Collagen gentamicin for prevention of sternal wound infection: Effective or not?

Thoracic and Cardiovascular Surgeon

Volumn 61, Issue 3, 2013, Pages 185-193

  Friberg, Örjan ^a   Bodin, Lennart ^b  

^a ÖREBRO UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

complications; statistics; surgery; wound healing; wound infection

Indexed keywords

CLINDAMYCIN; CLOXACILLIN; COLLAGEN GENTAMICIN; COLLAGEN SPONGE; COLLATAMP; GENTAMICIN; UNCLASSIFIED DRUG;

ADULT; ANTIBIOTIC THERAPY; ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; HEART SURGERY; HUMAN; INFECTION PREVENTION; INFECTION RISK; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; STERNAL WOUND INFECTION; SURGICAL INFECTION;

ADMINISTRATION, TOPICAL; AGED; ANTI-BACTERIAL AGENTS; CARDIAC SURGICAL PROCEDURES; COLLAGEN; DRUG COMBINATIONS; FEMALE; FOLLOW-UP STUDIES; GENTAMICINS; HEART DISEASES; HUMANS; INCIDENCE; MALE; ODDS RATIO; RETROSPECTIVE STUDIES; RISK FACTORS; STERNOTOMY; STERNUM; SURGICAL SPONGES; SURGICAL WOUND INFECTION; SWEDEN; TREATMENT OUTCOME;

EID: 84876158633     PISSN: 01716425     EISSN: 14391902     Source Type: Journal    
DOI: 10.1055/s-0032-1322626     Document Type: Article

References (20)

1. Kreter B., Woods M. Antibiotic prophylaxis for cardiothoracic operations. Meta-analysis of thirty years of clinical trials. J Thorac Cardiovasc Surg: 1992; 104 3 590 599
2. Friberg Ö, Jones I., Sjöberg L., Söderquist B., Vikerfors T., Källman J. Antibiotic concentrations in serum and wound fluid after local gentamicin or intravenous dicloxacillin prophylaxis in cardiac surgery. Scand J Infect Dis: 2003; 35 4 251 254 (Pubitemid 36806034)
3. Friberg Ö, Svedjeholm R., Söderquist B., Granfeldt H., Vikerfors T., Källman J. Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. Ann Thorac Surg: 2005; 79 1 153 161, discussion 161-162 (Pubitemid 40037458)
4. Friberg Ö, Dahlin L. G., Levin L. A., et al. Cost effectiveness of local collagen-gentamicin as prophylaxis for sternal wound infections in different risk groups. Scand Cardiovasc J: 2006; 40 2 117 125
5. Friberg O., Dahlin L-G, Källman J., Kihlström E., Söderquist B., Svedjeholm R. Collagen-gentamicin implant for prevention of sternal wound infection; long-term follow-up of effectiveness. Interact Cardiovasc Thorac Surg: 2009; 9 3 454 458
6. Avato J. L., Lai K. K. Impact of postdischarge surveillance on surgical-site infection rates for coronary artery bypass procedures. Infect Control Hosp Epidemiol: 2002; 23 7 364 367 (Pubitemid 34831377)
7. Mangram A. J., Horan T. C., Pearson M. L., Silver L. C., Jarvis W. R. Hospital Infection Control Practices Advisory Committee Guideline for prevention of surgical site infection, 1999. Infect Control Hosp Epidemiol: 1999; 20 4 250 278, quiz 279-280
8. Wilson A. P., Treasure T., Sturridge M. F., Grüneberg R. N. A scoring method (ASEPSIS) for postoperative wound infections for use in clinical trials of antibiotic prophylaxis. Lancet: 1986; 1 8476 311 313
9. Blackwell M., Iacus S., King G., Porro G. CEM: Coarsened Exact Matching in Stata. Stata Journal: 2009; 9 524 546
10. Schimmer C., Özkur M., Sinha B., et al. Gentamicin-collagen sponge reduces sternal wound complications after heart surgery: a controlled, prospectively randomized, double-blind study. J Thorac Cardiovasc Surg: 2012; 143 1 194 200
11. Eklund A. M., Valtonen M., Werkkala K. A. Prophylaxis of sternal wound infections with gentamicin-collagen implant: randomized controlled study in cardiac surgery. J Hosp Infect: 2005; 59 2 108 112 (Pubitemid 40058036)
12. Bennett-Guerrero E., Ferguson T. B. Jr, Lin M., et al. SWIPE-1 Trial Group Effect of an implantable gentamicin-collagen sponge on sternal wound infections following cardiac surgery: a randomized trial. JAMA: 2010; 304 7 755 762
13. Friberg Ö, Svedjeholm R., Källman J., Söderquist B. Incidence, microbiological findings, and clinical presentation of sternal wound infections after cardiac surgery with and without local gentamicin prophylaxis. Eur J Clin Microbiol Infect Dis: 2007; 26 2 91 97 (Pubitemid 46217756)
14. Bennett-Guerrero E., Pappas T. N., Koltun W. A., et al. SWIPE 2 Trial Group Gentamicin-collagen sponge for infection prophylaxis in colorectal surgery. N Engl J Med: 2010; 363 11 1038 1049
15. Innocoll. Colorectal and Cardiac Training Videos [Homepage on the Internet]. Available at: http://innocollinc.com/collarx-gentamicin-surgical- implant.html. Accessed December 14, 2011
16. Dhadwal K., Al-Ruzzeh S., Athanasiou T., et al. Comparison of clinical and economic outcomes of two antibiotic prophylaxis regimens for sternal wound infection in high-risk patients following coronary artery bypass grafting surgery: a prospective randomised double-blind controlled trial. Heart: 2007; 93 9 1126 1133 (Pubitemid 47310996)
17. Jonkers D., Elenbaas T., Terporten P., Nieman F., Stobberingh E. Prevalence of 90-days postoperative wound infections after cardiac surgery. Eur J Cardiothorac Surg: 2003; 23 1 97 102 (Pubitemid 35472105)
18. Risnes I., Abdelnoor M., Lundblad R., Baksaas S. T., Svennevig J. L. Sternal wound closure in patients undergoing open-heart surgery: a prospective randomized study comparing intracutaneous and zipper techniques. Eur J Cardiothorac Surg: 2002; 22 2 271 277 (Pubitemid 34831869)
19. Wilson A. PR, Hodgson B., Liu M., et al. Reduction in wound infection rates by wound surveillance with postdischarge follow-up and feedback. Br J Surg: 2006; 93 5 630 638
20. Blackstone E. H. Comparing apples and oranges. J Thorac Cardiovasc Surg: 2002; 123 1 8 15