Effect of vascular endothelial growth factor receptor 2 antagonism on adiposity in obese mice

Journal of Molecular Endocrinology

Volumn 50, Issue 3, 2013, Pages 319-324

  Lijnen, H Roger ^a   Scroyen, Ilse ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Adipose tissue; Angiogenesis; Insulin; Obesity; VEGF; VEGF receptor

Indexed keywords

ADIPONECTIN; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUCOSE; INSULIN; MONOCLONAL ANTIBODY DC101; PROTEIN KINASE B; TRIACYLGLYCEROL; VASCULOTROPIN RECEPTOR 2;

ADIPOCYTE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD VESSEL DIAMETER; BODY WEIGHT; CONTROLLED STUDY; DENSITY; ENZYME PHOSPHORYLATION; GLUCOSE BLOOD LEVEL; HISTOCHEMISTRY; IN VIVO STUDY; INSULIN BLOOD LEVEL; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RECEPTOR BLOCKING; SUBCUTANEOUS FAT; TRIACYLGLYCEROL BLOOD LEVEL; WHITE ADIPOSE TISSUE;

EID: 84876168869     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-12-0244     Document Type: Article

References (23)

1. Bocci G, Danesi R, Marangoni G, Fioravanti A, Boggi U, Esposito I, Fasciani A, Boschi E, Campani D, Bevilacqua G et al. 2004 Antiangiogenic versus cytotoxic therapeutic approaches to human pancreas cancer: an experimental study with a vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor and gemcitabine. European Journal of Pharmacology 498 9-18. (doi:10.1016/j.ejphar.2004.07.062)
2. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C et al. 1996 Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380 435-439. (doi:10.1038/380435a0)
3. Castellot JJ Jr, Karnovsky MJ
4. Donato MT & Gomez-Lechon MJ 2012 Drug-induced liver steatosis and phospholipidosis: cell-based assays for early screening of drug candidates. Current Drug Metabolism 13 1160-1173. (doi:10.2174/ 138920012802850001)
5. Elias I, Franckhauser S, Ferre T, Vila L, Tafuro S, Munoz S, Roca C, Ramos D, Pujol A, Riu E et al. 2012 Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance. Diabetes 61 1801-1813.(doi:10.2337/db11-0832)
6. Fischer C, Jonckx B, Mazzone M, Zacchigna S, Loges S, Pattarini L, Chorianopoulos E, Liesenborghs L, Koch M, De Mol M et al. 2007 Anti-PIGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell 131 463-475.(doi:10.1016/ j.cell.2007.08.038)
7. Fukumura D, Ushiyama A, Duda DG, Xu L, Tam J, Krishna V, Chatterjee K, Garkavstev I. Jain RK 2003 Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. Circulation Research 93 88-97.(doi:10.1161/01.RES.0000099243.20096.FA)
8. Hemmeryck B, Loeckx D, Dresselaers T, Himmelreich U, Hoylaerts M
9. Kadambi A, Mouta Carreira C, Yun CO, Padera TP, Dolmans DE, Carmeliet P, Fukumura D & Jain RK 2001 Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A. Cancer Research 61 2404-2408.
10. Keskin U, Totan Y, Karadag R, Erdurmus M & Aydin B 2012 Inhibitory effects of SU5416, a selective vascular endothelial growth factor receptor tyrosine kinase inhibitor, on experimental corneal neovascularization. Ophthalmic Research 47 13-18.(doi:10.1159/000324994)
11. Laitinen L. 1987 Griffonia simplicifolia lectins bind specifically to endothelial cells and some epithelial cells in mouse tissue. Histochemical Journal 19 225-234.(doi:10.1007/BF01680633)
12. Prewett M, Huber J, Li Y, Santiago A, O'Connor W, King K, Overholser J, Hooper A, Pytowski B, Witte L et al. 1999 Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Research 59 5209-5218.
13. Rasmussen JG, Frobert O, Pilgaard L, Kastrup J, Simonson U, Zachar V & Fink T 2011 Prolonged hypoxic culture and trypsinization increase the pro-angiogenic potential of human adipose tissue-derived stem cells. Cytotherapy 13 318-328.(doi:10.3109/14653249.2010.506505)
14. Rupnick MA, Panigrahy D, Zhang CY, Dallabrida SM, Lowell BB, Langer R & Folkman MJ 2002 Adipose tissue mass can be regulated through the vasculature. PNAS 99 10730-10735.(doi:10.1073/pnas.162349799)
15. Scroyen I, Frederix L & Lijnen HR 2012 Axl deficiency does not affect adipogenesis or adipose tissue development. Obesity 20 1168-1173.(doi:10.1038/oby.2011.399)
16. Sun K, Wernstedt Asterholm I, Kusminski CM, Bueno AC, Wang ZV, Pollard JW, Brekken RA & Scherer PE 2012 Dichotomous effects of VEGF-A on adipose tissue dysfunction. PNAS 109 5874-5879.(doi:10.1073/pnas.1200447109)
17. Tam J, Duda DG, Perentes JY, Quadri RS, Fukumura D & Jain RK 2009 Blockade of VEGFR2 and not VEGF1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells. PLoS ONE 4 e4974.(doi:10.1371/journal.pone.0004974)
18. Van de Veire S, Stalmans I, Heindrycks F, Oura H, Tijeras-Raballand A, Schmidt T, Loges S, Albrecht I, Jonckx B, Vinckier S et al. 2010 Further pharmacological and genetic evidence for the efficacy of PIGF inhibition in cancer and eye disease. Cell 141 178-190(doi:10.1016/ j.cell.2010.02.039)
19. Van Hul M, Bauters D, Himmelreich U, Kindt N, Noppen B, Vanhove M & Lijnen HR 2012 Effect of gelatinase inhibition on adipogenesis and adipose tissue development. Clinical and Experimental Pharmacology & Physiology 39 49-56.(doi:10.1111/j.1440-1681.2011.05635.x)
20. Van Hul M, Lupu F, Dresselaers T, Buyse J & Lijnen HR 2012 Matrix metalloproteinase inhibition affects adipose tissue mass in obese mice. Clinical and Experimental Pharmacology & Physiology 39 544-550.(doi:10.1111/j.1440-1681.2012.05714.x)
21. Varzaneh FE, Shillabeer G, Wong KL & Lau DC 1994 Extracellular matrix components secreted by microvascular endothelial cells stimulate preadipocyte differentiation in vitro. Metabolism 43 906-912.(doi:10.1016/0026-0495(94)90275-5)
22. Voros G, Maquoi E, Demeulemeester D, Clerx N, Collen D & Lijnen R 2005 Modulation of angiogenesis during adipose tissue development in murine models of obesity. Endocrinology 146 4545-4554.(doi:10.1210/ en.2005-0532)
23. Wada H, Satoh H, Kitaoka S, Ono K, Morimoto T, Kawamura T, Nakano T, Fujita M, Kita T, Shimatsu A et al. 2010 Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance. Atherosclerosis 208 512-517.(doi:10.1016/ j.atherosclerosis.2009.07.045)