메뉴 건너뛰기




Volumn 13, Issue 3, 2013, Pages 295-307

Relevance of molecular characterization of circulating tumor cells in breast cancer in the era of targeted therapies

Author keywords

biomarkers; breast cancer; circulating tumor cells; CTC detection methods; epithelial mesenchymal transition; liquid biopsy; molecular characterization; stem cell phenotype; targeted therapies

Indexed keywords

AFATINIB; AFLIBERCEPT; CARCINOEMBRYONIC ANTIGEN; CD45 ANTIGEN; CYTOKERATIN 18; CYTOKERATIN 19; DNA TOPOISOMERASE (ATP HYDROLYSING); EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPITHELIAL CELL ADHESION MOLECULE; ESTROGEN RECEPTOR; EVEROLIMUS; INIPARIB; LAPATINIB; MAMMAGLOBIN; MAYTANSINE; MUCIN 1; NERATINIB; OLAPARIB; PAZOPANIB; PERTUZUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PROGESTERONE RECEPTOR; PROTEIN KINASE B; SUNITINIB; TRASTUZUMAB;

EID: 84876142901     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/erm.13.7     Document Type: Review
Times cited : (32)

References (104)
  • 2
    • 2942538264 scopus 로고    scopus 로고
    • Dissecting the metastatic cascade
    • Pantel K, Brakenhoff RH. Dissecting the metastatic cascade. Nat. Rev. Cancer 4(6), 448-456 (2004
    • (2004) Nat. Rev. Cancer , vol.4 , Issue.6 , pp. 448-456
    • Pantel, K.1    Brakenhoff, R.H.2
  • 3
    • 37349079197 scopus 로고    scopus 로고
    • Systemic spread is an early step in breast cancer
    • Husemann Y, Geigl JB, Schubert F et al. Systemic spread is an early step in breast cancer. Cancer Cell 13(1), 58-68 (2008
    • (2008) Cancer Cell , vol.13 , Issue.1 , pp. 58-68
    • Husemann, Y.1    Geigl, J.B.2    Schubert, F.3
  • 4
    • 37549002543 scopus 로고    scopus 로고
    • Isolation of rare circulating tumour cells in cancer patients by microchip technology
    • Nagrath S, Sequist LV, Maheswaran S et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450(7173), 1235-1239 (2007
    • (2007) Nature , vol.450 , Issue.7173 , pp. 1235-1239
    • Nagrath, S.1    Sequist, L.V.2    Maheswaran, S.3
  • 5
    • 4143094988 scopus 로고    scopus 로고
    • Circulating tumor cells, disease progression, and survival in metastatic breast cancer
    • Cristofanilli M, Budd GT, Ellis MJ et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N. Engl. J. Med. 351(8), 781-791 (2004
    • (2004) N. Engl. J. Med. , vol.351 , Issue.8 , pp. 781-791
    • Cristofanilli, M.1    Budd, G.T.2    Ellis, M.J.3
  • 6
    • 20144385756 scopus 로고    scopus 로고
    • Circulating tumor cells: A novel prognostic factor for newly diagnosed metastatic breast cancer
    • Cristofanilli M, Hayes DF, Budd GT et al. Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. J. Clin. Oncol. 23(7), 1420-1430 (2005
    • (2005) J. Clin. Oncol. , vol.23 , Issue.7 , pp. 1420-1430
    • Cristofanilli, M.1    Hayes, D.F.2    Budd, G.T.3
  • 7
    • 57049162148 scopus 로고    scopus 로고
    • Circulating tumor cell detection predicts early metastatic relapse after neoadjuvant chemotherapy in large operable and locally advanced breast cancer in a Phase II randomized trial
    • Pierga JY, Bidard FC, Mathiot C et al. Circulating tumor cell detection predicts early metastatic relapse after neoadjuvant chemotherapy in large operable and locally advanced breast cancer in a Phase II randomized trial. Clin. Cancer Res. 14(21), 7004-7010 (2008
    • (2008) Clin. Cancer Res. , vol.14 , Issue.21 , pp. 7004-7010
    • Pierga, J.Y.1    Bidard, F.C.2    Mathiot, C.3
  • 8
    • 84876101138 scopus 로고    scopus 로고
    • Prognostic relevance of circulating tumor cells in the peripheral blood of primary breast cancer patients
    • 8-12 December 2010 (Abstract 503
    • Rack B, Schindlbeck C, Schneeweiss A et al: Prognostic relevance of circulating tumor cells in the peripheral blood of primary breast cancer patients. Presented at: 33rd San Antonio Breast Cancer Symposium. TX, USA, 8-12 December 2010 (Abstract 503
    • 33rd San Antonio Breast Cancer Symposium. TX, USA
    • Rack, B.1    Schindlbeck, C.2    Schneeweiss, A.3
  • 9
    • 77951707834 scopus 로고    scopus 로고
    • Single circulating tumor cell detection and overall survival in nonmetastatic breast cancer
    • Bidard FC, Mathiot C, Delaloge S et al. Single circulating tumor cell detection and overall survival in nonmetastatic breast cancer. Ann. Oncol. 21(4), 729-733 (2010
    • (2010) Ann. Oncol. , vol.21 , Issue.4 , pp. 729-733
    • Bidard, F.C.1    Mathiot, C.2    Delaloge, S.3
  • 10
    • 84863105627 scopus 로고    scopus 로고
    • Circulating tumour cells in non-metastatic breast cancer: A prospective study
    • Lucci A, Hall CS, Lodhi AK et al. Circulating tumour cells in non-metastatic breast cancer: a prospective study. Lancet Oncol. 13(7), 688-695 (2012
    • (2012) Lancet Oncol , vol.13 , Issue.7 , pp. 688-695
    • Lucci, A.1    Hall, C.S.2    Lodhi, A.K.3
  • 11
    • 84867556074 scopus 로고    scopus 로고
    • Meta-analysis of the prognostic value of circulating tumor cells in breast cancer
    • Zhang L, Riethdorf S, Wu G et al. Meta-analysis of the prognostic value of circulating tumor cells in breast cancer. Clin. Cancer Res. 18(20), 5701-5710 (2012
    • (2012) Clin. Cancer Res. , vol.18 , Issue.20 , pp. 5701-5710
    • Zhang, L.1    Riethdorf, S.2    Wu, G.3
  • 12
    • 58249083495 scopus 로고    scopus 로고
    • Micrometastatic spread in breast cancer: Detection, molecular characterization and clinical relevance
    • Fehm T, Muller V, Alix-Panabières C, Pantel K. Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance. Breast Cancer Res. 10(Suppl. 1), S1 (2008
    • (2008) Breast Cancer Res , vol.10 , Issue.SUPPL. 1
    • Fehm, T.1    Muller, V.2    Alix-Panabières, C.3    Pantel, K.4
  • 13
    • 33745455993 scopus 로고    scopus 로고
    • Isolation by size of epithelial tumor cells in peripheral blood of patients with breast cancer: Correlation with real-time reverse transcriptase-polymerase chain reaction results and feasibility of molecular analysis by laser microdissection
    • Pinzani P, Salvadori B, Simi L et al. Isolation by size of epithelial tumor cells in peripheral blood of patients with breast cancer: correlation with real-time reverse transcriptase-polymerase chain reaction results and feasibility of molecular analysis by laser microdissection. Hum. Pathol. 37(6), 711-718 (2006
    • (2006) Hum. Pathol. , vol.37 , Issue.6 , pp. 711-718
    • Pinzani, P.1    Salvadori, B.2    Simi, L.3
  • 14
    • 33646710101 scopus 로고    scopus 로고
    • Tumor cell detection in peripheral blood and bone marrow
    • Zach O, Lutz D. Tumor cell detection in peripheral blood and bone marrow. Curr. Opin. Oncol. 18(1), 48-56 (2006
    • (2006) Curr. Opin. Oncol. , vol.18 , Issue.1 , pp. 48-56
    • Zach, O.1    Lutz, D.2
  • 15
    • 34347353063 scopus 로고    scopus 로고
    • Circulating tumor cells (CTC) detection: Clinical impact and future directions
    • Paterlini-Brechot P, Benali NL. Circulating tumor cells (CTC) detection: clinical impact and future directions. Cancer Lett. 253(2), 180-204 (2007
    • (2007) Cancer Lett , vol.253 , Issue.2 , pp. 180-204
    • Paterlini-Brechot, P.1    Benali, N.L.2
  • 16
    • 33746754763 scopus 로고    scopus 로고
    • Prognostic significance of circulating tumour cells enumerated after filtration enrichment in early and metastatic breast cancer patients
    • Wong NS, Kahn HJ, Zhang L et al. Prognostic significance of circulating tumour cells enumerated after filtration enrichment in early and metastatic breast cancer patients. Breast Cancer Res. Treat. 99(1), 63-69 (2006
    • (2006) Breast Cancer Res. Treat. , vol.99 , Issue.1 , pp. 63-69
    • Wong, N.S.1    Kahn, H.J.2    Zhang, L.3
  • 17
    • 61449182121 scopus 로고    scopus 로고
    • Principles of cancer therapy: Oncogene and nononcogene addiction
    • Luo J, Solimini NL, Elledge SJ. Principles of cancer therapy: oncogene and nononcogene addiction. Cell 136(5), 823-837 (2009
    • (2009) Cell , vol.136 , Issue.5 , pp. 823-837
    • Luo, J.1    Solimini, N.L.2    Elledge, S.J.3
  • 18
    • 3042552362 scopus 로고    scopus 로고
    • HER-2 gene amplification can be acquired as breast cancer progresses
    • Meng S, Tripathy D, Shete S et al. HER-2 gene amplification can be acquired as breast cancer progresses. Proc. Natl Acad. Sci. USA 101(25), 9393-9398 (2004
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , Issue.25 , pp. 9393-9398
    • Meng, S.1    Tripathy, D.2    Shete, S.3
  • 19
    • 84860356499 scopus 로고    scopus 로고
    • Biomarkers characterization of circulating tumour cells in breast cancer patients
    • Nadal R, Fernandez A, Sanchez-Rovira P et al. Biomarkers characterization of circulating tumour cells in breast cancer patients. Breast Cancer Res. 14(3), R71 (2012
    • (2012) Breast Cancer Res , vol.14 , Issue.3
    • Nadal, R.1    Fernandez, A.2    Sanchez-Rovira, P.3
  • 20
    • 77951740458 scopus 로고    scopus 로고
    • Detection and HER2 expression of circulating tumor cells: Prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial
    • Riethdorf S, Muller V, Zhang L et al. Detection and HER2 expression of circulating tumor cells: prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial. Clin. Cancer Res. 16(9), 2634-2645 (2010
    • (2010) Clin. Cancer Res. , vol.16 , Issue.9 , pp. 2634-2645
    • Riethdorf, S.1    Muller, V.2    Zhang, L.3
  • 21
    • 77449088191 scopus 로고    scopus 로고
    • Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells
    • Fehm T, Hoffmann O, Aktas B et al. Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells. Breast Cancer Res. 11(4), R59 (2009
    • (2009) Breast Cancer Res. , vol.11 , Issue.4
    • Fehm, T.1    Hoffmann, O.2    Aktas, B.3
  • 22
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after adjuvant chemotherapy in HER2- positive breast cancer
    • Herceptin Adjuvant (HERA) Trial Study Team
    • Piccart-Gebhart MJ, Procter M, Leyland-Jones B et al.; Herceptin Adjuvant (HERA) Trial Study Team. Trastuzumab after adjuvant chemotherapy in HER2- positive breast cancer. N. Engl. J. Med. 353(16), 1659-1672 (2005
    • (2005) N. Engl. J. Med. , vol.353 , Issue.16 , pp. 1659-1672
    • Piccart-Gebhart, M.J.1    Procter, M.2    Leyland-Jones, B.3
  • 23
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • Ciardiello F, Tortora G. EGFR antagonists in cancer treatment. N. Engl. J. Med. 358(11), 1160-1174 (2008
    • (2008) N. Engl. J. Med. , vol.358 , Issue.11 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2
  • 24
    • 42549138379 scopus 로고    scopus 로고
    • Targeted therapy of cancer: New roles for pathologists in identifying GISTs and other sarcomas
    • Antonescu CR. Targeted therapy of cancer: new roles for pathologists in identifying GISTs and other sarcomas. Mod. Pathol. 21(Suppl. 2), S31-S36 (2008
    • (2008) Mod. Pathol. , vol.21 , Issue.SUPPL. 2
    • Antonescu, C.R.1
  • 25
    • 47949114668 scopus 로고    scopus 로고
    • Detection of mutations in EGFR in circulating lung-cancer cells
    • Maheswaran S, Sequist LV, Nagrath S et al. Detection of mutations in EGFR in circulating lung-cancer cells. N. Engl. J. Med. 359(4), 366-377 (2008
    • (2008) N. Engl. J. Med. , vol.359 , Issue.4 , pp. 366-377
    • Maheswaran, S.1    Sequist, L.V.2    Nagrath, S.3
  • 26
    • 84864302254 scopus 로고    scopus 로고
    • Trastuzumab decreases the incidence of clinical relapses in patients with early breast cancer presenting chemotherapyresistant CK-19 mRNA-positive circulating tumor cells: Results of a randomized Phase II study
    • Georgoulias V, Bozionelou V, Agelaki S et al. Trastuzumab decreases the incidence of clinical relapses in patients with early breast cancer presenting chemotherapyresistant CK-19 mRNA-positive circulating tumor cells: results of a randomized Phase II study. Ann. Oncol. 23(7), 1744-1750 (2012
    • (2012) Ann. Oncol. , vol.23 , Issue.7 , pp. 1744-1750
    • Georgoulias, V.1    Bozionelou, V.2    Agelaki, S.3
  • 27
    • 67649948941 scopus 로고    scopus 로고
    • Circulating tumor cells in HER-2 positive metastatic breast cancer patients treated with trastuzumab and chemotherapy
    • Nunes RA, Li X, Kang SP et al. Circulating tumor cells in HER-2 positive metastatic breast cancer patients treated with trastuzumab and chemotherapy. Int. J. Biol. Markers 24(1), 1-10 (2009
    • (2009) Int. J. Biol. Markers , vol.24 , Issue.1 , pp. 1-10
    • Nunes, R.A.1    Li, X.2    Kang, S.P.3
  • 28
    • 63049102497 scopus 로고    scopus 로고
    • Parallel progression of primary tumours and metastases
    • Klein CA. Parallel progression of primary tumours and metastases. Nat. Rev. Cancer 9(4), 302-312 (2009
    • (2009) Nat. Rev. Cancer , vol.9 , Issue.4 , pp. 302-312
    • Klein, C.A.1
  • 29
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 17(5), 548-558 (2005
    • (2005) Curr. Opin. Cell Biol. , vol.17 , Issue.5 , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 30
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer CL, Weinberg RA. A perspective on cancer cell metastasis. Science 331(6024), 1559-1564 (2011
    • (2011) Science , vol.331 , Issue.6024 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 31
    • 34547555607 scopus 로고    scopus 로고
    • Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer
    • Naume B, Zhao X, Synnestvedt M et al. Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer. Mol. Oncol. 1(2), 160-171 (2007
    • (2007) Mol. Oncol. , vol.1 , Issue.2 , pp. 160-171
    • Naume, B.1    Zhao, X.2    Synnestvedt, M.3
  • 32
    • 77954863256 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transitions and circulating tumor cells
    • Bonnomet A, Brysse A, Tachsidis A et al. Epithelial-to-mesenchymal transitions and circulating tumor cells. J. Mammary Gland Biol. Neoplasia 15(2), 261-273 (2010
    • (2010) J. Mammary Gland Biol. Neoplasia , vol.15 , Issue.2 , pp. 261-273
    • Bonnomet, A.1    Brysse, A.2    Tachsidis, A.3
  • 33
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133(4), 704-715 (2008
    • (2008) Cell , vol.133 , Issue.4 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3
  • 34
    • 19944426264 scopus 로고    scopus 로고
    • Circulating tumor cells in patients with breast cancer dormancy
    • Meng S, Tripathy D, Frenkel EP et al. Circulating tumor cells in patients with breast cancer dormancy. Clin. Cancer Res. 10(24), 8152-8162 (2004
    • (2004) Clin. Cancer Res. , vol.10 , Issue.24 , pp. 8152-8162
    • Meng, S.1    Tripathy, D.2    Frenkel, E.P.3
  • 35
    • 52049093195 scopus 로고    scopus 로고
    • Dormancy and surgery-driven escape from dormancy help explain some clinical features of breast cancer
    • Retsky MW, Demicheli R, Hrushesky WJ, Baum M, Gukas ID. Dormancy and surgery-driven escape from dormancy help explain some clinical features of breast cancer. APMIS 116(7-8), 730-741 (2008
    • (2008) APMIS , vol.116 , Issue.7-8 , pp. 730-741
    • Retsky, M.W.1    Demicheli, R.2    Hrushesky, W.J.3    Baum, M.4    Gukas, I.D.5
  • 36
    • 80052397158 scopus 로고    scopus 로고
    • Circulating cancer cells in division in an early breast cancer patient
    • Serrano MJ, Nadal R, Lorente JA et al. Circulating cancer cells in division in an early breast cancer patient. Ann. Oncol. 22(9), 2150-2151 (2011
    • (2011) Ann. Oncol. , vol.22 , Issue.9 , pp. 2150-2151
    • Serrano, M.J.1    Nadal, R.2    Lorente, J.A.3
  • 37
    • 72249093615 scopus 로고    scopus 로고
    • Tumor self-seeding by circulating cancer cells
    • Kim MY, Oskarsson T, Acharyya S et al. Tumor self-seeding by circulating cancer cells. Cell 139(7), 1315-1326 (2009
    • (2009) Cell , vol.139 , Issue.7 , pp. 1315-1326
    • Kim, M.Y.1    Oskarsson, T.2    Acharyya, S.3
  • 38
    • 0034034257 scopus 로고    scopus 로고
    • Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer: Comparison of quantitative polymerase chain reaction and immunocytochemical techniques
    • Smith BM, Slade MJ, English J et al. Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer: comparison of quantitative polymerase chain reaction and immunocytochemical techniques. J. Clin. Oncol. 18(7), 1432-1439 (2000
    • (2000) J. Clin. Oncol. , vol.18 , Issue.7 , pp. 1432-1439
    • Smith, B.M.1    Slade, M.J.2    English, J.3
  • 39
    • 0033996457 scopus 로고    scopus 로고
    • Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer
    • Braun S, Pantel K, Muller P et al. Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N. Engl. J. Med. 342(8), 525-533 (2000
    • (2000) N. Engl. J. Med. , vol.342 , Issue.8 , pp. 525-533
    • Braun, S.1    Pantel, K.2    Muller, P.3
  • 40
    • 6044259206 scopus 로고    scopus 로고
    • Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases
    • Allard WJ, Matera J, Miller MC et al. Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases. Clin. Cancer Res. 10(20), 6897-6904 (2004
    • (2004) Clin. Cancer Res. , vol.10 , Issue.20 , pp. 6897-6904
    • Allard, W.J.1    Matera, J.2    Miller, M.C.3
  • 41
    • 33847402612 scopus 로고    scopus 로고
    • Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: A validation study of the CellSearch system
    • Riethdorf S, Fritsche H, Muller V et al. Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system. Clin. Cancer Res. 13(3), 920-928 (2007
    • (2007) Clin. Cancer Res. , vol.13 , Issue.3 , pp. 920-928
    • Riethdorf, S.1    Fritsche, H.2    Muller, V.3
  • 42
    • 0034072199 scopus 로고    scopus 로고
    • Molecular detection of cancer cells in bone marrow and peripheral blood of patients with operable breast cancer. Comparison of CK19, MUC1 and CEA using RT-PCR
    • Berois N, Varangot M, Aizen B et al. Molecular detection of cancer cells in bone marrow and peripheral blood of patients with operable breast cancer. Comparison of CK19, MUC1 and CEA using RT-PCR. Eur. J. Cancer 36(6), 717-723 (2000
    • (2000) Eur. J. Cancer , vol.36 , Issue.6 , pp. 717-723
    • Berois, N.1    Varangot, M.2    Aizen, B.3
  • 43
    • 33644837133 scopus 로고    scopus 로고
    • Real-time RT-PCR detection of disseminated tumour cells in bone marrow has superior prognostic significance in comparison with circulating tumour cells in patients with breast cancer
    • Benoy IH, Elst H, Philips M et al. Real-time RT-PCR detection of disseminated tumour cells in bone marrow has superior prognostic significance in comparison with circulating tumour cells in patients with breast cancer. Br. J. Cancer 94(5), 672-680 (2006
    • (2006) Br. J. Cancer , vol.94 , Issue.5 , pp. 672-680
    • Benoy, I.H.1    Elst, H.2    Philips, M.3
  • 44
    • 84870055312 scopus 로고    scopus 로고
    • Prognostic impact of circulating tumor cells assessed with the CellSearch System™ and AdnaTest Breast™ in metastatic breast cancer patients: The DETECT study
    • on behalf of the DETECT study group
    • Muller V, Riethdorf S, Rack B et al.; on behalf of the DETECT study group. Prognostic impact of circulating tumor cells assessed with the CellSearch System™ and AdnaTest Breast™ in metastatic breast cancer patients: the DETECT study. Breast Cancer Res. 14(4), R118 (2012
    • (2012) Breast Cancer Res. , vol.14 , Issue.4
    • Muller, V.1    Riethdorf, S.2    Rack, B.3
  • 45
    • 26044436866 scopus 로고    scopus 로고
    • Standardized quantification of circulating peripheral tumor cells from lung and breast cancer
    • Pachmann K, Clement JH, Schneider CP et al. Standardized quantification of circulating peripheral tumor cells from lung and breast cancer. Clin. Chem. Lab. Med. 43(6), 617-627 (2005
    • (2005) Clin. Chem. Lab. Med. , vol.43 , Issue.6 , pp. 617-627
    • Pachmann, K.1    Clement, J.H.2    Schneider, C.P.3
  • 46
    • 19444363239 scopus 로고    scopus 로고
    • Characterization and enumeration of cells secreting tumor markers in the peripheral blood of breast cancer patients
    • Alix-Panabières C, Brouillet JP, Fabbro M et al. Characterization and enumeration of cells secreting tumor markers in the peripheral blood of breast cancer patients. J. Immunol. Methods 299(1-2), 177-188 (2005
    • (2005) J. Immunol. Methods , vol.299 , Issue.1-2 , pp. 177-188
    • Alix-Panabières, C.1    Brouillet, J.P.2    Fabbro, M.3
  • 47
    • 36849047716 scopus 로고    scopus 로고
    • Different prognostic value of cytokeratin-19 mRNA positive circulating tumor cells according to estrogen receptor and HER2 status in early-stage breast cancer
    • Ignatiadis M, Xenidis N, Perraki M et al. Different prognostic value of cytokeratin-19 mRNA positive circulating tumor cells according to estrogen receptor and HER2 status in early-stage breast cancer. J. Clin. Oncol. 25(33), 5194-5202 (2007
    • (2007) J. Clin. Oncol. , vol.25 , Issue.33 , pp. 5194-5202
    • Ignatiadis, M.1    Xenidis, N.2    Perraki, M.3
  • 48
    • 79953251573 scopus 로고    scopus 로고
    • A new device for rapid isolation by size and characterization of rare circulating tumor cells
    • Desitter I, Guerrouahen BS, Benali-Furet N et al. A new device for rapid isolation by size and characterization of rare circulating tumor cells. Anticancer Res. 31(2), 427-441 (2011
    • (2011) Anticancer Res. , vol.31 , Issue.2 , pp. 427-441
    • Desitter, I.1    Guerrouahen, B.S.2    Benali-Furet, N.3
  • 49
    • 84866509291 scopus 로고    scopus 로고
    • A novel method for the in vivo isolation of circulating tumor cells from peripheral blood of cancer patients using a functionalized and structured medical wire
    • doi:10.3892/ijo.2012.1557 Epub ahead of print
    • Saucedo-Zeni N, Mewes S, Niestroj R et al. A novel method for the in vivo isolation of circulating tumor cells from peripheral blood of cancer patients using a functionalized and structured medical wire. Int. J. Oncol. doi:10.3892/ijo.2012.1557 (2012) (Epub ahead of print
    • (2012) Int. J. Oncol.
    • Saucedo-Zeni, N.1    Mewes, S.2    Niestroj, R.3
  • 50
    • 33846814619 scopus 로고    scopus 로고
    • Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progressionfree and overall survival
    • Hayes DF, Cristofanilli M, Budd GT et al. Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progressionfree and overall survival. Clin. Cancer Res. 12(14 Pt 1), 4218-4224 (2006
    • (2006) Clin. Cancer Res. , vol.12 , Issue.14 PART 1 , pp. 4218-4224
    • Hayes, D.F.1    Cristofanilli, M.2    Budd, G.T.3
  • 51
    • 33751272999 scopus 로고    scopus 로고
    • Circulating tumor cells versus imaging - Predicting overall survival in metastatic breast cancer
    • Budd GT, Cristofanilli M, Ellis MJ et al. Circulating tumor cells versus imaging - predicting overall survival in metastatic breast cancer. Clin. Cancer Res. 12(21), 6403-6409 (2006
    • (2006) Clin. Cancer Res. , vol.12 , Issue.21 , pp. 6403-6409
    • Budd, G.T.1    Cristofanilli, M.2    Ellis, M.J.3
  • 52
    • 70449713638 scopus 로고    scopus 로고
    • Circulating tumor cells: A useful predictor of treatment efficacy in metastatic breast cancer
    • Liu MC, Shields PG, Warren RD et al. Circulating tumor cells: a useful predictor of treatment efficacy in metastatic breast cancer. J. Clin. Oncol. 27(31), 5153-5159 (2009
    • (2009) J. Clin. Oncol. , vol.27 , Issue.31 , pp. 5153-5159
    • Liu, M.C.1    Shields, P.G.2    Warren, R.D.3
  • 53
    • 33947286218 scopus 로고    scopus 로고
    • Circulating tumor cells in metastatic breast cancer: Biologic staging beyond tumor burden
    • Cristofanilli M, Broglio KR, Guarneri V et al. Circulating tumor cells in metastatic breast cancer: biologic staging beyond tumor burden. Clin. Breast Cancer 7(6), 471-479 (2007
    • (2007) Clin. Breast Cancer , vol.7 , Issue.6 , pp. 471-479
    • Cristofanilli, M.1    Broglio, K.R.2    Guarneri, V.3
  • 54
    • 84860491029 scopus 로고    scopus 로고
    • Circulating tumor cells in immunohistochemical subtypes of metastatic breast cancer: Lack of prediction in HER2-positive disease treated with targeted therapy
    • Giordano A, Giuliano M, De Laurentiis M et al. Circulating tumor cells in immunohistochemical subtypes of metastatic breast cancer: lack of prediction in HER2-positive disease treated with targeted therapy. Ann. Oncol. 23(5), 1144-1150 (2012
    • (2012) Ann. Oncol. , vol.23 , Issue.5 , pp. 1144-1150
    • Giordano, A.1    Giuliano, M.2    De Laurentiis, M.3
  • 55
    • 84856770191 scopus 로고    scopus 로고
    • Assessment of circulating tumor cells and serum markers for progression-free survival prediction in metastatic breast cancer: A prospective observational study
    • Bidard FC, Hajage D, Bachelot T et al. Assessment of circulating tumor cells and serum markers for progression-free survival prediction in metastatic breast cancer: a prospective observational study. Breast Cancer Res. 14(1), R29 (2012
    • (2012) Breast Cancer Res , vol.14 , Issue.1
    • Bidard, F.C.1    Hajage, D.2    Bachelot, T.3
  • 57
    • 77954904037 scopus 로고    scopus 로고
    • Detection of minimal residual disease in blood and bone marrow in early stage breast cancer
    • Krishnamurthy S, Cristofanilli M, Singh B et al. Detection of minimal residual disease in blood and bone marrow in early stage breast cancer. Cancer 116(14), 3330-3337 (2010
    • (2010) Cancer , vol.116 , Issue.14 , pp. 3330-3337
    • Krishnamurthy, S.1    Cristofanilli, M.2    Singh, B.3
  • 58
    • 65549086081 scopus 로고    scopus 로고
    • Cytokeratin-19 mRNA-positive circulating tumor cells after adjuvant chemotherapy in patients with early breast cancer
    • Xenidis N, Ignatiadis M, Apostolaki S et al. Cytokeratin-19 mRNA-positive circulating tumor cells after adjuvant chemotherapy in patients with early breast cancer. J. Clin. Oncol. 27(13), 2177-2184 (2009
    • (2009) J. Clin. Oncol. , vol.27 , Issue.13 , pp. 2177-2184
    • Xenidis, N.1    Ignatiadis, M.2    Apostolaki, S.3
  • 59
    • 79958181044 scopus 로고    scopus 로고
    • Cytokeratin-19 mRNA-positive circulating tumor cells during follow-up of patients with operable breast cancer: Prognostic relevance for late relapse
    • Saloustros E, Perraki M, Apostolaki S et al. Cytokeratin-19 mRNA-positive circulating tumor cells during follow-up of patients with operable breast cancer: prognostic relevance for late relapse. Breast Cancer Res. 13(3), R60 (2011
    • (2011) Breast Cancer Res , vol.13 , Issue.3
    • Saloustros, E.1    Perraki, M.2    Apostolaki, S.3
  • 60
    • 64249099411 scopus 로고    scopus 로고
    • American Joint Commission on Cancer Staging Springer, NY, USA
    • American Joint Commission on Cancer Staging. AJJC Cancer Staging Manual. Springer, NY, USA (2010
    • (2010) AJJC Cancer Staging Manual
  • 61
    • 58549113573 scopus 로고    scopus 로고
    • Anti-epithelial cell adhesion molecule antibodies and the detection of circulating normal-like breast tumor cells
    • Sieuwerts AM, Kraan J, Bolt J et al. Anti-epithelial cell adhesion molecule antibodies and the detection of circulating normal-like breast tumor cells. J. Natl Cancer Inst. 101(1), 61-66 (2009
    • (2009) J. Natl Cancer Inst. , vol.101 , Issue.1 , pp. 61-66
    • Sieuwerts, A.M.1    Kraan, J.2    Bolt, J.3
  • 62
    • 84858082008 scopus 로고    scopus 로고
    • CD49f-based selection of circulating tumor cells (CTCs) improves detection across breast cancer subtypes
    • Mostert B, Kraan J, Sieuwerts AM et al. CD49f-based selection of circulating tumor cells (CTCs) improves detection across breast cancer subtypes. Cancer Lett. 319(1), 49-55 (2012
    • (2012) Cancer Lett , vol.319 , Issue.1 , pp. 49-55
    • Mostert, B.1    Kraan, J.2    Sieuwerts, A.M.3
  • 63
    • 79151479127 scopus 로고    scopus 로고
    • Detection and clinical relevance of early disseminated breast cancer cells depend on their cytokeratin expression pattern
    • Effenberger KE, Borgen E, Eulenburg CZ et al. Detection and clinical relevance of early disseminated breast cancer cells depend on their cytokeratin expression pattern. Breast Cancer Res. Treat. 125(3), 729-738 (2011
    • (2011) Breast Cancer Res. Treat. , vol.125 , Issue.3 , pp. 729-738
    • Effenberger, K.E.1    Borgen, E.2    Eulenburg, C.Z.3
  • 64
    • 84857097186 scopus 로고    scopus 로고
    • Changes in keratin expression during metastatic progression of breast cancer: Impact on the detection of circulating tumor cells
    • Joosse SA, Hannemann J, Spotter J et al. Changes in keratin expression during metastatic progression of breast cancer: impact on the detection of circulating tumor cells. Clin. Cancer Res. 18(4), 993-1003 (2012
    • (2012) Clin. Cancer Res. , vol.18 , Issue.4 , pp. 993-1003
    • Joosse, S.A.1    Hannemann, J.2    Spotter, J.3
  • 65
    • 70349729970 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and cell cooperativity in metastasis
    • Tsuji T, Ibaragi S, Hu GF. Epithelial-mesenchymal transition and cell cooperativity in metastasis. Cancer Res. 69(18), 7135-7139 (2009
    • (2009) Cancer Res , vol.69 , Issue.18 , pp. 7135-7139
    • Tsuji, T.1    Ibaragi, S.2    Hu, G.F.3
  • 66
    • 0032843036 scopus 로고    scopus 로고
    • Cadherins and catenins: Role in signal transduction and tumor progression
    • Behrens J. Cadherins and catenins: role in signal transduction and tumor progression. Cancer Metastasis Rev. 18(1), 15-30 (1999
    • (1999) Cancer Metastasis Rev. , vol.18 , Issue.1 , pp. 15-30
    • Behrens, J.1
  • 67
    • 79954689654 scopus 로고    scopus 로고
    • Detection of circulating tumor cells in breast cancer may improve through enrichment with anti-CD146
    • Mostert B, Kraan J, Bolt-de Vries J et al. Detection of circulating tumor cells in breast cancer may improve through enrichment with anti-CD146. Breast Cancer Res. Treat. 127(1), 33-41 (2011
    • (2011) Breast Cancer Res. Treat. , vol.127 , Issue.1 , pp. 33-41
    • Mostert, B.1    Kraan, J.2    Bolt-De Vries, J.3
  • 68
    • 75449106680 scopus 로고    scopus 로고
    • Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
    • Aktas B, Tewes M, Fehm T, Hauch S, Kimmig R, Kasimir-Bauer S. Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients. Breast Cancer Res. 11(4), R46 (2009
    • (2009) Breast Cancer Res. , vol.11 , Issue.4
    • Aktas, B.1    Tewes, M.2    Fehm, T.3    Hauch, S.4    Kimmig, R.5    Kasimir-Bauer, S.6
  • 69
    • 83955165959 scopus 로고    scopus 로고
    • Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy
    • Mego M, Mani SA, Lee BN et al. Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: the effect of neoadjuvant therapy. Int. J. Cancer 130(4), 808-816 (2012
    • (2012) Int. J. Cancer , vol.130 , Issue.4 , pp. 808-816
    • Mego, M.1    Mani, S.A.2    Lee, B.N.3
  • 70
    • 82955187028 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients
    • Raimondi C, Gradilone A, Naso G et al. Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients. Breast Cancer Res. Treat. 130(2), 449-455 (2011
    • (2011) Breast Cancer Res. Treat. , vol.130 , Issue.2 , pp. 449-455
    • Raimondi, C.1    Gradilone, A.2    Naso, G.3
  • 71
    • 79957600406 scopus 로고    scopus 로고
    • Circulating tumour cells lacking cytokeratin in breast cancer: The importance of being mesenchymal
    • Gradilone A, Raimondi C, Nicolazzo C et al. Circulating tumour cells lacking cytokeratin in breast cancer: the importance of being mesenchymal. J. Cell. Mol. Med. 15(5), 1066-1070 (2011
    • (2011) J. Cell. Mol. Med. , vol.15 , Issue.5 , pp. 1066-1070
    • Gradilone, A.1    Raimondi, C.2    Nicolazzo, C.3
  • 72
    • 84855987633 scopus 로고    scopus 로고
    • Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells
    • Kasimir-Bauer S, Hoffmann O, Wallwiener D, Kimmig R, Fehm T. Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells. Breast Cancer Res. 14(1), R15 (2012
    • (2012) Breast Cancer Res , vol.14 , Issue.1
    • Kasimir-Bauer, S.1    Hoffmann, O.2    Wallwiener, D.3    Kimmig, R.4    Fehm, T.5
  • 73
    • 84860397754 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition markers expressed in circulating tumour cells of early and metastatic breast cancer patients
    • Kallergi G, Papadaki MA, Politaki E, Mavroudis D, Georgoulias V, Agelaki S. Epithelial to mesenchymal transition markers expressed in circulating tumour cells of early and metastatic breast cancer patients. Breast Cancer Res. 13(3), R59 (2011
    • (2011) Breast Cancer Res , vol.13 , Issue.3
    • Kallergi, G.1    Papadaki, M.A.2    Politaki, E.3    Mavroudis, D.4    Georgoulias, V.5    Agelaki, S.6
  • 74
    • 84869231518 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer
    • Giordano A, Gao H, Anfossi S et al. Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer. Mol. Cancer Ther. 11(11), 2526-2534 (2012
    • (2012) Mol. Cancer Ther. , vol.11 , Issue.11 , pp. 2526-2534
    • Giordano, A.1    Gao, H.2    Anfossi, S.3
  • 76
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier C, Hur MH, Charafe-Jauffret E et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1(5), 555-567 (2007
    • (2007) Cell Stem Cell , vol.1 , Issue.5 , pp. 555-567
    • Ginestier, C.1    Hur, M.H.2    Charafe-Jauffret, E.3
  • 77
    • 73649125337 scopus 로고    scopus 로고
    • Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer
    • Theodoropoulos PA, Polioudaki H, Agelaki S et al. Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer. Cancer Lett. 288(1), 99-106 (2010
    • (2010) Cancer Lett , vol.288 , Issue.1 , pp. 99-106
    • Theodoropoulos, P.A.1    Polioudaki, H.2    Agelaki, S.3
  • 78
    • 59449088408 scopus 로고    scopus 로고
    • Phosphorylated EGFR and PI3K/Akt signaling kinases are expressed in circulating tumor cells of breast cancer patients
    • Kallergi G, Agelaki S, Kalykaki A, Stournaras C, Mavroudis D, Georgoulias V. Phosphorylated EGFR and PI3K/Akt signaling kinases are expressed in circulating tumor cells of breast cancer patients. Breast Cancer Res. 10(5), R80 (2008
    • (2008) Breast Cancer Res. , vol.10 , Issue.5
    • Kallergi, G.1    Agelaki, S.2    Kalykaki, A.3    Stournaras, C.4    Mavroudis, D.5    Georgoulias, V.6
  • 79
    • 67649969473 scopus 로고    scopus 로고
    • Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling
    • Korkaya H, Paulson A, Charafe-Jauffret E et al. Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS Biol. 7(6), e1000121 (2009
    • (2009) PLoS Biol , vol.7 , Issue.6
    • Korkaya, H.1    Paulson, A.2    Charafe-Jauffret, E.3
  • 80
    • 78650328019 scopus 로고    scopus 로고
    • Circulating tumor cells (CTCs) in metastatic breast cancer (MBC): Prognosis, drug resistance and phenotypic characterization
    • Gradilone A, Naso G, Raimondi C et al. Circulating tumor cells (CTCs) in metastatic breast cancer (MBC): prognosis, drug resistance and phenotypic characterization. Ann. Oncol. 22(1), 86-92 (2011
    • (2011) Ann. Oncol. , vol.22 , Issue.1 , pp. 86-92
    • Gradilone, A.1    Naso, G.2    Raimondi, C.3
  • 81
    • 84866021276 scopus 로고    scopus 로고
    • Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cells
    • Domingo-Domenech J, Vidal SJ, Rodriguez-Bravo V et al. Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cells. Cancer Cell 22(3), 373-388 (2012
    • (2012) Cancer Cell , vol.22 , Issue.3 , pp. 373-388
    • Domingo-Domenech, J.1    Vidal, S.J.2    Rodriguez-Bravo, V.3
  • 82
    • 78649646316 scopus 로고    scopus 로고
    • Breast cancer assessment tools and optimizing adjuvant therapy
    • Oakman C, Santarpia L, Di Leo A. Breast cancer assessment tools and optimizing adjuvant therapy. Nat. Rev. Clin. Oncol. 7(12), 725-732 (2010
    • (2010) Nat. Rev. Clin. Oncol. , vol.7 , Issue.12 , pp. 725-732
    • Oakman, C.1    Santarpia, L.2    Di Leo, A.3
  • 83
    • 84871233229 scopus 로고    scopus 로고
    • Hormonal receptor, human epidermal growth factor receptor-2, and Ki67 discordance between primary breast cancer and paired metastases: Clinical impact
    • Ibrahim T, Farolfi A, Scarpi E et al. Hormonal receptor, human epidermal growth factor receptor-2, and Ki67 discordance between primary breast cancer and paired metastases: clinical impact. Oncology 84(3), 150-157 (2013
    • (2013) Oncology , vol.84 , Issue.3 , pp. 150-157
    • Ibrahim, T.1    Farolfi, A.2    Scarpi, E.3
  • 84
    • 70449561613 scopus 로고    scopus 로고
    • Correlation of HER2 status between primary tumors and corresponding circulating tumor cells in advanced breast cancer patients
    • Pestrin M, Bessi S, Galardi F et al. Correlation of HER2 status between primary tumors and corresponding circulating tumor cells in advanced breast cancer patients. Breast Cancer Res. Treat. 118(3), 523-530 (2009
    • (2009) Breast Cancer Res. Treat. , vol.118 , Issue.3 , pp. 523-530
    • Pestrin, M.1    Bessi, S.2    Galardi, F.3
  • 85
    • 77957814298 scopus 로고    scopus 로고
    • Changes of HER2 status in circulating tumor cells compared with the primary tumor during treatment for advanced breast cancer
    • Munzone E, Nole F, Goldhirsch A et al. Changes of HER2 status in circulating tumor cells compared with the primary tumor during treatment for advanced breast cancer. Clin. Breast Cancer 10(5), 392-397 (2010
    • (2010) Clin. Breast Cancer , vol.10 , Issue.5 , pp. 392-397
    • Munzone, E.1    Nole, F.2    Goldhirsch, A.3
  • 86
    • 33645688204 scopus 로고    scopus 로고
    • HER2-positive circulating tumor cells indicate poor clinical outcome in stage i to III breast cancer patients
    • Wulfing P, Borchard J, Buerger H et al. HER2-positive circulating tumor cells indicate poor clinical outcome in stage I to III breast cancer patients. Clin. Cancer Res. 12(6), 1715-1720 (2006
    • (2006) Clin. Cancer Res. , vol.12 , Issue.6 , pp. 1715-1720
    • Wulfing, P.1    Borchard, J.2    Buerger, H.3
  • 87
    • 78649327274 scopus 로고    scopus 로고
    • HER2 status of circulating tumor cells in patients with metastatic breast cancer: A prospective, multicenter trial
    • Fehm T, Muller V, Aktas B et al. HER2 status of circulating tumor cells in patients with metastatic breast cancer: a prospective, multicenter trial. Breast Cancer Res. Treat. 124(2), 403-412 (2010
    • (2010) Breast Cancer Res. Treat. , vol.124 , Issue.2 , pp. 403-412
    • Fehm, T.1    Muller, V.2    Aktas, B.3
  • 88
    • 77952120469 scopus 로고    scopus 로고
    • Improving the yield of circulating tumour cells facilitates molecular characterisation and recognition of discordant HER2 amplification in breast cancer
    • Flores LM, Kindelberger DW, Ligon AH et al. Improving the yield of circulating tumour cells facilitates molecular characterisation and recognition of discordant HER2 amplification in breast cancer. Br. J. Cancer 102(10), 1495-1502 (2010
    • (2010) Br. J. Cancer , vol.102 , Issue.10 , pp. 1495-1502
    • Flores, L.M.1    Kindelberger, D.W.2    Ligon, A.H.3
  • 89
    • 84862840385 scopus 로고    scopus 로고
    • Prognostic value of HER2-positive circulating tumor cells in patients with metastatic breast cancer
    • Hayashi N, Nakamura S, Tokuda Y et al. Prognostic value of HER2-positive circulating tumor cells in patients with metastatic breast cancer. Int. J. Clin. Oncol. 17(2), 96-104 (2012
    • (2012) Int. J. Clin. Oncol. , vol.17 , Issue.2 , pp. 96-104
    • Hayashi, N.1    Nakamura, S.2    Tokuda, Y.3
  • 90
    • 70349578779 scopus 로고    scopus 로고
    • Detection of occult HER2 mRNA-positive tumor cells in the peripheral blood of patients with operable breast cancer: Evaluation of their prognostic relevance
    • Apostolaki S, Perraki M, Kallergi G et al. Detection of occult HER2 mRNA-positive tumor cells in the peripheral blood of patients with operable breast cancer: evaluation of their prognostic relevance. Breast Cancer Res. Treat. 117(3), 525-534 (2009
    • (2009) Breast Cancer Res. Treat. , vol.117 , Issue.3 , pp. 525-534
    • Apostolaki, S.1    Perraki, M.2    Kallergi, G.3
  • 91
    • 84863116159 scopus 로고    scopus 로고
    • Loss of human epidermal growth factor receptor 2 (HER2) expression in metastatic sites of HER2-overexpressing primary breast tumors
    • Niikura N, Liu J, Hayashi N et al. Loss of human epidermal growth factor receptor 2 (HER2) expression in metastatic sites of HER2-overexpressing primary breast tumors. J. Clin. Oncol. 30(6), 593-599 (2012
    • (2012) J. Clin. Oncol. , vol.30 , Issue.6 , pp. 593-599
    • Niikura, N.1    Liu, J.2    Hayashi, N.3
  • 92
    • 33745903909 scopus 로고    scopus 로고
    • Comparison of HER2 status between primary tumor and disseminated tumor cells in primary breast cancer patients
    • Solomayer EF, Becker S, Pergola-Becker G et al. Comparison of HER2 status between primary tumor and disseminated tumor cells in primary breast cancer patients. Breast Cancer Res. Treat. 98(2), 179-184 (2006
    • (2006) Breast Cancer Res. Treat. , vol.98 , Issue.2 , pp. 179-184
    • Solomayer, E.F.1    Becker, S.2    Pergola-Becker, G.3
  • 93
    • 79251548904 scopus 로고    scopus 로고
    • HER2-positive circulating tumor cells in breast cancer
    • Ignatiadis M, Rothe F, Chaboteaux C et al. HER2-positive circulating tumor cells in breast cancer. PLoS ONE 6(1), e15624 (2011
    • (2011) PLoS ONE , vol.6 , Issue.1
    • Ignatiadis, M.1    Rothe, F.2    Chaboteaux, C.3
  • 94
    • 77958557955 scopus 로고    scopus 로고
    • Molecular biomarker analyses using circulating tumor cells
    • Punnoose EA, Atwal SK, Spoerke JM et al. Molecular biomarker analyses using circulating tumor cells. PLoS ONE 5(9), e12517 (2010
    • (2010) PLoS ONE , vol.5 , Issue.9
    • Punnoose, E.A.1    Atwal, S.K.2    Spoerke, J.M.3
  • 95
    • 11144248359 scopus 로고    scopus 로고
    • Trastuzumab administration can effectively target chemotherapy-resistant cytokeratin-19 messenger RNA-positive tumor cells in the peripheral blood and bone marrow of patients with breast cancer
    • Bozionellou V, Mavroudis D, Perraki M et al. Trastuzumab administration can effectively target chemotherapy-resistant cytokeratin-19 messenger RNA-positive tumor cells in the peripheral blood and bone marrow of patients with breast cancer. Clin. Cancer Res. 10(24), 8185-8194 (2004
    • (2004) Clin. Cancer Res. , vol.10 , Issue.24 , pp. 8185-8194
    • Bozionellou, V.1    Mavroudis, D.2    Perraki, M.3
  • 96
    • 84857919875 scopus 로고    scopus 로고
    • The influence of removal of primary tumor on incidence and phenotype of circulating tumor cells in primary breast cancer
    • Banys M, Krawczyk N, Becker S et al. The influence of removal of primary tumor on incidence and phenotype of circulating tumor cells in primary breast cancer. Breast Cancer Res. Treat. 132(1), 121-129 (2012
    • (2012) Breast Cancer Res. Treat. , vol.132 , Issue.1 , pp. 121-129
    • Banys, M.1    Krawczyk, N.2    Becker, S.3
  • 97
    • 79960453378 scopus 로고    scopus 로고
    • Comparison of estrogen and progesterone receptor status of circulating tumor cells and the primary tumor in metastatic breast cancer patients
    • Aktas B, Muller V, Tewes M et al. Comparison of estrogen and progesterone receptor status of circulating tumor cells and the primary tumor in metastatic breast cancer patients. Gynecol. Oncol. 122(2), 356-360 (2011
    • (2011) Gynecol. Oncol. , vol.122 , Issue.2 , pp. 356-360
    • Aktas, B.1    Muller, V.2    Tewes, M.3
  • 98
    • 67349253810 scopus 로고    scopus 로고
    • Molecular profiling and predictive value of circulating tumor cells in patients with metastatic breast cancer: An option for monitoring response to breast cancer related therapies
    • Tewes M, Aktas B, Welt A et al. Molecular profiling and predictive value of circulating tumor cells in patients with metastatic breast cancer: an option for monitoring response to breast cancer related therapies. Breast Cancer Res. Treat. 115(3), 581-590 (2009
    • (2009) Breast Cancer Res. Treat. , vol.115 , Issue.3 , pp. 581-590
    • Tewes, M.1    Aktas, B.2    Welt, A.3
  • 99
    • 0038460245 scopus 로고    scopus 로고
    • Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: Analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group
    • Mouridsen H, Gershanovich M, Sun Y et al. Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group. J. Clin. Oncol. 21(11), 2101-2109 (2003
    • (2003) J. Clin. Oncol. , vol.21 , Issue.11 , pp. 2101-2109
    • Mouridsen, H.1    Gershanovich, M.2    Sun, Y.3
  • 100
    • 20444436815 scopus 로고    scopus 로고
    • Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop
    • Goswami S, Sahai E, Wyckoff JB et al. Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res. 65(12), 5278-5283 (2005
    • (2005) Cancer Res , vol.65 , Issue.12 , pp. 5278-5283
    • Goswami, S.1    Sahai, E.2    Wyckoff, J.B.3
  • 101
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2- positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D et al. Lapatinib plus capecitabine for HER2- positive advanced breast cancer. N. Engl. J. Med. 355(26), 2733-2743 (2006
    • (2006) N. Engl. J. Med. , vol.355 , Issue.26 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 102
    • 78549294254 scopus 로고    scopus 로고
    • Eradication of EGFR-positive circulating tumor cells and objective tumor response with lapatinib and capecitabine
    • Liu Z, Fusi A, Schmittel A, Tinhofer I, Schneider A, Keilholz U. Eradication of EGFR-positive circulating tumor cells and objective tumor response with lapatinib and capecitabine. Cancer Biol. Ther. 10(9), 860-864 (2010
    • (2010) Cancer Biol. Ther. , vol.10 , Issue.9 , pp. 860-864
    • Liu, Z.1    Fusi, A.2    Schmittel, A.3    Tinhofer, I.4    Schneider, A.5    Keilholz, U.6
  • 103
    • 10744231079 scopus 로고    scopus 로고
    • Detection of breast cancer cells in the peripheral blood is positively correlated with estrogen-receptor status and predicts for poor prognosis
    • Gaforio JJ, Serrano MJ, Sanchez-Rovira P et al. Detection of breast cancer cells in the peripheral blood is positively correlated with estrogen-receptor status and predicts for poor prognosis. Int. J. Cancer 107(6), 984-990 (2003
    • (2003) Int. J. Cancer , vol.107 , Issue.6 , pp. 984-990
    • Gaforio, J.J.1    Serrano, M.J.2    Sanchez-Rovira, P.3
  • 104
    • 79956002915 scopus 로고    scopus 로고
    • Negative enrichment by immunomagnetic nanobeads for unbiased characterization of circulating tumor cells from peripheral blood of cancer patients
    • Liu Z, Fusi A, Klopocki E et al. Negative enrichment by immunomagnetic nanobeads for unbiased characterization of circulating tumor cells from peripheral blood of cancer patients. J. Transl. Med. 9, 70 (2011
    • (2011) J. Transl. Med. , vol.9 , pp. 70
    • Liu, Z.1    Fusi, A.2    Klopocki, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.