Targeting specific HATs for neurodegenerative disease treatment: Translating basic biology to therapeutic possibilities

Frontiers in Cellular Neuroscience

Volumn , Issue MAR, 2013, Pages

  Piroozniat, Sheila K ^a,b   Elefant, Felice ^a  

^a DREXEL UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell death; Epigenetics; Histone acetyltransferases (HATs); Histone code; Histone deacetylases (HDACs); Learning and memory; Neurodegenerative diseases; Synaptic plasticity

Indexed keywords

4 B; 4 PHENYLBUTYRIC ACID; ACYLTRANSFERASE INHIBITOR; ALPHA SYNUCLEIN; ALPHA TUBULIN; BUTYRIC ACID; CALCIUM; CCAAT ENHANCER BINDING PROTEIN; CELL PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOCHROME C; DOPAMINE; E1A ASSOCIATED P300 PROTEIN; GLUTAMIC ACID; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE INHIBITOR; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN BCL 2; PROTEIN C FOS; PROTEIN P50; SIRTUIN 2; TIP60 PROTEIN; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT;

AGING; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; BRAIN FUNCTION; CALCIUM SIGNALING; CELL SURVIVAL; DEGENERATIVE DISEASE; DOPAMINE RELEASE; DRUG EFFICACY; DRUG MECHANISM; EPIGENETICS; GENE EXPRESSION REGULATION; GENOTYPE ENVIRONMENT INTERACTION; HISTONE ACETYLATION; HISTONE MODIFICATION; HUMAN; HUNTINGTON CHOREA; LATENT INHIBITION; LEARNING; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MEMORY; NERVE CELL PLASTICITY; NEUROMODULATION; NEUROPATHOLOGY; NONHUMAN; PARKINSON DISEASE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REVIEW;

EID: 84876181160     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2013.00030     Document Type: Review

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