Renal pathophysiology: Lessons learned from the canine remnant kidney model

Journal of Veterinary Emergency and Critical Care

Volumn 23, Issue 2, 2013, Pages 115-121

  Brown, Scott A ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Chronic kidney disease; Dogs; Hypertension; Proteinuria

Indexed keywords

ANIMAL; ANIMAL DISEASE; CHRONIC KIDNEY FAILURE; DOG; DOG DISEASE; KIDNEY; PATHOLOGY; PATHOPHYSIOLOGY; REVIEW;

ANIMALS; DOG DISEASES; DOGS; KIDNEY; RENAL INSUFFICIENCY, CHRONIC;

CANIS FAMILIARIS;

EID: 84876132446     PISSN: 14793261     EISSN: 14764431     Source Type: Journal    
DOI: 10.1111/vec.12030     Document Type: Review

References (53)

1. Coleman TG, Guyton AC. Hypertension caused by salt loading in the dog III. Onset transients of cardiac output and other circulatory variables. Circ Res 1969; 25:153-160.
2. Finco DR. Association of systemic hypertension with renal injury in dogs with induced renal failure. J Vet Int Med 2004; 18:289-294.
3. Bricker NS, Morrin PA, Kime SW. The pathologic physiology of chronic Bright'sdisease. Am J Med 1960; 28:77-97.
4. Bricker NS, Klahr S, Riedelbach RE. The functional adaptation of the diseased kidney. J Clin Invest 1964; 43:1915-1921.
5. Damadian RV, Shwayri E, Bricker NS. On the existence of non-urine forming nephrons in the diseased kidney of the dog. J Lab Clin Med 1965; 65:26-39.
6. Platt R. Structural and functional adaptation in renal failure. Brit Med J 1952; 1:1372-1377.
7. Bright R. Reports of Medical Cases, Selected with a View of Illustrating the Symptoms and Cure of Diseases. Morbid Anatomy. London: Longmans; 1827.
8. Oliver J, Bloom F, MacDowell M. Structural and functional transformations in the epithelium of the dog's kidney in chronic Bright's disease and their relation to the mechanisms of renal compensation and failure. J Exp Med 1941; 73:141-159.
9. Brenner BM, Troy JL, Daugharty TM. The dynamics of glomerular ultrafiltration in the rat. J Clin Invest 1971; 50:1776-1780.
10. Shimamura T, Morrison AB. A progressive glomerulosclerosis occuring in partial five-sixths nephrectomized rats. Am J Path 1975; 79:95-106.
11. Hostetter TH, Olson JL, Rennke HG, et al. Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation. Am J Physiol 1981; 241:F85-F92.
12. Brenner B. Nephron adaptation to renal injury or ablation. Am J Physiol 1985; 249:F324-F337.
13. Anderson S, Brenner BM. Therapeutic implications of converting-enzyme inhibitors in renal disease. Am J Kidney Dis 1987; 10:81-87.
14. Brenner BM. Hemodynamically mediated glomerular injury and the progressive nature of kidney disease. Kidney Int 1983; 23:647-655.
15. Brenner BM, Meyer TW, Hostetter TH. The role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med 1982; 307:652-659.
16. Mitch WE. The influence of the diet on the progression of renal insufficiency. Ann Rev Med 1984; 35:249-264.
17. Fine LG. Preventing the progression of human renal disease: have rational therapeutic principles emerged? Kidney Int 1988; 33:116-128.
18. Allen TA, Jaenke RS, Fettman MJ. A technique for estimating progression of chronic renal failure in the dog. J Am Vet Med Assoc 1987; 190:866-868.
19. Finco DR, Crowell WA, Barsanti JA. Effects of three diets on dogs with induced chronic renal failure. Am J Vet Res 1985; 46:646-653.
20. Bovee KC, Abt DA, Kronfeld DS. The effects of dietary protein intake on renal function in dogs with experimentally reduced renal function. J Am Anim Hosp Assoc. 1979; 15:9-16.
21. Bovee KC, Kronfeld DS, Ramberg C, et al. Long-term measurement of renal function in partially nephrectomized dogs fed 56, 27, or 19% protein. Invest Urology 1979; 16:378-384.
22. Polzin DJ, Osborne CA, Hayden DW, et al. Influence of reduced protein diets on morbidity, mortality, and renal function in dogs with induced chronic renal failure. Am J Vet Med Assoc. 1983; 45:506-517.
23. Brown SA, Crowell WA, Barsanti JA, et al. Beneficial effects of dietary mineral restriction in dogs with marked reduction of functional renal mass. J Am Soc Nephrol 1991; 1:1169-1179.
24. Finco DR, Brown SA, Crowell WA, et al. Effects of dietary phosphorus and protein in dogs with chronic renal failure. Am J Vet Res 1992; 53:2264-2271.
25. Finn WF. Compensatory renal hypertrophy in Sprague-Dawley rats. Renal Physiol, Basel 1982; 5:222-234.
26. Navar LG, Bell PD, White RW, et al. Evaluation of the single nephron glomerular filtration coefficient in the dog. Kidney Int 1977; 12:137-149.
27. Navar LG, Chomdej B, Bell PD. Absence of estimated glomerular pressure autoregulation during interrupted distal delivery. Am J Physiol 1975; 229:1596-1603.
28. Navar LG, Gilmore JP, Joyner WL, et al. Direct assessment of renal microcirculatory dynamics. Federation Proceedings 1986; 45:2851-2861.
29. Brown SA, Finco DR, Crowell WA, et al. Single-nephron adaptations to partial renal ablation in the dog. Am J Physiol 1990; 258:F495-F503.
30. Brown SA, Finco DR, Navar LG. Renal and glomerular hemodynamics in 3/4 nephrectomized dogs. Kidney Int 1989; 35:424.
31. Brown SA, Brown CA, Crowell WA, et al. Beneficial effects of chronic administration of dietary omega-3 polyunsaturated fatty acids in dogs with renal insufficiency. J Lab Cin Med 1998; 131:447-455.
32. Brown SA, Brown CA, Crowell WA, et al. Effects of dietary polyunsaturated fatty acid supplementation in early renal insufficiency in dogs. J Lab Clin Med 2000; 135:275-286.
33. Brown SA, Finco DR, Brown CA, et al. Evaluation of the effects of inhibition of angiotensin converting enzyme with enalapril in dogs with induced chronic renal insufficiency. Am J Vet Res 2003; 64:321-327.
34. Brown SA, Brown CA. Single-nephron adaptations to partial renal ablation in cats. Am J Physiol (Regulatory Integrative Comp Physiol 38) 1995; 269:R1002-R1008.
35. Brown SA, Finco DR, Crowell WA, et al. Dietary protein intake and the glomerular adaptations to partial nephrectomy in dogs. J Nutr 1991; 121:S125-S127.
36. Brown SA, Navar LG. Single-nephron responses to systemic administration of amino acids in dogs. Am J Physiol 1990; 259:F739-F746.
37. Brown SA, Walton CL, Crawford P, et al. Long-term effects of antihypertensive regimens on renal hemodynamics and proteinuria. Kidney Int 1993; 43:1210-1218.
38. Finco DR, Brown SA, Brown CA, et al. Progression of chronic renal disease in the dog. J Vet Intern Med 1999; 13:516-528.
39. Chakrabarti S, Syme HM, Elliott J. Clinicopathological variables predicting progression of azotemia in cats. J Vet Intern Med 2012; 26:275-281.
40. Bovee KC, Littman MP, Saleh F, et al. Essential hereditary hypertension in dogs: a new animal model. J Hypertens Suppl 1986; 4:S172-171.
41. Navar L, Bell P, Burke T. Autoregulatory responses of superficial nephrons and their association with sodium excretion during arterial alterations in the dog. Circ Res 1977; 41:487-496.
42. Navar LG. Renal autoregulation: perspectives from whole kidney and single nephron studies. Am J Physiol 1978; 234:F357-F370.
43. Brown S, Finco D, Navar L. Impaired renal autoregulatory ability in dogs with reduced renal mass. J Am Soc Nephr 1995; 5:1768-1174.
44. Jacob F, Polzin DJ, Osborne CA, et al. Association between initial systolic blood pressure and risk of developing a uremic crisis or of dying in dogs with chronic renal failure. J Am Vet Med Assoc 2003; 222:322-329.
45. Slatopolsky E, Delmez JA. Pathogenesis of secondary hyperparathyroidism. Am J Kidney Dis 1994; 23:229-236.
46. Olgaard K, Finco D, Schwartz J, et al. Effect of 24, 25(OH)2D3 on PTH levels and bone histology in dogs with chronic uremia. Kidney Int 1984; 26:791-797.
47. Rutherford WE, Bordier P, Marie P, et al. Phosphate control and 25-hydroxycholecalciferol administration in preventing experimental renal osteodystrophy in the dog. J Clin Invest 1977; 60:332-341.
48. Slatopolsky E, Bricker NS. The role of phosphorus restriction in the prevention of secondary hyperparathyroidism in chronic renal disease. Kidney Int 1973; 4:141-145.
49. Slatopolsky E, Caglar S, Pennell JP, et al. On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog. J Clin Invest 1971; 50:492-499.
50. Slatopolsky E, Cagler S, Gradowska L, et al. On the prevention of secondary hyperparathyroidism in experimental chronic renal disease using "proportional reduction" of dietary phosphorus intake. Kidney Int 1972; 2:147-151.
51. Andress DL, Norris KC, Coburn JW, et al. Intravenous calcitriol in the treatment of refractory osteitis fibrosa of chronic renal failure. N Engl J Med 1989; 321:274-279.
52. Ramirez JA, Goodman WG, Belin TR, et al. Calcitriol therapy and calcium-regulated PTH secretion in patients with secondary hyperparathyroidism. Am J Physiol 1994; 267:E961-E967.
53. Ibels LS, Alfrey AC, Haut L, et al. Preservation of renal function in experimental renal disease by dietary restriction of phosphate. N Engl J Med 1978; 298:122-126.