Endoglin deficiency in bone marrow is sufficient to cause cerebrovascular dysplasia in the adult mouse after vascular endothelial growth factor stimulation

Stroke

Volumn 44, Issue 3, 2013, Pages 795-798

  Choi, Eun Jung ^a   Walker, Espen J ^a   Degos, Vincent ^a   Jun, Kristine ^a   Kuo, Robert ^a   Pile Spellman, John ^c   Su, Hua ^a   Young, William L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Neurological Surgery PC   (United States)

Author keywords

Adult mouse; Arteriovenous malformation; Brain angiogenesis

Indexed keywords

CD68 ANTIGEN; ENDOGLIN; GELATINASE B; NOTCH1 RECEPTOR; PARVOVIRUS VECTOR; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASAL GANGLION; BLOOD VESSEL PARAMETERS; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CEREBROVASCULAR DISEASE; CEREBROVASCULAR DYSPLASIA; CONTROLLED STUDY; DYSPLASIA; DYSPLASIA INDEX; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VASCULAR DENSITY; WILD TYPE;

ANIMALS; BONE MARROW; BONE MARROW TRANSPLANTATION; CEREBROVASCULAR DISORDERS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGES; MATRIX METALLOPROTEINASE 9; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; MONOCYTES; RECEPTOR, NOTCH1; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR MALFORMATIONS;

EID: 84876205807     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.112.671974     Document Type: Article

References (14)

1. Mahmoud M, Allinson KR, Zhai Z, Oakenfull R, Ghandi P, Adams RH, et al. Pathogenesis of arteriovenous malformations in the absence of endoglin. Circ Res. 2010;106:1425-1433.
2. Hao Q, Zhu Y, Su H, Shen F, Yang GY, Kim H, et al. VEGF Induces More Severe Cerebrovascular Dysplasia in Endoglin than in Alk1 Mice. Transl Stroke Res. 2010;1:197-201.
3. Hao Q, Liu J, Pappu R, Su H, Rola R, Gabriel RA, et al. Contribution of bone marrow-derived cells associated with brain angiogenesis is primarily through leukocytes and macrophages. Arterioscler Thromb Vasc Biol. 2008;28:2151-2157.
4. van Laake LW, van den Driesche S, Post S, Feijen A, Jansen MA, Driessens MH, et al. Endoglin has a crucial role in blood cell-mediated vascular repair. Circulation. 2006;114:2288-2297.
5. Holderfield MT, Hughes CC. Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis. Circ Res. 2008;102:637-652.
6. Li F, Lan Y, Wang Y, Wang J, Yang G, Meng F, et al. Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch. Dev Cell. 2011;20:291-302.
7. Outtz HH, Tattersall IW, Kofler NM, Steinbach N, Kitajewski J. Notch1 controls macrophage recruitment and Notch signaling is activated at sites of endothelial cell anastomosis during retinal angiogenesis in mice. Blood. 2011;118:3436-3439.
8. Sawano A, Iwai S, Sakurai Y, Ito M, Shitara K, Nakahata T, et al. Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans. Blood. 2001;97:785-791.
9. Hao Q, Su H, Palmer D, Sun B, Gao P, Yang GY, et al. Bone marrowderived cells contribute to vascular endothelial growth factor-induced angiogenesis in the adult mouse brain by supplying matrix metalloproteinase-9. Stroke. 2011;42:453-458.
10. Wang YC, He F, Feng F, Liu XW, Dong GY, Qin HY, et al. Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses. Cancer Res. 2010;70:4840-4849.
11. Gao D, Nolan DJ, Mellick AS, Bambino K, McDonnell K, Mittal V. Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science. 2008;319:195-198.
12. Choi EJ, Walker EJ, Shen F, Oh SP, Arthur HM, Young WL, et al. Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse. Cerebrovasc Dis. 2012;33:540-547.
13. Chen Y, Zhu W, Bollen AW, Lawton MT, Barbaro NM, Dowd CF, et al. Evidence of inflammatory cell involvement in brain arteriovenous malformations. Neurosurgery. 2008;62:1340-9; discussion 1349.
14. Gao P, Chen Y, Lawton MT, Barbaro NM, Yang GY, Su H, et al. Evidence of endothelial progenitor cells in the human brain and spinal cord arteriovenous malformations. Neurosurgery. 2010;67:1029-1035.