Topical therapies in the management of chronic rhinosinusitis: An evidence-based review with recommendations

International Forum of Allergy and Rhinology

Volumn 3, Issue 4, 2013, Pages 281-298

  Rudmik, Luke ^a   Hoy, Monica ^a   Schlosser, Rodney J ^b   Harvey, Richard J ^c   Welch, Kevin C ^d   Lund, Valerie ^e   Smith, Timothy L ^f  

^a UNIVERSITY OF CALGARY   (Canada)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^e ROYAL NATIONAL THROAT NOSE AND EAR HOSPITAL   (United Kingdom)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Chronic rhinosinusitis; Evidence based medicine; Medical therapy of chronic rhinosinusitis; Therapeutics; Topical therapy for chronic rhinosinusitis

Indexed keywords

BECLOMETASONE DIPROPIONATE; BUDESONIDE; BUDESONIDE RESPULE; CICLESONIDE; CIPROFLOXACIN PLUS DEXAMETHASONE; DEXAMETHASONE; FLUNISOLIDE; FLUTICASONE FUROATE; FLUTICASONE PROPIONATE; MOMETASONE FUROATE; NASOCORT; PREDNISOLONE; PSEUDOMONIC ACID; TOBRAMYCIN; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG;

CHRONIC RHINOSINUSITIS; COCHRANE LIBRARY; EMBASE; EVIDENCE BASED PRACTICE; HONEY; HUMAN; LAVAGE; MEDLINE; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SYSTEMATIC REVIEW; TOPICAL TREATMENT;

ADMINISTRATION, TOPICAL; ADRENAL CORTEX HORMONES; ADULT; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; CHRONIC DISEASE; COMPLEMENTARY THERAPIES; EVIDENCE-BASED MEDICINE; HUMANS; PRACTICE GUIDELINES AS TOPIC; RHINITIS; SINUSITIS; THERAPEUTIC IRRIGATION;

EID: 84876121553     PISSN: 20426976     EISSN: 20426984     Source Type: Journal    
DOI: 10.1002/alr.21096     Document Type: Review

References (74)

1. Soler ZM, Wittenberg E, Schlosser RJ, Mace JC, Smith TL. Health state utility values in patients undergoing endoscopic sinus surgery. Laryngoscope 2011;121:2672-2678.
2. Bhattacharyya N, Orlandi RR, Grebner J, Martinson M. Cost burden of chronic rhinosinusitis: a claims-based study. Otolaryngol Head Neck Surg 2011;144:440-445.
3. Harvey RJ, Goddard JC, Wise SK, Schlosser RJ. Effects of endoscopic sinus surgery and delivery device on cadaver sinus irrigation. Otolaryngol Head Neck Surg 2008;139:137-142.
4. Rudmik L, Smith TL. Development of an evidence-based review with recommendations using an online iterative process. Int Forum Allergy Rhinol 2011;1:431-437.
5. Rosenfeld RM, Andes D, Bhattacharyya N, et al. Clinical practice guideline: adult sinusitis. Otolaryngol Head Neck Surg 2007;137:S1-S31.
6. Benninger MS, Ferguson BJ, Hadley JA, et al. Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology. Otolaryngol Head Neck Surg 2003;129:S1-S32.
7. Oxford Centre for Evidence-based Medicine (CEBM). Levels of Evidence. 2009. http://www.cebm.net/index.aspx?o=1025. Accessed September 2, 2012.
8. American Academy of Pediatrics Steering Committee on Quality Improvement and Management (AAP SCQIM): classifying recommendations for clinical practice guidelines. Pediatrics 2004;114:874-877.
9. Rabago D, Barrett B, Marchand L, Maberry R, Mundt M. Qualitative aspects of nasal irrigation use by patients with chronic sinus disease in a multimethod study. Ann Fam Med 2006;4:295-301.
10. Rabago D, Zgierska A, Mundt M, Barrett B, Bobula J, Maberry R. Efficacy of daily hypertonic saline nasal irrigation among patients with sinusitis: a randomized controlled trial. J Fam Pract 2002;51:1049-1055.
11. Bachmann G, Hommel G, Michel O. Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. Eur Arch Otorhinolaryngol 2000;257:537-541.
12. Heatley DG, McConnell KE, Kille TL, Leverson GE. Nasal irrigation for the alleviation of sinonasal symptoms. Otolaryngol Head Neck Surg 2001;125:44-48.
13. Pinto JM, Elwany S, Baroody FM, Naclerio RM. Effects of saline sprays on symptoms after endoscopic sinus surgery. Am J Rhinol 2006;20:191-196.
14. Hauptman G, Ryan MW. The effect of saline solutions on nasal patency and mucociliary clearance in rhinosinusitis patients. Otolaryngol Head Neck Surg 2007;137:815-821.
15. Pynnonen MA, Mukerji SS, Kim HM, Adams ME, Terrell JE. Nasal saline for chronic sinonasal symptoms: a randomized controlled trial. Arch Otolaryngol Head Neck Surg 2007;133:1115-1120.
16. Freeman SR, Sivayoham ES, Jepson K, de Carpentier J. A preliminary randomised controlled trial evaluating the efficacy of saline douching following endoscopic sinus surgery. Clin Otolaryngol 2008;33:462-465.
17. Liang KL, Su MC, Tseng HC, Jiang RS. Impact of pulsatile nasal irrigation on the prognosis of functional endoscopic sinus surgery. J Otolaryngol Head Neck Surg 2008;37:148-153.
18. Harvey R, Hannan SA, Badia L, Scadding G. Nasal saline irrigations for the symptoms of chronic rhinosinusitis. Cochrane Database Syst Rev 2007:CD006394.
19. Nasonex. Product Information. 2010. http://www.spfiles.com/pinasonex.pdf. Accessed September 2, 2012.
20. Joe SA, Thambi R, Huang J. A systematic review of the use of intranasal steroids in the treatment of chronic rhinosinusitis. Otolaryngol Head Neck Surg 2008;139:340-347.
21. Kalish LH, Arendts G, Sacks R, Craig JC. Topical steroids in chronic rhinosinusitis without polyps: a systematic review and meta-analysis. Otolaryngol Head Neck Surg 2009;141:674-683.
22. Rudmik L, Schlosser RJ, Smith TL, Soler ZM. Impact of topical nasal steroid therapy on symptoms of nasal polyposis: a meta-analysis. Laryngoscope 2012;122:1431-1437.
23. Snidvongs K, Kalish L, Sacks R, Craig JC, Harvey RJ. Topical steroid for chronic rhinosinusitis without polyps. Cochrane Database Syst Rev 2011:CD009274.
24. Snidvongs K, Kalish L, Sacks R, R. S, D. C, Harvey RJ. Topical steroids for nasal polyps. Cochrane Database Syst Rev 2012.
25. DelGaudio JM, Wise SK. Topical steroid drops for the treatment of sinus ostia stenosis in the postoperative period. Am J Rhinol 2006;20:563-567.
26. Rotenberg BW, Zhang I, Arra I, Payton KB. Postoperative care for Samter's triad patients undergoing endoscopic sinus surgery: a double-blinded, randomized controlled trial. Laryngoscope 2011;121:2702-2705.
27. Steinke JW, Payne SC, Tessier ME, Borish LO, Han JK, Borish LC. Pilot study of budesonide inhalant suspension irrigations for chronic eosinophilic sinusitis. J Allergy Clin Immunol 2009;124:1352-1354.e7.
28. Snidvongs K, Pratt E, Chin D, Sacks R, Earls P, Harvey RJ. Corticosteroid nasal irrigations after endoscopic sinus surgery in the management of chronic rhinosinusitis. Int Forum Allergy Rhinol 2012.
29. Sachanandani NS, Piccirillo JF, Kramper MA, Thawley SE, Vlahiotis A. The effect of nasally administered budesonide respules on adrenal cortex function in patients with chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg 2009;135:303-307.
30. Kanowitz SJ, Batra PS, Citardi MJ. Topical budesonide via mucosal atomization device in refractory postoperative chronic rhinosinusitis. Otolaryngol Head Neck Surg 2008;139:131-136.
31. Bhalla RK, Payton K, Wright ED. Safety of budesonide in saline sinonasal irrigations in the management of chronic rhinosinusitis with polyposis: lack of significant adrenal suppression. J Otolaryngol Head Neck Surg 2008;37:821-825.
32. Welch KC, Thaler ER, Doghramji LL, Palmer JN, Chiu AG. The effects of serum and urinary cortisol levels of topical intranasal irrigations with budesonide added to saline in patients with recurrent polyposis after endoscopic sinus surgery. Am J Rhinol Allergy 2010;24:26-28.
33. Cervin A, Wallwork B. Macrolide therapy of chronic rhinosinusitis. Rhinology 2007;45:259-267.
34. Soler ZM, Smith TL. What is the role of long-term macrolide therapy in the treatment of recalcitrant chronic rhinosinusitis? Laryngoscope 2009;119:2083-2084.
35. Sykes DA, Wilson R, Chan KL, Mackay IS, Cole PJ. Relative importance of antibiotic and improved clearance in topical treatment of chronic mucopurulent rhinosinusitis. A controlled study. Lancet 1986;2:359-360.
36. Desrosiers MY, Salas-Prato M. Treatment of chronic rhinosinusitis refractory to other treatments with topical antibiotic therapy delivered by means of a large-particle nebulizer: results of a controlled trial. Otolaryngol Head Neck Surg 2001;125:265-269.
37. Videler WJ, van Drunen CM, Reitsma JB, Fokkens WJ. Nebulized bacitracin/colimycin: a treatment option in recalcitrant chronic rhinosinusitis with Staphylococcus aureus? A double-blind, randomized, placebo-controlled, cross-over pilot study. Rhinology 2008;46:92-98.
38. Lim M, Citardi MJ, Leong JL. Topical antimicrobials in the management of chronic rhinosinusitis: a systematic review. Am J Rhinol 2008;22:381-389.
39. Kamijyo A, Matsuzaki Z, Kikushima K, et al. Fosfomycin nebulizer therapy to chronic sinusitis. Auris Nasus Larynx 2001;28:227-232.
40. Kobayashi T, Baba S. Topical use of antibiotics for paranasal sinusitis. Rhinol Suppl 1992;14:77-81.
41. Leonard DW, Bolger WE. Topical antibiotic therapy for recalcitrant sinusitis. Laryngoscope 1999;109:668-670.
42. Solares CA, Batra PS, Hall GS, Citardi MJ. Treatment of chronic rhinosinusitis exacerbations due to methicillin-resistant Staphylococcus aureus with mupirocin irrigations. Am J Otolaryngol 2006;27:161-165.
43. Le T, Psaltis A, Tan LW, Wormald PJ. The efficacy of topical antibiofilm agents in a sheep model of rhinosinusitis. Am J Rhinol 2008;22:560-567.
44. Uren B, Psaltis A, Wormald PJ. Nasal lavage with mupirocin for the treatment of surgically recalcitrant chronic rhinosinusitis. Laryngoscope 2008;118:1677-1680.
45. Jervis-Bardy J, Wormald PJ. Microbiological outcomes following mupirocin nasal washes for symptomatic, Staphylococcus aureus-positive chronic rhinosinusitis following endoscopic sinus surgery. Int Forum Allergy Rhinol 2012;2:111-115.
46. Vaughan WC, Carvalho G. Use of nebulized antibiotics for acute infections in chronic sinusitis. Otolaryngol Head Neck Surg 2002;127:558-568.
47. Whatley WS, Chandra RK, MacDonald CB. Systemic absorption of gentamicin nasal irrigations. Am J Rhinol 2006;20:251-254.
48. Wong KK, Marglani O, Westerberg BD, Javer AR. Systemic absorption of topical gentamicin sinus irrigation. J Otolaryngol Head Neck Surgery 2008;37:395-398.
49. Cheer SM, Waugh J, Noble S. Inhaled tobramycin (TOBI): a review of its use in the management of Pseudomonas aeruginosa infections in patients with cystic fibrosis. Drugs 2003;63:2501-2520.
50. Conway SP. Nebulized antibiotic therapy: the evidence. Chron Respir Dis 2005;2:35-41.
51. Alothman GA, Ho B, Alsaadi MM, et al. Bronchial constriction and inhaled colistin in cystic fibrosis. Chest 2005;127:522-529.
52. Arias CA, Murray BE. Antibiotic-resistant bugs in the 21st century-a clinical super-challenge. N Engl J Med 2009;360:439-443.
53. Ebbens FA, Georgalas C, Rinia AB, van Drunen CM, Lund VJ, Fokkens WJ. The fungal debate: where do we stand today? Rhinology 2007;45:178-189.
54. Ponikau JU, Sherris DA, Kern EB, et al. The diagnosis and incidence of allergic fungal sinusitis. Mayo Clin Proc 1999;74:877-884.
55. Ponikau JU, Sherris DA, Kita H, Kern EB. Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis. J Allergy Clin Immunol 2002;110:862-866.
56. Sacks PL, Harvey RJ, Rimmer J, Gallagher RM, Sacks R. Topical and systemic antifungal therapy for the symptomatic treatment of chronic rhinosinusitis. Cochrane Database Syst Rev 2011:CD008263.
57. Ebbens FA, Scadding GK, Badia L, et al. Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis. J Allergy Clin Immunol 2006;118:1149-1156.
58. Gerlinger I, Fittler A, Fonai F, Patzko A, Mayer A, Botz L. Postoperative application of amphotericin B nasal spray in chronic rhinosinusitis with nasal polyposis, with a review of the antifungal therapy. Eur Arch Otorhinolaryngol 2009;266:847-855.
59. Liang KL, Su MC, Shiao JY, et al. Amphotericin B irrigation for the treatment of chronic rhinosinusitis without nasal polyps: a randomized, placebo-controlled, double-blind study. Am J Rhinol 2008;22:52-58.
60. Ponikau JU, Sherris DA, Weaver A, Kita H. Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo-controlled, double-blind pilot trial. J allergy Clin Immunol 2005;115:125-131.
61. Weschta M, Rimek D, Formanek M, Polzehl D, Podbielski A, Riechelmann H. Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial. J allergy Clin Immunol 2004;113:1122-1128.
62. Isaacs S, Fakhri S, Luong A, Citardi MJ. A meta-analysis of topical amphotericin B for the treatment of chronic rhinosinusitis. Int Forum Allergy Rhinol 2011;1:250-254.
63. Ebbens FA, Georgalas C, Luiten S, et al. The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: a multicenter randomized controlled study. Laryngoscope 2009;119:401-408.
64. Weschta M, Rimek D, Formanek M, Podbielski A, Riechelmann H. Effect of nasal antifungal therapy on nasal cell activation markers in chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg 2006;132:743-747.
65. Chiu AG, Palmer JN, Woodworth BA, et al. Baby shampoo nasal irrigations for the symptomatic post-functional endoscopic sinus surgery patient. Am J Rhinol 2008;22:34-37.
66. Isaacs S, Fakhri S, Luong A, Whited C, Citardi MJ. The effect of dilute baby shampoo on nasal mucociliary clearance in healthy subjects. Am J Rhinol Allergy 2011;25:e27-e29.
67. NeilMed Pharmaceuticals. SinuSurf® Information. August 2011. http://www.neilmed.com/usa/ssinfo.php. Accessed September 2, 2012.
68. Jervis-Bardy J, Foreman A, Bray S, Tan L, Wormald PJ. Methylglyoxal-infused honey mimics the anti-Staphylococcus aureus biofilm activity of manuka honey: potential implication in chronic rhinosinusitis. Laryngoscope 2011;121:1104-1107.
69. Alandejani T, Marsan J, Ferris W, Slinger R, Chan F. Effectiveness of honey on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. Otolaryngol Head Neck Surg 2009;141:114-118.
70. Kilty SJ, AlMutairi D, Duval M, Groleau MA, De Nanassy J, Gomes MM. Manuka honey: histological effect on respiratory mucosa. Am J Rhinol Allergy 2010;24:e63-e6.
71. Thamboo A, Thamboo A, Philpott C, Javer A, Clark A. Single-blind study of manuka honey in allergic fungal rhinosinusitis. Otolaryngol Head Neck Surg 2011;40:238-243.
72. Brown CL, Graham SM, Cable BB, Ozer EA, Taft PJ, Zabner J. Xylitol enhances bacterial killing in the rabbit maxillary sinus. Laryngoscope 2004;114:2021-2024.
73. Kurola P, Tapiainen T, Sevander J, et al. Effect of xylitol and other carbon sources on Streptococcus pneumoniae biofilm formation and gene expression in vitro. APMIS 2011;119:135-142.
74. Weissman JD, Fernandez F, Hwang PH. Xylitol nasal irrigation in the management of chronic rhinosinusitis: a pilot study. Laryngoscope 2011;121:2468-2472.