Acupuncture's cardiovascular actions: A mechanistic perspective

Medical Acupuncture

Volumn 25, Issue 2, 2013, Pages 101-113

  Longhurst, John ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autonomic Nervous System; Blood Pressure; Integrative Physiology; Parasympathetic Nervous System; Somatic Afferents; Sympathetic Nervous System

Indexed keywords

NEUROTRANSMITTER;

ACUPUNCTURE; BLOOD PRESSURE; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR REFLEX; CENTRAL NERVOUS SYSTEM; ELECTROACUPUNCTURE; EXPERIMENTAL STUDY; HEART MUSCLE ISCHEMIA; HUMAN; HYPOTHALAMUS; MESENCEPHALON; MUSCLE ISCHEMIA; NONHUMAN; PRIORITY JOURNAL; REVIEW; SENSORY NERVE; SENSORY STIMULATION; THORACIC SPINAL CORD;

EID: 84876158106     PISSN: 19336586     EISSN: 19336594     Source Type: Journal    
DOI: 10.1089/acu.2013.0960     Document Type: Review

References (84)

1. Han J-S, Ho YS. Global trends and performances of acupuncture research. Neurosci Biobehav Rev. 2011;35(3):680-687.
2. World Health Organization. Acupuncture: Review and Analysis of Reports on Controlled Clinical Trials [serial online]. 2003. Online document at: http://apps.who.int/medicinedocs/pdf/s4926e/s4926e.pdf Accessed February 12, 2013.
3. Han J-S. Acupuncture analgesia: Areas of consensus and controversy. Pain. 2011;152(3):S41-S81.
4. Li P, Yao T. Pressor effect of electroacupuncture or somatic nerve stimulation on experimental hypotension. In: Mechanism of the Modulatory Effect of Acupuncture on Abnormal Cardiovascular Functions. Shanghai, China: Shanghai Medical University Press; 1992:32-40.
5. Ballegaard S, Meyer CN, Trojaborg W. Acupuncture in angina pectoris: Does acupuncture have a specific effect? J Intern Med. 1991;229(4):357-362.
6. Ballegaard S, Pedersen F, Pietersen A, et al. Effects of acupuncture in moderate stable angina pectoris: A controlled study. J Intern Med. 1990;227(1):25-30.
7. Ballegaard S, Jensen G, Pedersen F, et al. Acupuncture in severe, stable angina pectoris: A randomized trial. Acta Med Scand. 1986;220(4):307-313.
8. Richter A, Herlitz J, Hjalmarson A. Effect of acupuncture in patients with angina pectoris. Eur Heart J. 1991;12(2): 175-178.
9. Li P, Pitsillides KF, Rendig SV, et al. Reversal of reflexinduced myocardial ischemia by median nerve stimulation: A feline model of electroacupuncture. Circulation. 1998;97(12): 1186-1194.
10. Pitsillides KF, Longhurst JC. An ultrasonic system for measurement of absolute myocardial thickness using a single transducer. Am J Physiol. 1995;37(3):H1358-H1367.
11. Li P, Longhurst JC. Neural mechanism of electroacupuncture's hypotensive effects. Auton Neurosci. 2010;157:24-30.
12. Chao DM, Shen LL, Tjen-A-Looi SC, et al. Naloxone reverses inhibitory effect of electroacupuncture on sympathetic cardiovascular reflex responses. Am J Physiol. 1999;276(45): H2127-H2134.
13. Tjen-A-Looi SC, Li P, Longhurst JC. Midbrain vIPAG inhibits rVLM cardiovascular sympathoexcitatory responses during acupuncture. Am J Physiol. 2006;290(6):H2543-H2553.
14. Tjen-A-Looi SC, Li P, Longhurst JC. Prolonged inhibition of rostral ventral lateral medullary premotor sympathetic neuron by electroacupuncture in cats. Auton Neurosci. 2003;106(2): 119-131.
15. Tjen-A-Looi SC, Li P, Longhurst JC. Medullary substrate and differential cardiovascular response during stimulation of specific acupoints. Am J Physiol. 2004;287(4):R852-R862.
16. Tjen-A-Looi SC, Li P, Longhurst JC. Role of medullary GABA, opioids, and nociceptin in prolonged inhibition of cardiovascular sympathoexcitatory reflexes during electroacupuncture in cats. Am J Physiol. 2007;293(6):H3627-H3635.
17. Huangfu D, Li P. Role of nucleus raphe obscurus in the inhibition of defence reaction by deep peroneal nerve stimulation. Chin J Physiol Sci. 1988;4(1):77-83.
18. Zhang Z, Lin RJ, Fan W, et al. Involvement of 5-HT and GABA in the inhibition induced by NRO stimulation of rVLM-defense-reaction-related neurons. Chin J Physiol. 1992;8(3):208-215.
19. Guo Z-L, Moazzami AR, Longhurst JC. Electroacupuncture induces c-Fos expression in the rostral ventrolateral medulla and periaqueductal gray in cats: Relation to opioid containing neurons. Brain Res. 2004;1030(1):103-115.
20. Li P, Tjen-A-Looi SC, Guo ZL, et al. Long-loop pathways in cardiovascular electroacupuncture responses. J Appl Physiol. 2009;106(2):620-630.
21. Li P, Tjen-A-Looi SC, Longhurst JC. Rostral ventrolateral medullary opioid receptor subtypes in the inhibitory effect of electroacupuncture on reflex autonomic response in cats. Autonomic Neuroscience. 2001;89(1-2):38-47.
22. Guo Z, Longhurst J. Expression of c-Fos in arcuate nucleus induced by electroacupuncture: Relations to neurons containing opioids and glutamate. Brain Res. 2007;1166:65-76.
23. Zhou W, Fu L-W, Guo ZL, et al. Role of glutamate in rostral ventrolateral medulla in acupuncture-related modulation of visceral reflex sympathoexcitation. Am J Physiol. 2007;292(4):H1868-H1875.
24. Cheung L, Li P, Wong C. The Mechanism of Acupuncture Therapy and Clinical Case Studies. New York: Taylor and Francis; 2001.
25. Li P, Tjen-A-Looi SC, Longhurst JC. Acupuncture's role in cardiovascular homeostasis. In: Xia Y, Dong G, Wu G-C, eds. Current Research in Acupuncture. New York: Springer Science + Business Media; 2012:457-486.
26. Guo Z-L, Longhurst JC. Activation of reciprocal pathways between arcuate nucleus and ventrolateral periaqueductal gray during electroacupuncture: Involvement of VGLUT3. Brain Res. 2010;1360:77-88.
27. Li P, Tjen-A-Looi SC, Guo ZL, et al. An arcuate-ventrolateral periaqueductal gray reciprocal circuit participates in electroacupuncture cardiovascular inhibition. Auton Neurosci. 2010;158(1-2):13-23.
28. Li P, Tjen-A-Looi SC, Longhurst JC. Excitatory projections from arcuate nucleus to ventrolateral periaqueductal gray in electroacupuncture inhibition of cardiovascular reflexes. Am J Physiol. 2006;209(6):H2535-H2542.
29. Guo Z-L, Moazzami A, Tjen-A-Looi S, et al. Responses of opioid and serotonin containing medullary raphe neurons to electroacupuncture. Brain Res. 2008;1229:125-136.
30. Li P, Tjen-A-Looi SC, Longhurst JC. Nucleus raphe pallidus participates in midbrain-medullary cardiovascular sympathoinhibition during electroacupuncture. Am J Physiol Regul Integr Comp Physiol. 2010;299(5):R1369- R1376.
31. Fu L-W, Longhurst C. Electroacupuncture modulates vlPAG release of GABA through presynaptic cannabinoid CB1 receptor. J Appl Physiol. 2009;106(6):1800-1809.
32. Tjen-A-Looi SC, Li P, Longhurst JC. Processing cardiovascular information in the vlPAG during electroacupuncture in rats: Roles of endocannabinoids and GABA. J Appl Physiol. 2009;106(6):1793-1799.
33. Moazzami A, Tjen-A-Looi SC, Guo Z-L, et al. Serotonergic projection from nucleus raphe pallidus to rostral ventrolateral medulla modulates cardiovascular reflex responses during acupuncture. J Appl Physiol. 2010;108(5):1336-1346.
34. Crisostomo M, Li P, Tjen-A-Looi SC, et al. Nociceptin in rVLM mediates electroacupuncture inhibition of cardiovascular reflex excitatory response in rats. J Appl Physiol. 2005;98(6):2056-2063.
35. Zhou W, Hsiao I, Lin V, et al. Modulation of cardiovascular excitatory responses in rats by transcutaneous magnetic stimulation: Role of the spinal cord. J Appl Physiol. 2006;100(3):926-932.
36. Zhou W, Mahajan A, Longhurst JC. Spinal nociceptin mediates electroacupuncture-related modulation of visceral sympathoexcitatory reflex responses in rats. Am J Physiol. 2009;297(2):H859-H865.
37. Xiao YF, Lin SX, Deng ZF, et al. Mechanism of pressor effect of electroacupuncture on nitroprusside hypotension in dogs [in Chinese]. Acta Physio Sin. 1983;35:257-263.
38. Syuu Y, Matsubara H, Hosogi S, et al. Pressor effect of electroacupuncture on hemorrhagic hypotension. Am J Physiol Heart Circ Physiol. 2003;285(6):R1446-R1452.
39. Coleridge H, Coleridge J. Cardiovascular afferents involved in regulation of peripheral vessels. Annu Rev Physiol. 1980;42: 413-427.
40. Fu L-W, Longhurst JC. Reflex pressor response to arterial phenylbiguanide: Role of abdominal sympathetic visceral afferents. Am J Physiol. 1998;275(6):H2025-H2035.
41. Jeggo R, Kellett D, Wang Y, et al. The role of central 5-HT3 receptors in vagal reflex inputs to neurones in the nucleus tractus solitarius of anaesthetized rats. J Physiol. 2005;566(3): 939-953.
42. Calkins H, Zipes DP. Hypotension and syncope. In: Libby P, Bonow RO, Mann D, et al., eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. Philadelphia: Saunders Elsevier; 2008:975-984.
43. Kapa S, Somers VK. Cardiovascular Manifestations of Autonomic Disorders. In: Libby P, Bonow RO, Mann D, et al., eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. Philadelphia: Saunders Elsevier; 2008:2171-2183.
44. Guo Z-L, Li M, Longhurst J. Nucleus ambiguus cholinergic neurons activated by acupuncture: Relation to enkephalin. Brain Res. 2012;1442:25-35.
45. Tjen-A-Looi SC, Li P, Li M, et al. Modulation of cardiopulmonary depressor reflex in nucleus ambiguus by electroacupuncture: Roles of opioids and gamma aminobutyric acid. Am J Physiol. 2012;302(7):R833-R844.
46. Tjen-A-Looi SC, Hsiao AF, Longhurst JC. Central and peripheral mechanisms underlying gastric distention inhibitory reflex responses in hypercapnic-acidotic rats. Am J Physiol. 2011;300(3):H1003-H1012.
47. Tjen-A-Looi SC, Li P, Hsiao A-F, et al. Central processing by electroacupuncture of cardiovascular reflex vasodepression [abstr]. FASEB J. 2012;26(702):2.
48. Longhurst J.C. Defining meridians: A modern basis of understanding. J Acupunct Meridian Stud. 2010;3(2):67-74.
49. Yu AS, Ahao YX, Li XL, et al. Morphological research in Neiguan (Pe 6)'s three dimensional structure. Shanghai J Acup Moxibustion. 1996;15:30-31.
50. Chiang CY, Chang HT, Cicero TJ, et al. Peripheral afferent pathway for acupuncture analgesia. Scientia Sinica. 1973;16: 210-217.
51. Han J-S. The Neurochemical Basis of Pain Relief by Acupuncture. Beijing: China Medical and Pharmaceutical Technology; 1987.
52. Kline RL, Yeung KY, Calaresu FR. Role of somatic nerves in the cardiovascular responses to stimulation of an acupuncture point in anesthetized rabbits. Exp Neurol. 1978;61(3):561-570.
53. Toda I, Ichioka M. Electroacupuncture: Relations between forelimb afferent impulses and suppression of jaw-opening reflex in the rat. Exp Neurol. 1978;61(2):465-470.
54. Pomeranz B, Paley D. Electroacupuncture hyperalgesia is mediated by afferent nerve impulses: An electrophysiological study in mice. Exp Neurol. 1979;66(2):398-402.
55. Lu G-W. Neurobiologic research on acupuncture in China as exemplified by acupuncture analgesia. Anesth Analg. 1983;62(3):335-340.
56. Tjen-A-Looi SC, Fu L-W, Zhou W, et al. Role of unmyelinated fibers in electroacupuncture cardiovascular responses. Auton Neurosci. 2005;118(1-2):43-50.
57. Zhou W, Fu L-W, Tjen-A-Looi SC, et al. Afferent mechanisms underlying stimulation modality-related modulation of acupuncture-related cardiovascular responses. J Appl Physiol. 2005;98(3):872-880.
58. Wang JQ, Mao L, Han JS. Comparison of the antinociceptive effects induced by electroacupuncture and transcutaneous electrical nerve stimulation in the rat. Int J Neurosci. 1992;65(1-4):117-129.
59. Huangdi Neijing: The Yellow Emperor's Inner Canon: Basic Questions. Beijing: Renmin Weisheng Press; 1983.
60. Jia Zhenjiu Yi Jing: A-Z Classic of Acupuncture and Moxibustion. Beijing: Renmin Weisheng Press; 1979.
61. The Academy of Traditional Chinese Medicine. An Outline of Chinese Acupuncture. Beijing: Foreign Languages Press; 1975.
62. Ulett G, Han S, Han J-S. Electroacupuncture: Mechanisms and clinical application. Biol Psychiatry. 1998;44(2):129-138.
63. Research Group of Acupuncture Analgesia BMC. The effect of acupuncture on the human skin pain threshold. Chin Med J. 1973;3:151-157.
64. Zhang H, Bian ZX, Lin. Are acupoints specific for diseases? A systematic review of the randomized controlled trials with sham acupuncture controls. Chin Med. 2010;5(1):1-7.
65. Mayer DJ. Acupuncture: An evidence-based review of the clinical literature. Annu Rev Med. 2000;51:49-63.
66. Li P, Longhurst JC. Long-lasting inhibitory effect of EA on blood pressure in patients with mild to moderate hypertension [abstr]. Soc Neurosci. 2007;37.
67. Li P, Ayannusi O, Reed C, et al. Inhibitory effect of electroacupuncture (EA) on the pressor response induced by exercise stress. Clinical Autonomic Research. 2004;14(3):182-188.
68. Li M, Tjen ALS, Guo ZL, et al. Repetitive electroacupuncture causes prolonged increased met-enkephalin expression in the rVLM of conscious rats. Auton Neurosci. 2012;170(1-2):30-35.
69. Andersson SA, Hansson G, Homgren E, et al. Evaluation of the pain suppressive effect of different frequencies of peripheral electrical stimulation in chronic pain conditions. Acta Orthop Scand. 1976;47(2):149-157.
70. Ng L, Katims J, Lee M. Acupuncture. In: Aronoff G, ed. Evaluation and Treatment of Chronic Pain. Baltimore, MD: Williams & Wilkins; 1992:291-298.
71. Thomas M, Lundeberg T. Importance of modes of acupuncture in the treatment of chronic nociceptive low back pain. Acta Anaesthesiol Scand. 1994;38(1):63-69.
72. Ulett G. Acupuncture. In: Tollison C, Kriegel M, eds. Interdisciplinary Rehabilitation of Low Back Pain. Baltimore, MD: Williams & Wilkins; 1989:85-100.
73. Li M, Tjen-A-Looi S, Choi E, et al. Cholecystokinin antagonizes opioid function during electroacupuncture modulation of reflex hypertension in rats [abstr]. FASEB J. 2012;26(1091):74.
74. Larsson L, Rehfeld J. Localization and molecular heterogeneity of cholecystokinin in the central and peripheral nervous system. Brain Res. 1979;165(2):201-218.
75. Ingram S, Krause II R, Baldino Jr F, et al. Neuronal localization of cholecystokinin mRNA in the rat brain by using in situ hybridization histochemistry. J Comp Neurol. 1989;287(2): 260-272.
76. Mantyh PW, Hunt SP. Evidence for cholecystokinin-like immunoreactive neurons in the rat medulla oblongata which project to the spinal cord. Brain Res. 1983;291(1): 49-54.
77. Mercer LD, Le VQ, Nunan J, et al. Direct visualization of cholecystokinin subtype2 receptors in rat central nervous system using anti-peptide antibodies. Neurosci Lett. 2004;293(3): 167-170.
78. Noble F, Derrien M, Roques BP. Modulation of opioid antinociception by CCK at the supraspinal level: Evidence of regulatory mechanisms between CCK and enkephalin systems in the control of pain. Br J Pharmacol. 1993;109(4):1064- 1070.
79. Tang NM, Dong HW, Wang XM, et al. Cholecystokinin antisense RNA increases the analgesic effect induced by electroacupuncture or low dose morphine: Conversion of low responder rats to high responders. Brain Res Mol Brain Res. 1997;71(1):71-80.
80. Zhao ZQ. Neural mechanism underlying acupuncture analgesia. Prog Neurobiol. 2008;85(4):355-375.
81. Heinricher MM, McGaraughty S, Tortorici V. Circuitry underlying antiopioid actions of cholecystokinin within the rostral ventromedial medulla. J Neurophysiol. 2001;85(1): 280-286.
82. Kim S, Moon H, Park J, et al. The maintenance of individual differences in the sensitivity of acute and neuropathic pain behaviors to electroacupuncture in rats. Brain Res Bull. 2007;74(5):357-360.
83. Ko ES, Kim SK, Kim JT, et al. The difference in mRNA expressions of hypothalamic CCK and CCK-A and-B receptors between responder and non-responder rats to high frequency electroacupuncture analgesia. Peptides. 2006; 27(7):1841-1845.
84. Lee G, Rho S, Shin M, et al. The association of cholecystokinin-A receptor expression with the responsiveness of electroacupuncture analgesic effects in rat. Neurosci Lett. 2002;325(1):17-20.