 26171374)
23. Pastushyn AI, Slin'ko EI, Mirzoyeva GM: Vertebral hemangiomas: diagnosis, management, natural history and clinicopathological correlates in 86 patients. Surg Neurol 50:535-547, 1998 (Pubitemid 29031334)
24. Pérez-Núñez A, Lagares A, Benítez J, Urioste M, Lobato RD, Ricoy JR, et al: Lhermitte-Duclos disease and Cowden disease: clinical and genetic study in five patients with Lhermitte-Duclos disease and literature review. Acta Neurochir (Wien) 146: 679-690, 2004 (Pubitemid 38856613)
25. Robinson S, Cohen AR: Cowden disease and Lhermitte-Duclos disease: an update. Case report and review of the literature. Neurosurg Focus 20 (1):E6, 2006
26. Roncaroli F, Scheithauer BW, Deen HG Jr: Multiple hemangiomas (hemangiomatosis) of the cauda equina and spinal cord. Case report. J Neurosurg 92 (2 Suppl):229-232, 2000 (Pubitemid 30207424)
27. Sainani NI, Pungavkar SA, Patkar DP, Lawande MA, Naik M: Multiple hemangiomas involving the vertebral column. Acta Radiol 46:510-513, 2005 (Pubitemid 41673271)
28. Sansal I, Sellers WR: The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol 22:2954-2963, 2004 (Pubitemid 41079915)
29. Scala S, Bruni P, Lo Muzio L, Mignogna M, Viglietto G, Fusco A: Novel mutation of the PTEN gene in an Italian Cowden's disease kindred. Int J Oncol 13:665-668, 1998 (Pubitemid 28435340)
30. Schnyder P, Fankhauser H, Mansouri B: Computed tomography in spinal hemangioma with cord compression. Report of two cases. Skeletal Radiol 15:372-375, 1986 (Pubitemid 16064499)
31. Turnbull MM, Humeniuk V, Stein B, Suthers GK: Arteriovenous malformations in Cowden syndrome. J Med Genet 42:E50, 2005
32. Yazici M, Iyigun OL, Gulman B, Rakunt C, Cizmeli O: Vertebral hemangioma presenting with intermittent claudication. Eur Spine J 5:131-133, 1996 (Pubitemid 26155160)