Antiviral therapy decreases viral reactivation in patients with hepatitis B virus-related hepatocellular carcinoma undergoing hepatectomy: A randomized controlled trial

Journal of Viral Hepatitis

Volumn 20, Issue 5, 2013, Pages 336-342

  Huang, L ^a   Li, J ^a   Yan, J ^a   Sun, J ^a   Zhang, X ^a   Wu, M ^a   Yan, Yiqun ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

hepatectomy; hepatitis B virus; hepatocellular carcinoma; low viral load; telbivudine; viral reactivation

Indexed keywords

TELBIVUDINE;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CONTROLLED STUDY; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER FAILURE; LIVER FUNCTION TEST; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PERIOPERATIVE PERIOD; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; VIRUS REACTIVATION; VIRUS REPLICATION;

ADULT; ANTIVIRAL AGENTS; CARCINOMA, HEPATOCELLULAR; FEMALE; HEPATECTOMY; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; MALE; MIDDLE AGED; THYMIDINE; TREATMENT OUTCOME; VIRAL LOAD; VIRUS ACTIVATION;

EID: 84876124246     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/jvh.12036     Document Type: Article

References (18)

1. El-Serag HB, Rudolph KL,. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007; 132: 2557-2576. (Pubitemid 46890874)
2. Parkin DM,. Global cancer statistics in the year 2000. Lancet Oncol 2001; 2: 533-543. (Pubitemid 33586866)
3. McGlynn KA, Tsao L, Hsing AW, Devesa SS, Fraumeni JF Jr,. International trends and patterns of primary liver cancer. Int J Cancer 2001; 94: 290-296. (Pubitemid 32911426)
4. Kirk GD, Lesi OA, Mendy M, Montesano R, Plymoth A, Sam O, et al,. The Gambia Liver Cancer Study: infection with hepatitis B and C and the risk of hepatocellular carcinoma in West Africa. Hepatology 2004; 39: 211-219. (Pubitemid 38461484)
5. Vizzini GB, Luca A, Marino IR,. Hepatitis B virus reactivation after a single session of transarterial chemoembolization in patients with hepatocellular carcinoma. Ann Intern Med 2003; 138: 691-692. (Pubitemid 38124670)
6. Jang WJ, Choi JY, Bae SH, Kim CW, Yoon SK, Cho SH, et al,. Transarterial chemo-lipiodolization can reactivate hepatitis B virus replication in patients with hepatocellular carcinoma. J Hepatol 2004; 41: 427-435. (Pubitemid 39158752)
7. Wong GL-H,. How does hepatitis B virus infection react to hepatocellular carcinoma treatment. J Gastroenterol Hepatol 2012; 27: 1-2.
8. Kubo S, Nishiguchi S, Hamba H, Hirohashi K, Tanaka H, Shuto T, et al,. Reactivation of viral replication after liver resection in patients infected with hepatitis B virus. Ann Surg 2001; 233: 139-145. (Pubitemid 32042784)
9. Huang L, Li J, Lau WY, Yan JJ, Zhou FG, Liu CF, et al,. Perioperative reactivation of hepatitis B virus replication in patients undergoing partial hepatectomy for hepatocellular carcinoma. J Gastroenterol Hepatol 2012; 27: 158-164.
10. Liaw YF, Leung N, Kao JH, Piratvisuth T, Gane E, Han KH, et al,. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update. Hepatol Int 2008; 2: 263-283.
11. Wu MC, Chen H, Shen F,. Surgical treatment of primary liver cancer: report of 5524 patients. Chin J Surg 2001; 39: 417-422.
12. Kubo S, Nishiguchi S, Kuroki T, Hirohashi K, Tanaka H, Tsukamato T, et al,. Poor association of GBV-C viremia with hepatocellular carcinoma. J Hepatol 1997; 27: 91-95. (Pubitemid 27357060)
13. Hung IF, Poon RT, Lai CL, Fung J, Fan ST, Yuen MF,. Recurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resection. Am J Gastroenterol 2008; 103: 1663-1673.
14. Jang JW, Choi JY, Bae SH, Yoon SK, Woo HY, Chang UI, et al,. The impact of hepatitis B viral load on recurrence after complete necrosis in patients with hepatocellular carcinoma who receive transarterial chemolipiodolization: implications for viral suppression to reduce the risk of cancer recurrence. Cancer 2007; 110: 1760-1767.
15. Huang Y, Wang Z, An S, Zhou B, Zhou Y, Chan HL, et al,. Role of hepatitis B virus genotypes and quantitative HBV DNA in metastasis and recurrence of hepatocellular carcinoma. J Med Virol 2008; 80: 591-597. (Pubitemid 351358554)
16. Kubo S, Tanaka H, Takemura S, Yamamoto S, Hai S, Ichikawa T, et al,. Effects of lamivudine on outcome after liver resection for hepatocellular carcinoma in patients with active replication of hepatitis B virus. Hepatol Res 2007; 37: 94-100. (Pubitemid 46403823)
17. Chuma M, Hige S, Kamiyama T, Meguro T, Nagasaka A, Nakanishi K, et al,. The influence of hepatitis B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma. J Gastroenterol 2009; 44: 991-999.
18. Wong JS, Wong GLH, Tsoi KK, Wong VW, Cheung SY, Chong CN, et al,. Meta-analysis: the efficacy of antiviral therapy in prevention of recurrence after curative treatment of chronic hepatitis B-related hepatocellular carcinoma. Aliment Pharmacol Ther 2011; 33: 1104-1112.