Etiology, clinical profile, and inhospital mortality of acute-on-chronic liver failure: A prospective study

Indian Journal of Gastroenterology

Volumn 32, Issue 2, 2013, Pages 108-114

  Jha, Ashish Kumar ^a   Nijhawan, Sandeep ^a   Rai, Ramesh Roop ^a   Nepalia, Subhash ^a   Jain, Pankaj ^a   Suchismita, Arya ^a  

^a SMS MEDICAL COLLEGE   (India)

Author keywords

Acute insults; Dengue; Malaria

Indexed keywords

ACUTE LIVER FAILURE; ADULT; ARTICLE; AUTOIMMUNE DISEASE; CAUSE OF DEATH; CHRONIC LIVER FAILURE; CLINICAL FEATURE; DENGUE; FEMALE; HEPATITIS; HUMAN; INDIA; JAUNDICE; MAJOR CLINICAL STUDY; MALARIA; MALE; MORTALITY; NONHUMAN; PATIENT ASSESSMENT; PLASMODIUM FALCIPARUM; PROSPECTIVE STUDY; TERTIARY HEALTH CARE;

EID: 84876109238     PISSN: 02548860     EISSN: 09750711     Source Type: Journal    
DOI: 10.1007/s12664-012-0295-9     Document Type: Article

References (43)

1. Sarin SK, Kumar A, Almeida JA, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL). Hepatol Int. 2009; 3: 269-82.
2. Sen S, Williams R, Jalan R. The pathophysiological basis of acute-on-chronic liver failure. Liver. 2002; 22 Suppl 2: 5-13.
3. Sen S, Davies NA, Mookerjee RP, et al. Pathophysiological effects of albumin dialysis in acute-on-chronic liver failure: a randomized controlled study. Liver Transpl. 2004; 10: 1109-19.
4. Laleman W, Wilmer A, Evenepoel P, et al. Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acute-on-chronic alcoholic liver failure. Crit Care. 2006; 10: R108.
5. Cui YL, Yan F, Wang YB, et al. Nucleoside analogue can improve the long-term prognosis of patients with hepatitis B virus infection-associated acute on chronic liver failure. Dig Dis Sci. 2010; 55: 2373-80.
6. Yu JW, Sun LJ, Zhao YH, Li SC. Prediction value of model for end-stage liver disease scoring system on prognosis in patients with acute-on-chronic hepatitis B liver failure after plasma exchange and lamivudine treatment. J Gastroenterol Hepatol. 2008; 23: 1242-9.
7. Acharya SK, Sharma PK, Singh R, et al. Hepatitis E virus (HEV) infection in patients with cirrhosis is associated with rapid decompensation and death. J Hepatol. 2007; 46: 387-94.
8. Kumar M, Sharma BC, Sarin SK. Hepatitis E virus as an etiology of acute exacerbation of previously unrecognized asymptomatic patients with hepatitis B virus-related chronic liver disease. J Gastroenterol Hepatol. 2008; 23: 883-7.
9. Radha Krishna Y, Saraswat VA, Das K, et al. Clinical features and predictors of outcome in acute hepatitis A and hepatitis E virus hepatitis on cirrhosis. Liver Int. 2009; 29: 392-8.
10. Ramachandran J, Eapen CE, Kang G, et al. Hepatitis E super-infection produces severe decompensation in patients with chronic liver disease. J Gastroenterol Hepatol. 2004; 19: 134-8.
11. Kumar A, Aggarwal R, Naik SR, Saraswat V, Ghoshal UC, Naik S. Hepatitis E virus is responsible for decompensation of chronic liver disease in an endemic region. Indian J Gastroenterol. 2004; 23: 59-62.
12. Monga R, Garg S, Tyagi P, Kumar N. Superimposed acute hepatitis E infection in patients with chronic liver disease. Indian J Gastroenterol. 2004; 23: 50-2.
13. Mahtab MA, Rahman S, Khan M, Karim MF. Hepatitis E virus is a leading cause of acute-on-chronic liver disease: experience from a tertiary centre in Bangladesh. Hepatob Pancreat Dis Int. 2009; 8: 50-2.
14. Duseja A, Chawla YK, Dhiman RK, Kumar A, Choudhary N, Taneja S. Non-hepatic insults are common acute precipitants in patients with acute on chronic liver failure (ACLF). Dig Dis Sci. 2010; 55: 3188-92.
15. Rajneesh AR, Rangan K, Thomas V. Acute on chronic liver failure. Calicut Med J. 2011; 9: e6.
16. El Sayed Zaki M, Othman W. Role of hepatitis E infection in acute on chronic liver failure in Egyptian patients. Liver Int. 2011; 31: 1001-5.
17. Jha AK, Nijhawan S, Suchismita A. Sepsis in acute on chronic liver failure. Dig Dis Sci. 2011; 56: 1245-6.
18. Jalan R, Williams R. Acute-on-chronic liver failure: pathophysiological basis of therapeutic options. Blood Purif. 2002; 20: 252-61.
19. Gustot T, Durand F, Lebrec D, Vincent JL, Morea R. Severe sepsis in cirrhosis. Hepatology. 2009; 50: 2022-33.
20. Wasmuth HE, Kunz D, Yagmur E, et al. Patients with acute on chronic liver failure display "sepsis-like" immune paralysis. J Hepatol. 2005; 42: 195-201.
21. Katoonizadeh A, Laleman W, Verslype C, et al. Early features of acute-on-chronic alcoholic liver failure: a prospective cohort study. Gut. 2010; 59: 1561-9.
22. Mookerjee RP, Stadlbauer V, Lidder S, et al. Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts outcome. Hepatology. 2007; 46: 831-40.
23. Chung RT, Friedman LS. Bacterial, parasitic, and fungal infections of the liver, including liver abscess. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 8th ed. Philadelphia: Saunders; 2006. p. 1731.
24. Deepak NA, Patel ND. Differential diagnosis of acute liver failure in India. Ann Hepatol. 2006; 5: 150-6.
25. Mudawi HM, Yousif BA. Fulminant hepatic failure in an African setting: etiology, clinical course, and predictors of mortality. Dig Dis Sci. 2007; 52: 3266-9.
26. Devarbhavi H, Alvares JF, Kumar KS. Severe falciparum malaria simulating fulminant hepatic failure. Mayo Clin Proc. 2005; 80: 355-8.
27. Ghoshal UC, Somani S, Chetri K, Akhtar P, Aggarwal R, Naik SR. Plasmodium falciparum and hepatitis E virus co-infection in fulminant hepatic failure. Indian J Gastroenterol. 2001; 20: 111.
28. Osorio J, Carvajal C, Sussman O, Buitrago R, Franco-Paredes C. Acute liver failure due to dengue virus infection. Int J Infect Dis. 2008; 12: 444-5.
29. Itha S, Kashyap R, Krishnani N, Saraswat VA, Choudhuri G, Aggarwal R. Profile of liver involvement in dengue virus infection. Natl Med J India. 2005; 18: 127-30.
30. Vinodh BN, Bammigatti C, Kumar A, Mittal V. Dengue fever with acute liver failure. J Postgrad Med. 2005; 51: 322-3.
31. Souza LJ, Coelho JM, Silva EJ, et al. Acute hepatitis due to dengue virus in a chronic hepatitis patient. Braz J Infect Dis. 2008; 12: 456-9.
32. Gharsangi K. Dengue causing fulminant hepatitis in a hepatitis B virus carrier. Biosci Trends. 2011; 5: 44-5.
33. Carvalho de Macedo F, Nicol AF, Cooper LD, et al. Histologic, viral, and molecular correlates of dengue fever infection of the liver using highly sensitive immunohistochemistry. Diagn Mol Pathol. 2006; 15: 223-8.
34. Couvelard A, Marianneau P, Bedel C, et al. Report of a fatal case of dengue infection with hepatitis: demonstration of dengue antigens in hepatocytes and liver apoptosis. Hum Pathol. 1999; 30: 1106-10.
35. Alcon-LePoder S, Drouet MT, Roux P, et al. The secreted form of dengue virus nonstructural protein NS1 is endocytosed by hepatocytes and accumulates in late endosomes: implications for viral infectivity. J Virol. 2005; 79: 11403-11.
36. Vázquez-Pichardoa M, Rosales-Jiménezb C, Rojas-Espinosaa O, López-Martínezb I, Moreno-Altamirano MMB. Is liver damage dependent on the serotype of dengue virus?-a study in Mexico. Dengue Bull. 2006; 30: 114-20.
37. Kato H, Ikeuchi H, Nakamura M. Acute exacerbation of liver disease induced by pegylated interferon alpha2a treatment for chronic hepatitis C. Int J Clin Med. 2010; 1: 1-5.
38. Kogure T, Ueno Y, Fukushima K, et al. Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-interferon-alpha 2b plus ribavirin treatment. World J Gastroenterol. 2007; 13: 4394-7.
39. Mao Q, Zhang HY, You JP, Zhang XQ. Severe acute exacerbation of chronic hepatitis B during pegylated interferon treatment and early intervention with corticosteroid. Virol J. 2012; 9: 136.
40. Ripoll C, Groszmann R, Garcia-Tsao G, Portal Hypertension Collaborative Group, et al. Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis. Gastroenterology. 2007; 133: 481-8.
41. Jalan R, Gines P, Olson JC, et al. Acute-on chronic liver failure. J Hepatol. 2012; 57: 1336-48.
42. Khuroo MS, Khuroo MS, Farahat KL. Molecular adsorbent recirculating system for acute and acute-on-chronic liver failure: a meta-analysis. Liver Transpl. 2004; 10: 1099-106.
43. Chan AC, Fan ST, Lo CM, et al. Liver transplantation for acute-on-chronic liver failure. Hepatol Int. 2009; 3: 571-81.